Design, synthesis and properties of self-assembled biomaterials

Mechanisms of regulation in inflammation and immunity by self-assembled biomaterials

Development of therapeutics for cancer immunotherapy and inflammatory diseases

Biomedical engineering, molecular biology and bioinformatics research

2014-09--2019-07   Ph.D.  Tsinghua University
2010-09--2014-07   B.Sc.   Tsinghua University

   

2023-06--now         Associate professor, Institute of Process Engineering, Chinese Academy of Sciences
2019-10--2023-05   Postdoc, Columbia University

   

First author publications

1.      Therapeutic Nanocarriers to Inhibit Chemotherapy-Induced Breast Cancer Metastasis

T. Li,# T. Akinade,# J. Zhou,# H. Wang, Q. Tong, S. He, E. Rinebold, L. Valencia Salazar, D. Bhansali, Y. Zhong, J. Ruan, J. Du, P. Dalerba, K. Leong* (# Co-first author)

Adv. Sci., 2022, 9, 2203949.

 2.      Polycationic PAMAM Ameliorates Obesity-Associated Chronic Inflammation and Focal Adiposity

B. Huang,# Q. Wan, # T. Li, # W. Du, C. Carmen, K. Leong,* L. Qiang* (# Co-first author)

Biomaterials, 2023, 293, 121850.

3.      Diselenide-Pemetrexed Assemblies for Combined Cancer Immuno-, Radio-, and Chemotherapies

T. Li,# S. Pan,# S. Gao,* W. Xiang, C. Sun, W. Cao, H. Xu* (# Co-first author)

Angew. Chem. Int. Ed., 2020, 132, 2722-2726. 

4.      Selenium-Containing Carrier-Free Assemblies with Aggregation-Induced Emission Property Combine Cancer Radiotherapy with Chemotherapy

T. Li, S. Pan, H. Zhuang, S. Gao, H. Xu*

ACS Appl. Bio Mater., 2020, 3, 1283-1292 

5.      Selenium-Containing Nanomaterials for Cancer Treatment

T. Li, H. Xu*

Cell Rep. Phys. Sci., 2020, 1, 100111. 

6.      Self-assembly Regulated Anticancer Activity of Platinum Coordinated Selenomethionine

T. Li, W. Xiang, F. Li, H. Xu*

Biomaterials, 2018, 157, 17-25. 

7.      Nanomedicine Assembled by Coordinated Selenium-Platinum Complexes Can Selectively Induce Cytotoxicity in Cancer Cells by Targeting the Glutathione Antioxidant Defense System

F. Li,# T. Li,# X. Han, H. Zhuang, G. Nie, H. Xu* (# Co-first author)

ACS Biomater. Sci. Eng., 2018, 4, 1954-1962.

 8.      Selenium-Containing Polymer: Perspectives toward Diverse Applications in Both Adaptive and Biomedical Materials

  J. Xia,# T. Li,# C. Lu, H. Xu* (# Co-first author)

   Macromolecules, 2018, 51, 7435-7455. 

9.      Selenium-containing Amphiphiles Reduced and Stabilized Gold Nanoparticles: Kill Cancer Cells via Reactive Oxygen Species

T. Li, F. Li, W. Xiang, Y. Yi, Y. Chen, L. Cheng, Z. Liu, H. Xu*

ACS Appl. Mater. Interfaces, 2016, 8, 22106-22112. 

10.   Selenium-Platinum Coordination Dendrimers with Controlled Anti-Cancer Activity

T. Li, M. Smet, W. Dehaen, H. Xu*

ACS Appl. Mater. Interfaces, 2016, 8, 3609-3614. 

11.   Selenium-Containing Coordinating Assemblies with Selective Anti-Cancer Activity: the Control of Reactive Oxygen Species

T. Li, Y. Yi, H. Xu*

Acta Chim. Sinica, 2014, 72, 1079-1084. 

Corresponding author publications

12.   A Nanotherapeutic Strategy to Reverse NK Cell Exhaustion

S. Pan, J. Guan, B. Xianyu, Y. Tan, T. Li,* H. Xu*

Adv. Mater., 2023, 35, 2211370. 

13.   Selenium‐Containing Nanocomplexes Achieve Dual Immune Checkpoint Blockade for NK Cell Reinvigoration

B. Xianyu, S. Pan, S. Gao, H. Xu.* T. Li*

Small, 2023, 2306225. 

14.   Antioxidant Activity Analysis of Collagen Peptide-Magnesium Chelate

C. Zhang, B. Du, Z. Song, G. Deng, Y. Shi,* T. Li,* Y. Huang*

Polym. Test., 2023, 177, 107822. 

15.   Applications of Gelatin in Biosensors: Recent Trends and Progress

Y. Guan, Y. Huang, T. Li*

Biosensors, 2022, 12, 670. 

16.   Antioxidant Cuttlefish Collagen Hydrolysate Against Ethyl Carbamate-Induced Oxidative Damage

B. Du,# G. Deng,# F. Zarman, H. Ma, X. Li, J. Chen, T. Li,* Y. Huang* (# Co-first author)

RSC Adv., 2021, 11, 2337-2345. 

17.   Recent Advances in Animal Origin Identification of Gelatin-Based Products Using Liquid Chromatography-Mass Spectrometry Methods: A Mini Review

G. Deng, S. Guo, F. Zarman, T. Li,* Y. Huang*

Rev. Anal. Chem., 2020, 39, 260-271. 

Co-author publications

18.   Comparative Analysis of Nucleic Acid-Binding Polymers as Potential Anti-Inflammatory Nanocarriers

D. Bhansali, T. Akinade, T. Li, Y. Zhong, F. Liu, H. Huang, Z. Tu, E. Devey, Y. Zhu, D. Jensen, K. Leong*

Pharmaceutics, 2024, 16, 10. 

19.   Intracellular Hyperbranched Polymerization for Circumventing Cancer Drug Resistance

C Liu, B Xianyu, Y Dai, S Pan, T Li, H Xu*

ACS Nano, 2023, 17, 11905. 

20.   A miRNA-Based Gene Therapy Nanodrug Synergistically Enhances Pro-inflammatory Antitumor Immunity Against Melanoma

Y. Ma, H. Lin, P. Wang, H. Yang, J. Yu, H. Tian, T. Li, S. Ge, Y. Wang,* R. Jia,* K. Leong, J. Ruan*

Acta Biomater., 2023, 155, 538. 

21.   Selective Targeting of Visceral Adiposity by Polycation Nanomedicine

Q. Wan, # B. Huang, # T. Li, Y. Xiao, Y. He, W. Du, B. Wang, G. Dakin, M. Rosenbaum, M. Goncalves, S. Chen, K. Leong,* L. Qiang* (# Co-first author)

Nat. Nanotech., 2022, 17, 1311-1321. 

22.   Targeting Proinflammatory Molecules Using Multifunctional MnO Nanoparticles to Inhibit Breast Cancer Recurrence and Metastasis

Y. Zhong, T. Li, Y. Zhu, J. Zhou, T. Akinade, J. Lee, F. Liu, D. Bhansali, Y. Lao, C. Quek, D. Shao, K. Leong*

ACS Nano, 2022, 16, 20430. 

23.   Selenium-Containing Nanoparticles Synergistically Enhance Pemetrexed&NK Cell-Based Chemoimmunotherapy

S. Pan, T. Li, Y. Tan, H. Xu*

Biomaterials, 2022, 280, 121321. 

24.   Drug Delivery Carriers with Therapeutic Functions

S. Cai, T. Li, T. Akinade, Y. Zhu, K. Leong*

Adv. Drug Deliv. Rev., 2021, 176, 113884. 

25.   Oxidative Polymerization in Living Cells

Y. Dai, T. Li, Z. Zhang, Y. Tan, S. Pan, L. Zhang, H. Xu*

J. Am. Chem. Soc., 2021, 143, 10709-10717. 

26.   CO/Chemosensitization/Antiangiogenesis Synergistic Therapy with H2O2-Responsive Diselenide-Containing Polymer

J. Yang, S. Pan, S. Gao, T. Li, H. Xu*

Biomaterials, 2021, 271, 120721. 

27.   Coordination and Redox Dual-Responsive Mesoporous Organosilica Nanoparticles Amplify Immunogenic Cell Death for Cancer Chemoimmunotherapy

F. Zhang, F. Chen, C. Yang, L. Wang, H. Hu, X. Li, X. Zheng, Z. Wang, Z. Chang, T. Li, L. Li, M. Ge, J. Du, W. Sun,* W. Dong,* D. Shao*

Small, 2021, 17, 2100006. 

28.   Selenium-Containing Nanoparticles Combine the NK Cells Mediated Immunotherapy with Radiotherapy and Chemotherapy

S. Gao, T. Li, Y. Guo, C. Sun, B. Xianyu, H. Xu*

Adv. Mater., 2020, 32, 1907568. 

29.   Biomimetic Diselenide-Bridged Mesoporous Organosilica Nanoparticles as an X-ray-Responsive Biodegradable Carrier for Chemo-Immunotherapy

D. Shao,* F. Zhang, F. Chen, X. Zheng, H. Hu, C. Yang, Z. Tu, Z. Wang, Z. Chang, J. Lu, T. Li, Y. Zhang, L. Chen, K. Leong,* W. Dong*

Adv. Mater., 2020, 32, 2004385. 

30.   Cancer Therapy by Targeting Thioredoxin Reductase Based on Selenium-Containing Dynamic Covalent Bond

S. Pan, J. Yang, S. Ji, T. Li, S. Gao, C. Sun, H. Xu*

CCS. Chem., 2020, 2, 225-235. 

31.   Selenoxide Elimination Manipulate the Oxidative Stress to Improve the Antitumor Efficacy

C. Sun, L. Wang, B. Xianyu, T. Li, S. Gao, H. Xu*

Biomaterials, 2019, 225, 119514. 

32.   Precise Nanomedicine for Intelligent Therapy of Cancer

H. Chen, Z. Gu, H. An, C. Chen, J. Chen, R. Cui, S. Chen, W. Chen, X. Chen, X. Chen, Z. Chen, B. Ding, Q. Dong, Q. Fan, T. Fu, D. Hou, Q. Jiang, H. Ke, X. Jiang, G. Liu, S. Li, T. Li, Z. Liu, G. Nie, M. Ovais, D. Pang, N. Qiu, Y. Shen, H. Tian, C. Wang, H. Wang, Z. Wang, H. Xu, J. Xu, X. Yang, S. Zhu, X. Zheng, X. Zhang, Y. Zhao, W. Tan,* X. Zhang,* Y. Zhao*

Sci. China Chem., 2018, 61, 1503-1552. 

33.   Selenium-Doped Carbon Quantum Dots for Free-Radical Scavenging

F. Li, T. Li, C. Sun, J. Xia, Y. Jiao, H. Xu*

Angew. Chem. Int. Ed., 2017, 56, 9910-9914. 

34.   Near-Infrared Light Stimuli-Responsive Synergistic Therapy Nanoplatforms Based on the Coordination of Tellurium-Containing Block Polymer and Cisplatin for Cancer Treatment

F. Li, T. Li, C. Sun, J. Xia, H. Xu*

Biomaterials, 2017, 133, 208-218. 

35.   Ultra-Sensitive ROS-Responsive Tellurium-Containing Polymers

W. Cao, Y. Gu, T. Li, H. Xu*

Chem. Commun., 2015, 51, 7069-7071. 

36.   Selenium-Platinum Coordination Compounds as Novel Anticancer Drugs: Selectively Killing Cancer Cells via a ROS-Mediated Apoptosis Route

L. Zeng,# Y. Li, # T. Li, W. Cao, Y. Yi, W. Geng, Z. Sun, H. Xu* (# Co-first author)

Chem. Asian J., 2014, 9, 2295-2302. 

37.   A Hydrogen Peroxide Biosensor with High Stability Based on Gelatin-Multiwalled Carbon Nanotubes Modified Glassy Carbon Electrode

Y. Wang, T. Li, W. Zhang, Y. Huang*

J. Solid State Electrochem., 2014, 18, 1981-1987. 

38.   Tellurium-Containing Polymer Micelles: Competitive-Ligand-Regulated Coordination Responsive Systems

W. Cao, Y. Gu, M. Meineck, T. Li, H. Xu*

J. Am. Chem. Soc., 2014, 136, 5132-5137.