1 Design, Construction and Characterization of Stimuli (redox potential, pH, light…) Responsive Polymeric Gene/Drug Delivery Systems;
2 Development of Nanomaterials for tumor diagnostic and therapeutic applications;
3 Development of Novel Biomaterials for Tissue Engineering.

1997.9~2001.6 

Bachelor of Science.   Department of Chemistry, Wuhan University @Wuhan, Hubei,   China. 

                                    Major: Chemistry

2001.9~2007.6

Ph.D.                           Biomedical   Polymers Key Laboratory of Ministry of Education, Department of Chemistry,   

                                    Wuhan University @Wuhan, Hubei, China.    

                                    Major: Polymer Chemistry   and Physics

 

2007.9~2008.9 Postdoctoral Fellow. Wayne State University @Detroit, MI, U.S. 

2009.2~2012.1 Postdoctoral Fellow. University of Manitoba @Winnipeg, MB, Canada.

2012.2~2013.1 Research Associate. University of Manitoba & Manitoba Institute of Child Health, @Winnipeg, MB, Canada. 

2021.10-Present      Professor. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, 

                                Institute of High Energy Physics, Chinese Academy of Sciences @Beijing, China.

2013.02-2021.09 Associate Professor. CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, 

                                Institute of High Energy Physics, Chinese Academy of Sciences @Beijing, China.

1.      Dongqing Wang, Mengxue Zhou, Hui Huang, Lifo Ruan, Huiru Lu, Jiayu Zhang, Jun Chen*, Jimin Gao, Zhifang Chai, Yi Hu*, Gold Nanoparticle-Based Probe for Analyzing Mitochondrial Temperature in Living Cells, ACS Appl. Bio Mater., DOI: 10.1021/acsabm.9b00463, July 8, 2019

2.      Hui Huang,  Mengxue Zhou,  Lifo Ruan,  Dongqing Wang,  Huiru Lu,  Jiayu Zhang,  Jun Chen*,  Yi Hu*, Zhifang Chai, AMPK mediates the neurotoxicity of iron oxide nanoparticles retained in mitochondria or lysosomes, Metallomics, 2019, 11: 1200-1206, DOI:10.1039/C9MT00103D, Jun-15 2019

3.      Zhou, Mengxue, Huang, Hui, Wang, Dongqing, Lu, Huiru, Chen, Jun*, Chai, Zhifang, Yao, Shao Q, Hu, Yi*, Light-Triggered PEGylation/dePEGylation of the Nanocarriers for Enhanced Tumor Penetration, Nano Letters, 2019, 19(6): 3671-3675 DOI:10.1021/acs.nanolett.9b00737, May-7 2019

4.      Wen, Kaikai#, Xu, Xiaozhou#, Chen, Jun#; Lv, Lei; Wu, Lifen; Hu, Yi; Wu, Xiaoxi; Liu, Guozhen; Peng, Aidong; Huang, Hui, Triplet Tellurophene-Based Semiconducting Polymer Nanoparticles for Near-Infrared-Mediated Cancer Theranostics. Acs Appl. Mater. Interfaces, 11(19):17884-17893, May-15 2019

5.      Wang, Dongqing; Huang, Hui; Zhou, Mengxue; Lu, Huiru; Chen, Jun*; Chang, Young-Tae; Gao, Jimin; Chai, Zhifang; Hu, Yi*, A thermoresponsive nanocarrier for mitochondria-targeted drug delivery. Chem. Commun., 55(28): 4051-4054, DOI: 10.1039/c9cc00603f, Apr-02 2019

6.      黄辉, 陈俊, 卢会茹, 周梦雪, 胡毅*, 柴之芳, 帕金森病中的关键金属元素（Neurotoxicity of Key Metals in Parkinson’s Disease）,化学进展（Progress in Chemistry）, 30(10): 1592-1600, Oct-15 2018

7.      Mengxue Zhou, Xingcai Zhang, Jin Xie, Rongxiang Qi, Huiru Lu, Stefano Leporatti*, Jun Chen*, Yi Hu*, pH-Sensitive Poly(β-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells, Nanomaterials, 8(11): 952, DOI: 10.3390/nano8110952, November 19, 2018

8.      Kaikai Wen, Mengxue Zhou, Huiru Lu, Ying Bi, Lifo Ruan, Jun Chen*, Yi Hu*, Near Infrared/pH Dual-Sensitive Nanocarriers for Enhanced Intracellular Delivery of Doxorubicin, Acs Biomater Sci Eng, 4 (12): 4244–4254, DOI: 10.1021/acsbiomaterials.8b01051, October 30, 2018

9.      Ye Tian, Mengxue Zhou, Haigang Shi, Sijia Gao, Guocheng Xie, Meng Zhu, Man Wu, Jun Chen, and Zhongwei Niu*, Integration of Cell-Penetrating Peptides with Rod-like Bionanoparticles: Virus-Inspired Gene-Silencing Technology, Nano Letters, 18(9): 5453–5460, DOI: 10.1021/acs.nanolett.8b01805, August 9, 2018

10.   Jun Chen*, Hui Gao, Ying Bi, MengXue Zhou, Yi Hu, In vivo evaluation of near-infrared mediated nanoplatforms for targeted chemo-photothermal therapy and photothermo-immunotherapy, Nanomedicine: Nanotechnology, Biology, and Medicine, 14: 1807–1808, 2018.

11.   Tao Dong#,  Kaikai Wen#,  Jun Chen#,  Jin Xie,  Weili Fan,  Han Ma,  Lei Yang,  Xiaoxi Wu,  Fujian Xu, Aidong Peng,  Hui Huang*, Significant Enhancement of Photothermal and Photoacoustic Efficiencies for Semiconducting Polymer Nanoparticles through Simply Molecular Engineering, Adv Funct Mater, 28(23): 1800135, Jun-06 2018

12.   Hui Gao, Ying Bi, Xin Wang, Miao Wang, Mengxue Zhou, Huiru Lu, Jimin Gao, Jun Chen*, Yi Hu, Near-Infrared Guided Thermal-Responsive Nanomedicine against Orthotopic Superficial Bladder Cancer, Acs Biomater Sci Eng, 3 (12): 3628–3634, DOI: 10.1021/acsbiomaterials.7b00405, October 20, 2017

13.   Hui Huang, Jun Chen, Huiru Lu, Mengxue Zhou, Zhifang Chai, Yi Hu, Two mTOR inhibitors, rapamycin and Torin 1, differentially regulate iron-induced generation of mitochondrial ROS, Biometals, 30(6): 975-980, DEC 2017

14.   Mengxue Zhou, Hui Gao, Ying Bi, Huiru Lu, Aiping Lan, Yi Hu, Jun Chen*, In vivo chemo/photothermal therapy using near-infrared light triggered switchable nanoparticles against subcutaneous and orthotopic superficial bladder cancer, J Control Release, 259: E92-E93, 2017.

15.   Jin Xie, Xingxing Fang, Mengxue Zhou, Yi Hu, Jun Ouyang, Jun Chen*, A facile construction of pH-sensitive shell-sheddable supramolecular nanoassembly codelivery anticancer drugs to combat drug resistance, J Control Release, 259: E64-E64, DOI:10.1016/j.jconrel.2017.03.148, August 10, 2017.

16.   Yi Liu, Huiru Lu, Aiping Lan, Yi Hu, Heping Li, Jun Chen*, Mitochondria-targeted nanocarriers using hyperbranched polycations wrapped carbon nanotubes for augment photodynamic therapeutic effects, J Control Release, 259: E170-E171, DOI: 10.1016/j.jconrel.2017.03.338, August 10, 2017.

17.   Huiru Lu, Jun Chen, Hui Huang, Mengxue Zhou, Qing Zhu, Shaoqing Yao, Zhifang Chai, Yi Hu*, Iron modulates the activity of monoamine oxidase B in SH-SY5Y cells, Biometals, 30(4): 599-607, 2017.

18.   Hui Huang, Jun Chen, Huiru Lu, Mengxue Zhou, Zhifang Chai, Yi Hu*, Iron-induced generation of mitochondrial ROS depends on AMPK activity, Biometals, 30(4): 623-628, 2017.

19.   Yi Liu, Heping Li*, Jin Xie, Mengxue Zhou, Hui Huang, Huiru Lu, Zhifang Chai, Jun Chen*, Yi Hu*, Facile construction of mitochondria-targeting nanoparticles for enhanced phototherapeutic effects, Biomater Sci, 5(5): 1022-1031, 2017.

20.   Mengxue Zhou, Kaikai Wen, Ying Bi, Huiru Lu, Jun Chen*, Yi Hu, Zhifang Chai, The Application of Stimuli-responsive Nanocarriers for Targeted Drug Delivery, Curr Top Med Chem, 17(20): 2319-2334, 2017.

21.   Aiping Lan, Jun Chen, Yuliang Zhao, Zhifang Chai, Yi Hu, mTOR Signaling in Parkinson's Disease., Neuromolecular Med, 19, 1-10, 2017.

22.   Aiping Lan, Xianjia Xiong, Jun Chen, Xi Wang, Zhifang Chai, Yi Hu, AMPK Inhibition Enhances the Neurotoxicity of Cu(II) in SH-SY5Y Cells. Neurotox Res, 30(3): 499-509, 2016.

23.   Aiping Lan, Jun Chen, Zhifang Chai, Yi Hu, The Neurotoxicity of Iron, Copper and Cobalt in Parkinson’s Disease Through ROS-Mediated Mechanisms. Biometals, 29(4): 665-678, 2016.

24.   Hui Gao, Ying Bi, Jun Chen*, Lirong Peng, Kaikai Wen, Pan Ji, Wefeng Ren, Xiaoqing Li, Ning Zhang, Jimin Gao*, Zhifang Chai, Yi Hu*, Near-Infrared Light-Triggered Switchable Nanoparticles for Targeted Chemo/Photothermal Cancer Therapy., ACS Appl Mater Interfaces, 8 (24): 15103–15112, DOI: 10.1021/acsami.6b03905, May 26, 2016

25.   Liqian Gao, Jun Chen, Yi Hu, Characterization and Preclinical Perspectives of Organic Small Molecule Drug Metabolites in Drug-Drug Interactions, Curr Org Chem, 20: 1827-1834, 2016.

26.   Ganchao Chen, Yusheng Xie, Raoul Peltier, Haipeng Lei, Ping Wang, Jun Chen, Yi Hu*, Feng Wang, Xi Yao, Hongyan Sun*, Peptide-Decorated Gold Nanoparticles as Functional Nano-Capping Agent of Mesoporous Silica Container for Targeting Drug Delivery, ACS Appl Mater Interfaces, 8(18): 11204-11209, 2016.

27.   Hui Zhou, Ying Bi, Hui Gao, Peng Chen, Jun Chen*, Yi Hu, Reduction sensitive micellar magnetic nanoparticles for cancer targeted chemotherapy., Nanomed.-Nanotechnol Biol Med, 12: 547-547, 2016.

28.   Liqian Gao, Suseong Lee, Jun Chen; Hongyan Sun, Yuliang Zhao, Zhifang Chai, Yi Hu, High-Throughput Screening of Substrate Specificity for Protein Tyrosine Phosphatases (PTPs) on Phosphopeptide Microarrays., Methods Mol Biol, 1368(1): 181-196, 2016.

29.   Huiru Lu; Huatang Zhang; Jun Chen; Jinchao Zhang; Ruochuan Liu; Hongyan Sun; Yuliang Zhao; Zhifang Chai; Yi Hu, A thiol fluorescent probe reveals the intricate modulation of cysteine's reactivity by Cu(II), Talanta, 146: 477-482, 2016.

30.   Yanping Qin; Jun Chen*; Ying Bi; Xiaohan Xu; Hui Zhou; Jimin Gao*; Yi Hu*, Yuliang Zhao; Zhifang Chai, Near-infrared light remote-controlled intracellular anti-cancer drug delivery using thermo/pH sensitive nanovehicle, Acta Biomater, 17: 201-209, DOI: 10.1016/j.actbio.2015.01.026, April 15, 2015.

31.   Huiru Lu, Shenghui Li, Jun Chen; Jing Xia, Jinchao Zhang*, Yan Huang, Xiaoxiao Liu, Hai-Chen Wu, Yuliang Zhao, Zhifang Chai, Yi Hu*, Metal ions modulate the conformation and stability of a G-quadruplex with or without a small-molecule ligand, Metallomics, 7(11): 1508-1514, 2015.

32.   Xia Li, Jin Zhou, Zhiqiang Liu, Jun Chen, Shuanghong Lu, Hongyu Sun, Junjie Li, Qiuxia Lin, Boguang Yang, Cuimi Duan, Malcolm Xing, Changyong Wang, A PNIPAAm-based thermosensitive hydrogel containing SWCNTs for stem cell transplantation in myocardial repair., Biomaterials, 35: 5679-88, 2014,

33.   Jin Zhou, Jun Chen (co-1^st), Hongyu Sun, Xiaozhong Qiu, Yongchao Mou, Zhiqiang Liu, Yuewei Zhao, Xia Li, Yao Han, Cuimi Duan, Rongyu Tang, Chunlan Wang, Wen Zhong, Jie Liu, Ying Luo, Malcolm Xing, Changyong Wang, Engineering the heart: Evaluation of conductive nanomaterials for improving implant integration and cardiac function., Sci Rep, 4: 3733, 2014,

34.   Jun Chen, Xiaozhong Qiu; Leyu Wang; Wen Zhong; Jiming Kong; Malcolm MQ Xing., Free-Standing Cell Sheet Assembled with Ultrathin Extracellular Matrix as an Innovative Approach for Biomimetic Tissues., Adv Funct Mater, 24: 2216-2223, 2014.

35.   Jun Chen, Min Shi; Pengmin Liu; Alex Ko; Wen Zhong; Wangjun Liao; Malcolm M.Q. Xing, Reducible polyamidoamine-magnetic iron oxide self-assembled nanoparticles for doxorubicin delivery., Biomaterials, 35: 1240-48, 2014.

36.   Jun Chen*, Xiaojian Li, Liqian Gao, Yi Hu, Wen Zhong, Malcolm Xing, A facile strategy for in-situ controlled delivery of doxorubicin with a pH-sensitive injectable hydrogel., Nano Life, 4: 1441001, 2014.

37.   Yi Hu, Huiru Lu, Jinchao Zhang, Jun Chen, Zhifang Chai, Jingxin Zhang, Essential role of AKT in tumor cells addicted to FGFR., Anti-Cancer Drugs, 25: 183-188, 2014.

38.   Chao Wu, Jing Li, Yu Zhu, Jun Chen, David Oupický, Opposing influence of intracellular and membrane thiols on the toxicity of reducible polycations., Biomaterials, 34: 8843-50, 2013.

39.   Jun Chen, Jun Ouyang, Jiming Kong, Wen Zhong, Malcolm Xing, Photo-cross-linked and pH-Sensitive Biodegradable Micelles for Doxorubicin Delivery. ACS Appl Mater Interfaces, 5: 3108–17, 2013.

40.   Jun Chen, Fatemeh Zehtabi, Jun Ouyang, Jiming Kong, Wen Zhong, Malcolm Xing, Reducible self-assembled micelles for enhanced intracellular delivery of doxorubicin. J Mater Chem, 22: 7121-29, 2012.

41.   Jun Chen, Xiaozhong Qiu, Jun Ouyang, Jiming Kong, Wen Zhong, Malcolm Xing, pH and Reduction Dual-Sensitive Copolymeric Micelles for Intracellular Doxorubicin Delivery., Biomacromolecules, 12 (10): 3601-11, 2012.

42.   Jing Li, Devika S. Manickam, Jun Chen, David Oupický, Effect of cell membrane thiols and reduction-triggered disassembly on transfection activity of bioreducible polyplexes, Eur J Pharm Sci, 46: 173-80, 2012.

43.   Jun Chen, Beth Zhou, Qi Li, Jun Ouyang, Jiming Kong, Wen Zhong, Malcolm Xing, Multifunctional Nanofibrous Scaffolds Based on Poly(L-lactic acid) and Poly(L-lactic acid)-Poly(ethylene glycol) for Tissue Engineering, Int J Nanomed, 6: 2533-42, 2011. 

44.   Jun Chen, Malcolm Xing, Zhong Wen, Degradable micelles based on hydrolytically degradable amphiphilic graft copolymers for doxorubicin delivery, Polymer, 52: 933-41, 2011.

45.   Ming Liu, Jun Chen, Yanping Cheng, Yanan Xue, Renxi Zhuo, Shiwen Huang, Novel Poly(amidoamine)s with Pendant Primary Amines as Highly Efficient Gene Delivery Vectors, Macromol Biosci, 10: 384-92, 2010.

46.   Ming Liu, Jun Chen, Yanan Xue, Wenming Liu, Renxi Zhuo, Shiwen Huang, Poly(beta-aminoester)s with pendant primary amines for efficient gene delivery, Bioconjugate Chem, 20: 2317-23, 2009.

47.   Chao Wu, Jun Chen, Jing Li, D Oupický, Effect of intracellular glutathione levels on the cytotoxicity of bioreducible polycations, Mol Ther, 17: S55-55, 2009.

48.   Jing Li, Devika S. Manickam, Jun Chen, David Oupický, Effect of Nucleic Acid Size on Physical Properties and Biological Activity of Redox-Responsive Polyplexes: Plasmid DNA vs. Antisense Oligonucleotides, Mol Ther, 17: S331-332, 2009.

49.   Jun Chen, Chao Wu, David Oupický, “Bioreducible hyperbranched poly(amido amine)s for gene delivery”, Biomacromolecules, 10: 2921–27, 2009.

50.   Jun Chen, Ximing Xia, Shiwen Huang, Renxi Zhuo, A cleavable-polycation template method for the fabrication of noncrosslinked, porous polyelectrolyte multilayered films，Adv Mater, 19: 979-83, 2007.

51.   Jun Chen, Shiwen Huang, Wenhai Lin, Renxi Zhuo, Tunable film degradation and sustained release of plasmid DNA from cleavable polycation/plasmid DNA multilayers under reductive conditions，Small, 3: 636-43, 2007.

52.   Jun Chen, Shiwen Huang, Wenhai Lin, Renxi Zhuo, Synthesis and degradation of poly(beta-aminoester) with pendant primary amine，Polymer, 48: 675-81, 2007. 

Biomaterials, Nanomedicine

已指导学生

周梦雪  博士研究生  070301-无机化学