基本信息

柳振峰  男  博导  中国科学院生物物理研究所
电子邮件: liuzf@ibp.ac.cn
通信地址: 北京市朝阳区大屯路15号中科院生物物理所
邮政编码: 100101

主要研究领域

膜蛋白结构生物学

招生信息

   
招生专业
071011-生物物理学
071010-生物化学与分子生物学
招生方向
膜蛋白结构生物学;细胞能量储存和代谢;新型离子通道结构与功能
膜蛋白生物化学;
光合膜蛋白与通道膜蛋白的结构生物学

教育背景

1998-09--2004-07   中国科学院生物物理研究所   理学博士

工作经历

   
工作简历
2011-01~现在, 中国科学院生物物理研究所, 研究员
2004-12~2010-12,美国加州理工学院/霍华德修斯医学研究所, 博士后/研究助理

教授课程

细胞的物理生物学
高等生物物理学
膜蛋白结构生物学前沿讲座
生物物理学系列讲座
光合膜蛋白以及离子通道的 结构生物学研究进展
膜脂与膜蛋白的相互作用
结构生物学导论

专利与奖励

   
奖励信息
(1) 谈家桢生命科学创新奖, 国家级, 2019
(2) 2017第二届中源协和生命医学创新突破奖, 国家级, 2016
(3) 北京市科学技术奖, 一等奖, 省级, 2014
(4) 国家自然科学奖, 二等奖, 国家级, 2014
(5) 贝时璋青年生物物理学家奖, 其他, 2011
(6) 全国优秀博士论文奖, , 国家级, 2006
(7) 中国生物化学和分子生物学学会 杰出研究论文奖,邹承鲁讲座奖, , 其他, 2005
(8) 中国科学院优秀博士论文奖, , 院级, 2005
(9) 中国科学院生物物理所所长奖学金特等奖, 特等奖, 研究所(学校), 2004

出版信息


发表论文
[1] Liu, Hao, Li, Anjie, JeanDavid, Rochaix, Liu, Zhenfeng. Architecture of chloroplast TOC-TIC translocon supercomplex. NATURE[J]. 2023, 第 4 作者  通讯作者  615(7951): http://dx.doi.org/10.1038/s41586-023-05744-y.
[2] Ishii, Asako, Shan, Jianyu, Sheng, Xin, Kim, Eunchul, Watanabe, Akimasa, Yokono, Makio, Noda, Chiyo, Song, Chihong, Murata, Kazuyoshi, Liu, Zhenfeng, Minagawa, Jun, Kramer, David M. The photosystem I supercomplex from a primordial green alga Ostreococcus tauri harbors three light-harvesting complex trimers. ELIFE[J]. 2023, 第 11 作者12: http://dx.doi.org/10.7554/eLife.84488.
[3] su xiaodong, cao duanfang, pan xiaowei, Shi, Lifang, Liu, Zhenfeng, Dall’Osto Luca, bassi roberto, Zhang, Xinzheng, 李梅. Supramolecular assembly of chloroplast NADH dehydrogenase-like complex with photosystem I from Arabidopsis thaliana. Molecular Plant[J]. 2022, 第 5 作者
[4] 郭江涛, 柳振峰. 温度感应和触觉受体研究进展——2021年度诺贝尔生理学或医学奖解读. 科学通报[J]. 2022, 第 2 作者67(6): 572-580, http://lib.cqvip.com/Qikan/Article/Detail?id=7106862507.
[5] Bowei Yang, Hebang Yao, Dianfan Li, Liu, Zhenfeng. The phosphatidylglycerol phosphate synthase PgsA utilizes a trifurcated amphipathic cavity for catalysis at the membrane-cytosol interface. CURR RES STRUCT BIOL[J]. 2021, 第 4 作者3: 312-323, 
[6] Pan, Xiaowei, Tokutsu, Ryutaro, Li, Anjie, Takizawa, Kenji, Song, Chihong, Murata, Kazuyoshi, Yamasaki, Tomohito, Liu, Zhenfeng, Minagawa, Jun, Li, Mei. Structural basis of LhcbM5-mediated state transitions in green algae. NATURE PLANTS[J]. 2021, 第 8 作者  通讯作者  7(8): 1119-+, http://dx.doi.org/10.1038/s41477-021-00960-8.
[7] Danfeng Song, Haizhan Jiao, Zhenfeng Liu. Phospholipid translocation captured in a bifunctional membrane protein MprF. NATURE COMMUNICATIONS[J]. 2021, 第 3 作者  通讯作者  12(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131360/.
[8] Jianli Guo, Zhenfeng Liu, Danfeng Song, Yiwei Gao, Yao Rong, Yan Zhao, Bailong Xiao, Jinghui Jiang, Mingmin Zhang, Wenhao Liu. TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells. ELIFE[J]. 2021, 第 2 作者10: http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA202110266514553ZK.
[9] Elife. 2021,   通讯作者  
[10] Haizhan, Jiao, Yan, Yin, 柳振峰. 线粒体CDP-DAG合成酶Tam41的结构揭示一种潜在的从膜到活性位点的脂质底物途径. 科学新闻[J]. 2020, 第 5 作者120-120, http://lib.cqvip.com/Qikan/Article/Detail?id=7102181395.
[11] Yang, Weixin, Wang, Youwang, Guo, Jianli, He, Lingli, Zhou, Ye, Zheng, Hui, Liu, Zhenfeng, Zhu, Ping, Zhang, Xuejun C. Cryo-electron microscopy structure ofCLHM1ion channel fromCaenorhabditis elegans. PROTEIN SCIENCE[J]. 2020, 第 7 作者29(8): 1803-1815, http://dx.doi.org/10.1002/pro.3904.
[12] Cao, Peng, Cao, Duanfang, Si, Long, Su, Xiaodong, Tian, Lijin, Chang, Wenrui, Liu, Zhenfeng, Zhang, Xinzheng, Li, Mei. Structural basis for energy and electron transfer of the photosystem I-IsiA-flavodoxin supercomplex. NATURE PLANTS[J]. 2020, 第 7 作者6(2): 167-+, http://dx.doi.org/10.1038/s41477-020-0593-7.
[13] Cao, Peng, Pan, Xiaowei, Su, Xiaodong, Liu, Zhenfeng, Li, Mei. Assembly of eukaryotic photosystem II with diverse light-harvesting antennas. CURRENT OPINION IN STRUCTURAL BIOLOGY. 2020, 第 4 作者63: 49-57, http://dx.doi.org/10.1016/j.sbi.2020.03.007.
[14] Pan, Xiaowei, Cao, Peng, Su, Xiaodong, Liu, Zhenfeng, Li, Mei. Structural analysis and comparison of light-harvesting complexes I and II. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS. 2020, 第 4 作者1861(4): http://dx.doi.org/10.1016/j.bbabio.2019.06.010.
[15] Sheng, Xin, Watanabe, Akimasa, Li, Anjie, Kim, Eunchul, Song, Chihong, Murata, Kazuyoshi, Song, Danfeng, Minagawa, Jun, Liu, Zhenfeng. Structural insight into light harvesting for photosystem II in green algae. NATURE PLANTS[J]. 2019, 第 9 作者  通讯作者  5(12): 1320-+, http://dx.doi.org/10.1038/s41477-019-0543-4.
[16] Liu, Xiuying, Chai, Jingchao, Ou, Xiaomin, Li, Mei, Liu, Zhenfeng. Structural Insights into Substrate Selectivity, Catalytic Mechanism, and Redox Regulation of Rice Photosystem II Core Phosphatase. MOLECULAR PLANT[J]. 2019, 第 5 作者  通讯作者  12(1): 86-98, http://dx.doi.org/10.1016/j.molp.2018.11.006.
[17] Su, Xiaodong, Ma, Jun, Pan, Xiaowei, Zhao, Xuelin, Chang, Wenrui, Liu, Zhenfeng, Zhang, Xinzheng, Li, Mei. Antenna arrangement and energy transfer pathways of a green algal photosystem-I-LHCI supercomplex. NATURE PLANTS[J]. 2019, 第 6 作者5(3): 273-281, https://www.webofscience.com/wos/woscc/full-record/WOS:000471017200011.
[18] Jiao, Haizhan, Yin, Yan, Liu, Zhenfeng. Structures of the Mitochondrial CDP-DAG Synthase Tam41 Suggest a Potential Lipid Substrate Pathway from Membrane to the Active Site. STRUCTURE[J]. 2019, 第 3 作者  通讯作者  27(8): 1258-+, http://dx.doi.org/10.1016/j.str.2019.04.017.
[19] Xiuying Liu, Jingchao Chai, Xiaomin Ou, Mei Li, Zhenfeng Liu. Structural Insights into Substrate Selectivity, Catalytic Mechanism,and Redox Regulation of Rice Photosystem Ⅱ Core Phosphatase. 分子植物:英文版[J]. 2019, 第 5 作者12(1): 86-98, http://lib.cqvip.com/Qikan/Article/Detail?id=6100265132.
[20] XinSheng, XiuyingLiu, PengCao, MeiLi, ZhenfengLiu. Structural roles of lipid molecules in the assembly of plant PSII-2LHCII supercomplex. Biophysics Reports[J]. 2018, 第 5 作者4(4): 189-203, http://www.biophysics-reports.org:80/en/article/doi/10.1007/s41048-018-0068-9.
[21] Mei Li, Xiaowei Pan, Jun Ma, Xiaodong Su, Wenrui Chang, Zhenfeng Liu, Xinzheng Zhang. Cryo-EM structure of maize PSI-LHCI-LHCII supercomplex. BBA - BIOENERGETICS. 2018, 第 6 作者1859: e34-e34, http://dx.doi.org/10.1016/j.bbabio.2018.09.109.
[22] Pan, Xiaowei, Ma, Jun, Su, Xiaodong, Cao, Peng, Chang, Wenrui, Liu, Zhenfeng, Zhang, Xinzheng, Li, Mei. Structure of the maize photosystem I supercomplex with light-harvesting complexes I and II. SCIENCE[J]. 2018, 第 6 作者360(6393): 1109-1112, https://www.webofscience.com/wos/woscc/full-record/WOS:000434635500043.
[23] Peng Cao, Xiaodong Su, Xiaowei Pan, Zhenfeng Liu, Wenrui Chang, Mei Li. Structure, assembly and energy transfer of plant photosystem II supercomplex. BBA - BIOENERGETICS. 2018, 第 4 作者1859(9): 633-644, http://dx.doi.org/10.1016/j.bbabio.2018.03.007.
[24] Xin Sheng, Xiuying Liu, Peng Cao, Mei Li, Zhenfeng Liu. Structural roles of lipid molecules in the assembly of plant PSII-LHCII supercomplex. 生物物理学报:英文版[J]. 2018, 第 5 作者4(4): 189-203, http://lib.cqvip.com/Qikan/Article/Detail?id=676327037.
[25] Xuejun CZhang, Hanting Yang, Zhenfeng Liu, Fei Sun. Thermodynamics of voltage-gated ion channels. 生物物理学报:英文版[J]. 2018, 第 3 作者4(6): 300-319, http://lib.cqvip.com/Qikan/Article/Detail?id=6100127336.
[26] Li AnJie, Liu ZhenFeng. Supramolecular Structural Basis of The Light-Harvesting Process in Plants. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2018, 第 2 作者  通讯作者  45(9): 935-946, https://www.webofscience.com/wos/woscc/full-record/WOS:000445847600005.
[27] Li AnJie, Liu ZhenFeng. Supramolecular Structural Basis of The Light-Harvesting Process in Plants. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2018, 第 2 作者  通讯作者  45(9): 935-946, https://www.webofscience.com/wos/woscc/full-record/WOS:000445847600005.
[28] Xuejun CZhang, Hanting Yang, Zhenfeng Liu, Fei Sun. Thermodynamics of voltage-gated ion channels. 生物物理学报:英文版[J]. 2018, 第 3 作者4(6): 300-319, http://lib.cqvip.com/Qikan/Article/Detail?id=6100127336.
[29] Cao, Peng, Su, Xiaodong, Pan, Xiaowei, Liu, Zhenfeng, Chang, Wenrui, Li, Mei. Structure, assembly and energy transfer of plant photosystem II supercomplex. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS[J]. 2018, 第 4 作者1859(9): 633-644, http://dx.doi.org/10.1016/j.bbabio.2018.03.007.
[30] Su, Xiaodong, Ma, Jun, Wei, Xuepeng, Cao, Peng, Zhu, Dongjie, Chang, Wenrui, Liu, Zhenfeng, Zhang, Xinzheng, Li, Mei. Structure and assembly mechanism of plant C2S2M2-type PSII-LHCII supercomplex. SCIENCE[J]. 2017, 第 7 作者  通讯作者  357(6353): 816-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000408327900046.
[31] Ou, Xiaomin, Guo, Jianli, Wang, Longfei, Yang, Hanting, Liu, Xiuying, Sun, Jianyuan, Liu, Zhenfeng. Ion- and water-binding sites inside an occluded hourglass pore of a trimeric intracellular cation (TRIC) channel. BMC BIOLOGY[J]. 2017, 第 7 作者  通讯作者  15(1): http://dx.doi.org/10.1186/s12915-017-0372-8.
[32] 常文瑞, 柳振峰. 光合作用与“人工叶片”研究立项报告. 科技资讯[J]. 2016, 第 2 作者14(20): 174-175, http://lib.cqvip.com/Qikan/Article/Detail?id=7000041120.
[33] Zhang, Xuejun C, Liu, Zhenfeng, Li, Jie. From membrane tension to channel gating: A principal energy transfer mechanism for mechanosensitive channels. PROTEIN SCIENCE. 2016, 第 2 作者25(11): 1954-1964, http://dx.doi.org/10.1002/pro.3017.
[34] 柳振峰, 刘秀颖. 基于结构的光合作用状态转换机理研究立项报告. 科技资讯[J]. 2016, 第 1 作者14(20): 178-178, http://lib.cqvip.com/Qikan/Article/Detail?id=7000041123.
[35] Yang, Hanting, Hu, Miaohui, Guo, Jianli, Ou, Xiaomin, Cai, Tanxi, Liu, Zhenfeng. Pore architecture of TRIC channels and insights into their gating mechanism. NATURE[J]. 2016, 第 6 作者  通讯作者  538(7626): 537-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000386654400064.
[36] Wei, Xuepeng, Su, Xiaodong, Cao, Peng, Liu, Xiuying, Chang, Wenrui, Li, Mei, Zhang, Xinzheng, Liu, Zhenfeng. Structure of spinach photosystem II-LHCII supercomplex at 3.2 angstrom resolution. NATURE[J]. 2016, 第 8 作者534(7605): 69-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000376962300034.
[37] Li, Jie, Guo, Jianli, Ou, Xiaomin, Zhang, Mingfeng, Li, Yuezhou, Liu, Zhenfeng. Mechanical coupling of the multiple structural elements of the large-conductance mechanosensitive channel during expansion. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2015, 第 6 作者  通讯作者  112(34): 10726-10731, https://www.webofscience.com/wos/woscc/full-record/WOS:000360005600058.
[38] Wei, Xuepeng, Guo, Jiangtao, Li, Mei, Liu, Zhenfeng. Structural Mechanism Underlying the Specific Recognition between the Arabidopsis State-Transition Phosphatase TAP38/PPH1 and Phosphorylated Light-Harvesting Complex Protein Lhcb1. PLANT CELL[J]. 2015, 第 4 作者  通讯作者  27(4): 1113-1127, http://www.corc.org.cn/handle/1471x/2376570.
[39] 常文瑞. Crystal structures of the PsbS protein essential for photoprotection in plants. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2015, 22(9): 729-U115, https://www.webofscience.com/wos/woscc/full-record/WOS:000360933200016.
[40] Liu, Xiuying, Yin, Yan, Wu, Jinjun, Liu, Zhenfeng. Structure and mechanism of an intramembrane liponucleotide synthetase central for phospholipid biosynthesis. NATURE COMMUNICATIONS[J]. 2014, 第 4 作者  通讯作者  5: https://www.webofscience.com/wos/woscc/full-record/WOS:000338840400003.
[41] Wan, Tao, Li, Mei, Zhao, Xuelin, Zhang, Jiping, Liu, Zhenfeng, Chang, Wenrui. Crystal Structure of a Multilayer Packed Major Light-Harvesting Complex: Implications for Grana Stacking in Higher Plants. MOLECULAR PLANT[J]. 2014, 第 5 作者7(5): 916-919, http://dx.doi.org/10.1093/mp/ssu005.
[42] Guo, Jiangtao, Wei, Xuepeng, Li, Mei, Pan, Xiaowei, Chang, Wenrui, Liu, Zhenfeng. Structure of the catalytic domain of a state transition kinase homolog from Micromonas algae. PROTEIN & CELL[J]. 2013, 第 6 作者4(8): 607-619, http://www.irgrid.ac.cn/handle/1471x/756663.
[43] Pan, Xiaowei, Liu, Zhenfeng, Li, Mei, Chang, Wenrui. Architecture and function of plant light-harvesting complexes II. CURRENT OPINION IN STRUCTURAL BIOLOGY[J]. 2013, 第 2 作者  通讯作者  23(4): 515-525, http://dx.doi.org/10.1016/j.sbi.2013.04.004.
[44] Liu, Zhenfeng, Gandhi, Chris S, Rees, Douglas C. Structure of a tetrameric MscL in an expanded intermediate state. NATURE[J]. 2009, 第 1 作者461(7260): 120-U132, https://www.webofscience.com/wos/woscc/full-record/WOS:000269478800042.
[45] 柳振峰, 常文瑞. 一种重要的光合膜蛋白——菠菜主要捕光复合物的晶体结构. 中国科学院院刊[J]. 2004, 第 1 作者19(3): 199-201, http://lib.cqvip.com/Qikan/Article/Detail?id=9774472.

科研活动

   
科研项目
( 1 ) 优秀博士论文启动基金, 主持, 部委级, 2011-01--2013-12
( 2 ) 自然科学基金创新群体项目, 参与, 国家级, 2011-01--2013-12
( 3 ) 光合作用与“人工叶片, 主持, 国家级, 2011-01--2015-12
( 4 ) 青年****, 主持, 国家级, 2012-01--2014-12
( 5 ) 磷脂酰甘油和心磷脂生物合成的结构基础, 主持, 国家级, 2012-01--2015-12
( 6 ) 重要新型膜离子通道的结晶与结构解析, 参与, 国家级, 2014-01--2018-12
( 7 ) 生物膜脂类生成与能量代谢过程, 参与, 部委级, 2014-01--2018-12
( 8 ) 光合作用捕光过程调节以及环式电子传递相关的超分子机器结构与功能研究, 主持, 部委级, 2016-08--2020-12
( 9 ) 真核生物磷脂和中性脂类生物合成过程的结构基础, 主持, 国家级, 2017-01--2020-12
( 10 ) 光合作用光能捕获、传递及其调节相关的超分子蛋白 质机器结构与功能研究, 主持, 国家级, 2017-07--2022-06
( 11 ) 膜蛋白结构生物学, 主持, 国家级, 2020-01--2024-12
( 12 ) 光合作用过程的超分子结构基础及其原位功能调节机理, 主持, 部委级, 2020-01--2024-12
参与会议
(1)绿藻光系统II捕光及其调节的超分子基础   2020年全国电子显微学学术年会   柳振峰   2020-11-24
(2)绿藻光系统II捕获光能的超分子结构基础   北京大学定量生物学中心青年学者生物物理研讨会   2019-12-07
(3)Light Harvesting in Plants and Green Algae:Supramolecular Insights from Structural Studies   2019-10-01
(4)植物光合作用捕光过程的超分子结构基础   第十七次 中国暨国际生物物理大会   2019-08-02
(5)植物光合作用捕光过程的超分子结构基础   2019全国光合作用学术研讨会   2019-04-26
(6)Supramolecular Basis of Light Harvesting and Its regulation in Plants   2018-11-28
(7) Structural Insights into Light Harvesting and Its Regulation in Plants   参加第56届日本生物物理学会年会   2018-09-14
(8)植物捕获光能及其调节过程的超分子基础   第九届中国光生物学学术会议   2018-07-12
(9)Structures Insights into the Supramolecular Light-Harvesting Machineries in Plant Photosynthesis   第十五次中国暨国际生物物理大会暨第十一次中国生物物理学会全国会员代表大会   2017-11-04
(10)Supramolecular Structures of Plant Light-Harvesting Machineries in Complex with Photosystem II   第五届全国冷冻电子显微学与结构生物学专题研讨会   2017-11-01
(11)植物捕光及其调节过程的超分子基础   第六届全国“跨学科蛋白质研究”学术讨论会   2017-09-22
(12)Structural Insights into Light Harvesting and Its Regulation in Plants   2017-07-16
(13)Supramolecular basis for light-harvesting processes in plants   2017-07-13
(14)Pore architecture and gating mechanism of TRIC channels   2017-06-03
(15)Structure-based Mechanistic Insights into the Function of Trimeric Intracellular Cation Channels   2017年冷泉港会议   2017-05-15
(16)Supramolecular basis for light-harvesting processes in plants   2016 世界生命科学大会   2016-11-01
(17)Structure of PSII-LHCII supercomplex: the supramolecular basis for light-harvesting processes in plants   国际光合作用大会   2016-08-04
(18)Phospholipid biosynthesis: the classical biochemical pathways renewed with structural insights   冷泉港亚洲会议   Zhenfeng Liu   2015-05-11
(19)Structure of a bacterial large-conductance mechanosensitive channel   第17届国际生物物理大会   Zhenfeng Liu   2011-10-30
(20)Crystal structure of MscL from Staphylococcus aureus and the structure-based gating mechanism   Zhenfeng Liu   2009-07-01
(21)Crystal structure of spinach major light-harvesting complex at 2.72 A resolution   Zhenfeng Liu*,1, Hanchi Yan1, Kebin Wang2, Tingyun Kuang2, Jiping Zhang1, Lulu Gui1, Xiaomin An1, Wenrui Chang   2004-08-01
(22)Crystallization and Phasing of LHC-II A novel type of membrane protein crystal   Zhenfeng Liu, Wenrui Chang   2004-06-01

指导学生

已指导学生

柴景超  硕士研究生  071010-生物化学与分子生物学  

尹妍  博士研究生  071011-生物物理学  

魏雪鹏  博士研究生  071011-生物物理学  

李婕  博士研究生  071011-生物物理学  

杨涵婷  博士研究生  071011-生物物理学  

胡苗会  博士研究生  071011-生物物理学  

焦海展  博士研究生  071011-生物物理学  

盛鑫  博士研究生  071011-生物物理学  

刘秀颖  博士研究生  071011-生物物理学  

现指导学生

厉玉梅  博士研究生  071011-生物物理学  

宋丹枫  博士研究生  071011-生物物理学  

杨博伟  博士研究生  071011-生物物理学  

单建宇  硕士研究生  071010-生物化学与分子生物学  

刘昊  博士研究生  071011-生物物理学  

李安节  博士研究生  071011-生物物理学  

王伊迪  博士研究生  071011-生物物理学  

荣耀  博士研究生  071011-生物物理学  

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