Biomaterials

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Sept.2005~Jun.2010 Ph.D in Polymer Science, Fudan University, Shanghai, CHINA Ph.D. Thesis Advisor: Prof. Jiandong Ding

Sept.2003～Jul.2005 M.S. in Polymer Science, Sun Yet-sen University, Guangzhou, CHINA M.S. Thesis Advisor: Prof. Kairong Liao and Daping Wang

Sept.1999~Jul.2003 B.S. in Material Science, Sun Yet-sen University, Guangzhou, CHINA

Oct.2018-present, Research Professor of Shenzhen Institutes of Advanced Technology, CAS

  Mar.2018-present Executive director of Center for Translational Medicine Research and Development, Shenzhen Institutes of Advanced Technology, CAS

 Oct.2013-Oct.2018,Associate Professor of Shenzhen Institutes of Advanced Technology, CAS

  Jul.2010~Oct.2013 Assistant Professor, Shenzhen Institutes of Advanced Technology, CAS

1.        Cairong Li, Jianqiao Sun, Keda Shi, Jing Long, Long Li, Yuxiao Lai*, Ling Qin, Preparation and evaluation of osteogenic nano-MgO/PMMA bone cement for bone healing in a rat critical size calvarial defect, J. Mater. Chem. B, 2020, DOI: 10.1039/d0tb00074d

2.        Olivier Guillaume, Mike A. Geven, Viktor Varjas, Peter Varga, Dominic Gehweiler, Vincent A. Stadelmann, Tanja Smidt, Stephan Zeiter, Christoph Sprecher, Ruud R.M. Bos, Dirk W. Grijpma, Mauro Alini, Huipin Yuan, Geoff R. Richards, Tingting Tang, Ling Qin, Lai Yuxiao, Peng Jiang, David Eglin∗, Orbital floor repair using patient specific osteoinductive implant made by stereolithography，Biomaterials, 2020，233 ： 119721

3.        Sien Lin, Liao Cui, Guanghua Chen, Jianping Huang, Yanhua Yang，Kaijie Zou, Yuxiao Lai, Xinluan Wang, Liyi Zou, Tie Wu, Jack Chun Yiu Cheng, Gang Li *, Bo Wei*, Wayne Yuk Wai Lee*. PLGA/beta-TCP composite scaffold incorporating salvianolic acid B promotes bone fusion by angiogenesis and osteogenesis in a rat spinal fusion model. Biomaterials. 2019.03, 196:109-121; (JCR一区，IF：9.315）

4.        Yuxiao Lai*^（#）, Ye Li^#, Huijuan Cao^#, Jing Long, Xinluan Wang∗, Long Li, Cairong Li, Qingyun Jia, Bin Teng, Tingting Tang, Jiang Peng, David Eglin, Mauro Alini, Dirk W. Grijpma, Geoff Richards, Ling Qin*. Osteogenetic Mg Incorporated into PLGA/TCP Porous Scaffold by 3D Printing for Repairing Challenging Bone Defect. Biomaterials, 2019.01, 197:207-219; (JCR一区，IF：10.273）

5.        Yufei Ma, Nan Hu, Juan Liu, Xinyun Zhai, Mingming Wu, Chengshen Hu, Long Li, Lai Yuxiao, Haobo Pan, et al., William Weijia Lu, Xinzhou Zhang, Yanfeng Luo*, and Changshun Ruan*. Three-Dimensional Printing of Biodegradable Piperazine-Based Polyurethane-Urea Scaffolds with Enhanced Osteogenesis for Bone Regeneration. ACS applied materials & interfaces. 2019.01.30, (DOI: 10.1021/acsami.8b20323) (JCR一区，IF：8.097）

6.        Zhengjiang Xu, Zhengjiang Xua, Jing Long, Ningfeng Zhang, Huijuan Cao, Wei Tang, Keda Shi, Xinluan Wang, Sergio Moya, Li Duan, Haobo Pan, Yuxiao Lai*, Daping Wang*, Guocheng Wang*. Strong Mineralization Ability of Strontium Zinc Silicate: Formation of a Continuous Biomorphic Mineralized Layer with Enhanced Osteogenic Activity. Colloids and Surfaces B: Biointerfaces, 2019.01.04,176:420-430；(JCR二区, IF=3.997)

7.        Huijuan Cao, Cairong Li, Linying Wang, Reihane Ziadlou, Sibylle Grad , Yan Zhang , Yan Cheng, Yuxiao Lai, Xinsheng Yao, Mauro Alini , Ling Qin* , Xinluan Wang* . Effect and mechanism of psoralidin on promoting osteogenesis and inhibiting adipogenesis. Phytomedicine. 61 (2019) 152860; (JCR一区，IF：4.18）

8.        Yuxiao Lai*, Huijuan Cao^#, Xinluan Wang *, Shukui Chen, Ming Zhang, Nan Wang， Zhihong Yao, Yi Dai, Xinhui Xie, Peng Zhang, Xinsheng Yao, Ling Qin. Porous composite scaffold incorporating osteogenic phytomolecule icariin for promoting skeletal regeneration in challenging osteonecrotic bone in rabbits. Biomaterials. 2018.01, 153:1-13; (JCR一区，IF：9.315，入选ESI）

9.        Wen Yu, Jing Long, Peng Chen，Angyang Hou, Long Li, Xun Sun, Guoquan Zheng, Haoye Meng, Yu Wang, Aiyuan Wang, Xiang Sui ，Quanyi Guo, Sheng Tao , Jiang Peng , Ling Qin*, Shibi Lu*, Yuxiao Lai*. Use of a three dimensional printed polylactide-co-glycolide/tricalcium phosphate composite scaffold incorporating magnesium powder to enhance bone defect repair in rabbits. Journal of Orthopaedic Translation. 2019，16：62-70; (JCR二区，IF：2.078）

10.    Cijun Shuai, Sheng Li, Shuping Peng, Pei Feng, Yuxiao Lai and Chengde Gao*.  Biodegradable metallic bone implants. Materials Chemistry Frontiers. 2019.01.30,10.1039/C8QM00507A.

11.    Jianghong Huang，Wei Liu，Yujie Liang，Long Lie，Li  Duan，Jielin Chen，Feiyan Zhu，Yuxiao Lai，Weimin Zhu，Wei You，ZhaoFeng Jia，Jianyi Xiong，Daping Wang*. Preparation and biocompatibility of diphasic magnetic nanocomposite scaffold. Materials Science and Engineering: C. 2018,87:70-77; (JCR二区，IF：5.08）

12.    Yiping Hu, Tiantian Zhang, Huan Huang, Wenxiang Cheng, Yuxiao Lai, Ling Qin*, Peng Zhang*. Fracture healing in a collagen‐induced arthritis rat model: Radiology and histology evidence. Journal of Orthopaedic Research.2018.05,36(11): 2876-2885; (JCR三区，IF：2.757）

13.    Cijun Shuai, Wenjing Yang, Shuping Peng, Chengde Gao,Wang Guo, Yuxiao Lai, Pei Feng*, Physical stimulations and their osteogenesis-inducing mechanisms, International Journal of Bioprinting, 2018, 4(2)138-157;

14.    O.Guillaume，M.A.Geven，C.M.Sprecher，V.A.Stadelmanna，D.W.Grijpm，TingTing Tang， Ling Qin ，Yuxiao Lai，H. Yuan，R.G. Richards，D. Eglin*. Surface-enrichment with hydroxyapatite nanoparticles in stereolithography-fabricated composite polymer scaffolds promotes bone repair. Acta Biomaterialia. 2017.05,54:  386-398; (JCR一区，IF：6.383）

15.    Ling Li, Jing Long, Long Li, Huijuan Cao, Tingting Tang, Xinghua Xi, Ling Qin, Yuxiao Lai*, Xinluan Wang*. Quantitative determination of residual 1,4-dioxane in three-dimensional printed bone scaffold. Journal of Orthopaedic Translation. 2017.07.17; (JCR二区，IF：2.078）

16.    Long Li, Ming Zhang, Ye Li, Jie Zhao, Ling Qin, Yuxiao Lai*. Corrosion and biocompatibility improvement of magnesium-based alloys as bone implant materials: a review. Regenerative Biomaterials. 2017, 129–137; （EI）

17.    Jian Li，Qiang Xu, Bin Teng, Chen Yu, Jian Li, Liang Song，Yuxiao Lai, Jian Zhang ，Wei Zheng*, PeiGen Ren*，Investigation of angiogenesis in bioactive 3-dimensional poly (D,L-lactide-co-glycolide)/nano-hydroxyapatite scaffolds by in vivo multiphoton microscopy in murine calvarial critical bone defect. Acta Biomaterialia. 2016.06, 42:389–399; (JCR一区，IF：6.383）

18.    Yiping Hu, Jinchao Li, Ling Qin, Wenxiang Cheng, Yuxiao Lai, Ye Yue, Peigen Ren, Xiaohua Pan, Peng Zhang*. Study in Treatment of Collagen-Induced Arthritis in DBA/1 Mice Model by Genistein. Current pharmaceutical design.2016,22(46):6975-6981; (JCR三区，IF：2.757）

19.    O. Guillaume，M. A. Geven，D. W. Grijpma，TingTing. Tang， Ling Qin ，Yuxiao Lai，H. Yuan，R.G. Richards，D. Eglin*. Poly(trimethylene carbonate) and nano-hydroxyapatite porous scaffolds manufactured by stereolithography. Polymers for advanced technologie. 2016.08.17,28(10):1219-1225; (JCR三区，IF：2.137）

20.    Huijuan Cao, Hanfeng Guan, Yuxiao Lai, Ling Qin, Xinluan Wang*. Review of various treatment options and potential therapies for osteonecrosis of the femoral head. Journal of Orthopaedic Translation. 2016, 4:57-70; (JCR二区，IF：2.078）

21.    Cairong  Li， Yuxiao Lai*， Long Li， Huijuan  Cao， Jing Long，Xinluan Wang，Ling Qin. The in vitro biocompatibility and osteoinductive activity study of magnesium composed PLGA/TCP porous scaffold for bone regeneration. Journal of Orthopaedic Translation. 2016.10, 7: 78; (JCR二区，IF：2.078）

22.    HuiJuan Cao, Li Zhen Zheng, NanWang, LinYing Wang, Ye Li, Dan Li， Yuxiao Lai, Xinluan Wang, Ling Qin*. Src blockage by siRNA inhibits VEGF-induced vascular hyperpemeability and osteoclast activity - an in vitro mechanism study for preventing destructive repair of osteonecrosis. Bone. 2015, 74:58-68; (JCR二区，IF：4.455）

23.    Rui Ma，Yuxiao Lai^#（共同一作），Long Li，Honglue Tan，Jiali Wang，Ye Li，Tingting Tang*，Ling Qin*. Antibacterial potential of 3D rapid-prototyped magnesium-based porous composite scaffolds–an in vitro efficacy study. Scientific Reports. 2015.09.08，5（13775）：1-14; (JCR一区，IF：4.609）

24.    Ye Li, Shukui Chen, Long Li, Ling Qin, Xinluan Wang, Yuxiao Lai*. Bone defect animal models for testing efficacy of bone substitute biomaterials. Journal of Orthopaedic Translation. 2015.07, 3（3）:95-104; (Top 10 most cited paper of the journal）

25.    XinLuan Wang, Yuxiao Lai, Helena Huei Leng Ng, ZhiJun Yang, Ling Qin*. Systemic Drug Delivery Systems for Bone Tissue Regeneration - A Mini Review. Current Pharmaceutical Design. 2015, 21: 1575-83; (JCR三区，IF：2.757）

26.    David Eglin, Mauro Alini, Joost de Bruijn, Julien Gautrot，Dirk W. Grijpma， Lukas Kamer, Yuxiao Lai, Shibi Lu, Ton Peijs, Jian Peng, Ting Ting Tang, Xianluan Wang, Xinjiang Wang, R. Geoff Richards*, Ling Qin*. The RAPIDOS project—European and Chinese collaborative research on biomaterials. Journal of Orthopaedic Translation. 2015, 3(2):78-84; (JCR二区，IF：2.078）

27.    Jianguo Sun, Graeter Stefan, Jian Tang, JingHuanm Huang, Peng Liu, YuXiao Lai, Lin Yu, Maher Gunter, Spatz Joachim P, JianDong Ding *. Preparation of stable micropatterns of gold on cell-adhesion-resistant hydrogels assisted by a hetero-bifunctional macromonomer linker. Science China Chemistry. 2014, 57(4): 645-653; (JCR二区，IF：4.448）

28.    Yuxiao Lai*, Long Li, Huijuan Cao, Xinluan Wang, Ling Qin. A Novel Magnesium Composed PLGA/TCP Porous Scaffold Fabricated by 3D Printing for Bone Regeneration. Journal of Orthopaedic Translation,2014, 2(4):218; (JCR二区，IF：2.078）

29.    Shihui Chen*, Lizhen Zheng, Xinhui Xie, Xinluan Wang, Yuxiao Lai, Ming Zhang, Yixiang Wang, James F.Griffith, Ling Qin*. Comparative study of poly (lactic-co-glycolic acid)/tricalcium phosphate scaffolds incorporated or coated with osteogenic growth factors for enhancement of bone regeneration. Journal of Orthopaedic Translation. 2014, 2(2): 91-104; (JCR二区，IF：2.078）

30.    Jian Tang, Jiali Wang, Xinhui Xie, Peng Zhang, Yuxiao Lai, Yangde Li, Ling Qin*. Surface coating reduces degradation rate of magnesium alloy developed for orthopaedic applications. Journal of Orthopaedic Translation. 2013.10, 1(1): 41-48; (JCR二区，IF：2.078）

31.    Jiali Wang, Jian Tang, Peng Zhang, Yangde Li, Jue Wang, Yuxiao Lai, Ling Qin*. Surface modification of magnesium alloys developed for bioabsorbable orthopedic implants: a general review. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2012, 100(6): 1691-1701; (JCR二区，IF：3.373）

32.    Xiaohua Pan *, Wenxiang Cheng*, Jiali Wang, Ling Qin, Yuxiao Lai, Jian Tang, Peng Shang, Peigen Ren, and Peng Zhang. ‘Old Drugs for New Applications’: Can Orthopedic Research Benefit from This Strategy?. Therapeutic advances in musculoskeletal disease. 2011.08; 3(4): 201–205; (JCR三区，IF：3.45）

33.    Yuxiao Lai，Cao Xie，Zheng Zhang，Weiyue Lu，Jiandong Ding*，Design and synthesisof a potent peptide containing both specific and non-specific cell-adhesion motifs. Biomaterials. 2010.06.01，31（18）：4809-4817; (JCR一区，IF：9.315）

34.    Zheng Zhang，Yuxiao Lai，Lin Yu，Jiandong Ding*，Effects of immobilizing sites of RGD peptides in amphiphilic block copolymers on efficacy of cell adhesion，Biomaterials，2010.11.01, 31（31）:7873-7882; (JCR一区，IF：9.315）

35.    李树袆，周苗，赖毓霄，耿远明，曹帅帅，陈晓明，三维打印聚乳酸-羟基乙酸/磷酸三钙骨修复支架的生物学评价，中华口腔医学杂志，2016，51（11）：10.3760/cma.j.issn.1002-0098.2016.11.005

36.    张明; 赖毓霄; 王新峦; 李龙; 张鹏; 秦岭，基于3D打印技术的新型生物活性复合镁骨修复支架，国际骨科学杂志, 2015.9.25, (05): 382~384

37.    尚鹏，石杜芳，白雪岭，赖毓霄，张明，新型表面活性改性人工腰椎融合器的研发新进展，中国科技纵横, 2012, (17)

38.    张正，赖毓霄，丁建东，人工合成多肽在生物材料上的修饰进展，中国医疗器械信息, 2008.9.25, (09): 1~7

（ 1 ） 骨修复材料及其制备技术, 发明, 2013, 第 1 作者, 专利号: 201110216591.2
（ 2 ） 多孔性骨支架, 实用新型, 2013, 第 1 作者, 专利号: 201220402014.2
（ 3 ） 多孔性骨支架及其制备方法, 发明, 2013, 第 1 作者, 专利号: 201210288452.5
（ 4 ） 3D打印方法, 发明, 2015, 第 1 作者, 专利号: 201510604994.2
（ 5 ） 3D打印设备和基于3D打印的物料供给搅拌系统, 发明, 2015, 第 1 作者, 专利号: 201510602862.6
（ 6 ） 3D打印设备和基于3D打印的物料供给搅拌系统, 实用新型, 2015, 第 1 作者, 专利号: 201520734358.7
（ 7 ） 智能控制3D打印喷头装置, 实用新型, 2016, 第 1 作者, 专利号: CN201621471167.7
（ 8 ） 3D打印喷头及智能控制3D打印喷头, 发明, 2016, 第 1 作者, 专利号: CN201611242052.5
（ 9 ） 可形成纳米复合骨水泥的组合物及其应用, 发明, 2016, 第 1 作者, 专利号: CN201610913810.5
（ 10 ） 一种生物复合材料及其制备方法, 发明, 2016, 第 1 作者, 专利号: CN201610084819.X

1.        Tissue regenerative biomaterials

2.        Synthesis and surface modification of biocompatible materials

3.        Design and synthesize biomaterials for bone regeneration.

已指导学生

李烨  硕士研究生  083100-生物医学工程  

郑子卓  硕士研究生  085204-材料工程  

张文静  博士研究生  070305-高分子化学与物理  

孙元艺  硕士研究生  085204-材料工程  

现指导学生

李龙  博士研究生  070304-物理化学  

李彩荣  博士研究生  070305-高分子化学与物理  

杜雨寒  博士研究生  070305-高分子化学与物理  

张雨洋  硕士研究生  086000-生物与医药