干细胞命运调控中代谢变化和线粒体的作用 
  干细胞命运调控中细胞信号的作用 
  人类线粒体疾病机理及干细胞治疗

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071009-细胞生物学

干细胞命运调控及人类疾病的干细胞治疗

2002-09--2007-01   清华大学   博士
1998-09--2002-07   山东大学   学士

博士​

2007年-2010年: Thomas Jefferson University, 博士后

2010年－至今： 中国科学院广州生物医药与健康研究院 研究员
2007年-2010年: Thomas Jefferson University, 博士后

（1） 2016年，获得广东省科技创新“领军人才”

（2） 2015年，获得首届广东省科技创新青年拔尖人才

（3） 2012年，获得首届广东省自然科学杰出青年基金（人才计划，共16人）

（4）2011年，入选中国科学院“****”，2012年获择优支持。

（5） 2011年，“因本领域的贡献与未来领导潜能”，获国际生物物理学会“Young Bioenergeticist Award”（每年只有一人获此奖项）。

[1] 刘兴国, 杨亮, 林晓冰, 唐海特. 生物标志物及其应用. CN: CN111411154B, 2021-01-15.

[2] 裴端卿, 王涛, 黄璐圆, 陈可实, 朱洁滢, 刘兴国, 曾小明, 杨建国, 赵丹芸. Map2k3或Map2k6在提高诱导成体细胞生成多能性干细胞效率中的用途. CN: CN112063656A, 2020-12-11.

[3] 刘兴国, 杨亮, 林晓冰, 唐海特. 检测mtDNA突变的方法和系统. CN: CN111621552A, 2020-09-04.

[4] 刘兴国, 杨亮, 唐海特. Opa1异形体蛋白在调控肝癌细胞增殖能力中的用途. CN: CN111518898A, 2020-08-11.

[5] 刘兴国, 杨亮, 唐海特. 分子标志物及其应用. CN: CN111518897A, 2020-08-11.

[6] 刘兴国, 应仲富, 郑玲君, 陈可实. 改变细胞命运的方法. CN: CN105483157B, 2020-01-03.

[7] 刘兴国, 杨亮, 龙琪, 刘景磊. 药物组合物及其用途. US: CN110099677A, 2019-08-06.

[8] 刘兴国, 杨亮, 林晓冰. 化合物在制备药物中的用途. CN: CN109394767A, 2019-03-01.

[9] 刘兴国, 裴端卿, 刘景磊, 刘雪宾. 外源线粒体导入到哺乳动物细胞中的方法. 中国: CN104630149B, 2018.08.21.

[10] 刘兴国, 邬毅, 陈可实, 刘西银. 改变细胞命运的方法及其应用. 中国: CN104774872B, 2018-07-27.

[11] Liu, Xingguo, Pei, Duanqing, Liu, Jinglei, Yao, Deyang, Liu, Xuebin. Method For Introducing Exogenous Mitochondria Into A Mammalian Cell. CN: US20170159017(A1), 2017-06-08.

[12] 刘兴国, 裴端卿, 陈可实, 赵丹芸. 改变细胞命运的手段. CN: CN106222199A, 2016-12-14.

[13] 刘兴国, 包飞翔, 石红岩, 龙琪. 体外细胞疾病模型及其制备方法. CN: CN105861482A, 2016-08-17.

[14] 刘兴国, 应仲富, 李生彪, 郭璟祎. 用于治疗Alpers-Huttenlocher综合征的药物组合物. CN: CN104524546A, 2015-04-22.

[15] 刘兴国, 裴端卿, 陈可实, 龙琪, 王涛. 改变细胞命运的方法. 中国: CN104250291A, 2014-12-31.

[16] 刘兴国, 杨亮, 龙琪, 胡忠国. 构建体及其应用. CN: CN103966246A, 2014-08-06.

   

[1] 刘兴国. Mitolysosome exocytosis, a mitophagy-independent mitochondrial quality control in flunarizine-induced parkinsonism-like symptoms. Science Advances[J]. 2022, [2] 刘兴国. Short-form OPA1 is a molecular chaperon in mitochondrial intermembrane space. Science China-Life Sciences[J]. 2021, [3] Guo, Jingyi, Duan, Lifan, He, Xueying, Li, Shengbiao, Wu, Yi, Xiang, Ge, Bao, Feixiang, Yang, Liang, Shi, Hongyan, Gao, Mi, Zheng, Lingjun, Hu, Huili, Liu, Xingguo. A Combined Model of Human iPSC-Derived Liver Organoids and Hepatocytes Reveals Ferroptosis in DGUOK Mutant mtDNA Depletion Syndrome. ADVANCED SCIENCE[J]. 2021, 8(10): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132052/.
[4] Xing, Guangsuo, Liu, Zichao, Huang, Luyuan, Zhao, Danyun, Wang, Tao, Yuan, Hao, Wu, Yi, Li, Linpeng, Long, Qi, Zhou, Yanshuang, Hao, Zhihong, Liu, Yang, Lu, Jianghuan, Li, Shiting, Zhu, Jieying, Wang, Bo, Wang, Junwei, Liu, Jing, Chen, Jiekai, Pei, Duanqing, Liu, Xingguo, Chen, Keshi. MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening. CELL DEATH AND DIFFERENTIATION[J]. 2021, [5] Long, Qi, Zhou, Yanshuang, Wu, Hao, Du, Shiwei, Hu, Mingli, Qi, Juntao, Li, Wei, Guo, Jingyi, Wu, Yi, Yang, Liang, Xiang, Ge, Wang, Liang, Ye, Shouhua, Wen, Jiayuan, Mao, Heng, Wang, Junwei, Zhao, Hui, Chan, WaiYee, Liu, Jinsong, Chen, Yonglong, Li, Pilong, Liu, Xingguo. Phase separation drives the self-assembly of mitochondrial nucleoids for transcriptional modulation (vol 28, pg 900, 2021). NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2021, [6] Zhou, Yanshuang, Long, Qi, Liu, Xingguo. A new sight: topology-dependent mitophagy. CELL BIOLOGY AND TOXICOLOGYnull. 2020, 36(3): 199-204, https://www.webofscience.com/wos/woscc/full-record/WOS:000539818300001.
[7] Li, Linpeng, Chen, Keshi, Wang, Tianyu, Wu, Yi, Xing, Guangsuo, Chen, Mengqi, Hao, Zhihong, Zhang, Cheng, Zhang, Jinye, Ma, Bochao, Liu, Zihuang, Yuan, Hao, Liu, Zijian, Long, Qi, Zhou, Yanshuang, Qi, Juntao, Zhao, Danyun, Gao, Mi, Pei, Duanqing, Nie, Jinfu, Ye, Dan, Pan, Guangjin, Liu, Xingguo. Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signalling cascade. NATURE METABOLISM[J]. 2020, 2(9): 882-+, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000571444300013.
[8] Yang, Liang, Lin, Xiaobing, Tang, Haite, Fan, Yuting, Zeng, Sheng, Jia, Lei, Li, Yukun, Shi, Yanan, He, Shujing, Wang, Hao, Hu, Zhijuan, Gong, Xiao, Liang, Xiaoyan, Yang, Yi, Liu, Xingguo. Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD(+)redox. AGING CELL[J]. 2020, 19(9): https://www.webofscience.com/wos/woscc/full-record/WOS:000554561600001.
[9] 刘兴国. Glis1 facilitates induction of pluripotency via an epigenome-metabolome-epigenome signaling cascade. Nature Metabolism[J]. 2020, [10] 苏士成, 宋保亮, 陈玲玲, 刘兴国. 线粒体定位circRNA调控肝脏免疫代谢性炎症机制. 生命的化学[J]. 2020, 40(10): 1914-1916, http://lib.cqvip.com/Qikan/Article/Detail?id=7103671951.
[11] Zhou, Yanshuang, Long, Qi, Wu, Hao, Li, Wei, Qi, Juntao, Wu, Yi, Xiang, Ge, Tang, Haite, Yang, Liang, Chen, Keshi, Li, Linpeng, Bao, Feixiang, Li, Heying, Wang, Yaofeng, Li, Min, Liu, Xingguo. Topology-dependent, bifurcated mitochondrial quality control under starvation. AUTOPHAGY[J]. 2020, 16(3): 562-574, https://www.webofscience.com/wos/woscc/full-record/WOS:000475050600001.
[12] Yang, Liang, Tang, Haite, Lin, Xiaobing, Wu, Yi, Zeng, Sheng, Li, Yukun, Xiang, Ge, Lin, YiFang, Zhuang, ShiMei, Song, Zhiyin, Jiang, Yiguo, Liu, Xingguo. OPA1-Exon4b Binds to mtDNA D-Loop for Transcriptional and Metabolic Modulation, Independent of Mitochondrial Fusion. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2020, 8: https://doaj.org/article/0d7372cd69674f4eba43e0a7c2063873.
[13] Chen, Keshi, Long, Qi, Xing, Guangsuo, Wang, Tianyu, Wu, Yi, Li, Linpeng, Qi, Juntao, Zhou, Yanshuang, Ma, Bochao, Schoeler, Hans R, Nie, Jinfu, Pei, Duanqing, Liu, Xingguo. Heterochromatin loosening by the Oct4 linker region facilitates Klf4 binding and iPSC reprogramming. EMBO JOURNAL[J]. 2020, 39(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939195/.
[14] Wu, Yi, Chen, Keshi, Xing, Guangsuo, Li, Linpeng, Ma, Bochao, Hu, Zhijuan, Duan, Lifan, Liu, Xingguo. Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition. SCIENCE ADVANCES[J]. 2019, 5(11): [15] 刘兴国. Phospholipid remodeling is critical for stem cell pluripotency via facilitating mesenchymal-to-epithelial transition. Science Advances. 2019, [16] Ying, Zhongfu, Xiang, Ge, Zheng, Lingjun, Tang, Haite, Duan, Lifan, Lin, Xiaobing, Zhao, Qiuge, Chen, Keshi, Wu, Yi, Xing, Guangsuo, Lv, Yiwang, Li, Linpeng, Yang, Liang, Bao, Feixiang, Long, Qi, Zhou, Yanshuang, He, Xueying, Wang, Yaofeng, Gao, Minghui, Pei, Duanqing, Chan, WaiYee, Liu, Xingguo. Short-Term Mitochondrial Permeability Transition Pore Opening Modulates Histone Lysine Methylation at the Early Phase of Somatic Cell Reprogramming. CELL METABOLISM[J]. 2018, 28(6): 935-+, http://www.corc.org.cn/handle/1471x/2204399.
[17] Bao, Feixiang, Shi, Hongyan, Gao, Mi, Yang, Liang, Zhou, Lingyan, Zhao, Qiuge, Wu, Yi, Chen, Keshi, Xiang, Ge, Long, Qi, Guo, Jingyi, Zhang, Jian, Liu, Xingguo. Polybrene induces neural degeneration by bidirectional Ca2+ influx-dependent mitochondrial and ER-mitochondrial dynamics. CELL DEATH & DISEASE[J]. 2018, 9(10): http://www.corc.org.cn/handle/1471x/2202271.
[18] Cao, JianJun, Tan, CaiPing, Chen, MuHe, Wu, Na, Yao, DeYang, Liu, XingGuo, Ji, LiangNian, Mao, ZongWan. Targeting cancer cell metabolism with mitochondria-immobilized phosphorescent cyclometalated iridium(III) complexes. CHEMICAL SCIENCE[J]. 2017, 8(1): 631-640, https://www.webofscience.com/wos/woscc/full-record/WOS:000391454500077.
[19] Liu, Jiangping, Jin, Chengzhi, Yuan, Bo, Liu, Xingguo, Chen, Yu, Ji, Liangnian, Chao, Hui. Selectively lighting up two-photon photodynamic activity in mitochondria with AIE-active iridium(III) complexes. CHEMICAL COMMUNICATIONS[J]. 2017, 53(12): 2052-2055, https://www.webofscience.com/wos/woscc/full-record/WOS:000395624400030.
[20] Xiang, Ge, Yang, Liang, Long, Qi, Chen, Keshi, Tang, Haite, Wu, Yi, Liu, Zihuang, Zhou, Yanshuang, Qi, Juntao, Zheng, Lingjun, Liu, Wenbo, Ying, Zhongfu, Fan, Weimin, Shi, Hongyan, Li, Hongmei, Lin, Xiaobing, Gao, Mi, Liu, Jinglei, Bao, Feixiang, Li, Linpeng, Duan, Lifan, Li, Min, Liu, Xingguo. BNIP3L-dependent mitophagy accounts for mitochondrial clearance during 3 factors-induced somatic cell reprogramming. AUTOPHAGY[J]. 2017, 13(9): 1543-1555, https://www.webofscience.com/wos/woscc/full-record/WOS:000412206800007.
[21] Liu, Jiangping, Jin, Chengzhi, Yuan, Bo, Chen, Yu, Liu, Xingguo, Ji, Liangnian, Chao, Hui. Enhanced cancer therapy by the marriage of metabolic alteration and mitochondrial-targeted photodynamic therapy using cyclometalated Ir(III) complexes. CHEMICAL COMMUNICATIONS[J]. 2017, 53(71): 9878-9881, http://dx.doi.org/10.1039/c7cc05518h.
[22] 刘兴国. BNIP3L-dependent Mitophagy Accounts for Mitochondrial Clearance during SKO-induced Somatic Cell Reprogramming. Autophagy. 2017, [23] Li, Linpeng, Chen, Keshi, Wu, Yi, Long, Qi, Zhao, Danyun, Ma, Bochao, Pei, Duanqing, Liu, Xingguo. Gadd45a opens up the promoter regions of miR-295 facilitating pluripotency induction. CELL DEATH & DISEASE[J]. 2017, 8: https://www.webofscience.com/wos/woscc/full-record/WOS:000414022900052.
[24] Xingguo Liu, Liang Yang, Qi Long, David Weaver, György Hajnóczky. Choosing proper fluorescent dyes, proteins, and imaging techniques to study mitochondrial dynamics in mammalian cells. Biophysics Reports[J]. 2017, 3(4-6): 64-72, http://dx.doi.org/10.1007/s41048-017-0037-8.
[25] Wu, Yi, Chen, Keshi, Liu, Xiyin, Huang, Lili, Zhao, Danyun, Li, Linpeng, Gao, Mi, Pei, Duanqing, Wang, Chenguang, Liu, Xingguo. Srebp-1 Interacts with c-Myc to Enhance Somatic Cell Reprogramming. STEM CELLS[J]. 2016, 34(1): 83-92, http://ir.gibh.ac.cn/handle/344009/923.
[26] Bao, FeiXiang, Shi, HongYan, Long, Qi, Yang, Liang, Wu, Yi, Ying, ZhongFu, Qin, DaJiang, Zhang, Jian, Guo, YiPing, Li, HongMei, Liu, XingGuo. Mitochondrial Membrane Potential-dependent Endoplasmic Reticulum Fragmentation is an Important Step in Neuritic Degeneration. CNS NEUROSCIENCE & THERAPEUTICS[J]. 2016, 22(8): 648-660, http://ir.foo.ac.cn/handle/2SETSVCV/323.
[27] Ying, Zhongfu, Chen, Keshi, Zheng, Lingjun, Wu, Yi, Li, Linpeng, Wang, Rui, Long, Qi, Yang, Liang, Guo, Jingyi, Yao, Deyang, Li, Yong, Bao, Feixiang, Xiang, Ge, Liu, Jinglei, Huang, Qiaoying, Wu, Zhiming, Hutchins, Andrew Paul, Pei, Duanqing, Liu, Xingguo. Transient Activation of Mitoflashes Modulates Nanog at the Early Phase of Somatic Cell Reprogramming. CELL METABOLISM[J]. 2016, 23(1): 220-226, http://dx.doi.org/10.1016/j.cmet.2015.10.002.
[28] Chen, Keshi, Long, Qi, Wang, Tao, Zhao, Danyun, Zhou, Yanshuang, Qi, Juntao, Wu, Yi, Li, Shengbiao, Chen, Chunlan, Zeng, Xiaoming, Yang, Jianguo, Zhou, Zisong, Qin, Weiwen, Liu, Xiyin, Li, Yuxing, Li, Yingying, Huang, Xiaofen, Qin, Dajiang, Chen, Jiekai, Pan, Guangjin, Schoeler, Hans R, Xu, Guoliang, Liu, Xingguo, Pei, Duanqing. Gadd45a is a heterochromatin relaxer that enhances iPS cell generation. EMBO REPORTS[J]. 2016, 17(11): 1641-1656, http://ir.gibh.ac.cn/handle/344009/800.
[29] Gao, Ying, Liu, Yajun, Hong, Liang, Yang, Zuolong, Cai, Xinran, Chen, Xiaoyun, Fu, Yuanyuan, Lin, Yujie, Wen, Weijie, Li, Sitong, Liu, Xingguo, Huang, Heqing, Vogt, Andreas, Liu, Peiqing, Yin, XiaoMing, Li, Min. Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy. CELL DEATH & DISEASE[J]. 2016, 7(8): e2330-, http://ir.gibh.ac.cn/handle/344009/822.
[30] Yang, Liang, Mei, Tingfang, Lin, Xiaobing, Tang, Haite, Wu, Yi, Wang, Rui, Liu, Jinglei, Shah, Zahir, Liu, Xingguo. Current approaches to reduce or eliminate mitochondrial DNA mutations. SCIENCE CHINA-LIFE SCIENCESnull. 2016, 59(5): 532-535, http://ir.gibh.ac.cn/handle/344009/855.
[31] Wu, Yasong, Li, Yuan, Zhang, Hui, Huang, Yinghua, Zhao, Ping, Tang, Yujia, Qiu, Xiaohui, Ying, Yue, Li, Wen, Ni, Su, Zhang, Meng, Liu, Longqi, Xu, Yan, Zhuang, Qiang, Luo, Zhiwei, Benda, Christina, Song, Hong, Liu, Baohua, Lai, Liangxue, Liu, Xingguo, Tse, HungFat, Bao, Xichen, Chan, WaiYee, Esteban, Miguel A, Qin, Baoming, Pei, Duanqing. Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming. NATURE CELL BIOLOGY[J]. 2015, 17(6): 715-+, http://ir.gibh.ac.cn/handle/344009/536.
[32] Yang, Liang, Long, Qi, Liu, Jinglei, Tang, Haite, Li, Yuxing, Bao, Feixiang, Qin, Dajiang, Pei, Duanqing, Liu, Xingguo. Mitochondrial fusion provides an 'initial metabolic complementation' controlled by mtDNA. CELLULAR AND MOLECULAR LIFE SCIENCES[J]. 2015, 72(13): 2585-2598, http://ir.gibh.ac.cn/handle/344009/526.
[33] Long, Qi, Zhao, Danyun, Fan, Weimin, Yang, Liang, Zhou, Yanshuang, Qi, Juntao, Wang, Xin, Liu, Xingguo. Modeling of Mitochondrial Donut Formation. BIOPHYSICAL JOURNAL[J]. 2015, 109(5): 892-899, http://ir.foo.ac.cn/handle/2SETSVCV/527.
[34] 刘兴国. 利用iPS技术建立丙戊酸肝毒理模型及药物筛选. 中国药理学通报. 2015, 31(B11): 52-53, http://lib.cqvip.com/Qikan/Article/Detail?id=666454086.
[35] Li, Shengbiao, Guo, Jingyi, Ying, Zhongfu, Chen, Shen, Yang, Liang, Chen, Keshi, Long, Qi, Qin, Dajiang, Pei, Duanqing, Liu, Xingguo. Valproic Acid-Induced Hepatotoxicity in Alpers Syndrome Is Associated With Mitochondrial Permeability Transition Pore Opening-Dependent Apoptotic Sensitivity in an Induced Pluripotent Stem Cell Model. HEPATOLOGY[J]. 2015, 61(5): 1730-1739, http://ir.gibh.ac.cn/handle/344009/553.
[36] David Weaver, Vernica Eisner, Xingguo Liu, Pter Vrnai, Lszl Hunyady, Atan Gross, Gyrgy Hajnczky. The distribution and apoptotic function of outer membrane proteins depend on mitochondrial fusion. Molecular cell. 2014, 54(5): 870-878, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4363113/.
[37] Liu, Wenbo, Long, Qi, Chen, Keshi, Li, Shengbiao, Xiang, Ge, Chen, Shen, Liu, Xiyin, Li, Yuxing, Yang, Liang, Dong, Delu, Jiang, Cheng, Feng, Zhenhua, Qin, Dajiang, Liu, Xingguo. Mitochondrial metabolism transition cooperates with nuclear reprogramming during induced pluripotent stem cell generation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2013, 431(4): 767-771, http://ir.gibh.ac.cn/handle/344009/763.
[38] Liu, X, Hajnoczky, G. Altered fusion dynamics underlie unique morphological changes in mitochondria during hypoxia-reoxygenation stress. CELL DEATH AND DIFFERENTIATION[J]. 2011, 18(10): 1561-1572, https://www.webofscience.com/wos/woscc/full-record/WOS:000294757800004.
[39] Twig, Gilad, Liu, Xingguo, Liesa, Marc, Wikstrom, Jakob D, Molina, Anthony J A, Las, Guy, Yaniv, Gal, Hajnoczky, Gyoergy, Shirihai, Orian S. Biophysical properties of mitochondrial fusion events in pancreatic beta-cells and cardiac cells unravel potential control mechanisms of its selectivity. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY[J]. 2010, 299(2): C477-C487, https://www.webofscience.com/wos/woscc/full-record/WOS:000280397600031.
[40] Liu, Xingguo, Weaver, David, Shirihai, Orian, Hajnoczky, Gyoergy. Mitochondrial 'kiss-and-run': interplay between mitochondrial motility and fusion-fission dynamics. EMBO JOURNAL[J]. 2009, 28(20): 3074-3089, https://www.webofscience.com/wos/woscc/full-record/WOS:000271008200003.
[41] Liu, Xingguo, Hajnoczky, Gyoergy. Ca2+-dependent regulation of mitochondrial dynamics by the Miro-Milton complex. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGYnull. 2009, 41(10): 1972-1976, http://dx.doi.org/10.1016/j.biocel.2009.05.013.
[42] Liu, Xingguo, Zhao, Jingjing, Wu, Qingyu. Sorbitol regulates energy transfer from allophycocyanin to the terminal emitter within phycobilisomes in Synechocystis sp. BIOTECHNOLOGY LETTERS[J]. 2007, 29(2): 253-259, https://www.webofscience.com/wos/woscc/full-record/WOS:000244292900010.
[43] Liu, X, Zhao, J, Wu, Q. Biogenesis of chlorophyll-binding proteins under iron stress in Synechocystis sp PCC 6803. BIOCHEMISTRY-MOSCOW[J]. 2006, 71: S101-S104, https://www.webofscience.com/wos/woscc/full-record/WOS:000236212300017.
[44] 刘兴国. Two-Component Signal Transduction Systems in the Cyanobacterium Synechocystis sp. PCC 6803. Tsinghua Science and Technology. 2006, [45] Liu, XG, Huang, W, Li, M, Wu, QY. Purification and characterization of two small heat shock proteins from Anabaena sp PCC 7120. IUBMB LIFEnull. 2005, 57(6): 449-454, [46] Xing-Guo Liu, Jing-Jing Zhao, Qing-Yu Wu. Oxidative stress and metal ions effects on the cores of phycobilisomes in Synechocystis sp. PCC 6803. FEBS Letters. 2005, 579(21): 4571-4576, http://dx.doi.org/10.1016/j.febslet.2005.07.020.

   

（ 1 ） 中国科学院战略性先导科技专项, 主持, 部委级, 2012-12--2015-12
（ 2 ） 重大科学研究计划, 主持, 国家级, 2013-01--2017-08
（ 3 ） 新功能人造生物器件的构建与集成, 参与, 国家级, 2012-01--2016-08
（ 4 ） 广东省高层次人才特殊支持计划科技创新青年拔尖人才, 主持, 省级, 2015-01--2017-12
（ 5 ） 缺氧/复氧对线粒体功能和动力学的调控机制, 主持, 国家级, 2013-01--2016-12
（ 6 ） 基于新方法的线粒体生物学, 主持, 省级, 2012-10--2016-10
（ 7 ） 利用干细胞进行丙戊酸诱发Alpers-Huttenlocher综合征肝毒性的机理研究, 主持, 国家级, 2016-01--2019-12

已指导学生

刘文波  硕士研究生  071010-生物化学与分子生物学  

赵丹芸  硕士研究生  071010-生物化学与分子生物学  

周子松  硕士研究生  085238-生物工程  

刘雪宾  硕士研究生  085238-生物工程  

邬毅  硕士研究生  085238-生物工程  

杨亮  博士研究生  071010-生物化学与分子生物学  

现指导学生

项鸽  博士研究生  071010-生物化学与分子生物学  

梅婷芳  硕士研究生  085238-生物工程  

李林鹏  博士研究生  071009-细胞生物学  

唐海特  硕士研究生  085238-生物工程  

邬毅  博士研究生  071009-细胞生物学  

周艳双  博士研究生  071009-细胞生物学  

齐俊涛  博士研究生  071009-细胞生物学