General
刘翠华 女 硕导 微生物研究所
Email: liucuihua@im.ac.cn
Telephone: 64807433
Mobile phone: 13439329416 
Address: NO.1 West Beichen Road, Chaoyang District, Beijing 100101,China
Postcode: 100101

Research Areas

Molecular pathogenesis and molecular mechanism of drug resistance in pathogenic bacteria. 

1. Interaction between pathogen and the host
2. Molecular mechanisms of drug resistance in M.tuberculosis
2. Molecular mechanisms of drug resistance in multidrug-resistant Klebsiella pneumoniae

Education

The Third Military Medical University, Chongqing, China.
Bachelor of Medicine, Medical Laboratory Science, 2000

Southern Medical University, Guangzhou, China.
Ph.D., Biochemistry and Molecular Biology, 2005 


Experience

   
Work Experience

2010-Present

Principle Investigator, Associate Professor,Professor, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

2009-2010

Associate professor, Institute for Tuberculosis research, The 309 Hospital of PLA, Beijing, China.

2007-2009

Associate professor, The State-Key Lab of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/ Peking Union Medical College, Tsinghua University, Beijing, China

2006-2007

Postdoc., Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

2003-2006

Ph.D. student and Postdoc., Channing Lab, Brigham and Women’s Hospital & Harvard Medical School, Boston, USA.

Honors & Distinctions

2003-2004 “Biomedicine and Bioengineering Research Fellowship”, from World Health Organization (WHO). 

2005 “Outstanding Graduate Student of Southern Guangdong”, awarded by the Department of Education of Guangdong Province.
 
2011 “Young Scientist Innovation promotion association”, Chinese Academy of Sciences.

Publications

   
Papers

1.  Qiyao Chai, Xudong Wang, Lihua Qiang, Yong Zhang, Pupu Ge, Zhe Lu, Yanzhao Zhong, Bingxi Li, Jing Wang, Lingqiang Zhang, Dawang Zhou, Wei Li, Wenzhu Dong, Yu Pang, George Fu Gao, Cui Hua Liu*. A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy. Nature Communications, 2019, 10:1973.  

2. Zhang Y, Li J, Li B, Wang J, Liu CH*. M. tuberculosis Mce3C promotes mycobacteria entry into macrophages through activation of β2 integrin-mediated signaling pathway. Cellular Microbiology. 2018, 20 (2): e12800.

3. Qiang L, Wang J, Zhang Y, Ge P, Chai Q, Li B, Shi Y, Zhang L, Gao GF, Liu CH*.   Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation. Cellular & Molecular Immunology, 2018, 14: 1-13.

4. Chai Q, Zhang Y, Liu CH*. Mycobacterium tuberculosis: An adaptable pathogen sssociated eith multiple human diseases. Front. Cell. Infect. Microbiol., 2018, 8: 158.

5. Wang S, Peng Zh, Wang S, Yang L, Chen Y, Kong X, Song Sh, Pei P, Tian Ch, Yan H, Ding P, Hu W, Liu CH, Zhang X, He F, Zhang L*. KRAB-type zinc-finger proteins PITA and PISA specifically regulate p53-dependent glycolysis and mitochondrial respiration. Cell Research, 2018, 28(5): 572-592.

6. Chen Y, Huang Q, Liu W, Zhu Q, Cui Ch, Xu L, Guo X, Wang P, Liu J, Dong G, Wei W, Liu CH, Feng Zh, He F*, Zhang L*. Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth. Nature Communications2018, 9 (1): 2464.

7. Cui CP#, Zhang Y#, Wang C#, Yuan F, Li H, Yao Y, Chen Y, Li C, Wei W, Liu CH, He F1 Liu Y*, Zhang L*. Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation. Nature Communications, 2018, 9:4648.

8. Sun L#, Xie C#, Wang G#, Wu Y#, Wu Q, Wang X, Liu J, Deng Y, Xia J, Chen B, Zhang S, Yun C, Lian G, Zhang X, Zhang H, Bisson WH, Shi J, Gao X, Ge P, Liu CH, Krausz KW, Nichols RG, Cai J, Rimal B, Patterson AD, Wang X, Gonzalez FJ, Jiang C*. Gut microbiota and intestinal FXR mediate the clinical benefits of metformin. Nature Medicine, 2018 Nov 5. doi: 10.1038/s41591-018-0222-4.

9. Wang J, Li BX, Ge PP, Li J, Wang Q, Gao GF*, Qiu XB*, Liu CH*. Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system. Nature Immunology 2015, 6(3): 237-245.

10. Li J, Chai Q, Zhang Y, Li B, Wang J, Qiu XB, Liu CH*. Mycobacterium tuberculosis Mce3E suppresses host innate immune responses by targeting ERK1/2 signaling. The Journal of Immunology 2015, 194:3756-3767.

11. Qian MX, Pang Y, Liu CH (Co-first author), Haratake K, Du BY, Ji DY, Wang GF, Zhu QQ, Song W, Yu Y, Zhang XX, Huang HT, Miao SY, Chen LB, Zhang ZH, Liang YN, Liu S, Cha H, Yang D, Zhai Y, Komatsu T, Tsuruta F, Li H, Cao C, Li W, Li GH, Cheng Y, Chiba T, Wang L, Goldberg AL, Shen Y, Qiu XB*. Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis. Cell 2013, 153: 1012-1024.

12. Liu CH, Lee SM, VanLare JM, Kasper DL, Mazmanian SK. Regulation of surface architecture by symbiotic bacteria mediates host colonization Proc Natl Acad Sci USA 2008, 105 (10): 3951-3956. 

13. Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 2005, 122: 107-118.

14. Li J, Liu F, Wang Q, Ge P, Woo PCY, Yan J, Zhao Y, Gao GF, Liu CH*, Liu C*.Genomic and transcriptomic analysis of NDM-1 Klebsiella pneumoniae in spaceflight reveal mechanisms underlying environmental adaptability. Scientific Reports 2014, 4: 6216. 

15. Liu F, Hu YF, Wang Q, Li HM, Gao GF, Liu CH*, Zhu B*. Comparative genomic analysis of gene variations among Mycobacterium tuberculosis clinical isolates with different antibiotic resistance profiles. BMC Genomics 2014, 15: 469.

16. Wang Q, Lau SK, Liu F, Zhao Y, Li HM, Li BX, Hu YL, Woo PC*, Liu CH*. Molecular epidemiology and clinical characteristics of drug-resistant Mycobacterium tuberculosis in a tuberculosis referral hospital in China. PLoS One 2014, 9(10): e110209.

17. Li B, Hu Y, Wang Q, Yi Y, Woo PCY, Jing H, Zhu B, Liu CH*. Structural diversity of class 1 Integrons and their associated hene cassettes in Klebsiella pneumoniae isolates from a hospital in China. PLoS ONE 2013, 8:e75805.
18. Wang Q, Li B, Tsang AK, Yi Y, Woo PC*, Liu CH*. Genotypic analysis of Klebsiella pneumoniae isolates in a Beijing hospital reveals high genetic diversity and clonal population structure of drug-resistant isolates. PloS ONE 2013
8e57091.

19. Liu CH*, Li HM, Lu N, Wang Q, Hu YL, Yang X, Woo PCY, Gao GF, Zhu BL*. Genome-wide molecular characterization and evolutionary analysis of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis. Journal of Infection 2012, 65: 412-422.

20. Yu HT, Yang N, Wang Q, Liang JQ, Liu CH*. Prevalence of and risk factors associated with kanamycin-resistant tuberculosis in a Beijing tuberculosis referral hospital. Journal of Medical Microbiology 2012, 61: 960-967.

21. Li B, Yi Yong, Wang Qi, Tan L, Jing H, Woo PCY, Gao GF*, Liu CH*. Analysis of genetic determinants of multidrug-resistant, extensively drug-resistant and pandrug-resistant Klebsiella pneumoniae isolates in a hospital in Beijing, China. PloS ONE 2012, 7: e42280.

22. Liu CH*, Li L, Chen Z, Wang Q, Hu YL, Zhu BL*, Woo PCY*. Characteristics and Treatment Outcomes of Patients with MDR and XDR Tuberculosis in a TB Referral Hospital in Beijing: A 13-Year Experience. PLoS ONE 2011, 6(4): e19399. 

23. Liu CH*, Li HM, Li L, Hu YL, Wang Q, Yang N, Wang SM, Zhu BL. Anti-tuberculosis drug resistance patterns and trends in a tuberculosis referral hospital, 1997–2009. Epidemiology and Infection 2011, 27:1-10. 

24. Liu CH*, Yang N, Wang Q, Hu YL, Zhang GY, Zhu BL. Risk factors associated with fluoroquinolone-resistant tuberculosis in a Beijing tuberculosis referral hospital. Respirology 2011, 16: 918-925. 

25. Liu CH, Ma WL, Shi R, Zhang B, Ou YQ, Zheng WL. Gene expression study of Saccharomyces cerevisiae with the Agilent 2100 bioanalyser. British Journal of Biomedical Science 2003, 60 (1): 22-25. 

26. Liu CH, Ma WL, Shi R, Ou YQ, Zhang B, Zheng WL. Possibility of using DNA chip technology for diagnosis of human Papillomavirus. Journal of Biochemistry and Molecular Biology 2003, 36 (4): 349-353.

 

Research Interests

Major research interests are molecular pathogenesis and molecular mechanism of drug resistance in pathogenic bacteria.

Conferences

1. Cui-Hua Liu, Alfred L. Goldberg, and Xiao-Bo Qiu. Regulation of the activity of the ubiquitin ligase, Nrdp1/RNF41, by the interacting protein, NIP. The fifth Cold Spring Harbor meeting on The Ubiquitin Family, April 21-25, 2009.New York, U.S.A.

2. Cui Hua Liu, S. Melanie Lee, Jordan M. VanLare, Dennis L. Kasper and Sarkis K. Mazmanian. Regulation of Surface Architecture by Symbiotic Bacteria Mediates Host Colonization. American Society for Microbiology, 108th General Meeting, June 1-5, 2008. Boston, Massachusetts, U.S.A.

3. Cui-Hua Liu, Fei Wang, Jianjun Han, Shiying Miao, Linfang Wang, and Xiao-Bo Qiu. Nip1, an Nrdp1 interacting protein, promotes the ubiquitin ligase activity of Nrdp1. SPMDB 2007, International Symposium on Protein Modification and Degradation in Beijing, Nov. 4-7.

4. Liu CH, Cieslewicz M, Kasper D, Wessels MR. Genetic analysis of CpsL, a putative polysaccharide repeat unit transporter in group B Streptococcus. 2003 PROC SOC, Channing Laboratory and Infectious Disease Division of the Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School. Boston, MA. U.S.A.



Students

已指导学生

李杰  硕士研究生  085238-生物工程  

葛浦浦  硕士研究生  085238-生物工程  

张勇  硕士研究生  077803-病原生物学  

胡建森  博士研究生  071010-生物化学与分子生物学  

柴琪瑶  博士研究生  100103-病原生物学  

葛浦浦  博士研究生  100103-病原生物学  

雷泽慧  硕士研究生  085238-生物工程  

何杰华  硕士研究生  077803-病原生物学  

现指导学生

强丽华  博士研究生  100103-病原生物学  

赵冬冬  博士研究生  100103-病原生物学  

赵梦圆  硕士研究生  077803-病原生物学  

陆喆  博士研究生  100103-病原生物学  

邱长根  硕士研究生  077803-病原生物学  

于洋  博士研究生  100103-病原生物学  

钟延昭  博士研究生  100103-病原生物学  

赵卓  硕士研究生  077803-病原生物学  

雷泽慧  博士研究生  100103-病原生物学  

强煜云  硕士研究生  077803-病原生物学  

张馨文  博士研究生  100103-病原生物学