李天予 男 博导 中国科学院过程工程研究所
电子邮件： lity@ipe.ac.cn
通信地址： 北京市海淀区中关村北二条1号，生化科研楼408
邮政编码： 100190
研究领域
- 生物自组装材料的设计、合成与性能研究
- 生物自组装材料调控炎症与免疫的机制研究
- 癌症免疫治疗与炎性疾病治疗手段开发
- 生物医学工程、分子生物学与生物信息学研究
招生信息
招生专业
招生方向
教育背景
工作经历
2023-06--现在 中国科学院过程工程研究所 项目研究员
2019-10--2023-05 美国哥伦比亚大学 博士后
专利与奖励
专利成果
（ 2 ） Kam Leong, Divya, Bhansali, Tianyu Li, Nanoparticulate system for treating oral cancer, 2021, PCT/US2021/046153
（ 3 ） Kam Leong, Divya, Bhansali, Tianyu Li, Nigel Bunnett, Brian Schimdt, Nanoparticulate system for delivery of pain relief agents, 2021, PCT/US2021/046146
（ 4 ） 许华平，戴以恒，李天予，含碲化合物、利用其制备碲金纳米颗粒的方法及碲金纳米颗粒在制备抗肿瘤药物中的应用, 2021, CN112707853A
（ 5 ） 许华平，李天予，徐俊，化合物及其制备方法和应用, 2018, CN105906540B
出版信息
发表论文
First author publications
1. Therapeutic Nanocarriers to Inhibit Chemotherapy-Induced Breast Cancer Metastasis
T. Li,# T. Akinade,# J. Zhou,# H. Wang, Q. Tong, S. He, E. Rinebold, L. Valencia Salazar, D. Bhansali, Y. Zhong, J. Ruan, J. Du, P. Dalerba, K. Leong* (# Co-first author)
Adv. Sci., 2022, 9, 2203949.
2. Polycationic PAMAM Ameliorates Obesity-Associated Chronic Inflammation and Focal Adiposity
B. Huang,# Q. Wan, # T. Li, # W. Du, C. Carmen, K. Leong,* L. Qiang* (# Co-first author)
Biomaterials, 2023, 293, 121850.
3. Diselenide-Pemetrexed Assemblies for Combined Cancer Immuno-, Radio-, and Chemotherapies
T. Li,# S. Pan,# S. Gao,* W. Xiang, C. Sun, W. Cao, H. Xu* (# Co-first author)
Angew. Chem. Int. Ed., 2020, 132, 2722-2726.
4. Selenium-Containing Carrier-Free Assemblies with Aggregation-Induced Emission Property Combine Cancer Radiotherapy with Chemotherapy
T. Li, S. Pan, H. Zhuang, S. Gao, H. Xu*
ACS Appl. Bio Mater., 2020, 3, 1283-1292
5. Selenium-Containing Nanomaterials for Cancer Treatment
T. Li, H. Xu*
Cell Rep. Phys. Sci., 2020, 1, 100111.
6. Self-assembly Regulated Anticancer Activity of Platinum Coordinated Selenomethionine
T. Li, W. Xiang, F. Li, H. Xu*
Biomaterials, 2018, 157, 17-25.
7. Nanomedicine Assembled by Coordinated Selenium-Platinum Complexes Can Selectively Induce Cytotoxicity in Cancer Cells by Targeting the Glutathione Antioxidant Defense System
F. Li,# T. Li,# X. Han, H. Zhuang, G. Nie, H. Xu* (# Co-first author)
ACS Biomater. Sci. Eng., 2018, 4, 1954-1962.
8. Selenium-Containing Polymer: Perspectives toward Diverse Applications in Both Adaptive and Biomedical Materials
J. Xia,# T. Li,# C. Lu, H. Xu* (# Co-first author)
Macromolecules, 2018, 51, 7435-7455.
9. Selenium-containing Amphiphiles Reduced and Stabilized Gold Nanoparticles: Kill Cancer Cells via Reactive Oxygen Species
T. Li, F. Li, W. Xiang, Y. Yi, Y. Chen, L. Cheng, Z. Liu, H. Xu*
ACS Appl. Mater. Interfaces, 2016, 8, 22106-22112.
10. Selenium-Platinum Coordination Dendrimers with Controlled Anti-Cancer Activity
T. Li, M. Smet, W. Dehaen, H. Xu*
ACS Appl. Mater. Interfaces, 2016, 8, 3609-3614.
11. Selenium-Containing Coordinating Assemblies with Selective Anti-Cancer Activity: the Control of Reactive Oxygen Species
T. Li, Y. Yi, H. Xu*
Acta Chim. Sinica, 2014, 72, 1079-1084.
Corresponding author publications
12. A Nanotherapeutic Strategy to Reverse NK Cell Exhaustion
S. Pan, J. Guan, B. Xianyu, Y. Tan, T. Li,* H. Xu*
Adv. Mater., 2023, 35, 2211370.
13. Selenium‐Containing Nanocomplexes Achieve Dual Immune Checkpoint Blockade for NK Cell Reinvigoration
B. Xianyu, S. Pan, S. Gao, H. Xu.* T. Li*
Small, 2023, 2306225.
14. Antioxidant Activity Analysis of Collagen Peptide-Magnesium Chelate
C. Zhang, B. Du, Z. Song, G. Deng, Y. Shi,* T. Li,* Y. Huang*
Polym. Test., 2023, 177, 107822.
15. Applications of Gelatin in Biosensors: Recent Trends and Progress
Y. Guan, Y. Huang, T. Li*
Biosensors, 2022, 12, 670.
16. Antioxidant Cuttlefish Collagen Hydrolysate Against Ethyl Carbamate-Induced Oxidative Damage
B. Du,# G. Deng,# F. Zarman, H. Ma, X. Li, J. Chen, T. Li,* Y. Huang* (# Co-first author)
RSC Adv., 2021, 11, 2337-2345.
17. Recent Advances in Animal Origin Identification of Gelatin-Based Products Using Liquid Chromatography-Mass Spectrometry Methods: A Mini Review
G. Deng, S. Guo, F. Zarman, T. Li,* Y. Huang*
Rev. Anal. Chem., 2020, 39, 260-271.
Co-author publications
18. Comparative Analysis of Nucleic Acid-Binding Polymers as Potential Anti-Inflammatory Nanocarriers
D. Bhansali, T. Akinade, T. Li, Y. Zhong, F. Liu, H. Huang, Z. Tu, E. Devey, Y. Zhu, D. Jensen, K. Leong*
Pharmaceutics, 2024, 16, 10.
19. Intracellular Hyperbranched Polymerization for Circumventing Cancer Drug Resistance
C Liu, B Xianyu, Y Dai, S Pan, T Li, H Xu*
ACS Nano, 2023, 17, 11905.
20. A miRNA-Based Gene Therapy Nanodrug Synergistically Enhances Pro-inflammatory Antitumor Immunity Against Melanoma
Y. Ma, H. Lin, P. Wang, H. Yang, J. Yu, H. Tian, T. Li, S. Ge, Y. Wang,* R. Jia,* K. Leong, J. Ruan*
Acta Biomater., 2023, 155, 538.
21. Selective Targeting of Visceral Adiposity by Polycation Nanomedicine
Q. Wan, # B. Huang, # T. Li, Y. Xiao, Y. He, W. Du, B. Wang, G. Dakin, M. Rosenbaum, M. Goncalves, S. Chen, K. Leong,* L. Qiang* (# Co-first author)
Nat. Nanotech., 2022, 17, 1311-1321.
22. Targeting Proinflammatory Molecules Using Multifunctional MnO Nanoparticles to Inhibit Breast Cancer Recurrence and Metastasis
Y. Zhong, T. Li, Y. Zhu, J. Zhou, T. Akinade, J. Lee, F. Liu, D. Bhansali, Y. Lao, C. Quek, D. Shao, K. Leong*
ACS Nano, 2022, 16, 20430.
23. Selenium-Containing Nanoparticles Synergistically Enhance Pemetrexed&NK Cell-Based Chemoimmunotherapy
S. Pan, T. Li, Y. Tan, H. Xu*
Biomaterials, 2022, 280, 121321.
24. Drug Delivery Carriers with Therapeutic Functions
S. Cai, T. Li, T. Akinade, Y. Zhu, K. Leong*
Adv. Drug Deliv. Rev., 2021, 176, 113884.
25. Oxidative Polymerization in Living Cells
Y. Dai, T. Li, Z. Zhang, Y. Tan, S. Pan, L. Zhang, H. Xu*
J. Am. Chem. Soc., 2021, 143, 10709-10717.
26. CO/Chemosensitization/Antiangiogenesis Synergistic Therapy with H2O2-Responsive Diselenide-Containing Polymer
J. Yang, S. Pan, S. Gao, T. Li, H. Xu*
Biomaterials, 2021, 271, 120721.
27. Coordination and Redox Dual-Responsive Mesoporous Organosilica Nanoparticles Amplify Immunogenic Cell Death for Cancer Chemoimmunotherapy
F. Zhang, F. Chen, C. Yang, L. Wang, H. Hu, X. Li, X. Zheng, Z. Wang, Z. Chang, T. Li, L. Li, M. Ge, J. Du, W. Sun,* W. Dong,* D. Shao*
Small, 2021, 17, 2100006.
28. Selenium-Containing Nanoparticles Combine the NK Cells Mediated Immunotherapy with Radiotherapy and Chemotherapy
S. Gao, T. Li, Y. Guo, C. Sun, B. Xianyu, H. Xu*
Adv. Mater., 2020, 32, 1907568.
29. Biomimetic Diselenide-Bridged Mesoporous Organosilica Nanoparticles as an X-ray-Responsive Biodegradable Carrier for Chemo-Immunotherapy
D. Shao,* F. Zhang, F. Chen, X. Zheng, H. Hu, C. Yang, Z. Tu, Z. Wang, Z. Chang, J. Lu, T. Li, Y. Zhang, L. Chen, K. Leong,* W. Dong*
Adv. Mater., 2020, 32, 2004385.
30. Cancer Therapy by Targeting Thioredoxin Reductase Based on Selenium-Containing Dynamic Covalent Bond
S. Pan, J. Yang, S. Ji, T. Li, S. Gao, C. Sun, H. Xu*
CCS. Chem., 2020, 2, 225-235.
31. Selenoxide Elimination Manipulate the Oxidative Stress to Improve the Antitumor Efficacy
C. Sun, L. Wang, B. Xianyu, T. Li, S. Gao, H. Xu*
Biomaterials, 2019, 225, 119514.
32. Precise Nanomedicine for Intelligent Therapy of Cancer
H. Chen, Z. Gu, H. An, C. Chen, J. Chen, R. Cui, S. Chen, W. Chen, X. Chen, X. Chen, Z. Chen, B. Ding, Q. Dong, Q. Fan, T. Fu, D. Hou, Q. Jiang, H. Ke, X. Jiang, G. Liu, S. Li, T. Li, Z. Liu, G. Nie, M. Ovais, D. Pang, N. Qiu, Y. Shen, H. Tian, C. Wang, H. Wang, Z. Wang, H. Xu, J. Xu, X. Yang, S. Zhu, X. Zheng, X. Zhang, Y. Zhao, W. Tan,* X. Zhang,* Y. Zhao*
Sci. China Chem., 2018, 61, 1503-1552.
33. Selenium-Doped Carbon Quantum Dots for Free-Radical Scavenging
F. Li, T. Li, C. Sun, J. Xia, Y. Jiao, H. Xu*
Angew. Chem. Int. Ed., 2017, 56, 9910-9914.
34. Near-Infrared Light Stimuli-Responsive Synergistic Therapy Nanoplatforms Based on the Coordination of Tellurium-Containing Block Polymer and Cisplatin for Cancer Treatment
F. Li, T. Li, C. Sun, J. Xia, H. Xu*
Biomaterials, 2017, 133, 208-218.
35. Ultra-Sensitive ROS-Responsive Tellurium-Containing Polymers
W. Cao, Y. Gu, T. Li, H. Xu*
Chem. Commun., 2015, 51, 7069-7071.
36. Selenium-Platinum Coordination Compounds as Novel Anticancer Drugs: Selectively Killing Cancer Cells via a ROS-Mediated Apoptosis Route
L. Zeng,# Y. Li, # T. Li, W. Cao, Y. Yi, W. Geng, Z. Sun, H. Xu* (# Co-first author)
Chem. Asian J., 2014, 9, 2295-2302.
37. A Hydrogen Peroxide Biosensor with High Stability Based on Gelatin-Multiwalled Carbon Nanotubes Modified Glassy Carbon Electrode
Y. Wang, T. Li, W. Zhang, Y. Huang*
J. Solid State Electrochem., 2014, 18, 1981-1987.
38. Tellurium-Containing Polymer Micelles: Competitive-Ligand-Regulated Coordination Responsive Systems
W. Cao, Y. Gu, M. Meineck, T. Li, H. Xu*
J. Am. Chem. Soc., 2014, 136, 5132-5137.