Molecular pathogenesis and molecular mechanism of drug resistance in pathogenic bacteria. 

1. Interaction between pathogen and the host
2. Molecular mechanisms of drug resistance in M.tuberculosis
2. Molecular mechanisms of drug resistance in multidrug-resistant Klebsiella pneumoniae

The Third Military Medical University, Chongqing, China.
Bachelor of Medicine, Medical Laboratory Science, 2000

Southern Medical University, Guangzhou, China.
Ph.D., Biochemistry and Molecular Biology, 2005 

   

2010-Present

Principle Investigator, Associate Professor,Professor, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.

2009-2010

Associate professor, Institute for Tuberculosis research, The 309 Hospital of PLA, Beijing, China.

2007-2009

Associate professor, The State-Key Lab of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/ Peking Union Medical College, Tsinghua University, Beijing, China

2006-2007

Postdoc., Institute of Microbiology, Chinese Academy of Sciences, Beijing, China

2003-2006

Ph.D. student and Postdoc., Channing Lab, Brigham and Women’s Hospital & Harvard Medical School, Boston, USA.

2003-2004 "Biomedicine and Bioengineering Research Fellowship", from World Health Organization (WHO)

2005 "Outstanding Graduate Student of Southern Guangdong", awarded by the Department of Education of Guangdong Province 

2011 "Young Scientist Innovation promotion association", Chinese Academy of Sciences.

2015 "Young Scientist Innovation Promotion Association Excellent Member", awarded by Chinese Academy of Sciences

2018 National Natural Science Foundation of China (NSFC) "Distinguished Young Investigator"

2018 National "Ten thousand people plan-science and technology innovation leader"

2019 "Outstanding Scientific Research Team Award", awarded by Qiu Shi Science and Technology Foundation

2022 "Excellent Supervisor", awarded by Chinese Academy of Sciences

   

1． Qiyao Chai^#, Shanshan Yu^#, Yanzhao Zhong^#, Zhe Lu, Changgen Qiu, Yang Yu, Xinwen Zhang, Yong Zhang, Zehui Lei, Lihua Qiang, Bing-Xi Li, Yu Pang, Xiao-Bo Qiu*, Jing Wang*, Cui Hua Liu*. A bacterial phospholipid phosphatase inhibits host pyroptosis by hijacking ubiquitin. Science, 2022, 378(6616): eabq0132. DOI: 10.1126/science.abq0132

2． Jing Wang^#, Bing-Xi Li ^#, Pu-Pu Ge^#, Jie Li, Qi Wang, George Fu Gao*, Xiao-Bo Qiu*, Cui Hua Liu*. Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system. Nature Immunology, 2015, 16(3): 237-245. DOI: 10.1038/ni.3096

3． Zhe Lu, Yong Zhang, Yanzhao Zhong, Lihua Qiang, Pupu Ge, Zehui Lei, Mengyuan Zhao, Yingxu Fang, Bingxi Li, Jing Wang, Qiyao Chai*, Cui Hua Liu*. A bacterial effector manipulates host lysosomal protease activity-dependent plasticity in cell death modalities to facilitate infection. Proc Natl Acad Sci U S A, 2025, 122(8): e2406715122. DOI: 10.1073/pnas.2406715122

4． Jing Wang^#, Qiyao Chai^#, Zehui Lei^#, Yiru Wang^#, Jiehua He^#, Pupu Ge, Zhe Lu, Lihua Qiang, Dongdong Zhao, Shanshan Yu, Changgen Qiu, Yanzhao Zhong, Bing-Xi Li, Lingqiang Zhang, Yu Pang*, George Fu Gao*, Cui Hua Liu*. LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis. EMBO Molecular Medicine, 2024, 16(8): 1755-1790. DOI: 10.1038/s44321-024-00106-1

5． Qiyao Chai, Xudong Wang, Lihua Qiang, Yong Zhang, Pupu Ge, Zhe Lu, Yanzhao Zhong, Bingxi Li, Jing Wang, Lingqiang Zhang, Dawang Zhou, Wei Li, Wenzhu Dong, Yu Pang, George Fu Gao, Cui Hua Liu*. A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy. Nature Communications, 2019, 10(1): 1973. DOI: 10.1038/s41467-019-09955-8

6． Yingwei Ge^#, Lijie Zhou^#, Yesheng Fu^#, Lijuan He, Yi Chen, Dingchang Li, Yuping Xie, Jun Yang, Haitao Wu, Hongmiao Dai, Zhiqiang Peng, Yong Zhang, Shaoqiong Yi, Bo Wu, Xin Zhang, Yangjun Zhang, Wantao Ying, Chun-Ping Cui, Cui Hua Liu*, Lingqiang Zhang*. Caspase-2 is a condensate-mediated deubiquitinase in protein quality control. Nature Cell Biology, 2024, 26(11): 1943-1957. DOI: 10.1038/s41556-024-01522-8

7． Yesheng Fu, Hongtian Wang, Hongmiao Dai, Qiong Zhu, Chun-Ping Cui, Xiaoxuan Sun, Yanchang Li, Zhikang Deng, Xuemei Zhou, Yingwei Ge, Zhiqiang Peng, Chao Yuan, Bo Wu, Xi Yang, Rongyu Li, Cui Hua Liu*, Fuchu He*, Wenyi Wei*, Lingqiang Zhang*. OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin. Molecular Cell, 2021, 81(15): 3187-3204.e7. DOI: 10.1016/j.molcel.2021.05.031

8． Jing Wang^#, Pupu Ge^#, Lihua Qiang, Feng Tian, Dongdong Zhao, Qiyao Chai, Mingzhao Zhu, Rongbin Zhou, Guangxun Meng, Yoichiro Iwakura, George Fu Gao, Cui Hua Liu*. The mycobacterial phosphatase PtpA regulates the expression of host genes and promotes cell proliferation. Nature Communications, 2017, 8(1): 244. DOI: 10.1038/s41467-017-00279-z

9． Lihua Qiang^#, Yong Zhang^#, Zehui Lei^#, Zhe Lu, Shasha Tan, Pupu Ge, Qiyao Chai, Mengyuan Zhao, Xinwen Zhang, Bingxi Li, Yu Pang, Lingqiang Zhang, Cui Hua Liu*, Jing Wang*. A mycobacterial effector promotes ferroptosis-dependent pathogenicity and dissemination. Nature Communications, 2023, 14(1): 1430. DOI: 10.1038/s41467-023-37148-x

10． Yesheng Fu^#, Lei Li^#, Xin Zhang^#, Zhikang Deng^#, Ying Wu^#, Wenzhe Chen, Yuchen Liu, Shan He, Jian Wang, Yuping Xie, Zhiwei Tu, Yadi Lyu, Yange Wei, Shujie Wang, Chun-Ping Cui, Cui Hua Liu*, Lingqiang Zhang*. Systematic HOIP interactome profiling reveals critical roles of linear ubiquitination in tissue homeostasis. Nature Communications, 2024, 15(1): 2974. DOI: 10.1038/s41467-024-47289-2

11． Yong Zhang^#, Yesheng Fu^#, Lihua Qiang^#, Mengyuan Zhao, Zhe Lu, Zhuo Zhao, Guoping Chen, Zehui Lei, Qiyao Chai, Pupu Ge, Bingxi Li, Jing Wang, Cui Hua Liu*, Lingqiang Zhang*. Spatiotemporal regulation of STING activity by linear ubiquitination governs antiviral immunity. Advanced Science, 2025, in press.

12． Jing Wang^#, Pupu Ge^#, Zehui Lei^#, Zhe Lu, Lihua Qiang, Qiyao Chai, Yong Zhang, Dongdong Zhao, Bingxi Li, Jiaqi Su, Ruchao Peng, Yu Pang, Yi Shi, Yu Zhang, George Fu Gao*, Xiao-Bo Qiu*, Cui Hua Liu*. Mycobacterium tuberculosis protein kinase G acts as an unusual ubiquitinating enzyme to impair host immunity. EMBO Reports, 2021, 22(6): e52175. DOI: 10.15252/embr.202052175

13． Dongdong Zhao^#, Lihua Qiang^#, Zehui Lei^#, Pupu Ge^#, Zhe Lu, Yiru Wang, Xinwen Zhang, Yuyun Qiang, Bingxi Li, Yu Pang, Lingqiang Zhang, Cui Hua Liu*, Jing Wang*. TRIM27 elicits protective immunity against tuberculosis by activating TFEB-mediated autophagy flux. Autophagy, 2024, 20(7):1483-1504. DOI: 10.1080/15548627.2024.2321831

14． Pupu Ge^#, Zehui Lei^#, Yang Yu, Zhe Lu, Lihua Qiang, Qiyao Chai, Yong Zhang, Dongdong Zhao, Bingxi Li, Yu Pang, Cui Hua Liu*, Jing Wang*. M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival. Autophagy, 2022, 18(3): 576-594. DOI: 10.1080/15548627.2021.1938912

15． Qiong Zhu^#, Yesheng Fu^#, Chun-Ping Cui, Yi Ding, Zhikang Deng, Chao Ning, Fan Hu, Chen Qiu, Biyue Yu, Xuemei Zhou, Guan Yang, Jiang Peng, Weiguo Zou, Cui Hua Liu*, Lingqiang Zhang*. OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2. Signal Transduction and Targeted Therapy, 2023, 8(1): 142. DOI: 10.1038/s41392-023-01354-2

16． Jing Wang^#, Dongdong Zhao^#, Zehui Lei^#, Pupu Ge^#, Zhe Lu, Qiyao Chai, Yong Zhang, Lihua Qiang, Yang Yu, Xinwen Zhang, Bingxi Li, Shu Zhu, Lingqiang Zhang*, Cui Hua Liu*. TRIM27 maintains gut homeostasis by promoting intestinal stem cell self-renewal. Cellular & Molecular Immunology, 2023, 20(2):158-174. DOI: 10.1038/s41423-022-00963-1

17． Lihua Qiang^#, Jing Wang^#, Yong Zhang, Pupu Ge, Qiyao Chai, Bingxi Li, Yi Shi, Lingqiang Zhang, George Fu Gao, Cui Hua Liu*. Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation. Cellular & Molecular Immunology, 2019, 16(4): 380-391. DOI: 10.1038/s41423-018-0016-0

18． Bo Wu^#, Lihua Qiang^#, Yong Zhang^#, Yesheng Fu^#, Mengyuan Zhao, Zehui Lei, Zhe Lu, Yan-Ge Wei, Hongmiao Dai, Yingwei Ge, Mingqiu Liu, Xuemei Zhou, Zhiqiang Peng, Hongchang Li, Chun-Ping Cui, Jing Wang, Hui Zheng, Cui Hua Liu*, Lingqiang Zhang*. The deubiquitinase OTUD1 inhibits colonic inflammation through suppressing RIPK1-mediated NF-κB signaling. Cellular & Molecular Immunology, 2022, 19(2): 276-289. DOI: 10.1038/s41423-021-00810-9

19． Tian-Xia Jiang^#, Jiang-Bo Zou^#, Qian-Qian Zhu^#, Cui Hua Liu^#, Guang-Fei Wang^#, Ting-Ting Du^#, Zi-Yu Luo, Fang Guo, Lu-Ming Zhou, Juan-Juan Liu, Wensheng Zhang, You-Sheng Shu, Li Yu, Peng Li, Ze'ev A Ronai, Shu-Ichi Matsuzawa, Alfred L Goldberg*, Xiao-Bo Qiu*. SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation. Proc Natl Acad Sci U S A, 2019, 116 (27): 13404-13413. DOI: 10.1073/pnas.1901039116

20． Mengyuan Zhao^#, Yong Zhang^#, Lihua Qiang, Zhe Lu, Zhuo Zhao, Yesheng Fu, Bo Wu, Qiyao Chai, Pupu Ge, Zehui Lei, Xinwen Zhang, Bingxi Li, Jing Wang, Lingqiang Zhang*, Cui Hua Liu*. A Golgi-resident GPR108 cooperates with E3 ubiquitin ligase Smurf1 to suppress antiviral innate immunity. Cell Reports, 2023, 42(6): 112655. DOI: 10.1016/j.celrep.2023.112655

21． Mengjiao Li, Dan Zhang, Qingxin Yang, Zhenzhen Zhao, Chunying Zhang, Yanbing Zhou, Yangjuan Bai, Lu Chen, Xiaoyan Tang, Cui Hua Liu*, Juan Zhou*, Xuerong Chen*, Binwu Ying*. Longitudinal metabolomics of human plasma reveal metabolic dynamics and predictive markers of antituberculosis drug-induced liver injury. Respiratory Research, 2024, 25(1): 254. DOI: 10.1186/s12931-024-02837-8

22． Guanghua Xu, Jing Wang, Cui Hua Liu*. Klebsiella pneumoniae NdpA suppresses ERK pathway-mediated host early inflammatory responses and is degraded through the ubiquitin-proteasome pathway. Protein & Cell, 2017, 8(2): 144-148. DOI: 10.1007/s13238-016-0341-y

23． Lihua Qiang, Yong Zhang, Cui Hua Liu*. Mycobacterium tuberculosis effector proteins: functional multiplicity and regulatory diversity. Cellular & Molecular Immunology, 2021, 18(5): 1343-1344. DOI: 10.1038/s41423-021-00676-x

24． Qiyao Chai^#, Lin Wang^#, Cui Hua Liu*, Baoxue Ge*. New insights into the evasion of host innate immunity by Mycobacterium tuberculosis. Cellular & Molecular Immunology, 2020, 17(9): 901-913. DOI: 10.1038/s41423-020-0502-z

25． Cui Hua Liu*, Haiying Liu*, Baoxue Ge*. Innate immunity in tuberculosis: host defense vs pathogen. Cellular Molecular Immunology, 2017, 14: 963-975. DOI: 10.1038/cmi.2017.88

26． Jie Li, Qi-Yao Chai, Cui Hua Liu*. The ubiquitin system: a critical regulator of innate immunity and pathogen-host interactions. Cellular & Molecular Immunology, 2016, 13: 560-576. DOI: 10.1038/cmi.2016.40

27． Qiyao Chai*, Zehui Lei, Cui Hua Liu*. Pyroptosis modulation by bacterial effector proteins. Seminars in Immunology, 2023, 69: 101804. DOI: 10.1016/j.smim.2023.101804

28． Qiong Zhu^#, Yesheng Fu^#, Lei Li, Cui Hua Liu*, Lingqiang Zhang*. The functions and regulation of Otubains in protein homeostasis and diseases. Ageing Research Reviews, 2021, 67: 101303. DOI: 10.1016/j.arr.2021.101303

29． Qiyao Chai*, Zhe Lu, Cui Hua Liu*. Host defense mechanisms against Mycobacterium tuberculosis. Cellular and Molecular Life Sciences, 2020, 77(10): 1859-1878. DOI: 10.1007/s00018-019-03353-5

30． Cui Hua Liu*, Yu Rao*, Daming Gao*, Lixin Wan*, Lingqiang Zhang*. Editorial: Ubiquitin Code: From Cell Biology to Translational Medicine. Frontiers in Cell and Developmental Biology, 2021, 9: 791967. DOI: 10.3389/fcell.2021.791967

31． Zehui Lei^#, Jing Wang^#, Lingqiang Zhang*, Cui Hua Liu*. Ubiquitination-Dependent Regulation of Small GTPases in Membrane Trafficking: From Cell Biology to Human Diseases. Frontiers in Cell and Developmental Biology, 2021, 9: 688352. DOI: 10.3389/fcell.2021.688352

32． Wenbin Gai^#, Zhiqiang Peng^#, Cui Hua Liu*, Lingqiang Zhang*, Hong Jiang*. Advances in cancer treatment by targeting the neddylation pathway. Frontiers in Cell and Developmental Biology, 2021, 9: 653882. DOI: 10.3389/fcell.2021.653882

33． Fuzhen Zhang^#, Shanshan Yu^#, Qiyao Chai^#, Jing Wang^#, Tuoya Wu, Rongmei Liu, Yi Liu, Cui Hua Liu*, Yu Pang*. HDAC6 contributes to human resistance against Mycobacterium tuberculosis infection via mediating innate immune responses. FASEB Journal, 2021, 35(11): e22009. DOI: 10.1096/fj.202100614R

34． Jing Wang^#, Conghui Han^#, Zhe Lu^#, Pupu Ge, Yu Cui, Dongdong Zhao, Xi Yang, Bo Wu, Lihua Qiang, Yong Zhang, Qiyao Chai, Zehui Lei, Ling Li*, Cui Hua Liu*, Lingqiang Zhang*. Simulated microgravity suppresses MAPK pathway-mediated innate immune response to bacterial infection and induces gut microbiota dysbiosis. FASEB Journal, 2020, 34(11): 14631-14644. DOI: 10.1096/fj.202001428R

35． Jie Li, Qi-Yao Chai, Yong Zhang, Bing-Xi Li, Jing Wang, Xiao-Bo Qiu, Cui Hua Liu*. Mycobacterium tuberculosis Mce3E suppresses host innate immune responses by targeting ERK1/2 signaling. The Journal of Immunology, 2015, 194 (8): 3756-3767. DOI: 10.4049/jimmunol.1402679

36． Jing Wang, Jade L L Teng, Dongdong Zhao, Pupu Ge, Bingxi Li, Patrick C Y Woo, Cui Hua Liu*. The ubiquitin ligase TRIM27 functions as a host restriction factor antagonized by Mycobacterium tuberculosis PtpA during mycobacterial infection. Scientific Reports, 2016, 6: 34827. DOI: 10.1038/srep34827

37． Yong Zhang, Jie Li, Bingxi Li, Jing Wang, Cui Hua Liu*. M. tuberculosis Mce3C promotes mycobacteria entry into macrophages through activation of β2 integrin-mediated signaling pathway. Cellular Microbiology, 2018, 20 (2): e12800. DOI: 10.1111/cmi.12800

38． Qiyao Chai^#, Zhe Lu^#, Zhidong Liu^#, Yanzhao Zhong, Fuzhen Zhang, Changgen Qiu, Bingxi Li, Jing Wang, Lingqiang Zhang, Yu Pang*, Cui Hua Liu*. Lung gene expression signatures suggest pathogenic links and molecular markers for pulmonary tuberculosis, adenocarcinoma and sarcoidosis. Communications Biology, 2020, 3(1): 604. DOI: 10.1038/s42003-020-01318-0

39． Jiansen Hu, Zheng Li, Jieyu Gao, Hongtao He, Huanqin Dai, Xuekui Xia, Cui Hua Liu*, Lixin Zhang*, Fuhang Song*. New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151. Marine Drugs, 2019, 17 (5): 262. DOI: 10.3390/md17050262

40． Qiyao Chai, Yong Zhang, Cui Hua Liu*. Mycobacterium tuberculosis: An adaptable pathogen associated with multiple human diseases. Frontiers in Cellular and Infection Microbiology, 2018, 8: 158. DOI: 10.3389/fcimb.2018.00158

41． Zehui Lei, Jing Wang, Cui Hua Liu*. Developing next-generation tuberculosis vaccines based on pathogen–host interactions: Towards a holistic perspective. hLife, 2025, online ahead of print. DOI: 10.1016/j.hlife.2024.11.003

42． Yingxu Fang^#, Zehui Lei^#, Lingqiang Zhang, Cui Hua Liu*, Qiyao Chai*. Regulatory functions and mechanisms of human microbiota in infectious diseases. hLife, 2024, 2(10): 496-513. DOI: 10.1016/j.hlife.2024.03.004

Xintong Gao, Cui Hua Liu*, Shuo Wang*. Mucosal immune responses in the lung during respiratory infection: the organization and regulation of iBALT structure. hLife, 2023, 1(2): 71-82. DOI: 10.1016/j.hlife.2023.09.001

1. Cui Hua Liu, Jing Wang; The combination of diagnostic and differential diagnostic markers for active pulmonary tuberculosis and their applicationsn; Patent number: ZL202411220117.0; Application date: September 2, 2024; Authorization date: January 21, 2025 (Authorization)

2. Cui Hua Liu, Yong Zhang, Jing Wang; A target against Mycobacterium tuberculosis invasion of host cells and its application; Patent number: ZL202110518930.6; Application date: May 13, 2021; Authorization date: December 1, 2023 (Authorization)

3. Cui Hua Liu, Jing Wang; A model of irritable bowel syndrome and its application; Patent number: ZL202010430662.8; Application date: May 20, 2020; Authorization date: May 18, 2023 (Authorization)

4. Cui Hua Liu, Qiyao Chai, Zhe Lu, Jing Wang; Biomarkers of Tuberculosis and their application; Patent number: ZL202010349875.8; Application date: April 28, 2020; Authorization date: December 2, 2021 (Authorization)

5. Cui Hua Liu, Jing Wang; An anti-Mycobacterium tuberculosis target and its application; Patent number: ZL201811430799.2; Application date: November 28, 2018; Authorization date: May 4, 2021 (Authorization)

6. Cui Hua Liu, Jing Wang; An anti-Mycobacterium tuberculosis target and its application; Patent number: ZL201811430645.3; Application date: November 28, 2018; Authorization date: May 4, 2021 (Authorization)

7. Cui Hua Liu, Jing Wang; An anti-Mycobacterium tuberculosis target and its application; Patent number: ZL201811431187.5; Application date: November 28, 2018; Authorization date: April 30, 2021 (Authorization)

8. Cui Hua Liu, Yong Zhang, Jing Wang; A macrophage phagocytosis accelerator; Authorization number: ZL201710898729.9; Application date: September 28, 2017; Authorization date: July 7, 2020 (Authorization)

9. Cui Hua Liu, Guanghua Xu, Jing Wang, Bingxi Li, Jinghua Yan; An ERK signaling pathway inhibitor NdpA; Authorization number: ZL201610213178.3; Application date: April 7, 2016; Authorization date: July 7, 2020 (Authorization)

10. Cui Hua Liu, Jing Wang; A protein TRIM27 defending against Mycobacterium tuberculosis infection; Authorization number: ZL201610381995.X; Application date: June 1, 2016; Authorization date: September 17, 2019 (Authorization)

11. Cui Hua Liu, Jing Wang, Bingxi Li, Yan Lu; Ubiquitin binding domain of Mycobacterium tuberculosis secreted protein; Authorization number: ZL201410061782.X; Application date: February 24, 2014; Authorization date: April 6, 2018 (Authorization)

12. Cui Hua Liu, Jing Wang, Bingxi Li, Pupu Ge; A recombinant BCG vaccine and its construction and application; Authorization number: ZL201410482225.5; Application date: September 19, 2014; Authorization date: March 1, 2019 (Authorization)

13. Cui Hua Liu, Jie Li, Jing Wang; An inhibitor of Erk signaling pathway; Authorization number: ZL201410523217.0; Application date: September 30, 2014; Authorization date: November 17, 2017 (Authorization)

14. Cui Hua Liu, Jing Wang; Protein PtpA secreted by Mycobacterium tuberculosis dephosphorylates p-JNK and p-p38; Authorization number: ZL201310466907.2; Application date: October 9, 2013; Authorization date: January 20, 2016 (Authorization)

15. Cui Hua Liu, Jing Wang, Zehui Lei; A target for treating autoimmune diseases and its application; Application number: 202411924391.6; Application date: December 25, 2025 (Application)

16. Cui Hua Liu, Qiyao Chai, Jing Wang; Long non-coding RNAs identified from plasma of Tuberculosis resisters and their applications; Application number: 202410521497.5; Application date: April 28, 2024 (Application)

17. Cui Hua Liu, Jing Wang, Qiyao Chai, Changgen Qiu, Zhe Lu; Biomarkers for indicating latent infection with progressive tuberculosis and their applications; Application number: 202410506181.9; Application date: April 25, 2024 (Application)

18. Cui Hua Liu, Jing Wang; A monoclonal antibody blocking the invasion of Mycobacterium tuberculosis and its application; Application number: 202410051929.0; Application date: January 15, 2024 (Application)

19. Cui Hua Liu, Jing Wang; A recombinant BCG vaccine drug against tuberculosis; Application number: 202310918921.5; Application date: July 25, 2023 (Application)

20. Cui Hua Liu, Jing Wang; A recombinant BCG vaccine drug for treating tuberculosis and its application; Application number: 2023104010707; Application date: April 14, 2023 (Application)

21. Cui Hua Liu, Yong Zhang, Jing Wang; A Mycobacterium tuberculosis protein and its polypeptide; Application number: 202211387664.9; Application date: November 8, 2022 (Application)

22. Cui Hua Liu, Jing Wang, Qiyao Chai, Zehui Lei; A LILRB1 monoclonal antibody and its application; Application number: 202211236332.0; Application date: October 11, 2022 (Application)

23. Lingqiang Zhang, Cui Hua Liu, Yong Zhang, Lihua Qiang, Jing Wang; Deubiquitinating enzyme OTULIN inhibitors in the treatment of STING-mediated infectious diseases; Application number: 202211165985.4; Application date: September 23, 2022 (Application)

24. Cui Hua Liu, Qiyao Chai, Zhe Lu, Jing Wang; Construction and application of recombinant BCG vaccine; Application number: 202210425903.9; Application date: April 21, 2022 (Application)

25. Jing Wang, Cui Hua Liu; NK cell receptors highly expressed in Tuberculosis patients and its application; Application number: 202111026159.7; Application date: September 2, 2021 (Application)

26. Cui Hua Liu, Jing Wang; A drug used to treat Tuberculosis; Application number: 202110367728.8; Application date: April 6, 2021 (Application)

27. Cui Hua Liu, Qiyao Chai, Zhe Lu, Jing Wang; Diagnostic markers of lung sarcoidosis and their application; Application number: 202010350286.1; Application date: April 28, 2020 (Application)

Major research interests are molecular pathogenesis and molecular mechanism of pathogenic bacteria.

1. Liu CH*. Molecular mechanisms underlying Mycobacterium tuberculosis pathogenesis and host defense. CSHA: Bacterial Infection & Host Defense. 2024.5.20-24. Suzhou, China.

2. Liu CH*. Modulation of host cell death by Mycobacterium tuberculosis effector proteins. Nature Conference “Cell Death Mechanisms and Diseases”. 2023.11.17. Sichuan, China.

3. Liu CH*. M. tuberculosis pathogenesis and host immune defense. Annual Meeting of Overseas Chinese Society of Microbiology. 2023.7.7-9. Changchun, China.

4. Liu CH^*. Mycobacterium tuberculosis infection and host innate immune defense. International Joint 

Forum on Infectious Disease Research 2019. 2019.12.17. Beijing, China.

5. Liu CH ^*. Host Innate Immune Regulation by Mycobacterium tuberculosis. 17TH International Congress of Immunology. 2019.10.19-23. Beijing, China.

6. Liu CH ^*Mycobacterium tuberculosis infection and host immune defense. The 5th China-Australia Academic Conference on Tuberculosis and Immunization. 2019. 11.5-8. Wuhan, China.

7. Liu CH ^*. Host Innate Immune Regulation by M. tuberculosis Effector Proteins. 2019 International TB Forum. 2019.5.25. Shanghai, China.

8. Liu CH ^*. A M. tuberculosis surface protein recruits ubiquitin to trigger host xenophagy. 2019 International Conference on Environmental and Health Microbiology and Annual Meeting of Overseas Chinese Microbiology Society. 2019.7.12-15. Beijing, China.

9. Liu CH ^*. M. tuberculosis-host interactions. The 2nd China Tuberculosis International Summit Forum. 2019.3.16-18. Shanghai, China.

10. Liu CH ^*_. Molecular mechanisms underlying Mycobacterium tuberculosis-host interactions. The 8th International Lorne Infection and Immunity Conference 2018 Australia. February 14–16, 2018. Lorne, Australia.

11. Liu CH ^*_. Identification of anti-TB drug targets based on M. tuberculosis-host interactions. The 17th Asia-Pacific Congress of Clinical Microbiology and Infection cum 8th International Infection Control Conference. August 30–September 1, 2018. Hong Kong, China.

12. Liu CH ^*_. Host regulation by Mycobacterium tuberculosis. SAKURA Exchange Program in Science. Octobor 7–13, 2018. Tokyo, Japan.

13. Liu CH ^*_. Regulation of host innate immune signaling pathways and cellular functions by Mycobacterium tuberculosis. 《Nature》International Symposium on inflammatory diseases. 2017.9.17-20. Beijing, China.

14. Liu CH ^*_. Regulation of host cellular functions by Mycobacterium. tuberculosis. Sino-Australia Summer Symposium on Emerging Pathogens. July 4-5, 2017. Beijing, China.

15. Liu CH ^*_. Regulation of host cellular functions by M. tuberculosis secreted effector proteins. IMMUNOLOGY 2017, the Annual Meeting of The American Association of Immunologists, Inc. (AAI). May 12–16, 2017. Washington, D.C., USA.

16. Liu CH ^*_. Regulation of host immune signaling pathways and cellular functions by M. tuberculosis secreted effector proteins. CSH: Bacterial Infection and Host Defense. April 17-21, 2017. Suzhou, China.

17. Liu CH ^*_. Mutual antagonism between Mycobacterium tuberculosis effector protein PtpA and host ubiquitin system. 6th Cross straight immunology conference. March 18-19, 2017. Taiwang, China.

18. Liu CH ^*_. Regulation of Host Innate Immunity by Mycobacterium Tuberculosis Secreted Effector Proteins (Keynote speaker at the symposium for the session on Infectious Diseases in 2016). 21st Research Postgraduate Symposium, “Research without limit: Unfolding the Mystery of Disease”, December 1-2, 2016. Hongkong, China.

19. Liu CH ^*_. Mycobacterium tuberculosis regulates innate immunity through coopting host ubiquitin system.  International Symposium on Ubiquitin and Diseases. June 15-19, 2015. Zhangjiajie, Hunan, China.

20. Liu CH*. M. tuberculosis secreted effector proteins promote intracellular survival of mycobacteria through exploiting the host ubiquitin system. CSH: Bacterial Infection and Host Defense. November 2-6, 2015. Suzhou, China.

21. Liu CH ^*_. Regulation of host innate immunity by Mycobacterium tuberculosis secreted effector protein. 5th Cross straight immunology conference. October 16-18, 2015. Shandong, China.

22. Liu CH*_. Regulation of host innate immune responses by mycobacterium tuberculosis secreted proteins. International Forum on Tuberculosis, Shanghai. April 23-24, 2015. Shanghai, China.

已指导学生

李杰  硕士研究生  085238-生物工程  

葛浦浦  硕士研究生  085238-生物工程  

张勇  硕士研究生  077803-病原生物学  

胡建森  博士研究生  071010-生物化学与分子生物学  

柴琪瑶  博士研究生  100103-病原生物学  

葛浦浦  博士研究生  100103-病原生物学  

雷泽慧  硕士研究生  085238-生物工程  

强丽华  博士研究生  100103-病原生物学  

赵冬冬  博士研究生  100103-病原生物学  

何杰华  硕士研究生  077803-病原生物学  

赵梦圆  硕士研究生  077803-病原生物学  

陆喆  博士研究生  100103-病原生物学  

邱长根  硕士研究生  077803-病原生物学  

于洋  博士研究生  100103-病原生物学  

现指导学生

钟延昭  博士研究生  100103-病原生物学  

赵卓  硕士研究生  077803-病原生物学  

雷泽慧  博士研究生  100103-病原生物学  

强煜云  硕士研究生  077803-病原生物学  

张馨文  博士研究生  100103-病原生物学  

房映旭  硕士研究生  077803-病原生物学  

赵梦圆  博士研究生  100103-病原生物学  

特日格乐  硕士研究生  077803-病原生物学  

邱长根  博士研究生  100103-病原生物学