Protein Homeostasis Regualtion:

Committed to tracking the dynamic balance of protein synthesis and degradation within cells, and analyzing the compensatory regulatory mechanisms involving interactions between autophagy and proteasome degradation system

Epigenetic Editing Techniques Development：

Developing epigenetic editing techniques based on histone modifications to regulate the function and expression levels of target genes

2021-03~Present, Associate Researcher, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences

2020-01~2021-03,Research Scientist, Southern California Research and Education Institute, Long Beach Veterans Affairs Hospital, California, USA

2011-10~2019-12,Postdoctoral Fellow, Baylor College of Medicine, Texas, USA

[1] 叶晓, 凌雪, 林佳雨, 张肖雅, 张子怡, 饶朗. α1-抗胰蛋白酶——一种可抵抗SARS-CoV-2细胞侵袭的多功能蛋白的研究. 中国细胞生物学学报[J]. 2023, 第 6 作者  通讯作者  45: 374-382, http://www.cjcb.org/cjcb/Upload/volpdf/23-03-31-10-33-50-954.pdf.

[2] Wang, Sijia, Huang, Wenxin, Feng, Zhaoxuan, Tian, Xiaoli, Wang, Dexin, Rao, Lang, Tan, Ming, Roongsawang, Niran, Song, Hui, Jiang, Wenxia, Bai, Wenqin. Laccase-mediated formation of hydrogels based on silk-elastin-like protein polymers with ultra-high molecular weight. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2023, 第 6 作者231: http://dx.doi.org/10.1016/j.ijbiomac.2023.123239.

[3] Ye, Xiao, Ling, Xue, Wu, Min, Bai, Guijie, Yuan, Meng, Rao, Lang. Improving Soluble Expression of SARS-CoV-2 Spike Priming Protease TMPRSS2 with an Artificial Fusing Protein. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2023, 第 6 作者  通讯作者  24(13): http://dx.doi.org/10.3390/ijms241310475.

[4] Zhang, Chenyang, Li, Nan, Rao, Lang, Li, Jingen, Liu, Qian, Tian, Chaoguang. Development of an Efficient C-to-T Base-Editing System and Its Application to Cellulase Transcription Factor Precise Engineering in Thermophilic Fungus Myceliophthora thermophila. MICROBIOLOGY SPECTRUM[J]. 2022, 第 3 作者10(3): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000800549600001.

[5] Shin, Jin Na, Rao, Lang, Eissa, N Tony. p38 MAPK Activity Is Required to Prevent Hyperactivation of NLRP3 Inflammasome. JOURNAL OF IMMUNOLOGY[J]. 2021, 第 2 作者  通讯作者  207(2): 661-670, 

[6] Rao Lang. A New Role Of The Proteasome In Alpha One Antitrypsin Regulation. Journal of Stem Cells Research Development and Therapy. 2020, 第 1 作者  通讯作者  

[7] Rao, Lang, Eissa, N Tony. Autophagy in Pulmonary Innate Immunity. JOURNAL OF INNATE IMMUNITY. 2020, 第 1 作者  通讯作者  12(1): 21-30, https://www.webofscience.com/wos/woscc/full-record/WOS:000506413300003.

[8] Lang Rao, Indhira De La Rosa, Yi Xu, Youbao Sha, Abhisek Bhattacharya, Michael J Holtzman, Brian E Gilbert, N Tony Eissa. Pseudomonas aeruginosa survives in epithelia by ExoS‐mediated inhibition of autophagy and mTOR. EMBO REPORTS. 2020, 第 1 作者22(2): 

[9] Rao, Lang, Xu, Yi, Reineke, Lucas Charles, Bhattacharya, Abhisek, Tyryshkin, Alexey, Shin, Jin Na, Eissa, N Tony. Post-Transcriptional Regulation of Alpha One Antitrypsin by a Proteasome Inhibitor. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2020, 第 1 作者  通讯作者  21(12): https://doaj.org/article/12d34421b508451da5850de14fbf8543.

[10] Lang Rao, Youbao Sha, N Tony Eissa. The E3 ubiquitin ligase STUB1 regulates autophagy and mitochondrial biogenesis by modulating TFEB activity. MOLECULAR & CELLULAR ONCOLOGY[J]. 2017, 第 1 作者4(6): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5706942/.

[11] Sha, Youbao, Rao, Lang, Settembre, Carmine, Ballabio, Andrea, Eissa, N Tony. STUB1 regulates TFEB-induced autophagy-lysosome pathway. EMBO JOURNAL[J]. 2017, 第 2 作者36(17): 2544-2552, https://www.webofscience.com/wos/woscc/full-record/WOS:000408828500007.

[12] Rao, Lang, Xue, Yanfen, Zheng, Yingying, Lu, Jian R, Ma, Yanhe. A Novel Alkaliphilic Bacillus Esterase Belongs to the 13th Bacterial Lipolytic Enzyme Family. PLOS ONE[J]. 2013, 第 1 作者8(4): http://dx.doi.org/10.1371/journal.pone.0060645.

[13] Rao, Lang, Xue, Yanfen, Zhou, Cheng, Tao, Jin, Li, Gang, Lu, Jian R, Ma, Yanhe. A thermostable esterase from Thermoanaerobacter tengcongensis opening up a new family of bacterial lipolytic enzymes. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS[J]. 2011, 第 1 作者1814(12): 1695-1702, http://dx.doi.org/10.1016/j.bbapap.2011.08.013.

[14] LI Gang, SONG YaJian, XUE YanFen, RAO Lang, ZHOU Chen, WANG QuanHui, MA YanHe. Comparative proteome analysis of alkaliphilic Bacillus sp.N16-5 grown on different carbon sources. 中国科学：生命科学英文版[J]. 2011, 第 4 作者54(1): 90-100, http://lib.cqvip.com/Qikan/Article/Detail?id=36441423.

[15] Li Gang, Song YaJian, Xue YanFen, Rao Lang, Zhou Chen, Wang QuanHui, Ma YanHe. Comparative proteome analysis of alkaliphilic Bacillus sp N16-5 grown on different carbon sources. SCIENCE CHINA-LIFE SCIENCES[J]. 2011, 第 4 作者54(1): 90-100, http://dx.doi.org/10.1007/s11427-010-4106-1.

[16] Lang Rao, Yanfen Xue, Cheng Zhou, Jin Tao, Gang Li, Jian R. Lu, Yanhe Ma. A thermostable esterase from Thermoanaerobacter tengcongensis opening up a new family of bacterial lipolytic enzymes. BBA - PROTEINS AND PROTEOMICS. 2011, 第 1 作者1814(12): 1695-1702, http://dx.doi.org/10.1016/j.bbapap.2011.08.013.

[17] 李刚, 宋亚囝, 薛艳芬, 饶朗, 周成, 王全会, 马延和. 嗜碱Bacillus sp.N16-5不同碳源条件下比较蛋白质组分析. 中国科学：生命科学[J]. 2010, 第 4 作者1117-1127, http://lib.cqvip.com/Qikan/Article/Detail?id=36475558.

[18] Li Gang, Rao, Lang, Xue, Yanfen, Zhou, Cheng, Zhang, Yun, Ma, Yanhe. Cloning, Expression, and Characterization of a Highly Active Alkaline Pectate Lyase from Alkaliphilic Bacillus sp N16-5. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2010, 第 2 作者20(4): 670-677, http://dx.doi.org/10.4014/jmb.0911.11019.

[19] Rao, Lang, Zhao, Xiubo, Pan, Fang, Li, Yin, Xue, Yanfen, Ma, Yanhe, Lu, Jian R. Solution Behavior and Activity of a Halophilic Esterase under High Salt Concentration. PLOS ONE[J]. 2009, 第 11 作者4(9): http://124.16.144.217/handle/311023/2354.

[20] Rao Lang, Bi Yunfeng, Xie Guiqiu, Zhang Fei, Wang Yan, Cao Shugui, Gao Renjun. Study on a Specific Site Tyr(444) on a Hyperthermophilic Enzyme APE1547. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES[J]. 2009, 第 1 作者25(3): 353-356, http://lib.cqvip.com/Qikan/Article/Detail?id=30478303.

[21] Zhang Guirong, Gao Renjun, Zhang Aijun, Rao Lang, Cao Shugui. High-throughput screening of the enantioselectivity of hyperthermophilic mutant esterases from Archaeon Aeropyrum pernix K1 for resolution of (R, S)-2-octanol acetate. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES[J]. 2007, 第 4 作者23(3): 319-324, http://lib.cqvip.com/Qikan/Article/Detail?id=24623051.

现指导学生

逯浩睿  硕士研究生  086000-生物与医药  

袁梦  博士研究生  071010-生物化学与分子生物学