1. 抗抑郁症、躁狂症等情感障碍神经系统疾病的药物发现和机制研究。
2. 以钾通道为靶点的高效抑制剂的高通量筛选和单通道功能研究。
3. 钾通道的晶体结构以及调控机制的研究。

博士研究生1人，欢迎有医学、生物学、神经科学、结构生物学背景的学生报考。

100706-药理学
071006-神经生物学
071010-生物化学与分子生物学

药理学
神经科学
生物制药

1999-09--2002-07   中国科学院上海药物研究所   博士
1996-09--1999-07   华东师范大学生物系   硕士
1988-09--1992-07   山东大学生物系   学士

-- 研究生

-- 博士

2002.7-2009.8 University of Texas Southwestern Medical Center

2009.9- 至今，中国科学院上海药物研究所“****”研究员

2009-09~现在, 中国科学院上海药物研究所, 研究员
2002-07~2009-09,美国德克萨斯大学, 博士后，researcher

2018-05-04-今,中国生理学会, 分会委员
2017-04-15-今,中国神经科学学会, 分会委员
2013-08-15-今,中国神经精神药理学学会, 副秘书长
2012-12-28-今,上海老年医学学会, 理事
2012-07-01-今,Frontier in Physiology, 编委
2011-07-18-今,中国生物物理学会, 分会委员

抗抑郁的新靶点及创新中
抗抑郁的新机制
离子通道的结构与功能

   

[1] 阳怀宇, 李扬, 郭飞, 蒋华良, 张乾森. 一种预防和治疗精神障碍性疾病的化合物及其应用. CN: CN114053256B, 2023-07-18.
[2] 阳怀宇, 李扬, 郭飞, 蒋华良, 张乾森. 一种预防和治疗精神障碍性疾病的化合物及其应用. CN: CN114053256A, 2022-02-18.
[3] 黄成钢, 李扬, 蒋华良, 谢阳, 郭飞, 田小亭, 陆伊虹, 陈明苍, 郭子琼, 李志雄, 孙兆林, 郑明月. 一种抗抑郁甾体化合物. CN: CN112142817B, 2021-10-22.
[4] 阳怀宇, 李扬, 郭飞, 蒋华良, 张乾森. 作为防治精神障碍疾病的苯胺类化合物. CN: CN110878048A, 2020-03-13.
[5] 黄成钢, 李扬, 蒋华良, 谢阳, 郭飞, 陆伊虹, 李志雄, 陈明苍, 郑明月, 孙兆林, 高羽, 田小亭, 胡培, 张兵. 一种菝葜皂苷元衍生物及其制备方法和应用. CN: CN109988218A, 2019-07-09.
[6] 李扬, 阳怀宇, 蒋华良, 黄蔚, 程曦, 周斌, 柴豪. 一类嘧啶类化合物及其作为TRPV2抑制剂的用途. CN: CN110563709A, 2019-12-13.
[7] 李扬, 阳怀宇, 蒋华良, 黄蔚, 程曦, 周斌, 柴豪. 一类嘧啶类化合物及其作为TRPV2抑制剂的用途. CN: CN110563709B, 2023-01-24.
[8] 谭昌恒, 李扬, 曲世津, 郭飞, 马玉琴. 一类多巴胺D5受体激动剂及其制备和应用. CN: CN110041318A, 2019-07-23.
[9] 黄成钢, 李扬, 蒋华良, 谢阳, 郭飞, 李志雄, 陈明苍, 郑明月, 孙兆林, 高羽, 田小亭, 胡培, 张兵. 一种抗抑郁化合物及其制备方法和应用. CN: CN110121502A, 2019-08-13.
[10] 黄成钢, 李扬, 蒋华良, 谢阳, 郭飞, 李志雄, 陈明苍, 郑明月, 孙兆林, 高羽, 田小亭, 胡培, 张兵. 一种抗抑郁化合物及其制备方法和应用. CN: CN108264535A, 2018-07-10.
[11] 阳怀宇, 李扬, 郭飞, 蒋华良. 预防和治疗抑郁症的化合物及其应用. CN: CN107789354A, 2018-03-13.
[12] 阳怀宇, 李扬, 郭飞, 蒋华良. 预防和治疗抑郁症的化合物及其应用. CN: CN107789354B, 2022-02-25.
[13] 李扬, 郭飞, 张兵. 一种焦虑性抑郁症动物模型的获得方法及其应用. CN: CN107771740A, 2018-03-09.
[14] 蒋华良, 柳红, 胡国渊, 罗小民, 姚志艺, 高召兵, 周宇, 郑苏欣, 沈建华, 朱维良, 于坤千, 李扬, 谭小健, 陈凯先. N,N'－二取代哌嗪类衍生物及其制备方法、药物组合物和用途. CN: CN101007794A, 2007-08-01.

编写《高等药理学》中的离子通道药理学三章

[1] Ma, Yuqin, Luo, Qichao, Fu, Jie, Che, Yanxin, Guo, Fei, Mei, Lianghe, Zhang, Qiansen, Li, Yang, Yang, Huaiyu. Discovery of an Inhibitor for the TREK-1 Channel Targeting an Intermediate Transition State of Channel Gating. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2020, 第 8 作者  通讯作者  63(19): 10972-10983, https://www.webofscience.com/wos/woscc/full-record/WOS:000580558700019.
[2] Zhang, Sensen, Liu, Yang, Zhang, Bing, Zhou, Jun, Li, Tianyu, Liu, Zhiqiang, Li, Yang, Yang, Maojun. Molecular insights into the human CLC-7/Ostm1 transporter. SCIENCE ADVANCES[J]. 2020, 第 7 作者  通讯作者  6(33): https://www.webofscience.com/wos/woscc/full-record/WOS:000560465800027.
[3] Li, Qian, Zhang, Bing, Cao, Hang, Liu, Wei, Guo, Fei, Shen, Fuyi, Ye, Binglu, Liu, Huan, Li, Yang, Liu, Zhiqiang. Oxytocin Exerts Antidepressant-like effect by potentiating dopaminergic synaptic transmission in the mPFC. NEUROPHARMACOLOGY[J]. 2020, 第 9 作者  通讯作者  162: http://dx.doi.org/10.1016/j.neuropharm.2019.107836.
[4] Ali, Tahir, Hao, Qiang, Ullah, Najeeb, Rahman, Shafiq Ur, Shah, Fawad Ali, He, Kaiwu, Zheng, Chengyou, Li, Weifen, Murtaza, Iram, Li, Yang, Jiang, Yuhua, Tan, Zhen, Li, Shupeng. Melatonin Act as an Antidepressant via Attenuation of Neuroinflammation by Targeting Sirt1/Nrf2/HO-1 Signaling. FRONTIERS IN MOLECULAR NEUROSCIENCE[J]. 2020, 第 10 作者13: https://doaj.org/article/49b3ef1420eb4bfe93c36ed08bbf3666.
[5] 李扬. 抗抑郁的新靶点与新机制研究. 2019, 第 1 作者34, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CPFD&dbname=CPFDLAST2019&filename=ZGDV201908001011&v=MTI3NzFxcXhkRWVNT1VLcmlmWmVadkhpbmlVTDNKSlYwZFB5clBlTEc0SDlqTXA0OUZaZXNPRFJOS3VoZGhuajk4VG5q.
[6] Yu, Jie, Zhang, Bing, Zhang, Yixiao, Xu, Congqiao, Zhuo, Wei, Ge, Jingpeng, Li, Jun, Gao, Ning, Li, Yang, Yang, Maojun. A binding-block ion selective mechanism revealed by a Na/K selective channel (vol 9, pg 629, 2018). PROTEIN & CELL. 2019, 第 9 作者  通讯作者  10(7): 543-543, http://dx.doi.org/10.1007/s13238-019-0619-y.
[7] Chai, Hao, Cheng, Xi, Zhou, Bin, Zhao, Lifen, Lin, Xianhua, Huang, Dongping, Lu, Weiqiang, Lv, Hao, Tang, Feng, Zhang, Qiansen, Huang, Wei, Li, Yang, Yang, Huaiyu. Structure-Based Discovery of a Subtype-Selective Inhibitor Targeting a Transient Receptor Potential Vanilloid Channel. Journal of Medicinal Chemistry[J]. 2019, 第 12 作者  通讯作者  62(3): 1373-1384, https://www.webofscience.com/wos/woscc/full-record/WOS:000459223600019.
[8] Yu, Jie, Zhang, Bing, Zhang, Yixiao, Xu, Congqiao, Zhuo, Wei, Ge, Jingpeng, Li, Jun, Gao, Ning, Li, Yang, Yang, Maojun. A binding-block ion selective mechanism revealed by a Na/K selective channel. PROTEIN & CELL[J]. 2018, 第 9 作者  通讯作者  9(7): 629-639, http://lib.cqvip.com/Qikan/Article/Detail?id=675643741.
[9] 郭飞, 张兵, 李扬. 新型化合物YY-21快速抗抑郁机制研究. 中国药理学与毒理学杂志[J]. 2018, 第 3 作者32(9): 730-730, http://lib.cqvip.com/Qikan/Article/Detail?id=6100099641.
[10] LI Yang, GUO Fei, MA Yuqin. K2P channels and NMDA receptor as new targets of fast onset antidepressants. 中国药理学与毒理学杂志[J]. 2018, 第 1 作者32(9): 711-711, http://lib.cqvip.com/Qikan/Article/Detail?id=6100099612.
[11] Shen, FuYi, Song, YingCai, Guo, Fei, Xu, ZhenDong, Li, Qian, Zhang, Bing, Ma, YuQin, Zhang, YueQi, Lin, Rong, Li, Yang, Liu, ZhiQiang. Cognitive Impairment and Endoplasmic Reticulum Stress Induced by Repeated Short-Term Sevoflurane Exposure in Early Life of Rats. FRONTIERS IN PSYCHIATRY[J]. 2018, 第 10 作者  通讯作者  9: https://doaj.org/article/b3c15004235544198e40cdba4fc8d582.
[12] Jie Yu, Bing Zhang, Yixiao Zhang, Congqiao Xu, Wei Zhuo, Jingpeng Ge, Jun Li, Ning Gao, Yang Li, Maojun Yang. A binding-block ion selective mechanism revealed by a Na/K selective channel. PROTEIN & CELL[J]. 2017, 第 9 作者9(7): 629-639, https://doaj.org/article/3c1876a7c53b416087e564b5599f36a0.
[13] Song, Yingcai, Zhang, Bing, Guo, Fei, Yang, Maojun, Li, Yang, Liu, ZhiQiang. Identification of Intracellular beta-Barrel Residues Involved in Ion Selectivity in the Mechanosensitive Channel of Thermoanaerobacter tengcongensis. FRONTIERS IN PHYSIOLOGY[J]. 2017, 第 5 作者  通讯作者  8: http://dx.doi.org/10.3389/fphys.2017.00832.
[14] Qichao Luo, Liping Chen, Xi Cheng, Yuqin Ma, Xiaona Li, Bing Zhang, Li Li, Shilei Zhang, Fei Guo, Yang Li, Huaiyu Yang. An allosteric ligand-binding site in the extracellular cap of K2P channels. Nature Communications[J]. 2017, 第 10 作者  通讯作者  8(1): https://doaj.org/article/035f4dcedb464c76988ae02317b4a10b.
[15] Zhang, Bing, Guo, Fei, Ma, Yuqin, Song, Yingcai, Lin, Rong, Shen, FuYi, Jin, GuoZhang, Li, Yang, Liu, ZhiQiang. Activation of D1R/PKA/mTOR signaling cascade in medial prefrontal cortex underlying the antidepressant effects of l-SPD. SCIENTIFIC REPORTS[J]. 2017, 第 8 作者  通讯作者  7(1): https://doaj.org/article/8fda276857c044b6b4df46fe5d93ac53.
[16] Wang, QiaoChu, Zheng, Qiaoxia, Tan, Haiyan, Zhang, Bing, Li, Xiaoling, Yang, Yuxiu, Yu, Jie, Liu, Yang, Chai, Hao, Wang, Xi, Sun, Zhongshuai, Wang, JiuQiang, Zhu, Shu, Wang, Fengli, Yang, Maojun, Guo, Caixia, Wang, Heng, Zheng, Qingyin, Li, Yang, Chen, Quan, Zhou, Aimin, Tang, TieShan. TMCO1 Is an ER Ca2+ Load-Activated Ca2+ Channel. CELL[J]. 2016, 第 19 作者165(6): 1454-1466, http://dx.doi.org/10.1016/j.cell.2016.04.051.
[17] Wang QiaoChu, Zheng Qiaoxia, Tan Haiyan, Zhang Bing, Li Xiaoling, Yang Yuxiu, Yu Jie, Liu Yang, Chai Hao, Wang Xi, Sun Zhongshuai, Wang JiuQiang, Zhu Shu, Wang Fengli, Yang Maojun, Guo Caixia, Wang Heng, Zheng Qingyin, Li Yang, Chen Quan, Zhou Aimin, Tang TieShan. TMCO1 Is an ER Ca 2+ Load-Activated Ca 2+ Channel. CELL[J]. 2016, 第 19 作者
[18] Wang, Jingjing, Li, Yang. KCNQ potassium channels in sensory system and neural circuits. ACTA PHARMACOLOGICA SINICA[J]. 2016, 第 2 作者  通讯作者  37(1): 25-33, http://dx.doi.org/10.1038/aps.2015.131.
[19] Guo, Fei, Zhang, Bing, Fu, Zhiwen, Ma, Yuqin, Gao, Yu, Shen, Fuyi, Huang, Chenggang, Li, Yang. The rapid antidepressant and anxiolytic-like effects of YY-21 involve enhancement of excitatory synaptic transmission via activation of mTOR signaling in the mPFC. EUROPEAN NEUROPSYCHOPHARMACOLOGY[J]. 2016, 第 8 作者  通讯作者  26(7): 1087-1098, http://dx.doi.org/10.1016/j.euroneuro.2016.05.006.
[20] Zhang, Qi, Guo, Fei, Fu, Zhiwen, Zhang, Bing, Huang, Chenggang, Li, Yang. Timosaponin derivative YY-23 acts as a non-competitive NMDA receptor antagonist and exerts a rapid antidepressant-like effect in mice. ACTA PHARMACOLOGICA SINICA[J]. 2016, 第 6 作者  通讯作者  37(2): 166-176, http://lib.cqvip.com/Qikan/Article/Detail?id=667992873.
[21] Zhou, Tingting, Quan, Lingling, Chen, Liping, Du, Te, Sun, KX, Zhang, JC, Yu, Liang, Li, Yang, Wan, Ping, Chen, Lili, Jiang, BH, Hu, Lihong, Chen, Jing, Shen, Xu. SP6616 as a new Kv2.1 channel inhibitor efficiently promotes β-cell survival involving both PKC/Erk1/2 and CaM/PI3K/Akt signaling pathways.. Cell Death Dis.[J]. 2016, 第 8 作者7: e2216, 
[22] QiZHANG, Fei GUO, Zhi-wen FU, Bing ZHANG, Cheng-gang HUANG, Yang LI. Timosaponin derivative YY-23 acts as a non- competitive NMDA receptor antagonist and exerts a rapid antidepressant-like effect in mice. 中国药理学报：英文版[J]. 2016, 第 6 作者166, http://lib.cqvip.com/Qikan/Article/Detail?id=667992873.
[23] Li Yang. Timosaponin derivative YY-23 acts as a n8on-competitive NMDA receptor antagonist and exerts a rapid antidepressant-like effect in mice.. Acta pharmacologica Sinica. 2016, 第 1 作者  通讯作者  
[24] Ye, Dongqing, Li, Yang, Zhang, Xiangrong, Guo, Fei, Geng, Leiyu, Zhang, Qi, Zhang, Zhijun. TREK1 channel blockade induces an antidepressant-like response synergizing with 5-HT1A receptor signaling. EUROPEAN NEUROPSYCHOPHARMACOLOGY[J]. 2015, 第 2 作者25(12): 2426-2436, http://dx.doi.org/10.1016/j.euroneuro.2015.09.007.
[25] Chen, Liping, Zhang, Qiansen, Qiu, Yunguang, Li, Zanyuan, Chen, Zhuxi, Jiang, Hualiang, Li, Yang, Yang, Huaiyu. Migration of PIP2 lipids on voltage-gated potassium channel surface influences channel deactivation. SCIENTIFIC REPORTS[J]. 2015, 第 7 作者  通讯作者  5: http://dx.doi.org/10.1038/srep15079.
[26] Zhong, Fuqing, Li, Yang, Mi, Xianqiang. Photobiomodulation on KATP Channels of Kir6.2-Transfected HEK-293 Cells. INTERNATIONALJOURNALOFPHOTOENERGY[J]. 2014, 第 2 作者  通讯作者  2014: https://doaj.org/article/490e8c57ee004b5eb28af9ffd5a02849.
[27] Geng, LeiYu, Ye, DongQing, Shi, YanYan, Xu, Zhi, Pu, MengJia, Li, ZanYuan, Li, XiaoLi, Li, Yang, Zhang, ZhiJun. Influence of Genetic Polymorphisms Involved in the Hypothalamic-Pituitary-Adrenal Axis and their Interactions with Environmental Factors on Antidepressant Response. CNS NEUROSCIENCE & THERAPEUTICS[J]. 2014, 第 8 作者20(3): 237-243, https://www.webofscience.com/wos/woscc/full-record/WOS:000331540800006.
[28] Guo, Fei, Zhang, Qi, Zhang, Bing, Fu, Zhiwen, Wu, Bin, Huang, Chenggang, Li, Yang. Burst-firing patterns in the prefrontal cortex underlying the neuronal mechanisms of depression probed by antidepressants. EUROPEAN JOURNAL OF NEUROSCIENCE[J]. 2014, 第 7 作者40(10): 3538-3547, https://www.doi.org/10.1111/ejn.12725.
[29] 张兵, 李扬. 针对谷氨酸能系统的抗抑郁药物的研究进展. 中国药理学通报[J]. 2014, 第 2 作者30(9): 1197, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFD2014&filename=YAOL201409004&v=MDI0ODBlWDFMdXhZUzdEaDFUM3FUcldNMUZyQ1VSN3FmYitabUZ5amhVcnZOUEN6RVlyRzRIOVhNcG85RllJUjg=.
[30] Guo, Fei, Zhang, Qi, Li, Yang. An antidepressant from Chinese herbs improves the burst firing of medial prefrontal cortex induced by chronic mild stress. ACTA PHARMACOLOGICA SINICA[J]. 2013, 第 3 作者34: 103-104, https://www.webofscience.com/wos/woscc/full-record/WOS:000322051500454.
[31] Zhang, Xiaozhe, Wang, Jingjing, Feng, Yue, Ge, Jingpeng, Li, Wenfei, Sun, Wending, Iscla, Irene, Yu, Jie, Blount, Paul, Li, Yang, Yang, Maojun. Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2012, 第 10 作者  通讯作者  109(44): 18180-18185, http://dx.doi.org/10.1073/pnas.1207977109.
[32] 李扬, 叶冬青, 张志珺. trek1钾通道与抑郁症. 药学学报[J]. 2012, 第 1 作者47(11): 1403, http://lib.cqvip.com/Qikan/Article/Detail?id=43830612.
[33] 李扬. 针对早老性痴呆等神经系统疾病的高通量筛选. 2011, 第 1 作者90, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CPFD&dbname=CPFD0914&filename=ZGYS201104002093&v=MTAyOTV0VTd2S0pWd1JQeXJTZmJHNEg5RE1xNDlGWnVzR0R4Tkt1aGRobmo5OFRuanFxeGRFZU1PVUtyaWZaZVp2SGlu.
[34] Shi, Ning, Zeng, Weizhong, Ye, Sheng, Li, Yang, Jiang, Youxing. Crucial Points within the Pore as Determinants of K+ Channel Conductance and Gating. JOURNAL OF MOLECULAR BIOLOGY[J]. 2011, 第 4 作者  通讯作者  411(1): 27-35, http://dx.doi.org/10.1016/j.jmb.2011.04.058.
[35] Derebe, Mehabaw G, Zeng, Weizhong, Li, Yang, Alam, Amer, Jiang, Youxing. Structural studies of ion permeation and Ca2+ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2011, 第 3 作者108(2): 592-597, https://www.webofscience.com/wos/woscc/full-record/WOS:000286097700033.
[36] Ye, Sheng, Li, Yang, Jiang, Youxing. Novel insights into K+ selectivity from high-resolution structures of an open K+ channel pore. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2010, 第 2 作者17(8): 1019-1865, https://www.webofscience.com/wos/woscc/full-record/WOS:000280670300020.
[37] Liu, Hong, Gao, ZhaoBing, Yao, Zhiyi, Zheng, Suxin, Li, Yang, Zhu, Weiliang, Tan, Xiaojian, Luo, Xiaomin, Shen, Jianhua, Chen, Kaixian, Hu, GuoYuan, Jiang, Hualiang. Discovering potassium channel blockers from synthetic compound database by using structure-based virtual screening in conjunction with electrophysiological assay. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2007, 第 5 作者50(1): 83-93, http://ir.simm.ac.cn/handle/153631/1871.
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[39] 孙心德, 李扬. NMDA受体与中枢神经系统的发育. 生命科学[J]. 1999, 第 2 作者11(5): 24, http://lib.cqvip.com/Qikan/Article/Detail?id=3649711.

（1） 高等药理学, The Advanced Pharmacology, 科技出版社, 2013-11, 第 1 作者
（2） 金国章院士集, 人民军医出版社, 2014-11, 第 2 作者
（3） 中药药效学研究思路与方法, 人民卫生出版社, 2015-10, 第 2 作者

   

（ 1 ） KCNQ钾通道的晶体结构及调控机制, 主持, 国家级, 2012-01--2015-12
（ 2 ） ****择优支持, 主持, 国家级, 2010-05--2014-05
（ 3 ） 新药创制重大专项, 参与, 国家级, 2010-05--2014-12
（ 4 ） 海外学者, 参与, 国家级, 2012-01--2013-12
（ 5 ） ****择优支持, 主持, 部委级, 2009-10--2013-10
（ 6 ） 重大研究计划973, 参与, 国家级, 2013-01--2017-12
（ 7 ） 膜张力和脂质分子调控TREK1钾通道的 分子机制, 主持, 国家级, 2014-01--2017-12
（ 8 ） 新药创制重大专项, 参与, 国家级, 2014-01--2016-12
（ 9 ） TRPV2通道的调节剂与功能研究, 主持, 国家级, 2017-01--2020-12
（ 10 ） 治疗焦虑性抑郁症1.1类候选新药的临床前个性化特征研究, 主持, 部委级, 2016-04--2019-06
（ 11 ） 靶向GPCR、离子通道等膜蛋白的新药发现技术任务, 主持, 国家级, 2017-01--2020-12

（1）快速抗抑郁的离子通道新靶标   第十二届钙信号和细胞功能研讨会   2018-07-17
（2）An allosteric ligand-binding site in the extracellular cap of K2P channels   Yang Li   2018-07-06
（3）快速抗抑郁的新靶点和新机制   第十八届世界临床与基础药理学会议   李扬   2018-07-01
（4）中药有效成分抗抑郁的机制   中医药与脑稳态调控专委会   李扬   2018-05-04
（5）压力敏感型离子通道的选择性机制   第三届（2018）离子通道青年学者学术论坛   2018-04-14
（6）左旋千金藤啶碱（l-SPD）的抗抑郁药理学研究   第十七届全国神经精神药理学会议   李扬   2016-05-13

已指导学生

张齐  博士研究生  100706-药理学  

陈丽萍  博士研究生  100706-药理学  

张兵  博士研究生  100706-药理学  

现指导学生

柴豪  博士研究生  100706-药理学  

马玉琴  博士研究生  100706-药理学  

李天宇  硕士研究生  078006-药理学  

张永梅  博士研究生  100706-药理学  

郝艳萍  硕士研究生  078006-药理学