Molecular mechanisms of pathogenesis and drug resistance/tolerance in pathogenic bacteria. 

1. Molecular mechanisms of host-pathogen Interaction

2. Molecular mechanisms of drug resistance and drug tolerance in pathogenic bacteria

The Third Military Medical University, Chongqing, China.
Bachelor of Medicine, Medical Laboratory Science, 2000

Southern Medical University, Guangzhou, China.
Ph.D., Biochemistry and Molecular Biology, 2005 

   

2019- Present

Deputy Director, Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences.

2014-Present

Principal Investigator, Professor, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

2010-2014

Principal Investigator, Associate Professor, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

2009-2010

Associate professor, Institute for Tuberculosis research, The 309 Hospital of PLA, Beijing, China.

2007-2009

Associate professor, The State-Key Lab of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/ Peking Union Medical College, Tsinghua University, Beijing, China

2006-2007

Postdoc., Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

2011 “Young Scientist Innovation Promotion Association Member”, awarded by Chinese Academy of Sciences

2015 “Young Scientist Innovation Promotion Association Excellent Member”, awarded by Chinese Academy of Sciences

2018 National Natural Science Foundation of China (NSFC) “Distinguished Young Investigator

2018 National “Ten thousand people plan-science and technology innovation leader”

2019 “Outstanding Scientific Research Team Award”, awarded by Qiu Shi Science and Technology Foundation

2022 “Excellent Supervisor”, awarded by Chinese Academy of Sciences

2023 Top ten hot articles that attract the most public attention of “Bulletin of the Chinese Academy of Sciences” Weibo in 2022

2023 “Outstanding Staff in 2023”, awarded by Institute of Microbiology, Chinese Academy of Sciences

2023 “Outstanding Contribution Award in 2022”, awarded by Institute of Microbiology, Chinese Academy of Sciences

2023 “Zhu Li Yuehua Outstanding Teacher Award”, awarded by Chinese Academy of Sciences

2023 “Lingyan Silver Medal • Flapping Wing Award”, awarded by University of Chinese Academy of Sciences                          

2023 “Outstanding editorial board member”, awarded by Life Medicine

2023 “Special Award of the 25th Director's Award” awarded by Institute of Microbiology, Chinese Academy of Sciences

2024 “Special government allowance”, awarded by the State Council of the People’s Republic of China

2024 “Top 10 scientific research progress in 2023”, awarded by Institute of Microbiology, Chinese Academy of Sciences

2024 “Outstanding Staff in 2024”, awarded by Institute of Microbiology, Chinese Academy of Sciences

2024 “Outstanding Contribution Award in 2023-2024”, awarded by hLife

2024 “Outstanding Contribution Award in 2023”, awarded by Institute of Microbiology, Chinese Academy of Sciences

2024 “Outstanding Expert”, awarded by the Chinese Journal of Immunology

2025 “Outstanding Contribution Award in 2024”, awarded by Institute of Microbiology, Chinese Academy of Sciences

2025 “First Prize of the 2024 Beijing Science and Technology Award” (The First Contributor), awarded by Beijing Science and Technology Awards

2025 “First Prize of the 2025 Beijing Science and Technology Award” (The Fourth Contributor), awarded by Beijing Science and Technology Awards

   

1. Qiyao Chai#, Zhe Lu#, Min Zhao#, Shanshan Yu#, Yanzhao Zhong, Changgen Qiu, Zehui Lei, Yingxu Fang, Bing-Xi Li, Lingqiang Zhang, Shuo Wang*, Yu Pang*, Jing Wang*, Cui Hua Liu*. Lipid accumulation in tuberculosis granulomas inhibits macrophage-CD4⁺ T

cell interactions and infection control. Nature Microbiology 2026, online ahead of print.

2.Yu S#, Chai Q#,*, Lu Z#, Qiu C, Zhong Y, Wang Y, Lei Z, Qiang L, Fang Y, Zhang X, Li B, Gao M, Zhang L, Cheng G, Wang J, Liu CH*, Pang Y*. A CLOCK-targeting lncRNA induces trained immunity against tuberculosis. Cell Host & Microbe 2025, S1931-3128(25)00521-9.

3. Yu Y#, Yu S#, Lu Z, Qiang L, Zhong Y, Ge P, Lei Z, Qiu C, Fang Y, Zhang X, Li B, Pang Y, Wang J, Zhang L*, Liu CH*, Chai Q*. Pathogenic phosphorylation of linear ubiquitin machinery causes inflammasome sensor degradation. Cell Reports, 2025, 44(9):116286.

4. Lu Z, Zhang Y, Zhong Y, Qiang L, Ge P, Lei Z, Zhao M, Fang Y, Li B, Wang J, Chai Q*, Liu CH*. A bacterial effector manipulates host lysosomal protease activity-dependent plasticity in cell death modalities to facilitate infection. Proc Natl Acad Sci U S A 2025, 122(8): e2406715122.

5. Zhang Y#, Fu Y#, Qiang L#, Zhao M, Lu Z, Zhao Z, Chen G, Lei Z, Chai Q, Ge P, Li B, Wang J, Liu CH*, Zhang L*. Spatiotemporal Regulation of STING Activity by Linear Ubiquitination Governs Antiviral Immunity. Advanced Science 2025, 12(28): e2417660.

6. Lei Z, Wang J, Liu CH*. Developing next-generation tuberculosis vaccines based on pathogen–host interactions: Towards a holistic perspective. hLife 2024, 3(4): 164-171.

7. Ge Y#, Zhou L#, Fu Y#, He L, Chen Y, Li D, Xie Y, Yang J, Wu H, Dai H, Peng Z, Zhang Y, Yi S, Wu B, Zhang X, Zhang Y, Ying W, Cui CP, Liu CH*, Zhang L*. Caspase-2 is a condensate-mediated deubiquitinase in protein quality control. Nature Cell Biology 2024, 26(11): 1943-1957.

8. Li L#, Ge Z#, Liu S#, Zheng K#, Li Y#, Chen K#, Fu Y#, Lei X, Cui Z, Wang Y, Huang J, Liu Y, Duan M, Sun Z, Chen J, Li L, Shen P, Wang G, Chen J, Li R, Li C, Yang Z, Ning Y, Luo A, Chen B, Seim I, Liu X, Wang F, Yao Y, Guo F, Yang M, Liu CH, Fan G*, Wang L*, Yang D*, Zhang L*. Multi-omics landscape and molecular basisof radiation tolerance in a tardigrade. Science 2024, 386(6720): eadl0799.

9. Wang J#, Chai Q#, Lei Z#, Wang Y#, He J#, Ge P, Lu Z, Qiang L, Zhao D, Yu S, Qiu C, Zhong Y, Li BX, Zhang L, Pang Y*, Gao GF*, Liu CH*. LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis. EMBO Molecular Medicine 2024, 16(8): 1755-1790.

10. Yu J, Guo H, Zhang J, Hu J, He H, Chen C, Yang N, Yang F, Lin Z, Dai H, Ouyang L, Liu CH, Lei X, Zhang L, Zhu G, Song F. Chrysomycins, Anti-Tuberculosis C-Glycoside Polyketides from Streptomyces sp. MS751. Marine Drugs 2024, 22(6): 259.

11. Li M, Zhang D, Yang Q, Zhao Z, Zhang C, Zhou Y, Bai Y, Chen L, Tang X, Liu CH*, Zhou J*, Chen X*, Ying B*. Longitudinal metabolomics of human plasma reveal metabolic dynamics and predictive markers of antituberculosis drug-induced liver injury. Respiratory Research 2024, 25(1): 254.

12. Fu Y#, Li L#, Zhang X#, Deng Z#, Wu Y#, Chen W, Liu Y, He S, Wang J, Xie Y, Tu Z, Lyu Y, Wei Y, Wang S, Cui CP, Liu CH*, Zhang L*. Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis. Nature Communications 2024, 15(1): 2974.

13. Zhao D#, Qiang L#, Lei Z#, Ge P#, Lu Z, Wang Y, Zhang X, Qiang Y, Li B, Pang Y, Zhang L, Liu CH*, Wang J*. TRIM27 elicits protective immunity against tuberculosis by activating TFEB-mediated autophagy flux. Autophagy 2024, 20(7):1483-1504.

14. Ke W#, Xie Y#, Chen Y#, Ding H, Ye L, Qiu H, Li H, Zhang L, Chen L, Tian X, Shen Z, Song Z, Fan X, Zong JF, Guo Z, Ma X, Xiao M, Liao G, Liu CH, Yin WB, Dong Z, Yang F, Jiang YY, Perlin DS, Chen Y, Fu YV*, Wang L*. Fungicide-tolerant persister formation during cryptococcal pulmonary infection. Cell Host & Microbe 2024, 32: 1-14.

15. He F*, Aebersold R*, Baker MS, Bian X, Bo X, Chan DW, Chang C, Chen L, Chen X, Chen YJ, Cheng H, Collins BC, Corrales F, Cox J, E W, Van Eyk JE, Fan J, Faridi P, Figeys D, Gao GF, Gao W, Gao ZH, Goda K, Goh WWB, Gu D, Guo C, Guo T, He Y, Heck AJR, Hermjakob H, Hunter T, Iyer NG, Jiang Y, Jimenez CR, Joshi L, Kelleher NL, Li M, Li Y, Lin Q, Liu CH, Liu F, Liu GH, Liu Y, Liu Z, Low TY, Lu B, Mann M, Meng A, Moritz RL, Nice E, Ning G, Omenn GS, Overall CM, Palmisano G, Peng Y, Pineau C, Poon TCW, Purcell AW, Qiao J, Reddel RR, Robinson PJ, Roncada P, Sander C, Sha J, Song E, Srivastava S, Sun A, Sze SK, Tang C, Tang L, Tian R, Vizcaíno JA, Wang C, Wang C, Wang X, Wang X, Wang Y, Weiss T, Wilhelm M, Winkler R, Wollscheid B, Wong L, Xie L, Xie W, Xu T, Xu T, Yan L, Yang J, Yang X, Yates J, Yun T, Zhai Q, Zhang B, Zhang H, Zhang L, Zhang L, Zhang P, Zhang Y, Zheng YZ, Zhong Q, Zhu Y; π-HuB Consortium. π-HuB: the proteomic navigator of the human body. Nature 2024, 636: 322-331.

16. Fang Y#, Lei Z#, Lingqiang Zhang*, Liu CH*, Chai Q*. Regulatory functions and mechanisms of human microbiota in infectious diseases. hLife 2024, 2(10): 496-513.

17. Zhao M#, Zhang Y#, Qiang L, Lu Z, Zhao Z, Fu Y, Wu B, Chai Q, Ge P, Lei Z, Zhang X, Li B, Wang J, Zhang L*, Liu CH*. A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity. Cell Reports 2023, 42(6): 112655.

18. Dai Y, Zhu C, Xiao W, Huang K, Wang X, Shi C, Lin D, Zhang H, Liu X, Peng B, Gao Y, Liu CH, Ge B, Kaufmann SH, Feng CG, Chen X*, Cai Y. Mycobacterium tuberculosis hijacks host TRIM21- and NCOA4-dependent ferritinophagy to enhance intracellular growth. Journal of Clinical Investigation 2023, 133(8): e159941.

19. Zhu Q#, Fu Y#, Cui CP, Ding Y, Deng Z, Ning C, Hu F, Qiu C, Yu B, Zhou X, Yang G, Peng J, Zou W, Liu CH*, Zhang L*. OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2. Signal Transduction and Targeted Therapy 2023, 8(1): 142.

20. Qiang L#, Zhang Y#, Lei Z#, Lu Z, Tan S, Ge P, Chai Q, Zhao M, Zhang X, Li B, Pang Y, Zhang L*, Liu CH*, Wang J*. A mycobacterial effector promotes ferroptosis-dependent pathogenicity and dissemination. Nature Communications 2023, 14(1): 1430.

21. Wang J#, Zhao D#, Lei Z#, Ge P#, Lu Z, Chai Q, Zhang Y, Qiang L, Yu Y, Zhang X, Li B, Zhu S, Zhang L*, Liu CH*. TRIM27 maintains gut homeostasis by promoting intestinal stem cell self-renewal. Cellular & Molecular Immunology 2023, 20(2): 158-174.

22. Gao X, Liu CH*, Wang S*. Mucosal immune responses in the lung during respiratory infection: the organization and regulation of iBALT structure. hLife 2023, 1(2): 71-82.

23. Chai Q*, Lei Z, Liu CH*. Pyroptosis modulation by bacterial effector proteins. Seminars in Immunology 2023, 69: 101804.

24. Chai Q#, Yu S#, Zhong Y#, Lu Z, Qiu C, Yu Y, Zhang X, Zhang Y, Lei Z, Qiang L, Li B, Pang Y, Qiu X-B*, Wang J*, Liu CH*. A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin. Science 2022, 378(6616): eabq0132.

25. Wu B#, Qiang L#, Zhang Y#, Fu Y#, Zhao M, Lei Z, Lu Z, Wei Y, Dai H, Ge Y, Liu M, Zhou X, Peng Z, Li H, Cui C, Wang J, Zheng H, Liu CH*, Zhang L*. The deubiquitinase OTUD1 inhibits colonic inflammation through suppressing RIPK1-mediated NF-κB signaling. Cellular & Molecular Immunology 2022, 19: 276-289.

26. Liu CH*, Rao Y*, Gao D*, Wan L*, Zhang L*. Editorial: Ubiquitin Code: From Cell Biology to Translational Medicine. Frontiers in Cell and Developmental Biology 2021, 9: 791967.

27. Zhang F#, Yu S#, Chai Q#, Wang J#, Wu T, Liu R, Liu Y, Liu CH*, Pang Y*. HDAC6 contributes to human resistance against Mycobacterium tuberculosis infection via mediating innate immune responses. FASEB Journal 2021, 35: e22009.

28. Hu Q#, Tong H#*, Wang J, Ge P, Zhu L, Liu CH, Zhang JR, Dong X*. A Novel Aquaporin Subfamily Imports Oxygen and Contributes to Pneumococcal Virulence by Controlling the Production and Release of Virulence Factors. mBio 2021, 12(4): e0130921.

29. Fu Y, Wang H, Dai H, Zhu Q, Cui CP, Sun X, Li Y, Deng Z, Zhou X, Ge Y, Peng Z, Yuan C, Wu B, Yang X, Li R, Liu CH*, He F*, Wei W*, Zhang L*. OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin. Molecular Cell 2021, 81(15): 3187-3204.e7.

30. Ge P#, Lei Z#, Yu Y, Lu Z, Qiang L, Chai Q, Zhang Y, Zhao D, Li B, Pang Y, Liu CH*, Wang J*. M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival. Autophagy 2021, 18(3): 576-594.

31. Wang J#, Ge P#, Lei ZH#, Lu Z, Qiang L, Chai Q, Zhang Y, Zhao D, Li B, Su J, Peng R, Shi Y, Zhang Y, Gao GF*, Qiu XB*, Liu CH*. M. tuberculosis protein kinase G impairs host immunity by acting as an unusual ubiquitinating enzyme. EMBO Reports 2021, 22(6): e52175.

32. Lei Z#, Wang J#, Zhang L*, Liu CH*. Ubiquitination-Dependent Regulation of Small GTPases in Membrane Trafficking: From Cell Biology to Human Diseases. Frontiers in Cell and Developmental Biology 2021, 9: 688352.

33. Gai W#, Peng Z#, Liu CH*, Zhang L*, Jiang H*. Advances in cancer treatment by targeting the neddylation pathway. Frontiers in Cell and Developmental Biology 2021, 9: 653882.

34. Qiang L, Zhang Y, Liu CH*. Mycobacterium tuberculosis effector proteins: functional multiplicity and regulatory diversity. Cellular & Molecular Immunology 2021, 18(5): 1343-1344.

35. Zhu Q#, Fu Y#, Li L, Liu CH*, Zhang L*. The functions and regulation of Otubains in protein homeostasis and diseases. Ageing Research Reviews 2021, 67: 101303.

36. Xie P#*, Peng Z#, Chen Y, Li H, Du M, Tan Y, Zhang X, Lu Z, Cui CP, Liu CH, He F, Zhang L*. Neddylation of PTEN regulates its nuclear import and promotes tumor development. Cell Research 2021, 31(3): 291-311.

37. Chai Q#, Lu Z#, Liu Z#, Zhong Y, Zhang F, Qiu C, Li B, Wang J, Zhang L, Pang Y*, Liu CH*. Lung gene expression signatures suggest pathogenic links and molecular markers for pulmonary tuberculosis, adenocarcinoma and sarcoidosis. Communications Biology 2020, 3: 604.

38. Wang J#, Han C#, Lu Z#, Ge P, Cui Y, Zhao D, Yang X, Wu B, Qiang L, Zhang Y, Chai Q, Lei Z, Li L*, Liu CH*, Zhang L*. Simulated microgravity suppresses MAPK pathway-mediated innate immune response to bacterial infection and induces gut microbiota dysbiosis. FASEB Journal 2020, 34(11): 14631-14644.

39. Chai Q#, Wang L#, Liu CH*, Ge B*. New insights into the evasion of host innate immunity by Mycobacterium tuberculosis. Cellular & Molecular Immunology 2020, 17(9): 901-913.

40. Chai Q*, Lu Z, Liu CH*. Host defense mechanisms against Mycobacterium tuberculosis. Cellular and Molecular Life Sciences 2020, 77(10): 1859-1878.

41. Chai Q, Wang X, Qiang L, Zhang Y, Ge P, Lu Z, Zhong Y, Li B, Wang J, Zhang L, Zhou D, Li W, Dong W, Pang Y, Gao GF, Liu CH*. A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy. Nature Communications 2019, 10: 1973.

42. Jiang TX#, Zou JB#, Zhu QQ#, Liu CH#, Wang GF#, Du TT#, Luo ZY, Guo F, Zhou Fnag, Zhou LM, Liu JJ, Zhang W, Shu YS, Yu L, Li P, Ronai ZA, Matsuzawa S, Goldberg AL*, Qiu XB*. SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation. Proc Natl Acad Sci U S A 2019, 116 (27): 13404-13413.

43. Zhang Y, Li J, Li B, Wang J, Liu CH*. M. tuberculosis Mce3C promotes mycobacteria entry into macrophages through activation of β2 integrin-mediated signaling pathway. Cellular Microbiology 2018, 20 (2): e12800.

44. Qiang L, Wang J, Zhang Y, Ge P, Chai Q, Li B, Shi Y, Zhang L, Gao GF, Liu CH*. Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation. Cellular & Molecular Immunology 2018, 14: 1-13.

45. Chai Q, Zhang Y, Liu CH*. Mycobacterium tuberculosis: An adaptable pathogen sssociated eith multiple human diseases. Frontiers in Cellular and Infection Microbiology 2018, 8: 158.

46. Fan J#, Liu L#, Liu Q, Cui Y, Yao B, Zhang M, Gao Y, Fu Y, Dai H, Pan J, Qiu Y, Liu CH, He F, Wang Y*, Zhang L*. CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ. Nature Communications 2019, 10 (1):425.

47. Sun L#, Xie C#, Wang G#, Wu Y#, Wu Q, Wang X, Liu J, Deng Y, Xia J, Chen B, Zhang S, Yun C, Lian G, Zhang X, Zhang H, Bisson WH, Shi J, Gao X, Ge P, Liu CH, Krausz KW, Nichols RG, Cai J, Rimal B, Patterson AD, Wang X, Gonzalez FJ, Jiang C*. Gut microbiota and intestinal FXR mediate the clinical benefits of metformin. Nature Medicine 2018, 24 (12): 1919-1929.

48. Wang S, Peng Zh, Wang S, Yang L, Chen Y, Kong X, Song Sh, Pei P, Tian Ch, Yan H, Ding P, Hu W, Liu CH, Zhang X, He F, Zhang L*. KRAB-type zinc-finger proteins PITA and PISA specifically regulate p53-dependent glycolysis and mitochondrial respiration. Cell Research, 2018, 28(5): 572-592.

49. Chen Y, Huang Q, Liu W, Zhu Q, Cui Ch, Xu L, Guo X, Wang P, Liu J, Dong G, Wei W, Liu CH, Feng Zh, He F*, Zhang L*. Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth. Nature Communications 2018, 9 (1): 2464.

50. Cui CP#, Zhang Y#, Wang C#, Yuan F, Li H, Yao Y, Chen Y, Li C, Wei W, Liu CH, He F1 Liu Y*, Zhang L*. Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation. Nature Communications, 2018, 9:4648.

51. Wang J, Ge P, Qiang L, Feng T, Zhao D, Chai Q, Zhu M, Zhou R, Meng G, Iwakura Y, Gao GF, Liu CH*. The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation. Nature Communications, 2017, 8(1): 244.

52. Xu G, Wang J, Liu CH*. Klebsiella pneumoniae NdpA suppresses ERK pathway-mediated host early inflammatory responses and is degraded through the ubiquitin-proteasome pathway. Protein & Cell 2017, 8(2): 144-148.

53. Liu CH*, Liu H*, Baoxue Ge B*. Innate immunity in tuberculosis: host defense vs pathogen evasion. Cellular & Molecular Immunology 2017, 14: 1-13.

54. Tan S, Lin N, Huang M, Wang Q, Tan Y, Li B, Zhang N, Guo T, Cui Y, Chen X, Wang D, Wang J, Xiao H, Liu WJ, Yan J, Zhang CW, Liu CH, Wan K, Gao GF. CTL immunogenicity of Rv3615c antigen and diagnostic performances of an ESAT-6/CFP-10/Rv3615c antigen cocktail for Mycobacterium tuberculosis infection. Tuberculosis 2017, 107: 5-12.

55. Zhang Y, Qian L, Wei W, Wang Y, Wang B, Lin P, Liu W, Xu L, Li X, Liu D, Cheng S, Li J, Ye Y, Li H, Zhang X, Dong Y, Zhao X, Liu CH, Zhang HM, Ouyang Q, Lou C. Paired design of dCas9 as a systematic platform for the detection of featured nucleic acid sequences in pathogenic strains. ACS Synth Biol 2017, 6 (2): 211-216.

56. Wang J, Teng JL, Zhao D, Ge P, Li B, Woo PC, Liu CH*. The ubiquitin ligase TRIM27 functions as a host restriction factor antagonized by Mycobacterium tuberculosis PtpA during mycobacterial infection. Scientific Reports 2016, 6:34827.

57. Abednego Moki Musyoki, Zhongyu Shi, Chunling Xuan, Guangwen Lu, Jianxun Qi, Feng Gao, Beiwen Zheng, Qiangmin Zhang, Yan Li, Joel Haywood, Liu CH, Jinghua Yan, Yi Shi, George F. Gao. Structural and functional analysis of Streptococcus suis FBPS: an anchorless fibronectin-binding protein from Gram-positive bacteria. Proc Natl Acad Sci U S A 2016, 113 (48): 13869-13974.

58. Li J, Chai QY, Liu CH*. The ubiquitin system: a critical regulator of innate immunity and pathogen-host interactions. Cell Mol Immunol 2016, 13(5):560-576. (Invited Review Article).

59. Ding Y, Zheng H, Feng C, Wang B, Liu CH, Mi K, Cao H, Meng S. Heat shock protein gp96 enhances T cell responses and protective potential to Bacillus Calmette-Guérin vaccine. Scand J Immunol 2016, 84 (4): 222-228.

60. Wang J, Li BX, Ge PP, Li J, Wang Q, Gao GF*, Qiu XB*, Liu CH*. Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system. Nature Immunology 2015, 6(3): 237-245.

61. Li J, Chai Q, Zhang Y, Li B, Wang J, Qiu XB, Liu CH*. Mycobacterium tuberculosis Mce3E suppresses host innate immune responses by targeting ERK1/2 signaling. The Journal of Immunology 2015, 194:3756-3767.

62. Xiong L, Teng JL, Watt RM, Liu CH*, Lau SK, Woo PC. Molecular characterization of arginine deiminase pathway in Laribacter hongkongensis and unique regulation of arginine catabolism and anabolism by multiple environmental stresses. Environmental Microbiology 2015, 17(11): 4469~4483.

63. Li J, Liu F, Wang Q, Ge P, Woo PCY, Yan J, Zhao Y, Gao GF, Liu CH*, Liu C*.Genomic and transcriptomic analysis of NDM-1 Klebsiella pneumoniae in spaceflight reveal mechanisms underlying environmental adaptability. Scientific Reports 2014, 4: 6216.

64. Liu F, Hu YF, Wang Q, Li HM, Gao GF, Liu CH*, Zhu B*. Comparative genomic analysis of gene variations among Mycobacterium tuberculosis clinical isolates with different antibiotic resistance profiles. BMC Genomics 2014, 15: 469.

65. Wang Q, Lau SK, Liu F, Zhao Y, Li HM, Li BX, Hu YL, Woo PC*, Liu CH*. Molecular epidemiology and clinical characteristics of drug-resistant Mycobacterium tuberculosis in a tuberculosis referral hospital in China. PLoS One 2014, 9(10): e110209.

66. Xu G, Wang J, Gao GF*, Liu CH*. Insights into battles between Mycobacterium tuberculosis and macrophages. Protein & Cell 2014, 5(10): 728-736 (Review Article).

67. Liu CH*. M. tuberculosis and macrophages: co-existence and co-evolution. J Pulmonar Respirat Med 2014, 4:2. http://dx.doi.org/10.4172/2161-105X.1000e133 (Invited Editorial Article).

68. Qian MX＃, Pang Y＃, Liu CH＃, Haratake K＃, Du BY＃, Ji DY＃, Wang GF, Zhu QQ, Song W, Yu Y, Zhang XX, Huang HT, Miao SY, Chen LB, Zhang ZH, Liang YN, Liu S, Cha H, Yang D, Zhai Y, Komatsu T, Tsuruta F, Li H, Cao C, Li W, Li GH, Cheng Y, Chiba T, Wang L, Goldberg AL, Shen Y, Qiu XB*. Acetylation-mediated proteasomal degradation of core histones during DNA repair and spermatogenesis. Cell 2013, 153: 1012-1024.

69. Li B, Hu Y, Wang Q, Yi Y, Woo PCY, Jing H, Zhu B, Liu CH*. Structural diversity of class 1 Integrons and their associated hene cassettes in Klebsiella pneumoniae isolates from a hospital in China. PLoS ONE 2013, 8:e75805.

70. Wang Q, Li B, Tsang AK, Yi Y, Woo PC*, Liu CH*. Genotypic analysis of Klebsiella pneumoniae isolates in a Beijing hospital reveals high genetic diversity and clonal population structure of drug-resistant isolates. PloS ONE 2013，8：e57091.

71. Liu CH*, Li HM, Lu N, Wang Q, Hu YL, Yang X, Woo PCY, Gao GF, Zhu BL*. Genome-wide molecular characterization and evolutionary analysis of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis. Journal of Infection 2012, 65: 412-422.

72. Yu HT, Yang N, Wang Q, Liang JQ, Liu CH*. Prevalence of and risk factors associated with kanamycin-resistant tuberculosis in a Beijing tuberculosis referral hospital. Journal of Medical Microbiology 2012, 61: 960-967.

73. Li B, Yi Yong, Wang Qi, Tan L, Jing H, Woo PCY, Gao GF*, Liu CH*. Analysis of genetic determinants of multidrug-resistant, extensively drug-resistant and pandrug-resistant Klebsiella pneumoniae isolates in a hospital in Beijing, China. PloS ONE 2012, 7: e42280.

74. Han HM, Liu CH, Wang QH, Xuan CL, Zheng BW, Tang JQ, Yan JH, Zhang JR, Li M, Cheng H, Gao GF. The two-component system Ihk/Irr contributes to the virulence of Streptococcus suis serotype 2 strain 05ZYH33 through induction of the bacterial cell metabolism. Microbiology 2012, 158: 1852-1866.

75. Zhang JX, Wu XQ, Shi LL, Liang Y, Xie ZS, Yang YR, Li ZX, Liu CH, Yang FC. Diagnostic serum proteomic analysis in patients with active tuberculosis. Clinica Chimica Acta 2012, 2012, 413: 883-887.

76. Liu CH*, Li L, Chen Z, Wang Q, Hu YL, Zhu BL*, Woo PCY*. Characteristics and Treatment Outcomes of Patients with MDR and XDR Tuberculosis in a TB Referral Hospital in Beijing: A 13-Year Experience. PLoS ONE 2011, 6(4): e19399.

77. Liu CH*, Li HM, Li L, Hu YL, Wang Q, Yang N, Wang SM, Zhu BL. Anti-tuberculosis drug resistance patterns and trends in a tuberculosis referral hospital, 1997–2009. Epidemiology and Infection 2011, 27:1-10.

78. Liu CH*, Yang N, Wang Q, Hu YL, Zhang GY, Zhu BL. Risk factors associated with fluoroquinolone-resistant tuberculosis in a Beijing tuberculosis referral hospital. Respirology 2011, 16: 918-925.

79. Ding JB, Pan YL, Jiang H, Cheng JS, Liu TT, Qin N, Yang Y, Cui BY, Chen C, Liu CH, Mao K, Zhu BL. The whole genome sequences of four Brucella strains. Journal of Bacteriology 2011 Jul; 193 (14):3674-3675.

80. Wu ZW, Li M, Wang CJ, Li J, Lu N, Zhang RF, Jiang YQ, Yang RF, Liu CH, Liao H, Gao GF, Tang JQ, Zhu BL. Probing genomic diversity and evolution of 1 Streptococcus suis 2 serotype 2 by NimbleGen tiling array. BMC Genomics 2011 May 10; 12(1):219.

81. Liu CH, Lee SM, VanLare JM, Kasper DL, Mazmanian SK. Regulation of surface architecture by symbiotic bacteria mediates host colonization Proc Natl Acad Sci USA 2008, 105 (10): 3951-3956.

82. Feng YJ, Zheng F, Pan X, Sun W, Wang C, Dong Y, Ju AP, Ge J, Liu D, Liu CH, Yan J, Tang J, Gao GF. Existence and characterization of allelic variants of Sao, a newly identified surface protein from Streptococcus suis. FEBS Microbiology Letter 2007, 275(1): 80-88.

83. Liu CH，Goldberg AL, Qiu XB. New insights into the role of the ubiquitin-proteasome pathway in the regulation of apoptosis. Chang Gung Medical Journal 2007 30 (6): 469-479. (Invited Review Article)

84. Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 2005, 122: 107-118.

85. Shi R, Ma WL, Liu CH, Song YB, Mao XM, Zheng WL. An oligonucleotide microarray bait for isolation of target gene fragment. Journal of Biochemistry and Molecular Biology 2004, 37 (2): 148-152.

86. Liu CH, Ma WL, Shi R, Zhang B, Ou YQ, Zheng WL. Gene expression study of Saccharomyces cerevisiae with the Agilent 2100 bioanalyser. British Journal of Biomedical Science 2003, 60 (1): 22-25.

87. Liu CH, Ma WL, Shi R, Ou YQ, Zhang B, Zheng WL. Possibility of using DNA chip technology for diagnosis of human Papillomavirus. Journal of Biochemistry and Molecular Biology 2003, 36 (4): 349-353.

88. Li L, Ma WL, Zhu J, Shi R, Liu CH, Chen JK, Zheng WL. A modified restriction display PCR method in sample-labelling of DNA microarray. Journal of Virological Methods 2003, 114 (1): 71-75.

1. Cui Hua Liu, Jing Wang, Zehui Lei; A recombinant BCG drug for the treatment of bladder cancer; Patent number: 202511873449.3; Application date: December 12, 2025 (Authorization)

2.Cui Hua Liu, Jing Wang; The combination of diagnostic and differential diagnostic markers for active pulmonary tuberculosis and their applicationsn; Patent number: ZL202411220117.0; Application date: September 2, 2024; Authorization date: January 21, 2025 (Authorization)

3. Cui Hua Liu, Yong Zhang, Jing Wang; A target against Mycobacterium tuberculosis invasion of host cells and its application; Patent number: ZL202110518930.6; Application date: May 13, 2021; Authorization date: December 1, 2023 (Authorization)

4. Cui Hua Liu, Jing Wang; A model of irritable bowel syndrome and its application; Patent number: ZL202010430662.8; Application date: May 20, 2020; Authorization date: May 18, 2023 (Authorization)

5. Cui Hua Liu, Qiyao Chai, Zhe Lu, Jing Wang; Biomarkers of Tuberculosis and their application; Patent number: ZL202010349875.8; Application date: April 28, 2020; Authorization date: December 2, 2021 (Authorization)

6. Cui Hua Liu, Jing Wang; An anti-Mycobacterium tuberculosis target and its application; Patent number: ZL201811430799.2; Application date: November 28, 2018; Authorization date: May 4, 2021 (Authorization)

7. Cui Hua Liu, Jing Wang; An anti-Mycobacterium tuberculosis target and its application; Patent number: ZL201811430645.3; Application date: November 28, 2018; Authorization date: May 4, 2021 (Authorization)

8. Cui Hua Liu, Jing Wang; An anti-Mycobacterium tuberculosis target and its application; Patent number: ZL201811431187.5; Application date: November 28, 2018; Authorization date: April 30, 2021 (Authorization)

9. Cui Hua Liu, Yong Zhang, Jing Wang; A macrophage phagocytosis accelerator; Authorization number: ZL201710898729.9; Application date: September 28, 2017; Authorization date: July 7, 2020 (Authorization)

10. Cui Hua Liu, Guanghua Xu, Jing Wang, Bingxi Li, Jinghua Yan; An ERK signaling pathway inhibitor NdpA; Authorization number: ZL201610213178.3; Application date: April 7, 2016; Authorization date: July 7, 2020 (Authorization)

11. Cui Hua Liu, Jing Wang; A protein TRIM27 defending against Mycobacterium tuberculosis infection; Authorization number: ZL201610381995.X; Application date: June 1, 2016; Authorization date: September 17, 2019 (Authorization)

12. Cui Hua Liu, Jing Wang, Bingxi Li, Yan Lu; Ubiquitin binding domain of Mycobacterium tuberculosis secreted protein; Authorization number: ZL201410061782.X; Application date: February 24, 2014; Authorization date: April 6, 2018 (Authorization)

13. Cui Hua Liu, Jing Wang, Bingxi Li, Pupu Ge; A recombinant BCG vaccine and its construction and application; Authorization number: ZL201410482225.5; Application date: September 19, 2014; Authorization date: March 1, 2019 (Authorization)

14. Cui Hua Liu, Jie Li, Jing Wang; An inhibitor of Erk signaling pathway; Authorization number: ZL201410523217.0; Application date: September 30, 2014; Authorization date: November 17, 2017 (Authorization)

15. Cui Hua Liu, Jing Wang; Protein PtpA secreted by Mycobacterium tuberculosis dephosphorylates p-JNK and p-p38; Authorization number: ZL201310466907.2; Application date: October 9, 2013; Authorization date: January 20, 2016 (Authorization)

16. Cui Hua Liu, Jing Wang, Zehui Lei; A target for treating autoimmune diseases and its application; Application number: 202411924391.6; Application date: December 25, 2025 (Application)

17. Cui Hua Liu, Qiyao Chai, Jing Wang; Long non-coding RNAs identified from plasma of Tuberculosis resisters and their applications; Application number: 202410521497.5; Application date: April 28, 2024 (Application)

18. Cui Hua Liu, Jing Wang, Qiyao Chai, Changgen Qiu, Zhe Lu; Biomarkers for indicating latent infection with progressive tuberculosis and their applications; Application number: 202410506181.9; Application date: April 25, 2024 (Application)

19. Cui Hua Liu, Jing Wang; A monoclonal antibody blocking the invasion of Mycobacterium tuberculosis and its application; Application number: 202410051929.0; Application date: January 15, 2024 (Application)

20. Cui Hua Liu, Jing Wang; A recombinant BCG vaccine drug against tuberculosis; Application number: 202310918921.5; Application date: July 25, 2023 (Application)

21. Cui Hua Liu, Jing Wang; A recombinant BCG vaccine drug for treating tuberculosis and its application; Application number: 2023104010707; Application date: April 14, 2023 (Application)

22. Cui Hua Liu, Yong Zhang, Jing Wang; A Mycobacterium tuberculosis protein and its polypeptide; Application number: 202211387664.9; Application date: November 8, 2022 (Application)

23. Cui Hua Liu, Jing Wang, Qiyao Chai, Zehui Lei; A LILRB1 monoclonal antibody and its application; Application number: 202211236332.0; Application date: October 11, 2022 (Application)

24. Lingqiang Zhang, Cui Hua Liu, Yong Zhang, Lihua Qiang, Jing Wang; Deubiquitinating enzyme OTULIN inhibitors in the treatment of STING-mediated infectious diseases; Application number: 202211165985.4; Application date: September 23, 2022 (Application)

25. Cui Hua Liu, Qiyao Chai, Zhe Lu, Jing Wang; Construction and application of recombinant BCG vaccine; Application number: 202210425903.9; Application date: April 21, 2022 (Application)

26. Jing Wang, Cui Hua Liu; NK cell receptors highly expressed in Tuberculosis patients and its application; Application number: 202111026159.7; Application date: September 2, 2021 (Application)

27. Cui Hua Liu, Jing Wang; A drug used to treat Tuberculosis; Application number: 202110367728.8; Application date: April 6, 2021 (Application)

28. Cui Hua Liu, Qiyao Chai, Zhe Lu, Jing Wang; Diagnostic markers of lung sarcoidosis and their application; Application number: 202010350286.1; Application date: April 28, 2020 (Application)

Major research interests are molecular pathogenesis and molecular mechanism of pathogenic bacteria.

1. Liu CH*. Mechanistic insights into linear ubiquitination-mediated anti-pathogen immunity. Lorne Ubiquitin 2025. 2025.11.20-23. Lorne, Australia.

2. Liu CH*. Modulation of Host Immunity by Lipid Hijacking: A Strategy for M. tuberculosis Immune Evasion. The 9th Australia-China Symposium on Immunity in Tuberculosis. 2025.11.2-6. Sydney, Australia.

3. Liu CH*. The Human-Microbiome Interaction Atlas. The 3rd Global Summit of the π-HuB Project and the 3rd Meeting of the International Council. 2025.10.11-12. Guangzhou, China.

4. Liu CH*. Developing next-generation TB vaccines based on pathogen–host interactions: Towards a holistic perspective. Human Mucosal Immunization. 2025.7.5-6. Shenzhen, China.

5.Liu CH*. Molecular mechanisms underlying natural killer cell exhaustion in tuberculosis. The 2024 China-Australia Symposium on Tuberculosis Immunology. 2024.10.21-22.Guangzhou, China.

6.Liu CH*. Molecular mechanisms underlying Mycobacterium tuberculosis pathogenesis and host defense. CSHA: Bacterial Infection & Host Defense. 2024.5.20-24. Suzhou, China.

7. Liu CH*. Modulation of host cell death by Mycobacterium tuberculosis effector proteins. Nature Conference “Cell Death Mechanisms and Diseases”. 2023.11.17. Sichuan, China.

8. Liu CH*. M. tuberculosis pathogenesis and host immune defense. Annual Meeting of Overseas Chinese Society of Microbiology. 2023.7.7-9. Changchun, China.

9. Liu CH^*. Mycobacterium tuberculosis infection and host innate immune defense. International Joint Forum on Infectious Disease Research 2019. 2019.12.17. Beijing, China.

10. Liu CH ^*. Host Innate Immune Regulation by Mycobacterium tuberculosis. 17TH International Congress of Immunology. 2019.10.19-23. Beijing, China.

11. Liu CH ^*Mycobacterium tuberculosis infection and host immune defense. The 5th China-Australia Academic Conference on Tuberculosis and Immunization. 2019. 11.5-8. Wuhan, China.

12. Liu CH ^*. Host Innate Immune Regulation by M. tuberculosis Effector Proteins. 2019 International TB Forum. 2019.5.25. Shanghai, China.

13. Liu CH ^*. A M. tuberculosis surface protein recruits ubiquitin to trigger host xenophagy. 2019 International Conference on Environmental and Health Microbiology and Annual Meeting of Overseas Chinese Microbiology Society. 2019.7.12-15. Beijing, China.

14. Liu CH ^*. M. tuberculosis-host interactions. The 2nd China Tuberculosis International Summit Forum. 2019.3.16-18. Shanghai, China.

15. Liu CH ^*_. Molecular mechanisms underlying Mycobacterium tuberculosis-host interactions. The 8th International Lorne Infection and Immunity Conference 2018 Australia. February 14–16, 2018. Lorne, Australia.

16. Liu CH ^*_. Identification of anti-TB drug targets based on M. tuberculosis-host interactions. The 17th Asia-Pacific Congress of Clinical Microbiology and Infection cum 8th International Infection Control Conference. August 30–September 1, 2018. Hong Kong, China.

17. Liu CH ^*_. Host regulation by Mycobacterium tuberculosis. SAKURA Exchange Program in Science. Octobor 7–13, 2018. Tokyo, Japan.

18. Liu CH ^*_. Regulation of host innate immune signaling pathways and cellular functions by Mycobacterium tuberculosis. 《Nature》International Symposium on inflammatory diseases. 2017.9.17-20. Beijing, China.

19. Liu CH ^*_. Regulation of host cellular functions by Mycobacterium. tuberculosis. Sino-Australia Summer Symposium on Emerging Pathogens. July 4-5, 2017. Beijing, China.

20. Liu CH ^*_. Regulation of host cellular functions by M. tuberculosis secreted effector proteins. IMMUNOLOGY 2017, the Annual Meeting of The American Association of Immunologists, Inc. (AAI). May 12–16, 2017. Washington, D.C., USA.

21. Liu CH ^*_. Regulation of host immune signaling pathways and cellular functions by M. tuberculosis secreted effector proteins. CSH: Bacterial Infection and Host Defense. April 17-21, 2017. Suzhou, China.

22. Liu CH ^*_. Mutual antagonism between Mycobacterium tuberculosis effector protein PtpA and host ubiquitin system. 6th Cross straight immunology conference. March 18-19, 2017. Taiwang, China.

23. Liu CH ^*_. Regulation of Host Innate Immunity by Mycobacterium Tuberculosis Secreted Effector Proteins (Keynote speaker at the symposium for the session on Infectious Diseases in 2016). 21st Research Postgraduate Symposium, “Research without limit: Unfolding the Mystery of Disease”, December 1-2, 2016. Hongkong, China.

24. Liu CH ^*_. Mycobacterium tuberculosis regulates innate immunity through coopting host ubiquitin system.  International Symposium on Ubiquitin and Diseases. June 15-19, 2015. Zhangjiajie, Hunan, China.

25. Liu CH*. M. tuberculosis secreted effector proteins promote intracellular survival of mycobacteria through exploiting the host ubiquitin system. CSH: Bacterial Infection and Host Defense. November 2-6, 2015. Suzhou, China.

26. Liu CH ^*_. Regulation of host innate immunity by Mycobacterium tuberculosis secreted effector protein. 5th Cross straight immunology conference. October 16-18, 2015. Shandong, China.

27. Liu CH*_. Regulation of host innate immune responses by mycobacterium tuberculosis secreted proteins. International Forum on Tuberculosis, Shanghai. April 23-24, 2015. Shanghai, China.

已指导学生

李杰  硕士研究生  085238-生物工程  

葛浦浦  硕士研究生  085238-生物工程  

张勇  硕士研究生  077803-病原生物学  

胡建森  博士研究生  071010-生物化学与分子生物学  

柴琪瑶  博士研究生  100103-病原生物学  

葛浦浦  博士研究生  100103-病原生物学  

雷泽慧  硕士研究生  085238-生物工程  

强丽华  博士研究生  100103-病原生物学  

赵冬冬  博士研究生  100103-病原生物学  

何杰华  硕士研究生  077803-病原生物学  

赵梦圆  硕士研究生  077803-病原生物学  

陆喆  博士研究生  100103-病原生物学  

邱长根  硕士研究生  077803-病原生物学  

于洋  博士研究生  100103-病原生物学  

钟延昭  博士研究生  100103-病原生物学  

赵卓  硕士研究生  077803-病原生物学  

强煜云  硕士研究生  077803-病原生物学  

现指导学生

雷泽慧  博士研究生  100103-病原生物学  

张馨文  博士研究生  100103-病原生物学  

房映旭  硕士研究生  077803-病原生物学  

赵梦圆  博士研究生  100103-病原生物学  

特日格乐  硕士研究生  077803-病原生物学  

邱长根  博士研究生  100103-病原生物学  

黄梓萱  硕士研究生  077803-病原生物学  

赵卓  博士研究生  100103-病原生物学