Lang Rao, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences
Email: raolang@tib.cas.cn
Mailing Address: Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences
Postal Code: 300308
Research Areas
Protein Homeostasis Regualtion:
Committed to tracking the dynamic balance of protein synthesis and degradation within cells, and analyzing the compensatory regulatory mechanisms involving interactions between autophagy and proteasome degradation system
Epigenetic Editing Techniques Development：
Developing epigenetic editing techniques based on histone modifications to regulate the function and expression levels of target genes
Education
2004-09--2007-08 M.S., Jilin University
2000-09--2004-08 B.S., Changchun Normal University
Experience
Work Experience
2021-03~Present, Associate Researcher, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences
2020-01~2021-03,Research Scientist, Southern California Research and Education Institute, Long Beach Veterans Affairs Hospital, California, USA
2011-10~2019-12,Postdoctoral Fellow, Baylor College of Medicine, Texas, USA
Publications
（1） Chaperone-mediated autophagy degrades SERPINA1 E342K /α1-antitrypsin Z variant and alleviates cell stress, AUTOPHAGY, 2025, 第 10 作者 通讯作者
（2） 靶向识别新型冠状病毒上刺突蛋白S1亚基的嵌合型E3泛素连接酶的设计与功能验证, 生物工程学报, 2024, 第 5 作者 通讯作者
（3） 体外重构STUB1介导α-1抗胰蛋白酶突变体Z蛋白泛素化修饰反应体系, 生物工程学报, 2024, 第 6 作者 通讯作者
（4） A programmable CRISPR/dCas9-based epigenetic editing system enabling loci-targeted histone citrullination and precise transcription regulation, JOURNAL OF GENETICS AND GENOMICS, 2024, 第 6 作者 通讯作者
（5） Citrullination in health and disease: From physiological function to gene regulation, GENES & DISEASES, 2024, 第 3 作者 通讯作者
（6） α1-抗胰蛋白酶——一种可抵抗SARS-CoV-2细胞侵袭的多功能蛋白的研究, 中国细胞生物学学报, 2023, 第 6 作者 通讯作者
（7） Laccase-mediated formation of hydrogels based on silk-elastin-like protein polymers with ultra-high molecular weight, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2023, 第 6 作者
（8） Improving Soluble Expression of SARS-CoV-2 Spike Priming Protease TMPRSS2 with an Artificial Fusing Protein, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 第 6 作者 通讯作者
（9） Development of an Efficient C-to-T Base-Editing System and Its Application to Cellulase Transcription Factor Precise Engineering in Thermophilic Fungus Myceliophthora thermophila, MICROBIOLOGY SPECTRUM, 2022, 第 3 作者
（10） p38 MAPK Activity Is Required to Prevent Hyperactivation of NLRP3 Inflammasome, JOURNAL OF IMMUNOLOGY, 2021, 第 2 作者 通讯作者
（11） Pseudomonas aeruginosa survives in epithelia by ExoS-mediated inhibition of autophagy and mTOR, EMBO REPORTS, 2021, 第 1 作者 通讯作者
（12） A New Role Of The Proteasome In Alpha One Antitrypsin Regulation, Journal of Stem Cells Research Development and Therapy, 2020, 第 1 作者 通讯作者
（13） Autophagy in Pulmonary Innate Immunity, JOURNAL OF INNATE IMMUNITY, 2020, 第 1 作者 通讯作者
（14） Pseudomonas aeruginosa survives in epithelia by ExoS‐mediated inhibition of autophagy and mTOR, EMBO REPORTS, 2020, 第 1 作者 通讯作者
（15） Post-Transcriptional Regulation of Alpha One Antitrypsin by a Proteasome Inhibitor, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 第 1 作者 通讯作者
（16） The E3 ubiquitin ligase STUB1 regulates autophagy and mitochondrial biogenesis by modulating TFEB activity, MOLECULAR & CELLULAR ONCOLOGY, 2017, 第 1 作者
（17） STUB 1 regulates TFEB ‐induced autophagy–lysosome pathway, EMBO JOURNAL, 2017, 第 2 作者
（18） A Novel Alkaliphilic Bacillus Esterase Belongs to the 13 th Bacterial Lipolytic Enzyme Family, PLOS ONE, 2013, 第 1 作者
（19） Comparative proteome analysis of alkaliphilic Bacillus sp.N16-5 grown on different carbon sources, Comparative proteome analysis of alkaliphilic Bacillus sp.N16-5 grown on different carbon sources, 中国科学：生命科学英文版, 2011, 第 4 作者
（20） Comparative proteome analysis of alkaliphilic Bacillus sp. N16-5 grown on different carbon sources, SCIENCE CHINA Life Sciences, 2011, 第 4 作者
（21） 嗜碱Bacillus sp.N16-5不同碳源条件下比较蛋白质组分析, 中国科学: 生命科学, 2010, 第 4 作者
（22） Cloning, Expression, and Characterization of a Highly Active Alkaline Pectate Lyase from Alkaliphilic Bacillus sp N16-5, JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, 2010, 第 2 作者
（23） Solution Behavior and Activity of a Halophilic Esterase under High Salt Concentration, PLOS ONE, 2009, 第 1 作者 通讯作者
（24） Study on a Specific Site Tyr~(444) on a Hyperthermophilic Enzyme APE1547, CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2009, 第 1 作者
（25） High-throughput Screening of the Enantioselectivity of Hyperthermophilic Mutant Esterases from Archaeon Aeropyrum pernix K1 for Resolution of ( R,S) -2-Octanol Acetate, CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2007, 第 4 作者