Molecular pathogenesis and molecular mechanism of drug resistance in pathogenic bacteria. 

1. Interaction between pathogen and the host
2. Molecular mechanisms of drug resistance in M.tuberculosis
2. Molecular mechanisms of drug resistance in multidrug-resistant Klebsiella pneumoniae

The Third Military Medical University, Chongqing, China.
Bachelor of Medicine, Medical Laboratory Science, 2000

Southern Medical University, Guangzhou, China.
Ph.D., Biochemistry and Molecular Biology, 2005 

   

2010-Present

Principle Investigator, Associate Professor,Professor, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

2009-2010

Associate professor, Institute for Tuberculosis research, The 309 Hospital of PLA, Beijing, China.

2007-2009

Associate professor, The State-Key Lab of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/ Peking Union Medical College, Tsinghua University, Beijing, China

2006-2007

Postdoc., Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

2003-2006

Ph.D. student and Postdoc., Channing Lab, Brigham and Women’s Hospital & Harvard Medical School, Boston, USA.

2003-2004 "Biomedicine and Bioengineering Research Fellowship", from World Health Organization (WHO)

2005 "Outstanding Graduate Student of Southern Guangdong", awarded by the Department of Education of Guangdong Province 

2011 "Young Scientist Innovation promotion association", Chinese Academy of Sciences.

2015 "Young Scientist Innovation Promotion Association Excellent Member", awarded by Chinese Academy of Sciences

2018 National Natural Science Foundation of China (NSFC) "Distinguished Young Investigator"

2018 National "Ten thousand people plan-science and technology innovation leader"

2019 "Outstanding Scientific Research Team Award", awarded by Qiu Shi Science and Technology Foundation

2022 "Excellent Supervisor", awarded by Chinese Academy of Sciences

   

1． Chai Q^#, Yu S^#, Zhong Y^#, Lu Z, Qiu C, Yu Y, Zhang X, Zhang Y, Lei Z, Qiang L, Li B, Pang Y, Qiu X-B*, Wang J*, Liu CH*. A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin. Science 2022, 378(6616): eabq0132.

2． Qian MX^#, Pang Y^#, Liu CH^#, Haratake K^#, Du BY^#, Ji DY^#, Wang GF, Zhu QQ, Song W, Yu Y, Zhang XX, Huang HT, Miao SY, Chen LB, Zhang ZH, Liang YN, Liu S, Cha H, Yang D, Zhai Y, Komatsu T, Tsuruta F, Li H, Cao C, Li W, Li GH, Cheng Y, Chiba T, Wang L, Goldberg AL, Shen Y, Qiu XB*. Acetylation-mediated degradation of core histones by PA200/Blm10-containing proteasomes. Cell 2013, 153(5): 1012-1024.

3． Wang J^#, Li B^#, Ge P^#, Li J, Wang Q, Gao GF*, Qiu XB*, Liu CH*. Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system. Nature Immunology 2015, 16(3): 237-245.

4． Chai Q, Wang X, Qiang L, Zhang Y, Ge P, Lu Z, Zhong Y, Li B, Wang J, Zhang L, Zhou D, Li W, Dong W, Pang Y, Gao GF, Liu CH*. A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy. Nature Communications 2019, 10(1): 1973.

5． Wang J^#, Ge P^#, Qiang L, Tian F, Zhao D, Chai Q, Zhu M, Zhou R, Meng G, Iwakura Y, Gao FG, Liu CH*. The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation. Nature Communications 2017, 8(1): 244.

6． Wang J^#, Ge P^#, Lei Z^#, Lu Z, Qiang L, Chai Q, Zhang Y, Zhao D, Li B, Su J, Peng R, Shi Y, Zhang Y, Gao GF*, Qiu XB*, Liu CH*. Mycobacterium tuberculosis protein kinase G acts as an unusual ubiquitinating enzyme to impair host immunity. EMBO Reports 2021, 22(6): e52175.

7． Qiang L^#, Zhang Y^#, Lei Z^#, Lu Z, Tan S, Ge P, Chai Q, Zhao M, Zhang X, Li B, Pang Y, Zhang L, Liu CH*, Wang J*. A mycobacterial effector promotes ferroptosis-dependent pathogenicity and dissemination. Nature Communications 2023, 14(1): 1430.

8． Wang J^#, Zhao D^#, Lei Z^#, Ge P^#, Lu Z, Chai Q, Zhang Y, Qiang L, Yu Y, Zhang X, Li B, Zhu S, Zhang L*, Liu CH*. TRIM27 maintains gut homeostasis by promoting intestinal stem cell self-renewal. Cellular & Molecular Immunology 2023, 20(2):158-174.

9． Zhao D^#, Qiang L^#, Lei Z^#, Ge P^#, Lu Z, Wang Y, Zhang X, Qiang Y, Li B, Pang Y, Zhang L, Liu CH*, Wang J*. TRIM27 elicits protective immunity against tuberculosis by activating TFEB-mediated autophagy flux. Autophagy 2024, online ahead of print.

10． Ge P^#, Lei Z^#, Yu Y, Lu Z, Qiang L, Chai Q, Zhang Y, Zhao D, Li B, Pang Y, Liu CH*, Wang J*. M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival. Autophagy 2022, 18(3): 576-594.

11． Fu Y, Wang H, Dai H, Zhu Q, Cui CP, Sun X, Li Y, Deng Z, Zhou X, Ge Y, Peng Z, Yuan C, Wu B, Yang X, Li R, Liu CH*, He F*, Wei W*, Zhang L*. OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin. Molecular Cell 2021, 81(15): 3187-3204.e7.

12． Liu CH, Lee SM, VanLare JM, Kasper DL, Mazmanian SK*. Regulation of surface architecture by symbiotic bacteria mediates host colonization. Proc Natl Acad Sci U S A 2008, 105 (10): 3951-3956.

13． Jiang TX^#, Zou JB^#, Zhu QQ^#, Liu CH^#, Wang GF^#, Du TT^#, Luo ZY, Guo F, Zhou Fnag, Zhou LM, Liu JJ, Zhang W, Shu YS, Yu L, Li P, Ronai ZA, Matsuzawa S, Goldberg AL*, Qiu XB*. SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation. Proc Natl Acad Sci U S A 2019, 116 (27): 13404-13413.

14． Zhu Q^#, Fu Y^#, Cui CP, Ding Y, Deng Z, Ning C, Hu F, Qiu C, Yu B, Zhou X, Yang G, Peng J, Zou W, Liu CH*, Zhang L*. OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2. Signal Transduction and Targeted Therapy 2023, 8(1): 142.

15． Qiang L^#, Wang J^#, Zhang Y, Ge P, Chai Q, Li B, Shi Y, Zhang L, Gao GF, Liu CH*. Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation. Cellular & Molecular Immunology 2019, 16(4): 380-391.

16． Wu B^#, Qiang L^#, Zhang Y^#, Fu Y^#, Zhao M, Lei Z, Lu Z, Wei Y, Dai H, Ge Y, Liu M, Zhou X, Peng Z, Li H, Cui C, Wang J, Zheng H, Liu CH*, Zhang L*. The deubiquitinase OTUD1 inhibits colonic inflammation through suppressing RIPK1-mediated NF-κB signaling. Cellular & Molecular Immunology 2022, 19(2): 276-289.

17． Zhao M^#, Zhang Y^#, Qiang L, Lu Z, Zhao Z, Fu Y, Wu B, Chai Q, Ge P, Lei Z, Zhang X, Li B, Wang J, Zhang L*, Liu CH*. A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity. Cell Reports 2023, 42(6): 112655.

18． Qiang L, Zhang Y, Liu CH*. Mycobacterium tuberculosis effector proteins: functional multiplicity and regulatory diversity. Cellular & Molecular Immunology 2021, 18(5): 1343-1344.

19． Zhu Q^#, Fu Y^#, Li L, Liu CH*, Zhang L*. The functions and regulation of Otubains in protein homeostasis and diseases. Ageing Research Reviews 2021, 67: 101303.

20． Chai Q^#, Wang L^#, Liu CH*, Ge B*. New insights into the evasion of host innate immunity by Mycobacterium tuberculosis. Cellular & Molecular Immunology 2020, 17(9): 901-913.

21． Chai Q*, Lei Z, Liu CH*. Pyroptosis modulation by bacterial effector proteins. Seminars in Immunology 2023, 69: 101804.

22． Liu CH*, Liu H*, Ge B*. Innate immunity in tuberculosis: host defense vs pathogen. Cellular Molecular Immunology 2017, 14: 963-975.

23． Chai Q*, Lu Z, Liu CH*. Host defense mechanisms against Mycobacterium tuberculosis. Cellular and Molecular Life Sciences 2020, 77(10): 1859-1878.

24． Xu G, Wang J, Liu CH*. Klebsiella pneumoniae NdpA suppresses ERK pathway-mediated host early inflammatory responses and is degraded through the ubiquitin-proteasome pathway. Protein & Cell. 2017, 8(2): 144-148.

25． Liu CH*, Rao Y*, Gao D*, Wan L*, Zhang L*. Editorial: Ubiquitin Code: From Cell Biology to Translational Medicine. Frontiers in Cell and Developmental Biology 2021, 9: 791967.

26． Lei Z^#, Wang J^#, Zhang L*, Liu CH*. Ubiquitination-Dependent Regulation of Small GTPases in Membrane Trafficking: From Cell Biology to Human Diseases.  Frontiers in Cell and Developmental Biology 2021, 9: 688352.

27． Gai W^#, Peng Z^#, Liu CH*, Zhang L*, Jiang H*. Advances in cancer treatment by targeting the neddylation pathway. Frontiers in Cell and Developmental Biology 2021, 9: 653882.

28． Li J, Chai Q, Liu CH*. The ubiquitin system: a critical regulator of innate immunity and pathogen-host interactions. Cellular & Molecular Immunology 2016, 13: 560-576.

29． Zhang F^#, Yu S^#, Chai Q^#, Wang J^#, Wu T, Liu R, Liu Y, Liu CH*, Pang Y*. HDAC6 contributes to human resistance against Mycobacterium tuberculosis infection via mediating innate immune responses. FASEB Journal 2021, 35(11): e22009.

30． Wang J^#, Han C^#, Lu Z^#, Ge P, Cui Y, Zhao D, Yang X, Wu B, Qiang L, Zhang Y, Chai Q, Lei Z, Li L*, Liu CH*, Zhang L*. Simulated microgravity suppresses MAPK pathway-mediated innate immune response to bacterial infection and induces gut microbiota dysbiosis. FASEB Journal 2020, 34(11): 14631-14644.

31． Li J, Chai Q, Zhang Y, Li B, Wang J, Qiu XB, Liu CH*. Mycobacterium tuberculosis Mce3E suppresses host innate immune responses by targeting ERK1/2 signaling. The Journal of Immunology 2015, 194 (8): 3756-3767.

32． Li J, Liu F, Wang Q, Ge P, Woo PCY, Yan J, Zhao Y, Gao GF, Liu CH*, Liu C*. Genomic and transcriptomic analysis of NDM-1 Klebsiella pneumoniae in spaceflight reveal mechanisms underlying environmental adaptability. Scientific Reports 2014, 4: 6216.

33． Wang J, Teng JL, Zhao D, Ge P, Li B, Woo PC, Liu CH*. The ubiquitin ligase TRIM27 functions as a host restriction factor antagonized by Mycobacterium tuberculosis PtpA during mycobacterial infection. Scientific Reports 2016, 6: 34827.

34． Zhang Y, Li J, Li B, Wang J, Liu CH*. M. tuberculosis Mce3C promotes mycobacteria entry into macrophages through activation of β2 integrin-mediated signaling pathway. Cellular Microbiology 2018, 20 (2): e12800.

35． Liu F, Hu YF, Wang Q, Li HM, Gao GF, Liu CH*, Zhu B*. Comparative genomic analysis of gene variations among  Mycobacterium tuberculosis clinical isolates with different antibiotic resistance profiles. BMC Genomics 2014, 15: 469.

36． Chai Q^#, Lu Z^#, Liu Z^#, Zhong Y, Zhang F, Qiu C, Li B, Wang J, Zhang L, Pang Y*, Liu CH*. Lung gene expression signatures suggest pathogenic links and molecular markers for pulmonary tuberculosis, adenocarcinoma and sarcoidosis. Communications Biology 2020, 3(1): 604.

37． Liu CH^#*, Li HM^#, Lu N^#, Wang Q, Hu YL, Yang X, Woo PCY, Gao GF, Zhu BL*. Genomic sequence based scanning for drug resistance-associated mutations and evolutionary analysis of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis. Journal of Infection 2012, 65(5): 412-422.

38． Hu J, Li Z, Gao J, He H, Dai H, Xia X, Liu CH*, Zhang L*, Song F*. New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151. Marine Drugs 2019, 17 (5): 262.

39． Liu CH^#*, Li L^#, Chen Z^#, Wang Q, Hu YL, Zhu BL*, Woo PCY*. Characteristics and treatment outcomes of patients with MDR and XDR tuberculosis in a TB referral hospital in Beijing: A 13-year experience. PLoS ONE 2011, 6(4): e19399.

40． Li B^#, Yi Y^#, Wang Q, Tan L, Jing H, Woo PCY, Gao GF*, Liu CH*. Analysis of drug resistance determinants in Klebsiella pneumoniae isolates from a tertiary-care hospital in Beijing, China. PloS ONE 2012, 7(7): e42280.

41． Li B^#, Hu Y^#, Wang Q^#, Yi Y, Woo PCY, Jing H, Zhu B, Liu CH*. Structural diversity of class 1 Integrons and their associated hene cassettes in Klebsiella pneumoniae isolates from a hospital in China. PLoS ONE 2013, 8(9): e75805.

42． Wang Q^#, Li B^#, Tsang AK^#, Yi Y, Woo PC*, Liu CH*. Genotypic analysis of Klebsiella pneumoniae isolates in a Beijing hospital reveals high genetic diversity and clonal population structure of drug-resistant isolates. PloS ONE 2013, 8(2): e57091.

43． Wang Q^#, Lau SK^#, Liu F^#, Zhao Y, Li HM, Li BX, Hu YL, Woo PC*, Liu CH*. Molecular epidemiology and clinical characteristics of drug-resistant Mycobacterium tuberculosis in a tuberculosis referral hospital in China. PLoS One 2014, 9(10): e110209. 

44． Chai Q, Zhang Y, Liu CH*. Mycobacterium tuberculosis: An adaptable pathogen associated with multiple human diseases. Frontiers in Cellular and Infection Microbiology 2018, 8: 158.

45． Xu G, Wang J, Gao GF*, Liu CH*. Insights into battles between Mycobacterium tuberculosis and macrophages. Protein & Cell 2014, 5(10): 728-736.

46． Yu HT^#, Yang N^#, Wang Q^#, Liang JQ, Liu CH*. Risk factors associated with kanamycin-resistant tuberculosis in a Beijing tuberculosis referral hospital. Journal of Medical Microbiology 2012, 61(7): 960-967.

47． Liu CH^#*, Li HM^＃, Li L^＃, Hu YL, Wang Q, Yang N, Wang SM, Zhu BL*. Anti-tuberculosis drug resistance patterns and trends in a tuberculosis referral hospital, 1997–2009. Epidemiology and Infection 2011, 139(12): 1909-1918.

48． Liu CH^#*, Yang N^＃, Wang Q, Hu YL, Li L, Zhang GY, Zhu BL. Risk factors associated with fluoroquinolone-resistant tuberculosis in a Beijing tuberculosis referral hospital. Respirology 2011, 16(6): 918-925.

49． Liu CH, Ma WL*, Shi R, Ou YQ, Zhang B, Zheng WL*. Possibility of Using DNA Chip Technology for Diagnosis of Human Papillomavirus. Journal of Biochemistry and Molecular Biology 2003, 36 (4): 349-353.

50． Liu CH, Ma WL*, Shi R, Zhang B, Ou YQ, Zheng WL. Gene expression study of Saccharomyces cerevisiae with the Agilent 2100 bioanalyser. British Journal of Biomedical Science 2003, 60 (1): 22-25.

51． Fang Y^#, Lei Z^#, Liu CH*, Chai Q*. Regulatory functions and mechanisms of human microbiota in infectious diseases. hLife 2023.

52． Gao X, Liu CH*, Wang S*. Mucosal immune responses in the lung during respiratory infection: the organization and regulation of iBALT structure. hLife 2023, 1(2): 71-82.

53． Liu CH*. M. tuberculosis and macrophages: co-existence and co-evolution. Journal of Pulmonary & Respiratory Medicine 2014, 4: 2.

54． Liu CH, Goldberg AL, Qiu XB*. New insights into the role of the ubiquitin-proteasome pathway in the regulation of apoptosis. Chang Gung Medical Journal 2007, 30 (6): 469-479.

55． Liu CH*. Effects of Asian sand dust on respiratory health. Journal of Pulmonary & Respiratory Medicine 2013, 3: 3.

56． Liu CH*. Open access publication: an important pathway for the advancement of science and patient care. Journal of Pulmonary & Respiratory Medicine 2012, 2: 1.

1. Cui Hua Liu, Yong Zhang, Jing Wang; A target against Mycobacterium tuberculosis invasion of host cells and its application; Patent number: ZL202110518930.6; Application date: May 13, 2021; Authorization date: December 1, 2023 (Authorization)

2. Cui Hua Liu, Jing Wang; A model of irritable bowel syndrome and its application; Patent number: ZL202010430662.8; Application date: May 20, 2020; Authorization date: May 18, 2023 (Authorization)

3. Cui Hua Liu, Qiyao Chai, Zhe Lu, Jing Wang; Biomarkers of Tuberculosis and their application; Patent number: ZL202010349875.8; Application date: April 28, 2020; Authorization date: December 2, 2021 (Authorization)

4. Cui Hua Liu, Jing Wang; An anti-Mycobacterium tuberculosis target and its application; Patent number: ZL201811430799.2; Application date: November 28, 2018; Authorization date: May 4, 2021 (Authorization)

5. Cui Hua Liu, Jing Wang; An anti-Mycobacterium tuberculosis target and its application; Patent number: ZL201811430645.3; Application date: November 28, 2018; Authorization date: May 4, 2021 (Authorization)

6. Cui Hua Liu, Jing Wang; An anti-Mycobacterium tuberculosis target and its application; Patent number: ZL201811431187.5; Application date: November 28, 2018; Authorization date: April 30, 2021 (Authorization)

7. Cui Hua Liu, Yong Zhang, Jing Wang; A macrophage phagocytosis accelerator; Authorization number: ZL201710898729.9; Application date: September 28, 2017; Authorization date: July 7, 2020 (Authorization)

8. Cui Hua Liu, Guanghua Xu, Jing Wang, Bingxi Li, Jinghua Yan; An ERK signaling pathway inhibitor NdpA; Authorization number: ZL201610213178.3; Application date: April 7, 2016; Authorization date: July 7, 2020 (Authorization)

9. Cui Hua Liu, Jing Wang; A protein TRIM27 defending against Mycobacterium tuberculosis infection; Authorization number: ZL201610381995.X; Application date: June 1, 2016; Authorization date: September 17, 2019 (Authorization)

10. Cui Hua Liu, Jing Wang, Bingxi Li, Yan Lu; Ubiquitin binding domain of Mycobacterium tuberculosis secreted protein; Authorization number: ZL201410061782.X; Application date: February 24, 2014; Authorization date: April 6, 2018 (Authorization)

11. Cui Hua Liu, Jing Wang, Bingxi Li, Pupu Ge; A recombinant BCG vaccine and its construction and application; Authorization number: ZL201410482225.5; Application date: September 19, 2014; Authorization date: March 1, 2019 (Authorization)

12. Cui Hua Liu, Jie Li, Jing Wang; An inhibitor of Erk signaling pathway; Authorization number: ZL201410523217.0; Application date: September 30, 2014; Authorization date: November 17, 2017 (Authorization)

13. Cui Hua Liu, Jing Wang; Protein PtpA secreted by Mycobacterium tuberculosis dephosphorylates p-JNK and p-p38; Authorization number: ZL201310466907.2; Application date: October 9, 2013; Authorization date: January 20, 2016 (Authorization)

14. Cui Hua Liu, Qiyao Chai, Jing Wang; Long non-coding RNAs identified from plasma of Tuberculosis resisters and their applications; Application number: 202410521497.5; Application date: April 28, 2024 (Application)

15. Cui Hua Liu, Jing Wang, Qiyao Chai, Changgen Qiu, Zhe Lu; Biomarkers for indicating latent infection with progressive tuberculosis and their applications; Application number: 202410506181.9; Application date: April 25, 2024 (Application)

16. Cui Hua Liu, Jing Wang; A monoclonal antibody blocking the invasion of Mycobacterium tuberculosis and its application; Application number: 202410051929.0; Application date: January 15, 2024 (Application)

17. Cui Hua Liu, Jing Wang; A recombinant BCG vaccine drug against tuberculosis; Application number: 202310918921.5; Application date: July 25, 2023 (Application)

18. Cui Hua Liu, Jing Wang; A recombinant BCG vaccine drug for treating tuberculosis and its application; Application number: 2023104010707; Application date: April 14, 2023 (Application)

19. Cui Hua Liu, Yong Zhang, Jing Wang; A Mycobacterium tuberculosis protein and its polypeptide; Application number: 202211387664.9; Application date: November 8, 2022 (Application)

20. Cui Hua Liu, Jing Wang, Qiyao Chai, Zehui Lei; A LILRB1 monoclonal antibody and its application; Application number: 202211236332.0; Application date: October 11, 2022 (Application)

21. Lingqiang Zhang, Cui Hua Liu, Yong Zhang, Lihua Qiang, Jing Wang; Deubiquitinating enzyme OTULIN inhibitors in the treatment of STING-mediated infectious diseases; Application number: 202211165985.4; Application date: September 23, 2022 (Application)

22. Cui Hua Liu, Qiyao Chai, Zhe Lu, Jing Wang; Construction and application of recombinant BCG vaccine; Application number: 202210425903.9; Application date: April 21, 2022 (Application)

23. Jing Wang, Cui Hua Liu; NK cell receptors highly expressed in Tuberculosis patients and its application; Application number: 202111026159.7; Application date: September 2, 2021 (Application)

24. Cui Hua Liu, Jing Wang; A drug used to treat Tuberculosis; Application number: 202110367728.8; Application date: April 6, 2021 (Application)

25. Cui Hua Liu, Qiyao Chai, Zhe Lu, Jing Wang; Diagnostic markers of lung sarcoidosis and their application; Application number: 202010350286.1; Application date: April 28, 2020 (Application)

Major research interests are molecular pathogenesis and molecular mechanism of pathogenic bacteria.

1. Liu CH*. Molecular mechanisms underlying Mycobacterium tuberculosis pathogenesis and host defense. CSHA: Bacterial Infection & Host Defense. 2024.5.20-24. Suzhou, China.

2. Liu CH*. Modulation of host cell death by Mycobacterium tuberculosis effector proteins. Nature Conference “Cell Death Mechanisms and Diseases”. 2023.11.17. Sichuan, China.

3. Liu CH*. M. tuberculosis pathogenesis and host immune defense. Annual Meeting of Overseas Chinese Society of Microbiology. 2023.7.7-9. Changchun, China.

4. Liu CH^*. Mycobacterium tuberculosis infection and host innate immune defense. International Joint 

Forum on Infectious Disease Research 2019. 2019.12.17. Beijing, China.

5. Liu CH ^*. Host Innate Immune Regulation by Mycobacterium tuberculosis. 17TH International Congress of Immunology. 2019.10.19-23. Beijing, China.

6. Liu CH ^*Mycobacterium tuberculosis infection and host immune defense. The 5th China-Australia Academic Conference on Tuberculosis and Immunization. 2019. 11.5-8. Wuhan, China.

7. Liu CH ^*. Host Innate Immune Regulation by M. tuberculosis Effector Proteins. 2019 International TB Forum. 2019.5.25. Shanghai, China.

8. Liu CH ^*. A M. tuberculosis surface protein recruits ubiquitin to trigger host xenophagy. 2019 International Conference on Environmental and Health Microbiology and Annual Meeting of Overseas Chinese Microbiology Society. 2019.7.12-15. Beijing, China.

9. Liu CH ^*. M. tuberculosis-host interactions. The 2nd China Tuberculosis International Summit Forum. 2019.3.16-18. Shanghai, China.

10. Liu CH ^*_. Molecular mechanisms underlying Mycobacterium tuberculosis-host interactions. The 8th International Lorne Infection and Immunity Conference 2018 Australia. February 14–16, 2018. Lorne, Australia.

11. Liu CH ^*_. Identification of anti-TB drug targets based on M. tuberculosis-host interactions. The 17th Asia-Pacific Congress of Clinical Microbiology and Infection cum 8th International Infection Control Conference. August 30–September 1, 2018. Hong Kong, China.

12. Liu CH ^*_. Host regulation by Mycobacterium tuberculosis. SAKURA Exchange Program in Science. Octobor 7–13, 2018. Tokyo, Japan.

13. Liu CH ^*_. Regulation of host innate immune signaling pathways and cellular functions by Mycobacterium tuberculosis. 《Nature》International Symposium on inflammatory diseases. 2017.9.17-20. Beijing, China.

14. Liu CH ^*_. Regulation of host cellular functions by Mycobacterium. tuberculosis. Sino-Australia Summer Symposium on Emerging Pathogens. July 4-5, 2017. Beijing, China.

15. Liu CH ^*_. Regulation of host cellular functions by M. tuberculosis secreted effector proteins. IMMUNOLOGY 2017, the Annual Meeting of The American Association of Immunologists, Inc. (AAI). May 12–16, 2017. Washington, D.C., USA.

16. Liu CH ^*_. Regulation of host immune signaling pathways and cellular functions by M. tuberculosis secreted effector proteins. CSH: Bacterial Infection and Host Defense. April 17-21, 2017. Suzhou, China.

17. Liu CH ^*_. Mutual antagonism between Mycobacterium tuberculosis effector protein PtpA and host ubiquitin system. 6th Cross straight immunology conference. March 18-19, 2017. Taiwang, China.

18. Liu CH ^*_. Regulation of Host Innate Immunity by Mycobacterium Tuberculosis Secreted Effector Proteins (Keynote speaker at the symposium for the session on Infectious Diseases in 2016). 21st Research Postgraduate Symposium, “Research without limit: Unfolding the Mystery of Disease”, December 1-2, 2016. Hongkong, China.

19. Liu CH ^*_. Mycobacterium tuberculosis regulates innate immunity through coopting host ubiquitin system.  International Symposium on Ubiquitin and Diseases. June 15-19, 2015. Zhangjiajie, Hunan, China.

20. Liu CH*. M. tuberculosis secreted effector proteins promote intracellular survival of mycobacteria through exploiting the host ubiquitin system. CSH: Bacterial Infection and Host Defense. November 2-6, 2015. Suzhou, China.

21. Liu CH ^*_. Regulation of host innate immunity by Mycobacterium tuberculosis secreted effector protein. 5th Cross straight immunology conference. October 16-18, 2015. Shandong, China.

22. Liu CH*_. Regulation of host innate immune responses by mycobacterium tuberculosis secreted proteins. International Forum on Tuberculosis, Shanghai. April 23-24, 2015. Shanghai, China.

Graduated students

Jie Li  M.D  085238-Bioengineering  

Pupu Ge  M.D  085238-Bioengineering   

Yong Zhang  M.D  077803-Pathogen Biology  

Jiansen Hu  Ph.D  071010-Biochemistry and Molecular Biology

Qiyao Chai  Ph.D  100103-Pathogen Biology  

Pupu Ge  Ph.D  100103-Pathogen Biology  

Zehui Lei  M.D  085238-Bioengineering    

Jiehua He  M.D  077803-Pathogen Biology

Lihua Qiang  Ph.D  100103-Pathogen Biology

Mengyuan Zhao  M.D  077803-Pathogen Biology

Present students

Dongdong Zhao  Ph.D  100103-Pathogen Biology 

Zhe Lu  Ph.D  100103-Pathogen Biology   

Yanzhao Zhong  Ph.D  100103-Pathogen Biology

Yang Yu  Ph.D  100103-Pathogen Biology

Zehui Lei  Ph.D  100103-Pathogen Biology   

Xinwen Zhang  Ph.D  100103-Pathogen Biology

Mengyuan Zhao  Ph.D  100103-Pathogen Biology   

Changgen Qiu  M.D  077803-Pathogen Biology

Zhuo Zhao  M.D  077803-Pathogen Biology

Yuyun Qiang  M.D  077803-Pathogen Biology

Yingxu Fang M.D  077803-Pathogen Biology