· 肝脏发育和成体肝脏干细胞的分子调控机理研究；

· 环境因素及酒精的先天致畸原理和预防研究；

· 组织修复，纤维化及成体干细胞功能的调控探讨；

· 人群中胆固醇状况，Hedgehog信息通路与成体干细胞健康和老化研究

·  生物标志物筛选和疾病基因诊断的研发

   

071010-生物化学与分子生物学

干细胞与组织修复和再生

1987-09--1991-06   协和医科大学   博士
1979-09--1985-06   中南大学湘雅医学院   学士

分子发育学
分子发育学和细胞生物学

   

[1] 李尹雄, 熊月, 方霁. 一种人胰高血糖素样肽-1受体激活剂及其应用. CN: CN112451515A, 2021-03-09.

[2] 李尹雄, 游凯. SAA抑制剂在制备治疗急性肝损伤、急性肝衰竭或慢加急性肝衰竭的药物中的应用. CN: CN111920953A, 2020-11-13.

[3] 李尹雄, 陈彦, 游凯, 谭圣林. 一种病毒性肺炎的标志物及其应用. CN: CN113376386A, 2021-09-10.

[4] 李尹雄, 伍飞马, 陈彦, 谭圣林, 潘廷才. 一种淘选和扩增培养肝脏干细胞的方法及其应用. CN: CN111500528A, 2020-08-07.

[5] 李尹雄, 王宁, 庄苑琦, 袁方. 一种抗体及其制备方法和应用. CN: CN111499739B, 2022-03-25.

[6] 李尹雄, 潘廷才, 陈彦, 庄苑琦, 杨帆. 一种培养扩增人肝祖细胞的培养基及其应用. CN: CN111607556A, 2020-09-01.

[7] 吴芬芳, 陈立勇, 寇尚龙, 侯健, 李尹雄. 一种CIDE3多肽及其抗体的制备和应用. CN: CN104311654A, 2015-01-28.

[8] 李尹雄, 庄苑琦, 潘廷才, 陈彦. 一种组合物及其应用. CN: CN111500525B, 2023-05-02.

   

[1] You, Kai, Wang, Yan, Chen, Xiaoxia, Yang, Zhen, Chen, Yan, Tan, Shenglin, Tao, Jiawang, Getachew, Anteneh, Pan, Tingcai, Xu, Yingying, Zhuang, Yuanqi, Yang, Fan, Lin, Xianhua, Li, Yinxiong. Neutralizing serum amyloid a protects against sinusoidal endothelial cell damage and platelet aggregation during acetaminophen-induced liver injury. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2023, 第 14 作者  通讯作者  639: 20-28, http://dx.doi.org/10.1016/j.bbrc.2022.11.079.
[2] zhiwu jiang, Lin Cheng, Zhiping Wu, Linfu Zhou, Haitao Wang, Qilan Hong, Qiting Wu, Youguo Long, Yunlin Huang, Gaoqi Xu, Zhaoyang Tang, Yao Yao, Zhenfeng Zhang, Lili Yang, Wei Luo, Jie Yang, Likun Gong, Pentao Liu, Xinwen Chen, Shuzhong Cui, Qi Zhang, Yinxiong Li, Peng Li. Transforming primary human hepatocytes into hepatocellular carcinoma with genetically defined factors. EMBOREPORTS[J]. 2022, 第 22 作者  通讯作者  23(6): https://www.embopress.org/doi/abs/10.15252/embr.202154275.
[3] Pan, Tingcai, Wang, Ning, Zhang, Jiaye, Yang, Fan, Chen, Yan, Zhuang, Yuanqi, Xu, Yingying, Fang, Ji, You, Kai, Lin, Xianhua, Li, Yang, Li, Shao, Liang, Kangyan, Li, YinXiong, Gao, Yi. Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy. STEM CELL RESEARCH & THERAPY[J]. 2022, 第 14 作者  通讯作者  13(1): http://dx.doi.org/10.1186/s13287-022-02831-1.
[4] Tao, Jiawang, Chen, Yan, Zhuang, Yuanqi, Wei, Ruzhi, Getachew, Anteneh, Pan, Tingcai, Yang, Fan, Li, Yinxiong. Inhibition of Hedgehog Delays Liver Regeneration through Disrupting the Cell Cycle. CURRENT ISSUES IN MOLECULAR BIOLOGY[J]. 2022, 第 8 作者  通讯作者  44(2): 470-482, http://dx.doi.org/10.3390/cimb44020032.
[5] Li, Penghui, Liu, Ying, Cheng, Ziqi, Yu, Xiaorui, Li, Yinxiong. COVID-19-associated liver injury: Clinical characteristics, pathophysiological mechanisms and treatment management. BIOMEDICINE & PHARMACOTHERAPY. 2022, 第 5 作者  通讯作者  154: http://dx.doi.org/10.1016/j.biopha.2022.113568.
[6] Yang, Zhen, Huang, Xinping, Zhang, Jiaye, You, Kai, Xiong, Yue, Fang, Ji, Getachew, Anteneh, Cheng, Ziqi, Yu, Xiaorui, Wang, Yan, Wu, Feima, Wang, Ning, Feng, Shufen, Lin, Xianhua, Yang, Fan, Chen, Yan, Wei, Hongcheng, Li, Yinxiong. Hepatic DKK1-driven steatosis is CD36 dependent. LIFE SCIENCE ALLIANCE[J]. 2022, 第 18 作者  通讯作者  6(2): http://dx.doi.org/10.26508/lsa.202201665.
[7] Cheng, Ziqi, Guo, Dongsheng, Ruzi, Aynisahan, Pan, Tingcai, You, Kai, Chen, Yan, Huang, Xinping, Zhang, Jiaye, Yang, Fan, Niu, Lizhi, Xu, Kecheng, Li, YinXiong. Modeling MEN1 with Patient-Origin iPSCs Reveals GLP-1R Mediated Hypersecretion of Insulin. CELLS[J]. 2022, 第 12 作者  通讯作者  11(15): http://dx.doi.org/10.3390/cells11152387.
[8] Yue Xiong, Yan Chen, Xinping Huang, Zhen Yang, Jiaye Zhang, Xiaorui Yu, Ji Fang, Jiawang Tao, Kai You, Ziqi Cheng, Shenglin Tan, Yingying Xu, Fang Yuan, Ying Liu, Yuanqi Zhuang, Fan Yang, Yinxiong Li. Icaritin ameliorates hepatic steatosis via promoting fatty acid β-oxidation and insulin sensitivity. LIFE SCIENCES. 2021, 第 17 作者  通讯作者  268: http://dx.doi.org/10.1016/j.lfs.2020.119000.
[9] Pan, Tingcai, Tao, Jiawang, Chen, Yan, Zhang, Jiaye, Getachew, Anteneh, Zhuang, Yuanqi, Wang, Ning, Xu, Yingying, Tan, Shenglin, Fang, Ji, Yang, Fan, Lin, Xianhua, You, Kai, Gao, Yi, Li, Yinxiong. Robust expansion and functional maturation of human hepatoblasts by chemical strategy. STEM CELL RESEARCH & THERAPY[J]. 2021, 第 15 作者  通讯作者  12(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7908723/.
[10] Getachew, Anteneh, Abbas, Nasir, You, Kai, Yang, Zhen, Hussain, Muzammal, Huang, Xinping, Cheng, Ziqi, Tan, Shenglin, Tao, Jiawang, Yu, Xiaorui, Chen, Yan, Yang, Fan, Pan, Tingcai, Xu, Yingying, Xu, Guosheng, Zhuang, Yuanqi, Wu, FeiMa, Li, Yinxiong. SAA1/TLR2 axis directs chemotactic migration of hepatic stellate cells responding to injury. ISCIENCE[J]. 2021, 第 18 作者  通讯作者  24(5): http://dx.doi.org/10.1016/j.isci.2021.102483.
[11] Yuan, Fang, Wang, Ning, Chen, Yan, Huang, Xinping, Yang, Zhen, Xu, Yingying, You, Kai, Zhang, Jiaye, Wang, Guodong, Zhuang, Yuanqi, Pan, Tingcai, Xiong, Yue, Yu, Xiaorui, Yang, Fan, Li, Yinxiong. Calcitriol promotes the maturation of hepatocyte-like cells derived from human pluripotent stem cells. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY[J]. 2021, 第 15 作者  通讯作者  211: http://dx.doi.org/10.1016/j.jsbmb.2021.105881.
[12] Getachew, Anteneh, Hussain, Muzammal, Huang, Xinping, Li, Yinxiong. Toll-like receptor 2 signaling in liver pathophysiology. LIFE SCIENCES. 2021, 第 4 作者  通讯作者  284: http://dx.doi.org/10.1016/j.lfs.2021.119941.
[13] Yang, Zhen, Yuan, Fang, Wang, Ning, Liu, Yanli, Zhang, Jiaye, Wei, Ruzhi, Wu, FeiMa, Wu, Yuhang, You, Kai, Chen, Yan, Yang, Fan, Li, YinXiong. Generation of a DKK1 homozygous knockout human embryonic stem cell line WAe001-A-21 using CRISPR/Cas9. STEM CELL RESEARCH[J]. 2021, 第 12 作者  通讯作者  51: http://dx.doi.org/10.1016/j.scr.2021.102161.
[14] Wu, Feima, Chen, Yan, You, Kai, Tan, Shenglin, Xu, Yingying, Wang, PeiHui, Liu, Shiming, Li, Yinxiong. Generation of WAe001-A-58 human embryonic stem cell line with inducible expression of the SARS-CoV-2 nucleocapsid protein. STEM CELL RESEARCH[J]. 2021, 第 8 作者  通讯作者  53: http://dx.doi.org/10.1016/j.scr.2021.102197.
[15] Xu, Yingying, Tao, Jiawang, Yu, Xiaorui, Wu, Yuhang, Chen, Yan, You, Kai, Zhang, Jiaye, Getachew, Anteneh, Pan, Tingcai, Zhuang, Yuanqi, Yuan, Fang, Yang, Fan, Lin, Xianhua, Li, Yinxiong. Hypomorphic ASGR1 modulates lipid homeostasis via INSIG1-mediated SREBP signaling suppression. JCI INSIGHT[J]. 2021, 第 14 作者  通讯作者  6(19): 
[16] Getachew, Anteneh, Yang, Zhen, Huang, Xinping, Wu, Feima, Liu, Yan Ying, Yan, Chen, Yang, Fan, Li, Yinxiong. Generation of a TLR2 homozygous knockout human embryonic stem cell line WAe001-A-64 using CRISPR/Cas9 editing. STEM CELL RESEARCH[J]. 2021, 第 8 作者  通讯作者  54: http://dx.doi.org/10.1016/j.scr.2021.102401.
[17] Xiong, Yue, Chen, Yan, Huang, Xinping, Yang, Zhen, Zhang, Jiaye, Yu, Xiaorui, Fang, Ji, Tao, Jiawang, You, Kai, Cheng, Ziqi, Tan, Shenglin, Xu, Yingying, Yuan, Fang, Liu, Ying, Zhuang, Yuanqi, Yang, Fan, Li, Yinxiong. Icaritin ameliorates hepatic steatosis via promoting fatty acid beta-oxidation and insulin sensitivity. LIFE SCIENCES[J]. 2021, 第 17 作者  通讯作者  268: http://dx.doi.org/10.1016/j.lfs.2020.119000.
[18] Anteneh Getachew, Muzammal Hussain, Xinping Huang, Yinxiong Li. Toll-like receptor 2 signaling in liver pathophysiology. LIFE SCIENCES. 2021, 第 4 作者  通讯作者  284: http://dx.doi.org/10.1016/j.lfs.2021.119941.
[19] Fang Yuan, Yingying Xu, Kai You, Jiaye Zhang, Fan Yang, Yinxiong Li. Calcitriol alleviates ethanol-induced hepatotoxicity via AMPK/mTOR-mediated autophagy. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2021, 第 6 作者697: 
[20] Abbas, Nasir, Getachew, Anteneh, You, Kai, Shah, Zahir, Chen, Yan, Tao, Jiawang, Hussain, Muzammal, Yang, Fan, Zhuang, Yuanqi, Xu, Yingying, Li, YinXiong. Kupffer cells mediate the recruitment of hepatic stellate cells into the localized liver damage. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2020, 第 11 作者  通讯作者  529(2): 474-479, http://dx.doi.org/10.1016/j.bbrc.2020.06.041.
[21] Liu, Jingfeng, Pan, Tingcai, Chen, Yan, Liu, Ying, Yang, Fan, Chen, Qu, Abbas, Nasir, Zhong, Mingyan, Zhang, Qianbing, Xu, Yang, Li, Yinxiong. Repair of acute liver damage with immune evasive hESC derived hepatoblasts. STEM CELL RESEARCH[J]. 2020, 第 11 作者  通讯作者  49: http://dx.doi.org/10.1016/j.scr.2020.102010.
[22] Liu, Yanli, Zhang, Jiaye, Chen, Yan, Sohel, Hasan, Ke, Xinrong, Chen, Jingqi, Li, YinXiong. The correlation and role analysis of COL4A1 and COL4A2 in hepatocarcinogenesis. AGING-US[J]. 2020, 第 7 作者  通讯作者  12(1): 204-223, https://www.webofscience.com/wos/woscc/full-record/WOS:000507233100014.
[23] Xu, Yingying, Wu, Yuhang, Xiong, Yue, Tao, Jiawang, Pan, Tingcai, Tan, Shenglin, Gao, Ge, Chen, Yan, Abbas, Nasir, Getachew, Anteneh, Zhuang, Yuanqi, You, Kai, Yang, Fan, Li, Yinxiong. Ascorbate protects liver from metabolic disorder through inhibition of lipogenesis and suppressor of cytokine signaling 3 (SOCS3). NUTRITION & METABOLISM[J]. 2020, 第 14 作者  通讯作者  17(1): http://dx.doi.org/10.1186/s12986-020-0431-y.
[24] Hong, Wenxin, Chen, Yan, You, Kai, Tan, Shenglin, Wu, Feima, Tao, Jiawang, Chen, Xudan, Zhang, Jiaye, Xiong, Yue, Yuan, Fang, Yang, Zhen, Chen, Tingting, Chen, Xinwen, Peng, Ping, Tai, Qiang, Wang, Jian, Zhang, Fuchun, Li, YinXiong. Celebrex Adjuvant Therapy on Coronavirus Disease 2019: An Experimental Study. FRONTIERS IN PHARMACOLOGY[J]. 2020, 第 18 作者  通讯作者  11: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7703865/.
[25] Xu, Guosheng, Wu, Feima, Gu, Xiaotong, Zhang, Jiaye, You, Kai, Chen, Yan, Getachew, Anteneh, Zhuang, Yuanqi, Zhong, Xiaofen, Lin, Zuoxian, Guo, Dongsheng, Yang, Fan, Pan, Tingcai, Wei, Hongcheng, Li, Yinxiong. Direct Conversion of Human Urine Cells to Neurons by Small Molecules. SCIENTIFICREPORTS[J]. 2019, 第 15 作者  通讯作者  9(1): http://dx.doi.org/10.1038/s41598-019-53007-6.
[26] Pan, Tingcai, Chen, Yan, Zhuang, Yuanqi, Yang, Fan, Xu, Yingying, Tao, Jiawang, You, Kai, Wang, Ning, Wu, Yuhang, Lin, Xianhua, Wu, Feima, Liu, Yanli, Li, Yingrui, Wang, Guodong, Li, Yinxiong. Synergistic modulation of signaling pathways to expand and maintain the bipotency of human hepatoblasts. STEM CELL RESEARCH & THERAPY[J]. 2019, 第 15 作者  通讯作者  10(1): http://dx.doi.org/10.1186/s13287-019-1463-y.
[27] Wu, Feima, Gao, Ge, Pan, Tingcai, Yang, Zhen, Xu, Guosheng, Abbas, Nasir, Liu, Yanli, Chen, Yan, Tan, Shenglin, You, Kai, Ke, Xinrong, Zhuang, Yuanqi, Lin, Xianhua, Yang, Fan, Li, Yinxiong. Generation of a SMO homozygous knockout human embryonic stem cell line WAe001-A-16 by CRISPR/Cas9 editing. STEM CELL RESEARCH[J]. 2018, 第 15 作者  通讯作者  27: 5-9, https://www.webofscience.com/wos/woscc/full-record/WOS:000427533700002.
[28] He, Xiangjun, Li, YinXiong, Feng, Bo. New Turns for High Efficiency Knock-In of Large DNA in Human Pluripotent Stem Cells. STEM CELLS INTERNATIONAL[J]. 2018, 第 2 作者2018: https://doaj.org/article/2e27d4096fa14cea954b258f979373e5.
[29] Liu, Yanli, Wu, Feima, Liu, Dong, Wei, Ruzhi, Abbas, Nasir, Xia, Jianhong, Li, Dongwei, Wang, Haiyun, Zhuang, Yuanqi, Guo, Dongsheng, Chen, Yan, Wu, Yuhang, Ke, Xinrong, Tao, Jiawang, Yang, Fan, Lai, Keyu, Shu, Xiaodong, Li, Yinxiong. Generation of WAe001-A-15, a human embryonic stem cell line with miR-122 doxycycline-inducible expression. STEM CELL RESEARCH[J]. 2018, 第 18 作者  通讯作者  29: 84-87, http://dx.doi.org/10.1016/j.scr.2018.03.007.
[30] Wei, Ruzhi, Yuan, Fang, Wu, Yuhang, Liu, Yanli, You, Kai, Yang, Zhen, Chen, Yan, Getachew, Anteneh, Wang, Ning, Xu, Yingying, Zhuang, Yuanqi, Yang, Fan, Li, Yinxiong. Construction of a GLI3 compound heterozygous knockout human embryonic stem cell line WAe001-A-20 by CRISPR/Cas9 editing. STEM CELL RESEARCH[J]. 2018, 第 13 作者  通讯作者  32: 139-144, https://www.webofscience.com/wos/woscc/full-record/WOS:000447301200021.
[31] Hou, Jian, Long, Yan, Hu, Bo, Huang, Shaojie, Xu, Guangtao, Gao, Tesheng, Wu, Fenfang, Li, Yinxiong, Wu, Zhongkai. Retaining mTeSR1 Medium during Hepatic Differentiation Facilitates Hepatocyte-Like Cell Survival by Decreasing Apoptosis. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY[J]. 2018, 第 8 作者  通讯作者  51(4): 1533-1543, https://doaj.org/article/90bde15a7a4747f483293be3a03d181a.
[32] Yuan, Fang, Guo, Dongsheng, Liu, Yanli, Xu, Yingying, Gao, Ge, Wu, Yuhang, Yang, Fan, Ke, Xinrong, Lai, Keyu, Wei, Hongcheng, Li, YinXiong. Generation of an ASS1 heterozygous knockout human embryonic stem cell line, WAe001-A-13, using CRISPR/Cas9. STEM CELL RESEARCH[J]. 2018, 第 11 作者  通讯作者  26: 67-71, http://dx.doi.org/10.1016/j.scr.2017.11.007.
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[38] Dongsheng Guo, Haikun Liu, Aynisahan Ruzi, Ge Gao, Abbas Nasir, Yanli Liu, Fan Yang, Feima Wu, Guosheng Xu, Yinxiong Li. Modeling Congenital Hyperinsulinism with ABCC8-Deficient Human Embryonic Stem Cells Generated by CRISPR/Cas9. SCIENTIFIC REPORTS[J]. 2017, 第 10 作者  通讯作者  7(1): https://doaj.org/article/2eef6fa0dafc4b3492d08947d95ff76c.
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（ 1 ） 现代分子生物学实验技术, 现代分子生物学实验技术, 高等教育出版社, 1993-07, 第 1 作者

   

（ 1 ） 院启动项目, 主持, 市地级, 2011-09--2016-09
（ 2 ） 干细胞修复动物肝病模型中受损肝组织 的方法及机理研究, 主持, 国家级, 2015-01--2019-08
（ 3 ） 系统解析干细胞肝系分化及介导修复慢性肝纤维化的分子机制, 主持, 省级, 2015-07--2018-06
（ 4 ） 血液黄曲霉毒素高效特异吸附材料的研发, 主持, 省级, 2015-10--2018-09

（1）Stem cell biology and injured tissue repair   参加三城经济联盟2016奥克兰峰会   2016-05-16
（2）Adult liver stem cell identification, in vitro proliferation and function test in transplantation animal disease model   中国科学院-香港中文大学合作指导委员会第三次会议   2016-03-22
（3）肝脏干细胞修复慢性肝硬化的动物 模型研究   中国细胞生物治疗年会   2015-12-13
（4）肝脏干细胞修复慢性肝硬化的动物 模型研究   中英高层战略研讨会议   2015-12-03
（5）肝脏干细胞修复慢性肝硬化的动物 模型研究   国际生物研究进展会议   2015-11-03
（6）干细胞调控慢性肝损伤修复和再生 的动物模型探讨   第五届中澳生物医学研究大会   2015-10-30
（7）干细胞介导慢性肝损伤修复的动物 模型探讨   第六届广东省细胞生物 学学会学术年会暨第二 届广东省抗癌协会生物 治疗专业委员会学术年会   2015-10-24
（8）Liver adult stem and regeneration liver chronic diseases   2013-03-02
（9）Adult Hepatic Progenitor Cell and Injured Liver Regeneration in Fish Models   2012-10-03
（10）Hedgehog Signaling and tumorigenesis   2011-10-19
（11）Laser microdissection captured cells gene expression profile analysis hunting down ventral axis molecular players in vertebrates involved in three human genetic syndromes   2002-04-24
（12）issection of connecxin 43 promoter regulatory elements of tissue specificity   2001-08-16

已指导学生

寇尚龙  02  63228  

现指导学生

伍飞马  01  19183  

郭东升  01  19183  

庄苑琦  02  19183  

徐莹莹  01  19183  

阿依妮萨罕·如则  02  19434  

谭圣林  02  19183  

柯欣荣  02  63228  

陶家旺  02  19183  

徐国胜  01  19183  

刘艳丽  01  19183  

熊月  01  19183  

潘廷才  01  19183  

1985.07-1987.09        中国医学科学院基础所                       助理研究员

1991.07-1987.09         协和医科大学                                    助理教授

1992.10-1993.09         范德堡大学医学院                             博士后

1993.10-2001.03         乔治亚医学院                                    博士后

2001.04-2010.05         杜克大学医学院                                 助理教授

2010.06-2011.05         南卡罗莱纳医科大学                           副教授

2011.06-2012.05         美国SMT公司                                     首席技术官/副总裁

2012.05-至今              中科院广州生物医药与健康研究院        研究员/国家**A类