基本信息
刘翠华  女  博导  中国科学院微生物研究所
电子邮件: liucuihua@im.ac.cn
通信地址: 北京市朝阳区北辰西路1号院3号A426房
邮政编码: 100101

研究领域

主要研究方向:
病原菌致病及耐药机理研究

主要研究内容:
1. 重要病原菌与宿主互作的分子机制
2. 重要病原菌耐药的分子机制

招生信息

   
招生专业
071010-生物化学与分子生物学
100103-病原生物学
100102-免疫学
招生方向
病原菌与宿主互作的分子机制
病原感染与宿主免疫
炎症免疫稳态调控机制

教育背景

2006-05--2006-12   中国科学院微生物研究所   博士后
2003-04--2006-04   美国哈佛大学医学院,微生物学与分子遗传学系   联合培养博士研究生/博士后
2000-08--2005-06   南方医科大学   生物化学与分子生物学专业,博士学历学位
1997-09--2000-06   第三军医大学   医学检验学,本科学历,学士学位
学历
南方医科大学 -- 研究生
学位
南方医科大学 -- 博士
出国学习工作
2003.4-2005.6    哈佛大学医学院微生物学及分子遗传学系,WHO奖学金Research Fellow/联合培养博士研究生 
 
2005.6-2006.4    哈佛大学医学院微生物学及分子遗传学系,博士后

2008.6-2008.9    哈佛大学医学院细胞生物学系,高级访问学者

工作经历

   
工作简历
2014-07~现在, 中国科学院微生物研究所, 研究员
2010-10~2014-07,中国科学院微生物研究所, 副研究员
2009-05~2010-10,解放军第309医院全军结核病研究中心, 副研究员
2008-06~2008-09,美国哈佛大学医学院,细胞生物学系, 高级访问学者
2007-01~2009-05,中国医学科学院基础所医学分子生物学国家重点实验室, 副研究员
社会兼职
2020-01-01-今,中国免疫学杂志, 第九届编委
2019-03-11-今,中国生物化学与分子生物学会医学生物化学与分子生物学分会, 第七届委员会基础学组委员
2018-05-28-今,中华医学会结核病学分会第十七届委员会专业, 学组成员
2017-11-01-今,中国抗癌协会肿瘤精准医学专业委员会, 委员
2017-11-01-今,北京细胞生物学会, 理事会成员
2016-12-20-今,中国研究型医院学会空间微生物与感染专业委员会, 副主任委员
2015-01-01-今,中国防痨协会结核病基础专业分委会, 委员
2015-01-01-今,中国免疫学会青年工作委员会, 委员
2015-01-01-今,中国医促会结核病防治分会, 专业学组委员
2015-01-01-今,国际期刊Scientific Reports, 编委成员
2011-01-01-今,国际期刊Journal of Pulmonory & Respiratory Medicine, 编委成员

专利与奖励

   
奖励信息
(1) 求是杰出科技成就集体奖, , 其他, 2019
(2) 中国科学院微生物研究所2019年导师教书育人奖, , 研究所(学校), 2019
(3) 2018年微生物所第二十届所长奖教金, , 研究所(学校), 2018
(4) 国家“万人计划科技创新领军人才”, 国家级, 2018
专利成果
[1] 刘翠华, 柴琪瑶, 汪静. 一种重组卡介苗的构建与应用. 202210425903.9, 2022-04-21.

[2] 刘翠华, 汪静. 结核病患者特异性高表达NK细胞受体及其应用. 202111026159.7, 2021-09-02.

[3] 刘翠华, 张勇, 汪静. 一种抗结核分枝杆菌入侵细胞的靶点及其应用. 202110518930.6, 2021-05-12.

[4] 汪静, 刘翠华. 一种治疗结核病的药物. 202110367728.8, 2021-04-06.

[5] 刘翠华, 柴琪瑶, 陆喆, 汪静. 肺结节诊断标志物及应用. CN: CN111876478A, 2020-11-03.

[6] 刘翠华, 柴琪瑶, 陆喆, 汪静. 肺结核、肺腺癌标志物及应用. CN: CN111879940A, 2020-11-03.

[7] 刘翠华, 汪静. 一种肠易激综合征小鼠模型及其应用. 202010430662.8, 2020-05-20.

[8] 刘翠华, 汪静. 一种抗结核分枝杆菌感染的蛋白TRIM27. CN: CN106039286B, 2019-09-17.

[9] 刘翠华, 汪静. 一种抗结核分枝杆菌的靶点及其应用. CN: CN109536471A, 2019-03-29.

[10] 刘翠华, 汪静. 一种抗结核分枝杆菌的靶点及其应用. CN: CN109536471A, 2019-03-29.

[11] 刘翠华, 汪静. 一种抗结核分枝杆菌的靶点及其应用. 中国: CN109517047A, 2019-03-26.

[12] 刘翠华, 汪静, 李冰曦, 葛浦浦. 一种重组卡介苗及其构建与应用. CN: CN105477631B, 2019-03-01.

[13] 刘翠华, 柴琪瑶, 汪静. 表面蛋白Rv1468c在消除病原菌方面的应用. 中国: CN108607093A, 2018.10.02.

[14] 刘翠华, 张勇, 汪静. 一种巨噬细胞吞噬能力促进剂. 中国: CN107722111A, 2018.02.23.

[15] 刘翠华, 汪静, 李冰曦, 鲁燕. 一种结核分枝杆菌分泌蛋白的泛素结合结构域. 中国: CN104862289B, 2018-04-06.

[16] 刘翠华, 李杰, 汪静. 一种Erk信号通路抑制剂. 中国: CN104327172B, 2017-11-17.

[17] 刘翠华, 汪静, 强丽华, 葛浦浦. 一种肺癌细胞生长抑制剂. 中国: CN106420838A, 2017-02-22.

[18] 刘翠华, 许光华, 汪静, 李冰曦, 严景华. 一种ERK信号通路抑制剂NdpA. 中国: CN105859844A, 2016-08-17.

[19] 刘翠华, 汪静. 一种使p-JNK和p-P38去磷酸化的结核分枝杆菌分泌蛋白PtpA. 中国: CN103525781A, 2014-01-22.

出版信息

   
发表论文
[1] 刘翠华, 任小波, 汪静, 逄宇, 仝舟, 高福. 科技助力结核病防控:现状、进展与对策. 中国科学院院刊. 2022, 112-122, https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CJFD&dbname=CJFDLAST2022&filename=KYYX202201014&v=MDk3NzZVNzdCTGpUU2RyRzRITlBNcm85RVlJUjhlWDFMdXhZUzdEaDFUM3FUcldNMUZyQ1VSN2lmWk9kdkZpcms=.
[2] Qingqing Hu, Huichun Tong, Jing Wang, Pupu Ge, Lin Zhu, Cuihua Liu, Jingren Zhang, Xiuzhu Dong. A Novel Aquaporin Subfamily Imports Oxygen and Contributes to Pneumococcal Virulence by Controlling the Production and Release of Virulence Factors. MBIO[J]. 2021, 12(4): [3] Zhu, Qiong, Fu, Yesheng, Li, Lei, Liu, Cui Hua, Zhang, Lingqiang. The functions and regulation of Otubains in protein homeostasis and diseases. AGEING RESEARCH REVIEWSnull. 2021, 67: http://dx.doi.org/10.1016/j.arr.2021.101303.
[4] Lei, Zehui, Wang, Jing, Zhang, Lingqiang, Liu, Cui Hua. Ubiquitination-Dependent Regulation of Small GTPases in Membrane Trafficking: From Cell Biology to Human Diseases. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGYnull. 2021, 9: http://dx.doi.org/10.3389/fcell.2021.688352.
[5] Wang, Jing, Ge, Pupu, Lei, Zehui, Lu, Zhe, Qiang, Lihua, Chai, Qiyao, Zhang, Yong, Zhao, Dongdong, Li, Bingxi, Su, Jiaqi, Peng, Ruchao, Pang, Yu, Shi, Yi, Zhang, Yu, Gao, George Fu, Qiu, XiaoBo, Liu, Cui Hua. Mycobacterium tuberculosis protein kinase G acts as an unusual ubiquitinating enzyme to impair host immunity. EMBO REPORTS[J]. 2021, 22(6): http://dx.doi.org/10.15252/embr.202052175.
[6] Lihua Qiang, Yong Zhang, Cui Hua Liu. Mycobacterium tuberculosis effector proteins: functional multiplicity and regulatory diversity. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2021, 18(5): 1343-1344, http://dx.doi.org/10.1038/s41423-021-00676-x.
[7] Du, Mengge, Peng, Zhiqiang, Gai, Wenbin, Liu, Fan, Liu, Wei, Chen, Yujiao, Li, Hongchang, Zhang, Xin, Liu, Cui Hua, Zhang, Lingqiang, Jiang, Hong, Xie, Ping. The Absence of PTEN in Breast Cancer Is a Driver of MLN4924 Resistance. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2021, 9: https://doaj.org/article/3c87fb38ff0a408cb756b5a0ad97f1ab.
[8] Fu, Yesheng, Wang, Hongtian, Dai, Hongmiao, Zhu, Qiong, Cui, ChunPing, Sun, Xiaoxuan, Fu, Yesheng, Li, Yanchang, Deng, Zhikang, Wang, Hongtian, Zhou, Xuemei, Ge, Yingwei, Peng, Zhiqiang, Yuan, Chao, Wu, Bo, Yang, Xi, Li, Rongyu, Liu, Cui Hua, He, Fuchu, Wei, Wenyi, Zhang, Lingqiang. OTULIN allies with LUBAC to govern angiogenesis by editing ALK1 linear polyubiquitin. MOLECULAR CELL[J]. 2021, 81(15): 3187-+, http://dx.doi.org/10.1016/j.molcel.2021.05.031.
[9] Gai, Wenbin, Peng, Zhiqiang, Liu, Cui Hua, Zhang, Lingqiang, Jiang, Hong. Advances in Cancer Treatment by Targeting the Neddylation Pathway. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGYnull. 2021, 9: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8060460/.
[10] 刘翠华. 线性泛素化修饰对免疫系统的调控作用研究进展. 中国免疫学杂志. 2021, [11] Zhang, Fuzhen, Yu, Shanshan, Chai, Qiyao, Wang, Jing, Wu, Tuoya, Liu, Rongmei, Liu, Yi, Liu, Cui Hua, Pang, Yu. HDAC6 contributes to human resistance against Mycobacterium tuberculosis infection via mediating innate immune responses. FASEB JOURNAL[J]. 2021, 35(11): [12] 刘翠华. The deubiquitinase OTUD1 inhibits colonic inflammation through suppressing RIPK1-mediated NF-κB signaling. Cellular & Molecular Immunology[J]. 2021, [13] Ge, Pupu, Lei, Zehui, Yu, Yang, Lu, Zhe, Qiang, Lihua, Chai, Qiyao, Zhang, Yong, Zhao, Dongdong, Li, Bingxi, Pang, Yu, Liu, Cui Hua, Wang, Jing. M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival. AUTOPHAGY. 2021, [14] Liu, Cui Hua, Rao, Yu, Gao, Daming, Wan, Lixin, Zhang, Lingqiang. Editorial: Ubiquitin Code: From Cell Biology to Translational Medicine. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGYnull. 2021, 9: http://dx.doi.org/10.3389/fcell.2021.791967.
[15] Ping Xie, Zhiqiang Peng, Yujiao Chen, Hongchang Li, Mengge Du, Yawen Tan, Xin Zhang, Zhe Lu, ChunPing Cui, Cui Hua Liu, Fuchu He, Lingqiang Zhang. Neddylation of PTEN regulates its nuclear import and promotes tumor development. Cell Research. 2020, 31(3): 291-311, [16] Qiyao Chai, Lin Wang, Cui Hua Liu, Baoxue Ge. New insights into the evasion of host innate immunity by Mycobacterium tuberculosis. Cellular and Molecular Immunology. 2020, 17(9): 901-913, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608469/.
[17] 刘翠华. 感染在神经退行性疾病中的调控机制研究进展. 微生物学报. 2020, [18] 雷泽慧, 汪静, 刘翠华. 自噬在抗感染免疫中的作用机制研究进展. 中国免疫学杂志[J]. 2020, 36(12): 1409-1418, http://lib.cqvip.com/Qikan/Article/Detail?id=7102196525.
[19] Chai, Qiyao, Lu, Zhe, Liu, Cui Hua. Host defense mechanisms against Mycobacterium tuberculosis. CELLULAR AND MOLECULAR LIFE SCIENCESnull. 2020, 77(10): 1859-1878, http://dx.doi.org/10.1007/s00018-019-03353-5.
[20] Chai, Qiyao, Lu, Zhe, Liu, Zhidong, Zhong, Yanzhao, Zhang, Fuzhen, Qiu, Changgen, Li, Bingxi, Wang, Jing, Zhang, Lingqiang, Pang, Yu, Liu, Cui Hua. Lung gene expression signatures suggest pathogenic links and molecular markers for pulmonary tuberculosis, adenocarcinoma and sarcoidosis. COMMUNICATIONS BIOLOGY[J]. 2020, 3(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000586513500012.
[21] Wang, Jing, Han, Conghui, Lu, Zhe, Ge, Pupu, Cui, Yu, Zhao, Dongdong, Yang, Xi, Wu, Bo, Qiang, Lihua, Zhang, Yong, Chai, Qiyao, Lei, Zehui, Li, Ling, Hua Liu, Cui, Zhang, Lingqiang. Simulated microgravity suppresses MAPK pathway-mediated innate immune response to bacterial infection and induces gut microbiota dysbiosis. FASEB JOURNAL[J]. 2020, 34(11): 14631-14644, https://www.webofscience.com/wos/woscc/full-record/WOS:000570683700001.
[22] Chai, Qiyao, Wang, Lin, Liu, Cui Hua, Ge, Baoxue. New insights into the evasion of host innate immunity byMycobacterium tuberculosis. CELLULAR & MOLECULAR IMMUNOLOGYnull. 2020, 17(9): 901-913, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7608469/.
[23] Cui, ChunPing, Zhang, Yuan, Wang, Chanjuan, Yuan, Fang, Li, Hongchang, Yao, Yuying, Chen, Yuhan, Li, Chunnan, Wei, Wenyi, Liu, Cui Hua, He, Fuchu, Liu, Yan, Zhang, Lingqiang. Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation (vol 9, 4648, 2018). NATURE COMMUNICATIONSnull. 2019, 10: https://www.webofscience.com/wos/woscc/full-record/WOS:000455104800001.
[24] Fan, Jiao, Liu, Lifeng, Liu, Qingyan, Cui, Yu, Yao, Binwei, Zhang, Minghua, Gao, Yabing, Fu, Yesheng, Dai, Hongmiao, Pan, Jingkun, Qiu, Ya, Liu, Cui Hua, He, Fuchu, Wang, Yu, Zhang, Lingqiang. CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REG gamma. NATURE COMMUNICATIONS[J]. 2019, 10: http://dx.doi.org/10.1038/s41467-018-07895-3.
[25] Hu, Jiansen, Li, Zheng, Gao, Jieyu, He, Hongtao, Dai, Huanqin, Xia, Xuekui, Liu, Cuihua, Zhang, Lixin, Song, Fuhang. New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151. MARINE DRUGS[J]. 2019, 17(5): http://dx.doi.org/10.3390/md17050262.
[26] Jiang, TianXia, Zou, JiangBo, Zhu, QianQian, Liu, Cui Hua, Wang, GuangFei, Du, TingTing, Luo, ZiYu, Guo, Fang, Zhou, LuMing, Liu, JuanJuan, Zhang, Wensheng, Shu, YouSheng, Yu, Li, Li, Peng, Ronai, Zeev A, Matsuzawa, Shuichi, Goldberg, Alfred L, Qiu, XiaoBo. SIP/CacyBP promotes autophagy by regulating levels of BRUCE/Apollon, which stimulates LC3-I degradation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2019, 116(27): 13404-13413, [27] Qiyao Chai, Xudong Wang, Lihua Qiang, Yong Zhang, Pupu Ge, Zhe Lu, Yanzhao Zhong, Bingxi Li, Jing Wang, Lingqiang Zhang, Dawang Zhou, Wei Li, Wenzhu Dong, Yu Pang, George Fu Gao, Cui Hua Liu. A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy. NATURE COMMUNICATIONS[J]. 2019, 10(1): https://doaj.org/article/7cbb0f3c46d842489f4a4c75d699520e.
[28] 强丽华, 张勇, 刘翠华. 组织定居巨噬细胞在维持免疫稳态中的研究进展. 中国免疫学杂志[J]. 2019, 35(10): 1153-1159, http://lib.cqvip.com/Qikan/Article/Detail?id=7002109301.
[29] Jiansen Hu, Zheng Li, Jieyu Gao, Hongtao He, Huanqin Dai, Xuekui Xia, Cuihua Liu, Lixin Zhang, Fuhang Song. New Diketopiperazines from a Marine-Derived Fungus Strain Aspergillus versicolor MF180151. Marine Drugs[J]. 2019, 17(5): https://doaj.org/article/213ea6e0e50b486798e07efc4329966a.
[30] Qiang, Lihua, Wang, Jing, Zhang, Yong, Ge, Pupu, Chai, Qiyao, Li, Bingxi, Shi, Yi, Zhang, Lingqiang, Gao, George Fu, Liu, Cui Hua. Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation. CELLULAR & MOLECULAR IMMUNOLOGY[J]. 2019, 16(4): 380-391, https://www.webofscience.com/wos/woscc/full-record/WOS:000463353400008.
[31] Liu Cuihua. Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferati. Cellular Molecular Immunology. 2018, [32] Zhang, Yong, Li, Jie, Li, Bingxi, Wang, Jing, Liu, Cui Hua. Mycobacterium tuberculosis Mce3C promotes mycobacteria entry into macrophages through activation of beta 2 integrin-mediated signalling pathway. CELLULAR MICROBIOLOGY[J]. 2018, 20(2): https://www.webofscience.com/wos/woscc/full-record/WOS:000419773900002.
[33] Liu Cuihua. Mycobacterium tuberculosis: An adaptable pathogen sssociated eith multiple human diseases.. Frontiers in Cellular and Infection Microbiology. 2018, [34] ChunPing Cui, Yuan Zhang, Chanjuan Wang, Fang Yuan, Hongchang Li, Yuying Yao, Yuhan Chen, Chunnan Li, Wenyi Wei, Cui Hua Liu, Fuchu He, Yan Liu, Lingqiang Zhang. Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation. NATURE COMMUNICATIONS[J]. 2018, 9(1): https://doaj.org/article/45905577dc8841ac9b0b46e61de14b8e.
[35] Liu Cuihua. Mycobacterium tuberculosis Mce3C promotes mycobacteria entry into macrophages through activation of β2 integrin-mediated signalling pathway.. Cellular Microbiology. 2018, [36] Chai, Qiyao, Zhang, Yong, Liu, Cui Hua. Mycobacterium tuberculosis: An Adaptable Pathogen Associated With Multiple Human Diseases. FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGYnull. 2018, 8: https://doaj.org/article/c38bf3260a204b5a81ab90e6c99137e6.
[37] Wang, Shan, Peng, Zhiqiang, Wang, Siying, Yang, Lihua, Chen, Yuhan, Kong, Xue, Song, Shanshan, Pei, Pei, Tian, Chunyan, Yan, Hui, Ding, Peipei, Hu, Weiguo, Liu, Cui Hua, Zhang, Xin, He, Fuchu, Zhang, Lingqiang. KRAB-type zinc-finger proteins PITA and PISA specifically regulate p53-dependent glycolysis and mitochondrial respiration. CELL RESEARCH[J]. 2018, 28(5): 572-592, http://lib.cqvip.com/Qikan/Article/Detail?id=675657272.
[38] Sun, Lulu, Xie, Cen, Wang, Guang, Wu, Yue, Wu, Qing, Wang, Xuemei, Liu, Jia, Deng, Yangyang, Xia, Jialin, Chen, Bo, Zhang, Songyang, Yun, Chuyu, Lian, Guan, Zhang, Xiujuan, Zhang, Heng, Bisson, William H, Shi, Jingmin, Gao, Xiaoxia, Ge, Pupu, Liu, Cuihua, Krausz, Kristopher W, Nichols, Robert G, Cai, Jingwei, Rimal, Bipin, Patterson, Andrew D, Wang, Xian, Gonzalez, Frank J, Jiang, Changtao. Gut microbiota and intestinal FXR mediate the clinical benefits of metformin. NATURE MEDICINE[J]. 2018, 24(12): 1919-+, http://dx.doi.org/10.1038/s41591-018-0222-4.
[39] 魏文毅, 孙毅, 曹诚, 常智杰, 陈策实, 陈佺, 程金科, 冯仁田, 高大明, 胡荣贵, 贾立军, 姜天霞, 金建平, 李汇华, 李卫, 刘翠华, 刘萱, 马蕾娜, 缪时英, 饶枫, 商瑜, 宋质银, 万勇, 王恒彬, 王平, 王占新, 吴缅, 吴乔, 谢旗, 谢松波, 谢志平, 徐平, 许执恒, 杨波, 阳成伟, 应美丹, 张宏冰, 张令强, 赵永超, 周军, 朱军, 王琳芳, 张宏, 王琛, 邱小波. 类泛素蛋白及其中文命名. 科学通报[J]. 2018, 63(25): 2564-2569, http://lib.cqvip.com/Qikan/Article/Detail?id=676354836.
[40] Shan Wang, Zhiqiang Peng, Siying Wang, Lihua Yang, Yuhan Chen, Xue Kong, Shanshan Song, Pei Pei, Chunyan Tian, Hui Yan, Peipei Ding, Weiguo Hu, Cui Hua Liu, Xin Zhang, Fuchu He, Lingqiang Zhang. Author Correction: KRAB-type zinc-finger proteins PITA and PISA specifically regulate p53-dependent glycolysis and mitochondrial respiration. Cell Research. 2018, 28(5): 605-605, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5951815/.
[41] Yuhan Chen, Qingyang Huang, Wen Liu, Qiong Zhu, ChunPing Cui, Liang Xu, Xing Guo, Ping Wang, Jingwen Liu, Guanglong Dong, Wenyi Wei, Cui Hua Liu, Zhichun Feng, Fuchu He, Lingqiang Zhang. Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth. NATURE COMMUNICATIONS[J]. 2018, 9(1): https://doaj.org/article/92fcbc49e2cc43b08965746496427e3e.
[42] Wang, Shan, Peng, Zhiqiang, Wang, Siying, Yang, Lihua, Chen, Yuhan, Kong, Xue, Song, Shanshan, Pei, Pei, Tian, Chunyan, Yan, Hui, Ding, Peipei, Hu, Weiguo, Liu, Cui Hua, Zhang, Xin, He, Fuchu, Zhang, Lingqiang. KRAB-type zinc-finger proteins PITA and PISA specifically regulate p53-dependent glycolysis and mitochondrial respiration (vol 0, pg 1, 2018). CELL RESEARCHnull. 2018, 28(5): 605-605, https://www.webofscience.com/wos/woscc/full-record/WOS:000432032500013.
[43] Zhang, Yihao, Qian, Long, Wei, Weijia, Wang, Yu, Wang, Beining, Lin, Pingping, Liu, Wenchao, Xu, Luze, Li, Xiang, Liu, Dongming, Cheng, Sida, Li, Jiaofeng, Ye, Yixuan, Li, Hang, Zhang, Xiaohan, Dong, Yiming, Zhao, Xuejin, Liu, Cuihua, Zhang, Haoqian M, Ouyang, Qi, Lou, Chunbo. Paired Design of dCas9 as a Systematic Platform for the Detection of Featured Nucleic Acid Sequences in Pathogenic Strains. ACS SYNTHETIC BIOLOGY[J]. 2017, 6(2): 211-216, https://www.webofscience.com/wos/woscc/full-record/WOS:000394736400006.
[44] 柴琪瑶, 刘翠华. 泛素系统在结核分枝杆菌与宿主相互作用中的调控机制研究进展. 中国免疫学杂志[J]. 2017, 33(2): 161-169, http://lib.cqvip.com/Qikan/Article/Detail?id=671466900.
[45] Liu Cuihua. Innate immunity in tuberculosis: host defense vs pathogen.. Cellular Molecular Immunology. 2017, [46] Tan Shuguang, Lin Nan, Huang Mingxiang, Wang Qing, Tan Yunhong, Li Bingxi, Zhang Ning, Guo Tianling, Cui Yingbin, Chen Xinchao, Wang Dongping, Wang Jue, Xiao Haixia, Liu William J, Yan Jinghua, Zhang Catherine WH, Liu Cui Hua, Wan Kanglin, Gao George F. CTL immunogenicity of Rv3615c antigen and diagnostic performances of an ESAT-6/CFP-10/Rv3615c antigen cocktail for Mycobacterium tuberculosis infection. Tuberculosis[J]. 2017, [47] Xu, Guanghua, Wang, Jing, Liu, Cui Hua. Klebsiella pneumoniae NdpA suppresses ERK pathway-mediated host early inflammatory responses and is degraded through the ubiquitin-proteasome pathway. PROTEIN & CELLnull. 2017, 8(2): 144-148, http://lib.cqvip.com/Qikan/Article/Detail?id=671411288.
[48] Tan, Shuguang, Lin, Nan, Huang, Mingxiang, Wang, Qing, Tan, Yunhong, Li, Bingxi, Zhang, Ning, Guo, Tianling, Cui, Yingbin, Chen, Xinchao, Wang, Dongping, Wang, Jue, Xiao, Haixia, Liu, William J, Yan, Jinghua, Zhang, Catherine W H, Liu, Cui Hua, Wan, Kanglin, Gao, George F. CTL immunogenicity of Rv3615c antigen and diagnostic performances of an ESAT-6/CFP-10/Rv3615c antigen cocktail for Mycobacterium tuberculosis infection. TUBERCULOSIS[J]. 2017, 107: 5-12, http://dx.doi.org/10.1016/j.tube.2017.07.011.
[49] Liu, Cui Hua, Liu, Haiying, Ge, Baoxue. Innate immunity in tuberculosis: host defense vs pathogen evasion. CELLULAR & MOLECULAR IMMUNOLOGYnull. 2017, 14(12): 963-975, https://www.webofscience.com/wos/woscc/full-record/WOS:000416912600005.
[50] GePupu, IwakuraYoichiro, QiangLihua, ZhouRongbin, ZhuMingzhao, ChaiQiyao, TianFeng, WangJing, MengGuangxun, ZhaoDongdong. The mycobacterial phosphatase ptpa regulates the expression of host genes and promotes cell proliferation.. Nat commun[J]. 2017, Vol.8 no.1: 244-, http://www.corc.org.cn/handle/1471x/2200946.
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[53] Songdong Meng. Heat shock protein gp96 enhances T cell responses and protective potential to Bacillus Calmette-Guérin vaccine. Scand J Immunol.. 2016, [54] Wang, Jing, Teng, Jade L L, Zhao, Dongdong, Ge, Pupu, Li, Bingxi, Woo, Patrick C Y, Liu, Cui Hua. The ubiquitin ligase TRIM27 functions as a host restriction factor antagonized by Mycobacterium tuberculosis PtpA during mycobacterial infection. SCIENTIFIC REPORTS[J]. 2016, 6: http://www.corc.org.cn/handle/1471x/2375771.
[55] Musyoki, Abednego Moki, Shi, Zhongyu, Xuan, Chunling, Lu, Guangwen, Qi, Jianxun, Gao, Feng, Zheng, Beiwen, Zhang, Qiangmin, Li, Yan, Haywood, Joel, Liu, Cuihua, Yan, Jinghua, Shi, Yi, Gao, George F. Structural and functional analysis of an anchorless fibronectin-binding protein FBPS from Gram-positive bacterium Streptococcus suis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2016, 113(48): 13869-13874, https://www.webofscience.com/wos/woscc/full-record/WOS:000388835700087.
[56] Jie Li Qi-Yao Chai Cui Hua Liu. The ubiquitin system: a critical regulator of innate immunity and pathogen-host interactions. 中国免疫学杂志:英文版. 2016, 13(5): 560-576, http://lib.cqvip.com/Qikan/Article/Detail?id=670093827.
[57] Li, Jie, Chai, QiYao, Liu, Cui Hua. The ubiquitin system: a critical regulator of innate immunity and pathogen-host interactions. CELLULAR & MOLECULAR IMMUNOLOGYnull. 2016, 13(5): 560-576, http://lib.cqvip.com/Qikan/Article/Detail?id=670093827.
[58] Wang, Jing, Li, BingXi, Ge, PuPu, Li, Jie, Wang, Qi, Gao, George Fu, Qiu, XiaoBo, Liu, Cui Hua. Mycobacterium tuberculosis suppresses innate immunity by coopting the host ubiquitin system. NATURE IMMUNOLOGY[J]. 2015, 16(3): 237-U189, https://www.webofscience.com/wos/woscc/full-record/WOS:000349842100007.
[59] BingXi Li, XiaoBo Qiu, QiYao Chai, Cui Hua Liu, Jie Li, Jing Wang, Yong Zhang. Mycobacterium tuberculosis Mce3E Suppresses Host Innate Immune Responses by Targeting ERK1/2 Signaling. American Association of Immunologists. 2015, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902020294376ZK.
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[61] Xiong, Lifeng, Teng, Jade L L, Watt, Rory M, Liu, Cuihua, Lau, Susanna K P, Woo, Patrick C Y. Molecular characterization of arginine deiminase pathway in Laribacter hongkongensis and unique regulation of arginine catabolism and anabolism by multiple environmental stresses. ENVIRONMENTAL MICROBIOLOGY[J]. 2015, 17(11): 4469-4483, https://www.webofscience.com/wos/woscc/full-record/WOS:000366139500025.
[62] Liu Cuihua. Comparative genomic analysis of gene variations among Mycobacterium tuberculosis clinical isolates with different antibiotic resistance profiles. BMC Genomics. 2014, [63] Liu, Fei, Hu, Yongfei, Wang, Qi, Li, Hong Min, Gao, George F, Liu, Cui Hua, Zhu, Baoli. Comparative genomic analysis of Mycobacterium tuberculosis clinical isolates. BMC GENOMICS[J]. 2014, 15(1): http://dx.doi.org/10.1186/1471-2164-15-469.
[64] Xu, Guanghua, Wang, Jing, Gao, George Fu, Liu, Cui Hua. Insights into battles between Mycobacterium tuberculosis and macrophages. PROTEIN & CELLnull. 2014, 5(10): 728-736, http://www.corc.org.cn/handle/1471x/2203498.
[65] Li, Jia, Liu, Fei, Wang, Qi, Ge, Pupu, Woo, Patrick C Y, Yan, Jinghua, Zhao, Yanlin, Gao, George F, Liu, Cui Hua, Liu, Changting. Genomic and transcriptomic analysis of NDM-1 Klebsiella pneumoniae in spaceflight reveal mechanisms underlying environmental adaptability. SCIENTIFIC REPORTS[J]. 2014, 4: https://www.webofscience.com/wos/woscc/full-record/WOS:000340936000002.
[66] Wang, Qi, Lau, Susanna K P, Liu, Fei, Zhao, Yanlin, Li, Hong Min, Li, Bing Xi, Hu, Yong Liang, Woo, Patrick C Y, Liu, Cui Hua. Molecular Epidemiology and Clinical Characteristics of Drug-Resistant Mycobacterium tuberculosis in a Tuberculosis Referral Hospital in China. PLOS ONE[J]. 2014, 9(10): https://doaj.org/article/67c8443af80b44f18b4b0707294279a8.
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[68] Liu Cuihua. Structural diversity of class 1 Integrons and their associated hene cassettes in Klebsiella pneumoniae isolates from a hospital in China. PLOS ONE. 2013, [69] Li, Bin, Hu, Yongfei, Wang, Qi, Yi, Yong, Woo, Patrick C Y, Jing, Hua, Zhu, Baoli, Liu, Cui Hua. Structural Diversity of Class 1 Integrons and Their Associated Gene Cassettes in Klebsiella pneumoniae Isolates from a Hospital in China. PLOS ONE[J]. 2013, 8(9): https://www.webofscience.com/wos/woscc/full-record/WOS:000325423500100.
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[71] Liu, Cui Hua, Li, Hong Min, Lu, Na, Wang, Qi, Hu, Yong Liang, Yang, Xi, Hu, Yong Fei, Woo, Patrick C Y, Gao, George F, Zhu, Baoli. Genomic sequence based scanning for drug resistance-associated mutations and evolutionary analysis of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis. JOURNAL OF INFECTION[J]. 2012, 65(5): 412-422, http://dx.doi.org/10.1016/j.jinf.2012.06.007.
[72] Li, Bin, Yi, Yong, Wang, Qi, Woo, Patrick C Y, Tan, Lin, Jing, Hua, Gao, George F, Liu, Cui Hua. Analysis of Drug Resistance Determinants in Klebsiella pneumoniae Isolates from a Tertiary-Care Hospital in Beijing, China. PLOS ONE[J]. 2012, 7(7): http://dx.doi.org/10.1371/journal.pone.0042280.
[73] Yu, Hao Tian, Wang, Qi, Yang, Nan, Li, Hong Min, Liang, Jian Qin, Liu, Cui Hua. Risk factors associated with kanamycin-resistant tuberculosis in a Beijing tuberculosis referral hospital. JOURNAL OF MEDICAL MICROBIOLOGY[J]. 2012, 61(7): 960-967, https://www.webofscience.com/wos/woscc/full-record/WOS:000307206700011.
[74] Han, Huiming, Liu, Cuihua, Wang, Quanhui, Xuan, Chunling, Zheng, Beiwen, Tang, Jiaqi, Yan, Jinghua, Zhang, Jingren, Li, Ming, Cheng, Hao, Lu, Guangwen, Gao, George F. The two-component system Ihk/Irr contributes to the virulence of Streptococcus suis serotype 2 strain 05ZYH33 through alteration of the bacterial cell metabolism. MICROBIOLOGY-SGM[J]. 2012, 158: 1852-1866, http://dx.doi.org/10.1099/mic.0.057448-0.
[75] Liu Cuihua. Analysis of genetic determinants of multidrug-resistant, extensively drug-resistant and pandrug-resistant Klebsiella pneumoniae isolates in a hospital in Beijing, China. PloS ONE. 2012, [76] Liu Cuihua. Genome-wide molecular characterization and evolutionary analysis of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis. Journal of Infection. 2012, [77] 刘翠华, 黄红娜, 王琪, 郑焙文, 朱宝利. 结核分枝杆菌中的泛素样蛋白-蛋白酶体系统研究进展. 中国防痨杂志. 2011, 33(7): 445-448, http://lib.cqvip.com/Qikan/Article/Detail?id=38666245.
[78] Liu, Cui Hua, Li, Ling, Chen, Zhi, Wang, Qi, Hu, Yong Liang, Zhu, Baoli, Woo, Patrick C Y. Characteristics and Treatment Outcomes of Patients with MDR and XDR Tuberculosis in a TB Referral Hospital in Beijing: A 13-Year Experience. PLOS ONE[J]. 2011, 6(4): https://doaj.org/article/368fdad8ed1f4b3dbc5a63e9ecf08be8.
[79] Liu, Cui Hua, Yang, Nan, Wang, Qi, Hu, Yong Liang, Li, Ling, Zhang, Guang Yu, Zhu, Baoli. Risk factors associated with fluoroquinolone-resistant tuberculosis in a Beijing tuberculosis referral hospital. RESPIROLOGY[J]. 2011, 16(6): 918-925, https://www.webofscience.com/wos/woscc/full-record/WOS:000293124600008.
[80] Liu, C H, Li, H M, Li, L, Hu, Y L, Wang, Q, Yang, N, Wang, S, Zhu, B. Anti-tuberculosis drug resistance patterns and trends in a tuberculosis referral hospital, 1997-2009. EPIDEMIOLOGY AND INFECTION[J]. 2011, 139(12): 1909-1918, https://www.webofscience.com/wos/woscc/full-record/WOS:000297291300012.
[81] Wu, Zuowei, Li, Ming, Wang, Changjun, Li, Jing, Lu, Na, Zhang, Ruifen, Jiang, Yongqiang, Yang, Ruifu, Liu, Cuihua, Liao, Hui, Gao, George F, Tang, Jiaqi, Zhu, Baoli. Probing genomic diversity and evolution of Streptococcus suis serotype 2 by NimbleGen tiling arrays. BMC GENOMICS[J]. 2011, 12: 219-219, https://www.webofscience.com/wos/woscc/full-record/WOS:000291940000001.
[82] Ding, Jiabo, Pan, Yuanlong, Jiang, Hai, Cheng, Junsheng, Liu, Taotao, Qin, Nan, Yang, Yi, Cui, Buyun, Chen, Chen, Liu, Cuihua, Mao, Kairong, Zhu, Baoli. Whole Genome Sequences of Four Brucella Strains. JOURNAL OF BACTERIOLOGY[J]. 2011, 193(14): 3674-3675, https://www.webofscience.com/wos/woscc/full-record/WOS:000292134900032.
[83] Liu, Cui Hua, Lee, S Melanie, VanLare, Jordan M, Kasper, Dennis L, Mazmanian, Sarkis K. Regulation of surface architecture by symbiotic bacteria mediates host colonization. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2008, 105(10): 3951-3956, https://www.webofscience.com/wos/woscc/full-record/WOS:000253930600053.
[84] Liu Cuihua. New insights into the role of the ubiquitin-proteasome pathway in the regulation of apoptosis. Chang Gung Medical Journal. 2007, [85] 欧阳谦, 马文丽, 刘翠华, 郑文岭. PhoB缺失突变株的构建及其性状的初步研究. 广东医学[J]. 2006, 27(1): 49-51, http://lib.cqvip.com/Qikan/Article/Detail?id=20975784.
[86] 欧阳谦, 马文丽, 刘翠华, 石嵘, 郑文岭. ΔLuxS的表型分析及其在GBS毒力调控机制研究中的应用. 南方医科大学学报[J]. 2006, 26(1): 117-121, http://lib.cqvip.com/Qikan/Article/Detail?id=21194048.
[87] 欧阳谦, 马文丽, 刘翠华, 石嵘, 郑文岭. B型链球菌数量感应通路测定及LuxS缺失突变株的构建. 第一军医大学学报[J]. 2005, 25(9): 1135-1139, http://lib.cqvip.com/Qikan/Article/Detail?id=20195045.
[88] Mazmanian, SK, Liu, CH, Tzianabos, AO, Kasper, DL. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. CELL[J]. 2005, 122(1): 107-118, http://dx.doi.org/10.1016/j.cell.2005.05.007.
[89] Liu Cuihua. An Oligonucleotide Microarray Bait for Isolation of Target Gene Fragment. Journal of Biochemistry and Molecular Biology. 2004, [90] 石嵘, 马文丽, 刘翠华, 宋艳斌, 吴清华, 郭秋野, 郑文岭. 应用70mer Oligo基因芯片从限制性cDNA片段中钓取目的基因. 第一军医大学学报[J]. 2004, 24(7): 738-741, http://lib.cqvip.com/Qikan/Article/Detail?id=10195355.
[91] 刘翠华, 马文丽, 张宝, 石嵘, 郑文岭. 人乳头瘤病毒(HPV)基因芯片的研究. 微生物学报[J]. 2003, 43(5): 613-618, http://lib.cqvip.com/Qikan/Article/Detail?id=8614455.
[92] 石嵘, 马文丽, 宋艳斌, 李凌, 刘翠华, 郑文岭. 两种限制性标记方法提高基因芯片杂交结果的信噪比. 第一军医大学学报[J]. 2003, 23(2): 124-126, http://lib.cqvip.com/Qikan/Article/Detail?id=7639192.
[93] Li, L, Ma, WL, Zhu, J, Shi, R, Liu, CH, Chen, JK, Zheng, WL. A modified restriction display sample-labelling of DNA PCR method in microarray. JOURNAL OF VIROLOGICAL METHODS[J]. 2003, 114(1): 71-75, https://www.webofscience.com/wos/woscc/full-record/WOS:000186824000009.
[94] Liu, CH, Ma, WL, Shi, R, On, YQ, Zhang, B, Zheng, WL. Possibility of using DNA chip technology for diagnosis of human papillomavirus. JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY[J]. 2003, 36(4): 349-353, https://www.webofscience.com/wos/woscc/full-record/WOS:000184411300003.
[95] Liu, CH, Ma, WL, Shi, R, Zhang, B, Ou, YQ, Zheng, WL. Gene expression study of Saccharomyces cerevisiae with the Agilent 2100 bioanalyser. BRITISH JOURNAL OF BIOMEDICAL SCIENCE[J]. 2003, 60(1): 22-25, https://www.webofscience.com/wos/woscc/full-record/WOS:000182067700006.
[96] 刘翠华, 彭翼飞, 郑文岭, 马文丽, 石嵘, 欧谦. Agilent 2100 Bioanalyzer在人乳头瘤病毒检测中的应用. 第一军医大学学报[J]. 2003, 23(3): 213-215, http://lib.cqvip.com/Qikan/Article/Detail?id=7478099.
[97] 刘翠华, 郑文岭. 基因差异表达分析技术及其在肿瘤研究中的应用. 医学综述. 2002, 8(8): 444-446, http://lib.cqvip.com/Qikan/Article/Detail?id=6730511.
[98] 李凌, 马文丽, 甄莉, 吴清华, 刘翠华, 郑文岭. 限制性显示技术制备HIV—1B亚型基因片段的研究. 病毒学报[J]. 2002, 18(2): 177-180, http://lib.cqvip.com/Qikan/Article/Detail?id=6421944.
[99] 刘翠华, 马文丽, 石嵘, 欧阳谦, 郑文岭. Agilent 2100 Bioanalyzer在基因差异表达研究中的应用. 第一军医大学学报[J]. 2002, 22(12): 1066-1069, http://lib.cqvip.com/Qikan/Article/Detail?id=7222830.
[100] 刘翠华. 人乳头瘤病毒的诊断研究进展. 国外医学:妇产科学分册. 2002, 29(4): 213-216, http://lib.cqvip.com/Qikan/Article/Detail?id=6756770.
发表著作
(1) 泛素介导的蛋白质降解, Ubiquitin-Mediated Proteolysis, 中国协和医科大学出版社, 2008-11, 第 4 作者

科研活动

   
科研项目
( 1 ) 病原菌致病与耐药机理研究, 主持, 部委级, 2010-11--2014-05
( 2 ) 病原微生物广泛耐药机理及相关药物研究, 参与, 市地级, 2011-01--2013-12
( 3 ) 重要病原菌与宿主相互作用分子机制的研究, 主持, 国家级, 2012-01--2016-12
( 4 ) 医院内感染相关性肺炎克雷伯菌的分子耐药机制研究, 主持, 研究所(学校), 2012-06--2014-05
( 5 ) 结核病免疫原的系统发现和新型疫苗的临床前研究, 主持, 国家级, 2013-01--2015-12
( 6 ) 结核病耐药相关的基础和应用研究, 参与, 部委级, 2013-01--2015-12
( 7 ) PknG 促进结核分枝杆菌胞内存活的分子机制研究, 主持, 国家级, 2014-01--2017-12
( 8 ) 空间环境诱变病原菌产生致病性改变的机制研究, 参与, 国家级, 2014-01--2018-12
( 9 ) 青年创新促进会优秀会员, 主持, 部委级, 2016-01--2018-12
( 10 ) Mce3C促进结核分枝杆菌入胞及胞内存活的分子机制研究, 主持, 国家级, 2016-01--2019-12
( 11 ) 与病原菌感染致病密切相关的新型病原菌蛋白分子的研究, 主持, 国家级, 2017-07--2022-06
( 12 ) 病原菌的致病与耐药机制, 主持, 部委级, 2017-07--2018-06
( 13 ) 结核分枝杆菌调控宿主细胞自噬的分子机制, 主持, 国家级, 2019-01--2023-12
( 14 ) 病原菌与宿主互作的分子机制, 主持, 国家级, 2019-01--2023-12
( 15 ) 病原菌的致病与耐药机制, 主持, 部委级, 2018-07--2023-06
参与会议
(1)Mycobacterium tuberculosis infection and host immune defense   第五届中澳结核病与免疫学术会议   2019-11-05
(2)Host Innate Immune Regulation by mycobacterium tuberculosis   2019-10-19
(3)结核感染与宿主免疫   第五届潇湘肿瘤学高峰论坛   2019-09-06
(4)结核分枝杆菌调控宿主泛素系统的分子机制   2019年结核病东方论坛   2019-08-15
(5)结核分枝杆菌与宿主互作   2019年儿童结核病诊断和治疗新进展论坛   2019-07-19
(6)A M. tuberculosis surface protein recruits ubiquitin to trigger host xenophagy   2019国际环境和健康微生物学会议暨海外华人微生物学会年会   2019-07-12
(7)Molecular Mechanisms underlying M. tuberculosis-host interactions   2019一带一路暨发展中国家分枝杆菌病研究进展培训班会议暨“星火抗分枝杆菌药物研发联盟”成立大会   2019-06-18
(8)结核分枝杆菌感染与宿主泛素系统   中华医学会2019年全国结核病学术大会   2019-06-12
(9)Host Innate Immune Regulation by M. tuberculosis Effector Proteins   2019年国际结核病论坛   2019-05-25
(10)M. tuberculosis-host interactions   第二届华夏结核病国际高峰论坛   2019-03-17
(11)结核分枝杆菌感染与免疫逃逸机制   第一届全国结核病基础研究论坛   2018-11-17
(12)结核分枝杆菌与宿主互作   2018年儿童耐药结核病诊断和治疗新进展学习班   2018-11-10
(13)Host regulation by Mycobacterium tuberculosis   2018-10-12
(14)结核分枝杆菌与宿主互作的分子机制   吉林大学首届未来科学论坛   2018-09-18
(15)Identification of anti-TB drug targets based on M. tuberculosis-host interactions   2018-08-30
(16)基于结核分枝杆菌-宿主互作机制的抗结核新药靶发现   中国防痨协会第32届全国学术大会暨首届中国防痨科技奖颁奖大会   2018-04-26
(17)结核菌致病及耐药机理研究   深圳“结核感染与免疫调控”研讨会   2018-04-10
(18)Molecular mechanisms underlying Mycobacterium tuberculosis-host interactions   2018-02-14
(19)基于结核分枝杆菌-宿主互作界面的抗结核新药靶发现   北京生命科学论坛“一带 一路”生物安全与传染病防控研讨会暨北京生命科学研究院和赛诺菲巴斯德生物医学杰出研究生奖颁奖典礼   2018-02-02
(20)结核分枝杆菌感染的宿主免疫调控   复旦大学基础医学院感染免疫高峰论坛   2017-12-04
(21)Molecular mechanisms of Mycobacterium tuberculosis-host interactions   2017年中国免疫学青年工作委员会年会   2017-12-01
(22)基于结核分枝杆菌-宿主互作的新药靶发现   中国防痨协会第二届结核病防控科技创新与转化医学临床应用高峰论坛   2017-11-02
(23)结核分枝杆菌和宿主细胞间的互作机制   北京细胞生物学会2017学术年会暨京津冀联合年会   2017-10-29
(24)结核分枝杆菌效应蛋白调控宿主细胞功能的分子机制   中国研究型医院学会空间微生物学与感染专业委员会第二届学术研讨   2017-10-27
(25)Regulation of host cellular functions by Mycobacterium tuberculosis.    2017-07-04
(26)结核分枝杆菌-宿主间互作的分子调控机制   湖南省抗癌协会肿瘤病因学专业委员会暨第三届微生物与肿瘤前沿论坛   2017-06-30
(27)结核分枝杆菌对宿主细胞信号通路和功能的调控:狡猾的敌人   全国杰出女科学家生命科学前沿论坛   2017-06-17
(28)结核分枝杆菌效应蛋白PtpA调控宿主细胞功能的分子机制   2017年全国结核病学术大会   2017-05-24
(29)Regulation of host cellular functions by M. tuberculosis secreted effector proteins   2017-05-12
(30)Regulation of host immune signaling pathways and cellular functions by M. tuberculosis secreted effector proteins   2017-04-17
(31)Mutual antagonism between Mycobacterium tuberculosis effector protein PtpA and host ubiquitin system   2017-03-18
(32)M. tuberculosis Mce3C promotes mycobacterial mammalian cell entrance and enhances mycobactrial intracellular survival   2016年度美国免疫学家协会AAI免疫学年会   Cuihua Liu   2016-05-13
(33)结核分枝杆菌与宿主互作的分子调控机制   中国防痨协会2016年全国学术大会   刘翠华   2016-04-26
(34)结核感染的免疫逃逸机制   中国防痨协会第十一届基础专业分会常委会扩大会议暨新诊断技术应用研讨会   刘翠华   2015-12-15
(35)Mycobacterium tuberculosis secreted    刘翠华   2015-11-02
(36)结核分枝杆菌调控宿主固有免疫的分子机制   中国免疫学会第四届青年免疫学者学术年会   刘翠华   2015-10-23
(37)Regulation of host innate immunity by Mycobacterium tuberculosis secreted effector protein.   第五届海峡两岸免疫学会议   刘翠华   2015-10-16
(38)Mycobacterium tuberculosis regulates innate immunity through coopting host ubiquitin system.   2015年泛素与疾病国际研讨会   刘翠华   2015-10-15
(39)结核分枝杆菌效应蛋白调控宿主免疫炎症相关信号通路的分子机制   2015年度中国细胞生物学会免疫细胞生物学分会年会   刘翠华   2015-09-14
(40)结核杆菌感染宿主免疫的分子机制   2015年科学研究与结核病防治高峰论坛   刘翠华   2015-06-10
(41)Regulation of host innate immune responses    刘翠华   2015-04-23
(42)A secreted protein from M. tuberculosis suppresses NF-κB signaling pathway and promotes intracellular survival of mycobacteria   Jing Wang, Cui Hua Liu   2014-10-05
(43)PtpA from M. tuberculosis promotes intracellular survival of mycobacteria and suppresses host inflammation through inhibition of NF-kB signaling pathway   Jing Wang, Cui Hua Liu   2013-11-18
(44)Regulation of the activity of the ubiquitin ligase, Nrdp1/RNF41, by the interacting protein, NIP.   1. Cui-Hua Liu, Alfred L. Goldberg, and Xiao-Bo Qiu   2009-04-21
(45)Regulation of Surface Architecture by Symbiotic Bacteria Mediates Host Colonization   2. Cui Hua Liu, S. Melanie Lee, Jordan M. VanLare, Dennis L. Kasper and Sarkis K. Mazmanian.   2008-06-01

指导学生

已指导学生

李杰  硕士研究生  085238-生物工程  

葛浦浦  硕士研究生  085238-生物工程  

张勇  硕士研究生  077803-病原生物学  

胡建森  博士研究生  071010-生物化学与分子生物学  

现指导学生

柴琪瑶  博士研究生  100103-病原生物学  

葛浦浦  博士研究生  100103-病原生物学  

雷泽慧  硕士研究生  085238-生物工程  

钟延昭  硕士研究生  077803-病原生物学  

强丽华  博士研究生  100103-病原生物学  

赵冬冬  博士研究生  100103-病原生物学  

何杰华  硕士研究生  077803-病原生物学  

赵梦圆  硕士研究生  077803-病原生物学  

陆喆  博士研究生  100103-病原生物学  

教授课程

医学微生物学及进展
重大慢性传染病
病原微生物与免疫学