干细胞命运调控中代谢变化和线粒体的作用 
  干细胞命运调控中细胞信号的作用 
  人类线粒体疾病机理及干细胞治疗

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071009-细胞生物学
071010-生物化学与分子生物学

干细胞命运调控及人类疾病的干细胞治疗

2002-09--2007-01   清华大学   博士
1998-09--2002-07   山东大学   学士

博士​

2007年-2010年: Thomas Jefferson University, 博士后

2010年－至今： 中国科学院广州生物医药与健康研究院 研究员
2007年-2010年: Thomas Jefferson University, 博士后

2010-07~现在, 中国科学院广州生物医药与健康研究院, 研究员
2007-02~2010-07,Thomas Jefferson University, 博士后

   

（1） The naked mole-rat cGAS promotes homologous recombination repair and delays aging, Science Bulletin, 2026, 第 6 作者  通讯作者
（2） A new role of Iridium(III) Complexes in regulating pluripotency acquisition via mitochondrial remodulation, SCIENCE CHINA Life Sciences, 2026, 第 14 作者  通讯作者
（3） MAP2K6 directly phosphorylates BCL2L13 to mediate mitophagy for suppressing tumorigenicity, Cell Reports, 2026, 第 28 作者  通讯作者
（4） Post-transcriptional control of endogenous retroviruses by L1td1 suppresses totipotency acquisition in pluripotent stem cells, CELL DISCOVERY, 2026, 第 11 作者  通讯作者
（5） Transplantation of encapsulated mitochondria alleviates dysfunction in mitochondrial and Parkinson’s disease models, Cell, 2026, 第 37 作者  通讯作者
（6） Perinuclear mitochondrial clustering for mesenchymal-to-epithelial transition in pluripotency induction, STEM CELL REPORTS, 2025, 第 25 作者  通讯作者
（7） β-hydroxybutyrate enhances mitochondrial function via mitochondrial-derived vesicles, SCIENCE BULLETIN, 2025, 第 5 作者  通讯作者
（8） The role of protein post-translational modifications and their crosstalk in determining pluripotent stem cells fate, SCIENCE BULLETIN, 2025, 第 6 作者  通讯作者
（9） Phase separation in mitochondrial fate and mitochondrial diseases, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2025, 第 5 作者  通讯作者
（10） Lactate-driven histone lactylation enhances GDF15 secretion in skeletal muscle under mtDNA mutation-induced mitochondrial stress, Science Bulletin, 2025, 第 17 作者  通讯作者
（11） Microprotein PLUM encoded by Lin28b uORF is a cytoplasmic determinant of pluripotency and embryonic development, NATURE COMMUNICATIONS, 2025, 第 21 作者  通讯作者
（12） Glucose restriction induces degeneration of neurons with mitochondrial DNA depletion by altering ER-mitochondria calcium transfer, MOLECULAR PSYCHIATRY, 2025, 第 24 作者  通讯作者
（13） Roads diverged in a wood: Proteins and RNAs encoded by cytochrome b ( CYTB ) gene in health and disease, CLINICAL AND TRANSLATIONAL DISCOVERY, 2025, 第 6 作者  通讯作者
（14） The mitochondrial unfolded protein response inhibits pluripotency acquisition and mesenchymal-to-epithelial transition in somatic cell reprogramming, NATURE METABOLISM, 2025, 第 32 作者  通讯作者
（15） 线粒体与细胞命运调控, 中国细胞生物学学报, 2024, 第 5 作者  通讯作者
（16） Impact of mtDNA-encoded proteins arising from cytosolic translation(mPACT), 线粒体DNA编码胞质翻译蛋白的重要性, SCIENCE BULLETIN, 2024, 第 7 作者  通讯作者
（17） Biomolecular condensates and disease pathogenesis, Biomolecular condensates and disease pathogenesis, SCIENCE CHINA-LIFE SCIENCES, 2024, 第 6 作者  通讯作者
（18） NAD + dependent UPR mt activation underlies intestinal aging caused by mitochondrial DNA mutations, NATURE COMMUNICATIONS, 2024, 第 15 作者  通讯作者
（19） 钙离子和活性氧在多能干细胞中的功能和调控作用, 中国科学：生命科学, 2024, 第 9 作者  通讯作者
（20） Lactylation regulated DNA damage repair and cancer cell chemosensitivity, SCIENCE BULLETIN, 2024, 第 3 作者  通讯作者
（21） A novel protein CYTB-187AA encoded by the mitochondrial gene CYTB modulates mammalian early development, CELL METABOLISM, 2024, 第 31 作者  通讯作者
（22） Multi-phase separation in mitochondrial nucleoids and eukaryotic nuclei, BIOPHYSICS REPORTS, 2023, 第 5 作者  通讯作者
（23） Mitochondria as multifaceted regulators of ferroptosis, LIFE METABOLISM, 2023, 第 7 作者  通讯作者
（24） The Aging Biomarker Consortium represents a new era for aging research in China, NATURE MEDICINE, 2023, 第 33 作者
（25） Biomarkers of aging, Biomarkers of aging, SCIENCE CHINA-LIFE SCIENCES, 2023, 第 84 作者  通讯作者
（26） BCL11B and the NuRD complex cooperatively guard T-cell fate and inhibit OPA1-mediated mitochondrial fusion in T cells, EMBO JOURNAL, 2023, 第 17 作者  通讯作者
（27） Mitolysosome exocytosis: a novel mitochondrial quality control pathway linked with parkinsonism-like symptoms, BIOCHEMICAL SOCIETY TRANSACTIONS, 2022, 第 4 作者  通讯作者
（28） NAD + is critical for maintaining acetyl-CoA and H3K27ac in embryonic stem cells by Sirt1-dependent deacetylation of AceCS1, LIFE MEDICINE, 2022, 第 4 作者  通讯作者
（29） Autophagy‐independent mitochondrial quality control: Mechanisms and disease associations, MEDCOMM – FUTURE MEDICINE, 2022, 第 7 作者  通讯作者
（30） Epigenome-Metabolome-Epigenome signaling cascade in cell biological processes, Epigenome-Metabolome-Epigenome signaling cascade in cell biological processes, JOURNAL OF GENETICS AND GENOMICS, 2022, 第 5 作者  通讯作者
（31） Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation, CELL DEATH AND DIFFERENTIATION, 2022, 第 20 作者  通讯作者
（32） MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening, CELL DEATH AND DIFFERENTIATION, 2022, 第 21 作者  通讯作者
（33） Nuclear localization of mitochondrial TCA cycle enzymes modulates pluripotency via histone acetylation, NATURE COMMUNICATIONS, 2022, 第 25 作者  通讯作者
（34） Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms, Science Advances, 2022, 第 34 作者  通讯作者
（35） Protocols for analysis of mitochondrial permeability transition pore opening in mouse somatic cell reprogramming, STAR PROTOCOLS, 2021, 第 6 作者  通讯作者
（36） Protocol for detecting chromatin dynamics and screening chromatin relaxer by FRAP assay, STAR PROTOCOLS, 2021, 第 7 作者  通讯作者
（37） Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation (vol 28, pg 900, 2021), NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2021, 第 22 作者  通讯作者
（38） Short-form OPA1 is a molecular chaperon in mitochondrial intermembrane space, Science China-Life Sciences, 2021, 第 14 作者  通讯作者
（39） A Combined Model of Human iPSC-Derived Liver Organoids and Hepatocytes Reveals Ferroptosis in DGUOK Mutant mtDNA Depletion Syndrome, ADVANCED SCIENCE, 2021, 第 13 作者  通讯作者
（40） Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD + redox, AGING CELL, 2020, 第 15 作者  通讯作者
（41） The Zscan4-Tet2 Transcription Nexus Regulates Metabolic Rewiring and Enhances Proteostasis to Promote Reprogramming, CELL REPORTS, 2020, 第 22 作者
（42） Organelle remodeling in somatic cell reprogramming, JOURNAL OF MOLECULAR CELL BIOLOGY, 2020, 第 4 作者  通讯作者
（43） A new sight: topology-dependent mitophagy, CELL BIOLOGY AND TOXICOLOGY, 2020, 第 3 作者  通讯作者
（44） Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade, NATURE METABOLISM, 2020, 第 23 作者  通讯作者
（45） 线粒体定位circRNA调控肝脏免疫代谢性炎症机制, 生命的化学, 2020, 第 4 作者
（46） Topology-dependent, bifurcated mitochondrial quality control under starvation, AUTOPHAGY, 2020, 第 16 作者  通讯作者
（47） OPA1-Exon4b Binds to mtDNA D-Loop for Transcriptional and Metabolic Modulation, Independent of Mitochondrial Fusion, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2020, 第 12 作者  通讯作者
（48） Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming, EMBO JOURNAL, 2020, 第 13 作者  通讯作者
（49） A novel mitochondrial micropeptide MPM enhances mitochondrial respiratory activity and promotes myogenic differentiation, CELL DEATH & DISEASE, 2019, 第 9 作者  通讯作者
（50） Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition, SCIENCE ADVANCES, 2019, 第 8 作者  通讯作者
（51） Phospholipid remodeling is critical for stem cell pluripotency via facilitating mesenchymal-to-epithelial transition, Science Advances, 2019, 第 1 作者  通讯作者
（52） Short-term mitochondrial permeability transition pore opening modulates histone lysine methylation at the early phase of somatic cell reprogramming, CELL METABOLISM, 2018, 第 22 作者  通讯作者
（53） Polybrene induces neural degeneration by bidirectional Ca2+ influx-dependent mitochondrial and ER-mitochondrial dynamics, CELL DEATH & DISEASE, 2018, 第 13 作者  通讯作者
（54） Selectively lighting up two-photon photodynamic activity in mitochondria with AIE-active iridium(III) complexes, CHEMICAL COMMUNICATIONS, 2017, 第 4 作者
（55） Targeting cancer cell metabolism with mitochondria-immobilized phosphorescent cyclometalated iridium(III) complexes, CHEMICAL SCIENCE, 2017, 第 6 作者
（56） BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming, AUTOPHAGY, 2017, 第 23 作者  通讯作者
（57） Enhanced cancer therapy by the marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(III) complexes, CHEMICAL COMMUNICATIONS, 2017, 第 5 作者
（58） Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction, CELL DEATH & DISEASE, 2017, 第 8 作者  通讯作者
（59） Choosing proper fluorescent dyes, proteins, and imaging techniques to study mitochondrial dynamics in mammalian cells, Biophysics Reports, 2017, 第 1 作者  通讯作者
（60） Srebp-1 Interacts with c-Myc to Enhance Somatic Cell Reprogramming, STEM CELLS, 2016, 第 10 作者  通讯作者
（61） Mitochondrial Membrane Potential‐dependent Endoplasmic Reticulum Fragmentation is an Important Step in Neuritic Degeneration, CNS NEUROSCIENCE & THERAPEUTICS, 2016, 第 11 作者  通讯作者
（62） Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming, CELL METABOLISM, 2016, 第 19 作者  通讯作者
（63） Gadd45a is a heterochromatin relaxer that enhances iPS cell generation, EMBO REPORTS, 2016, 第 23 作者  通讯作者
（64） Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy, CELL DEATH & DISEASE, 2016, 第 11 作者
（65） Current approaches to reduce or eliminate mitochondrial DNA mutations, SCIENCE CHINA Life Sciences, 2016, 第 9 作者  通讯作者
（66） Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming, NATURE CELL BIOLOGY, 2015, 第 20 作者
（67） Mitochondrial fusion provides an 'initial metabolic complementation' controlled by mtDNA, CELLULAR AND MOLECULAR LIFE SCIENCES, 2015, 第 9 作者  通讯作者
（68） Modeling of Mitochondrial Donut Formation, BIOPHYSICAL JOURNAL, 2015, 第 8 作者  通讯作者
（69） Valproic Acid-Induced Hepatotoxicity in Alpers Syndrome Is Associated With Mitochondrial Permeability Transition Pore Opening-Dependent Apoptotic Sensitivity in an Induced Pluripotent Stem Cell Model, HEPATOLOGY, 2015, 第 10 作者  通讯作者
（70） The distribution and apoptotic function of outer membrane proteins depend on mitochondrial fusion, MOLECULAR CELL, 2014, 第 3 作者
（71） Mitochondrial metabolism transition cooperates with nuclear reprogramming during induced pluripotent stem cell generation, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2013, 第 14 作者  通讯作者
（72） Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia-reoxygenation stress, CELL DEATH AND DIFFERENTIATION, 2011, 第 1 作者
（73） Biophysical properties of mitochondrial fusion events in pancreatic beta-cells and cardiac cells unravel potential control mechanisms of its selectivity, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2010, 第 2 作者
（74） Mitochondrial 'kiss-and-run': interplay between mitochondrial motility and fusion-fission dynamics, EMBO JOURNAL, 2009, 第 1 作者
（75） Ca2+-dependent regulation of mitochondrial dynamics by the Miro-Milton complex, INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2009, 第 1 作者
（76） Sorbitol regulates energy transfer from allophycocyanin to the terminal emitter within phycobilisomes in Synechocystis sp, BIOTECHNOLOGY LETTERS, 2007, 第 1 作者
（77） Biogenesis of chlorophyll-binding proteins under iron stress in Synechocystis sp PCC 6803, BIOCHEMISTRY-MOSCOW, 2006, 第 1 作者
（78） Two-Component Signal Transduction Systems in the Cyanobacterium Synechocystis sp. PCC 6803, Tsinghua Science and Technology, 2006, 第 1 作者
（79） Purification and characterization of two small heat shock proteins from Anabaena sp PCC 7120, IUBMB LIFE, 2005, 第 1 作者
（80） Oxidative stress and metal ions effects on the cores of phycobilisomes in Synechocystis sp. PCC 6803, FEBS LETTERS, 2005, 第 1 作者