​主要从事骨科相关生物材料的应用研究

2005-09--2010-06   复旦大学   博士研究生

2005-09至2010-06，复旦大学，高分子科学系，理学博士，导师：丁建东

2003-09至2005-06，中山大学，化学与化学工程学院高分子科学系，理学硕士，导师：廖凯荣、全大萍

1999-09至2003-06，中山大学，化学与化学工程学院高分子科学系，理学学士

2018-11至今，中国科学院深圳先进技术研究院，生物医学与健康工程研究所转化医学研究与发展中心，研究员

2018-09至今，中国科学院深圳先进技术研究院，生物医学与健康工程研究所，所长助理

2018-03至今，中国科学院深圳先进技术研究院，生物医学与健康工程研究所转化医学研究与发展中心，执行主任

2013-10至2018-10，中国科学院深圳先进技术研究院，生物医学与健康工程研究所转化医学研究与发展中心，副研究员

2010-07至2013-09，中国科学院深圳先进技术研究院，生物医学与健康工程研究所转化医学研究与发展中心，助理研究员

2022-10-01-2026-12-31,中国医学装备协会, 理事
2019-06-29-今,中国生物医学工程学会青年委员会, 常务委员
2018-12-31-今,广东省生物医用材料增材制造工程, 主任
2018-09-01-今,华人骨研学会, 终身会员
2018-06-30-今,中国医学装备协会医用增材制造专委会, 常务委员兼秘书
2016-03-01-2020-03-01,深圳市青年科技者协会, 常务理事
2015-06-01-2018-06-01,中国生物材料学会生物制造分会, 理事
2014-01-01-今,中国科学院青年创新促进会会员, 会员

   

（1） 粤港澳大湾区高价值专利培育布局大赛, 一等奖, 省级, 2023
（2） 全国巾帼建功标兵, 一等奖, 部委级, 2023
（3） 广东医学科学技术奖, 二等奖, 其他, 2020
（4） 深圳市技术发明二等奖, 二等奖, 市地级, 2020
（5） 中国专利奖, 二等奖, 部委级, 2019
（6） 中国产学研合作创新奖, 一等奖, 部委级, 2017
（7） 日内瓦国际发明奖, 二等奖, 其他, 2016
（8） 高交会优秀产品奖, 一等奖, 市地级, 2014
（9） 高交会优秀产品奖, 一等奖, 市地级, 2013
（10） 高交会优秀产品奖, 一等奖, 市地级, 2012

[1] 张卫, 赖毓霄. 一类抗肿瘤四价铂配合物前药及其制备方法和应用. CN: CN115068501A, 2022-09-20.
[2] 张卫, 赖毓霄. 一类抗肿瘤四价铂配合物前药及其制备方法和应用. CN: CN115068501B, 2023-08-11.
[3] 赖毓霄, 张文静, 张卫, 李彩荣, 姚振宇. 金属过氧化物复合可注射水凝胶及其制备方法和应用. CN: CN113908332A, 2022-01-11.
[4] 赖毓霄, 孙元艺. 一种骨修复支架及其制备方法和应用. CN: CN115671384A, 2023-02-03.
[5] 张卫, 刘奔, 赖毓霄. 用于肿瘤治疗的双亲性分子自组装纳米药物及制备方法和用途. CN: CN112675305A, 2021-04-20.
[6] 张卫, 赖毓霄, 李彩荣, 秦岭. 一种骨用复合材料及其制备方法和应用. CN: CN112604033A, 2021-04-06.
[7] 赖毓霄, 李彩荣, 陈英奇, 秦岭. 一种具备光热抗肿瘤及促成骨复合材料及其制备方法. CN: CN112516382A, 2021-03-19.
[8] 赖毓霄, 郑子卓, 秦岭. 一种双网络生物墨水及其制备方法和用途. CN: CN113577386A, 2021-11-02.
[9] 张鹏, 李健, 白雪岭, 成文翔, 王新峦, 赖毓霄. 镁锶-磷酸硅盐材料及制备方法、包含其的结构可控的多孔骨修复复合支架材料. CN: CN110776315B, 2022-03-15.
[10] 赖毓霄, 陈英奇, 龙晶, 秦岭. 一种骨修复材料及其制备方法. CN: CN110433327A, 2019-11-12.
[11] 赖毓霄, 龙晶, 陈英奇, 李龙, 秦岭. 用于治疗骨肉瘤的光热骨修复材料及其应用. CN: CN110302421A, 2019-10-08.
[12] 王海, 刘洁颖, 赖毓霄, 郑子卓, 吴志宏, 邱贵兴. 一种磁性纳米骨修复支架及其制备方法. CN: CN110227179A, 2019-09-13.
[13] 赖毓霄, 李龙, 秦岭, 王新峦, 张鹏. 3D打印方法. CN: CN109591287A, 2019-04-09.
[14] 赖毓霄, 李龙, 秦岭. 一种制备异质异构骨修复支架的3D打印装置. CN: CN209285828U, 2019-08-23.
[15] 赖毓霄, 李龙, 秦岭. 一种制备异质异构骨修复材料的方法和装置. CN: CN108904103A, 2018-11-30.
[16] 赖毓霄, 李龙, 秦岭, 王新峦, 张鹏. 3D打印喷头及智能控制3D打印喷头. CN: CN206484898U, 2017-09-12.
[17] 赖毓霄, 李龙, 秦岭, 王新峦, 张鹏. 3D打印喷头及智能控制3D打印喷头. CN: CN106493945A, 2017-03-15.
[18] 赖毓霄, 李彩荣, 秦岭, 孙健乔, 李龙. 可形成纳米复合骨水泥的组合物及其应用. CN: CN107050522A, 2017-08-18.
[19] 王新峦, 秦岭, 赖毓霄, 曹会娟, 李玲, 李龙, 成文翔, 张鹏. 一种生物复合材料及其制备方法. CN: CN105727374A, 2016-07-06.
[20] 赖毓霄, 李龙, 秦岭, 王新峦, 张鹏. 3D打印设备和基于3D打印的物料供给搅拌系统. CN: CN204977485U, 2016-01-20.
[21] 赖毓霄, 李龙, 秦岭, 王新峦, 张鹏. 3D打印设备和基于3D打印的物料供给搅拌系统. CN: CN105690757A, 2016-06-22.
[22] 赖毓霄, 李龙, 秦岭, 王新峦, 张鹏. 3D打印方法. CN: CN105711090B, 2017-11-21.
[23] 赖毓霄",null,null,null,"张鹏. 3D打印方法. CN: CN105711090B, 2017-11-21.
[24] 张明, 赖毓霄, 秦岭, 陈淑奎, 张鹏, 陈诗慧. 骨支架成型系统. CN: CN103876862A, 2014-06-25.
[25] 赖毓霄, 张明, 陈淑奎, 秦岭. 多孔性骨支架及其制备方法. CN: CN102784014A, 2012-11-21.
[26] 赖毓霄, 张明, 陈淑奎, 秦岭. 多孔性骨支架. CN: CN202751469U, 2013-02-27.
[27] 赖毓霄, 秦岭. 骨修复材料及其制备方法. CN: CN102824657A, 2012-12-19.

   

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[12] Yao, Zhidong, Li, Liuxun, Zhang, Peng, Yang, Lei, Bai, Xueling, Peng, Songlin, Lai, Yuxiao. Biomechanics evaluation of sacroiliac joint pain after lumbosacral fusion: A finite element analysis. JOURNAL OF ORTHOPAEDIC RESEARCH. 2022, 第 7 作者  通讯作者  41(4): 
[13] Chen, Sheng, Wu, Xiaohao, Lai, Yumei, Chen, Di, Bai, Xiaochun, Liu, Sheng, Wu, Yongchao, Chen, Mingjue, Lai, Yuxiao, Cao, Huiling, Shao, Zengwu, Xiao, Guozhi. Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc. BONE RESEARCH[J]. 2022, 第 9 作者10(1): 165-177, http://dx.doi.org/10.1038/s41413-021-00179-5.
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[15] Zhou, Feifei, Yang, Yuan, Zhang, Wenjing, Liu, Shuyu, Shaikh, Atik Badshah, Yang, Lei, Lai, Yuxiao, Ouyang, Hongwei, Zhu, Weimin. Bioinspired, injectable, tissue-adhesive and antibacterial hydrogel for multiple tissue regeneration by minimally invasive therapy. APPLIED MATERIALS TODAY[J]. 2022, 第 7 作者  通讯作者  26: http://dx.doi.org/10.1016/j.apmt.2021.101290.
[16] Zhang, Wenjing, Zhang, Wei, Li, Cairong, Zhang, Jianhua, Qin, Ling, Lai, Yuxiao. Recent Advances of Microneedles and Their Application in Disease Treatment. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2022, 第 6 作者  通讯作者  23(5): http://dx.doi.org/10.3390/ijms23052401.
[17] 张剑华, 孙元艺, 郭阿龙, 赵宇, 赖毓霄. 3D打印含镁生物医用材料用于骨缺损修复研究进展. 中华骨与关节外科杂志[J]. 2021, 第 5 作者14(10): 826-831, http://lib.cqvip.com/Qikan/Article/Detail?id=00002EGM55407JP0MNDG9JP1MHR.
[18] Du, XiangFu, Li, Yi, Long, Jing, Zhang, Wei, Wang, Dou, Li, CaiRong, Zhao, MeiXia, Lai, Yuxiao. Fabrication of cisplatin-loaded polydopamine nanoparticles via supramolecular self-assembly for photoacoustic imaging guided chemo-photothermal cancer therapy. APPLIED MATERIALS TODAY[J]. 2021, 第 8 作者  通讯作者  23: 101019, http://dx.doi.org/10.1016/j.apmt.2021.101019.
[19] ZizhuoZhengDavidEglinMauroAliniGeoffRRichardsLingQinYuxiaoLai. Visible Light-Induced 3D Bioprinting Technologies and Corresponding Bioink Materials for Tissue Engineering: A Review. Engineering[J]. 2021, 7(7): 966-978, https://journal.hep.com.cn/engi/EN/10.1016/j.eng.2020.05.021.
[20] Meng, Xiangbo, Grad, Sibylle, Wen, Chunyi, Lai, Yuxiao, Alini, Mauro, Qin, Ling, Wang, Xinluan. An impaired healing model of osteochondral defect in papain-induced arthritis. JOURNAL OF ORTHOPAEDIC TRANSLATION[J]. 2021, 第 4 作者26: 101-110, http://dx.doi.org/10.1016/j.jot.2020.07.005.
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[22] Jing Long, Bin Teng, Wei Zhang, Long Li, Ming Zhang, Yingqi Chen, Zhenyu Yao, Xiangbo Meng, Xinluan Wang, Ling Qin, Yuxiao Lai. Article Preclinical evaluation of acute systemic toxicity of magnesium incorporated poly(lactic-co-glycolic acid)porous scaffolds by three-dimensional printing Jing. 生物材料转化电子杂志(英文)[J]. 2021, 第 11 作者2(3): 272-284, http://lib.cqvip.com/Qikan/Article/Detail?id=7107476953.
[23] 郑玉峰, 夏丹丹, 谌雨农, 刘云松, 徐钰倩, 温鹏, 田耘, 赖毓霄. 增材制造可降解金属医用植入物. 金属学报[J]. 2021, 第 8 作者57(11): 1499-1520, https://www.ams.org.cn/CN/10.11900/0412.1961.2021.00294.
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[26] Xiangbo Meng, Reihane Ziadlou, Sibylle Grad, Mauro Alini, Chunyi Wen, Yuxiao Lai, Ling Qin, Yanyan Zhao, Xinluan Wang. Animal Models of Osteochondral Defect for Testing Biomaterials. BIOCHEMISTRY RESEARCH INTERNATIONAL[J]. 2020, 第 6 作者2020: https://doaj.org/article/752b9107d83745ecb286fce523071a75.
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[29] Zhou, Liangbin, GJVM, Van Osch, Malda, Jos, Stoddart, Martin J, Lai, Yuxiao, Richards, R Geoff, Kiwai Ho, Kevin, Qin, Ling. Innovative Tissue-Engineered Strategies for Osteochondral Defect Repair and Regeneration: Current Progress and Challenges. ADVANCED HEALTHCARE MATERIALS. 2020, 第 5 作者9(23): http://dx.doi.org/10.1002/adhm.202001008.
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（1） 可降解金属, 科学出版社, 2016-10, 第 5 作者
（2） 生物医用高分子材料第14章, 科学出版社, 2022-02, 第 1 作者

   

（ 1 ） 具有促成骨活性的PLGA/TCP/Mg 复合多孔支, 负责人, 国家任务, 2013-01--2015-12
（ 2 ） 青年创新促进会, 负责人, 研究所自主部署, 2014-01--2017-12
（ 3 ） 基于新型快速成型技术构建的活性骨修复, 参与, 国家任务, 2013-02--2016-12
（ 4 ） 基于新型快速成型技术的具有促成骨活性的, 负责人, 地方任务, 2013-01--2015-12
（ 5 ） 多功能活性含镁支架的影像引导精细设计与3D精准打印技术研究, 负责人, 国家任务, 2016-01--2019-12
（ 6 ） 医学影像数据引导的3D打印精准成型的生物活性材料的研制及应用, 负责人, 国家任务, 2015-01--2017-12
（ 7 ） 基于3D打印技术的骨修复材料研究, 负责人, 地方任务, 2015-10--2018-12
（ 8 ） 生物医用与高分子材料高通量实验平台, 参与, 地方任务, 2019-04--2022-04
（ 9 ） 增材制造硬组织修复材料体系设计及研发, 负责人, 地方任务, 2019-07--2022-06
（ 10 ） 骨科植入性功能材料, 负责人, 国家任务, 2021-01--2023-12
（ 11 ） 2020年度中国科学院创新交叉团队-治疗与修复一体化3D打印生物材料创新交叉团队, 负责人, 中国科学院计划, 2021-01--2023-12
（ 12 ） 2020年度院高端人才配套经费, 负责人, 研究所自主部署, 2021-01--2023-12
（ 13 ） 骨肿瘤治疗与骨缺损修复一体化支架的3D打印可控制备及其生物学效应研究, 负责人, 国家任务, 2021-08--2023-07
（ 14 ） 西丽湖国际生物技术中试基地-生物适配器械中试实验室, 参与, 地方任务, 2022-01--2025-12

已指导学生

李烨  硕士研究生  083100-生物医学工程  

郑子卓  硕士研究生  085204-材料工程  

张文静  博士研究生  070305-高分子化学与物理  

孙元艺  硕士研究生  085204-材料工程  

现指导学生

李龙  博士研究生  070304-物理化学  

李彩荣  博士研究生  070305-高分子化学与物理  

杜雨寒  博士研究生  070305-高分子化学与物理  

张雨洋  硕士研究生  086000-生物与医药