1 Design, Construction and Characterization of Stimuli (redox potential, pH, light…) Responsive Polymeric Gene/Drug Delivery Systems; 
2 Development of Nanomaterials for tumor diagnostic and therapeutic applications; 
3 Development of Novel Biomaterials for Tissue Engineering.

硕士生每年一名

070301-无机化学
070305-高分子化学与物理
0703J1-纳米科学与技术

纳米材料，生物材料
抗肿瘤治疗，基因治疗

2001-09--2007-06   武汉大学   理学博士
1997-09--2001-06   武汉大学   理学学士

Ph.D

陈俊，博士，中国共产党党员。研究员，硕士生导师、博士生副导师。2001年毕业于武汉大学化学基地班专业，获理学学士学位；2007年毕业于武汉大学高分子物理与化学专业，获理学博士学位；2007-2012年美国韦恩州立大学、加拿大曼尼托巴大学，博士后、助理研究员；2013-2021年高能物理研究所的多学科研究中心，任副研究员。2021年至今，任研究员。围绕生物医学关键问题，发展基于高分子的生物医用新策略。重点关注生物医用材料的可控合成，其中多个聚合物已经商业化并广泛用于生物医用研究；首创性证明肿瘤细胞线粒体的高温特性，并以此发展响应性药物靶向递送策略。目前的研究兴趣集中于：（1）肿瘤诊疗中纳米技术的基础研究与应用; （2）基于生物医用高分子构建的纳米尺度材料的基础研究及应用。

2021-10~现在, 中国科学院高能物理研究所, 研究员
2013-02~2021-09,中国科学院高能物理研究所, 副研究员
2012-02~2013-01,University of Manitoba, 助理研究员
2009-02~2012-01,University of Manitoba, 博士后
2007-09~2008-11,Wayne State University, 博士后

   

（1） 中科院高能物理研究优秀青年, 研究所（学校）, 2018
（2） 中科院青年创新促进会, 特等奖, 部委级, 2015

（ 1 ） Multifunctional nanoparticle for doxorubicin enhanced intracellular delivery, 发明, 2012, 第 1 作者, 专利号: 61/586,833
（ 2 ） 阿霉素前药及其制备方法和可注射的组合物, 实用新型, 2013, 第 1 作者, 专利号: CN103381273-A
（ 3 ） 一种两亲性聚合物以及由其形成的磁性胶束纳米载体和其用途, 发明, 2018, 第 1 作者, 专利号: ZL201610819749.8
（ 4 ） 一种聚乙二醇/聚酰胺胺共聚物、其制备方法及包含该共聚物的两亲性siRNA载体, 发明, 2019, 第 1 作者, 专利号: ZL201610817502.2
（ 5 ） 一种粒径可控的阿霉素纳米颗粒及其制备方法, 发明, 2019, 第 1 作者, 专利号: ZL201610819358.6

   

[1] Zhang, Jiayu, Song, Xiaofang, Xia, Miaoren, Xue, Yanan, Zhou, Mengxue, Ruan, Lifo, Lu, Huiru, Chen, Jun, Wang, Dongqi, Chai, Zhifang, Hu, Yi. The proximity of the G-quadruplex to hemin impacts the intrinsic DNAzyme activity in mitochondria. CHEMICAL COMMUNICATIONS[J]. 2021, 57(24): 3038-3041, https://www.webofscience.com/wos/woscc/full-record/WOS:000631568300013.
[2] Geng, Huan, Zhou, Mengxue, Li, Bin, Liu, Liang, Yang, Xu, Wen, Yinxian, Yu, Haijun, Wang, Hui, Chen, Jun, Chen, Liaobin. Metal-drug nanoparticles-mediated osteolytic microenvironment regulation for enhanced radiotherapy of orthotopic osteosarcoma. CHEMICAL ENGINEERING JOURNAL[J]. 2021, 417: http://dx.doi.org/10.1016/j.cej.2020.128103.
[3] Du, Chuanchao, Zhou, Mengxue, Jia, Fei, Ruan, Lifo, Lu, Huiru, Zhang, Jiayu, Zhu, Bin, Liu, Xiaoguang, Chen, Jun, Chai, Zhifang, Hu, Yi. D-arginine-loaded metal-organic frameworks nanoparticles sensitize osteosarcoma to radiotherapy. BIOMATERIALS[J]. 2021, 269: http://dx.doi.org/10.1016/j.biomaterials.2020.120642.
[4] Ju, Xiaoyan, Chen, Jun, Zhou, Mengxue, Zhu, Meng, Li, Zhuang, Gao, Sijia, Ou, Jinzhao, Xu, Dandan, Wu, Man, Jiang, Shidong, Hu, Yi, Tian, Ye, Niu, Zhongwei. Combating Pseudomonas aeruginosa Biofilms by a Chitosan-PEG-Peptide Conjugate via Changes in Assembled Structure. ACS APPLIED MATERIALS & INTERFACES[J]. 2020, 12(12): 13731-13738, https://www.webofscience.com/wos/woscc/full-record/WOS:000526552100014.
[5] Bi, Ying, Wang, Miao, Peng, Lirong, Ruan, Lifo, Zhou, Mengxue, Hu, Yi, Chen, Jun, Gao, Jimin. Photo/thermo-responsive and size-switchable nanoparticles for chemo-photothermal therapy against orthotopic breast cancer. NANOSCALE ADVANCES[J]. 2020, 2(1): 210-213, https://www.webofscience.com/wos/woscc/full-record/WOS:000508943100012.
[6] Wang, Miao, Ruan, Lifo, Zheng, Tianyu, Wang, Dongqing, Zhou, Mengxue, Lu, Huiru, Gao, Jimin, Chen, Jun, Hu, Yi. A surface convertible nanoplatform with enhanced mitochondrial targeting for tumor photothermal therapy. COLLOIDS AND SURFACES B-BIOINTERFACES[J]. 2020, 189: http://dx.doi.org/10.1016/j.colsurfb.2020.110854.
[7] Ruan, Lifo, Zhou, Mengxue, Chen, Jun, Huang, Hui, Zhang, Jiayu, Sun, Hongyan, Chai, Zhifang, Hu, Yi. Thermoresponsive drug delivery to mitochondria in vivo. CHEMICAL COMMUNICATIONS[J]. 2019, 55(97): 14645-14648, https://www.webofscience.com/wos/woscc/full-record/WOS:000501150200018.
[8] Zhou, Mengxue, Huang, Hui, Wang, Dongqing, Lu, Huiru, Chen, Jun, Chai, Zhifang, Yao, Shao Q, Hu, Yi. Light-Triggered PEGylation/dePEGylation of the Nanocarriers for Enhanced Tumor Penetration. NANO LETTERS[J]. 2019, 19(6): 3671-3675, https://www.webofscience.com/wos/woscc/full-record/WOS:000471834900036.
[9] Wang, Dongqing, Zhou, Mengxue, Huang, Hui, Ruan, Lifo, Lu, Huiru, Zhang, Jiayu, Chen, Jun, Gao, Jimin, Chai, Zhifang, Hu, Yi. Gold Nanoparticle-Based Probe for Analyzing Mitochondrial Temperature in Living Cells. ACS APPLIED BIO MATERIALS[J]. 2019, 2(8): 3178-3182, [10] Huang, Hui, Zhou, Mengxue, Ruan, Lifo, Wang, Dongqing, Lu, Huiru, Zhang, Jiayu, Chen, Jun, Hu, Yi, Chai, Zhifang. AMPK mediates the neurotoxicity of iron oxide nanoparticles retained in mitochondria or lysosomes. METALLOMICS[J]. 2019, 11(7): 1200-1206, https://www.webofscience.com/wos/woscc/full-record/WOS:000475799400001.
[11] Wen, Kaikai, Xu, Xiaozhou, Chen, Jun, Lv, Lei, Wu, Lifen, Hu, Yi, Wu, Xiaoxi, Liu, Guozhen, Peng, Aidong, Huang, Hui. Triplet Tellurophene-Based Semiconducting Polymer Nanoparticles for Near-Infrared-Mediated Cancer Theranostics. ACS APPLIED MATERIALS & INTERFACES[J]. 2019, 11(19): 17884-17893, https://www.webofscience.com/wos/woscc/full-record/WOS:000468364500084.
[12] Ruan, Lifo, Wang, Miao, Zhou, Mengxue, Lu, Huiru, Zhang, Jiayu, Gao, Jimin, Chen, Jun, Hu, Yi. Doxorubicin-Metal Coordinated Micellar Nanoparticles for Intracellular Codelivery and Chemo/Chemodynamic Therapy in Vitro. ACS APPLIED BIO MATERIALS[J]. 2019, 2(11): 4703-4707, [13] Wang, Dongqing, Huang, Hui, Zhou, Mengxue, Lu, Huiru, Chen, Jun, Chang, YoungTae, Gao, Jimin, Chai, Zhifang, Hu, Yi. A thermoresponsive nanocarrier for mitochondria-targeted drug delivery. CHEMICAL COMMUNICATIONS[J]. 2019, 55(28): 4051-4054, [14] Dong, Tao, Wen, Kaikai, Chen, Jun, Xie, Jin, Fan, Weili, Ma, Han, Yang, Lei, Wu, Xiaoxi, Xu, Fujian, Peng, Aidong, Huang, Hui. Significant Enhancement of Photothermal and Photoacoustic Efficiencies for Semiconducting Polymer Nanoparticles through Simply Molecular Engineering. ADVANCED FUNCTIONAL MATERIALS[J]. 2018, 28(23): http://www.corc.org.cn/handle/1471x/2177504.
[15] Tian, Ye, Zhou, Mengxue, Shi, Haigang, Gao, Sijia, Xie, Guocheng, Zhu, Meng, Wu, Man, Chen, Jun, Niu, Zhongwei. Integration of Cell-Penetrating Peptides with Rod-like Bionanoparticles: Virus-Inspired Gene-Silencing Technology. NANO LETTERS[J]. 2018, 18(9): 5453-5460, https://www.webofscience.com/wos/woscc/full-record/WOS:000444793500016.
[16] Mengxue Zhou, Xingcai Zhang, Jin Xie, Rongxiang Qi, Huiru Lu, Stefano Leporatti, Jun Chen, Yi Hu. pH-Sensitive Poly(β-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells. Nanomaterials[J]. 2018, 8(11): https://doaj.org/article/7bbc1c41ab954409afef1dcd520f1ca7.
[17] Wen, Kaikai, Zhou, Mengxue, Lu, Huiru, Bi, Ying, Ruan, Lifo, Chen, Jun, Hu, Yi. Near-Infrared/pH Dual-Sensitive Nanocarriers for Enhanced Intracellular Delivery of Doxorubicin. ACS BIOMATERIALS SCIENCE & ENGINEERING[J]. 2018, 4(12): 4244-4254, [18] Gao, Hui, Bi, Ying, Wang, Xin, Wang, Miao, Zhou, Mengxue, Lu, Huiru, Gao, Jimin, Chen, Jun, Hu, Yi. Near-Infrared Guided Thermal-Responsive Nanomedicine against Orthotopic Superficial Bladder Cancer. ACS BIOMATERIALS SCIENCE & ENGINEERING[J]. 2017, 3(12): 3628-3634, http://www.corc.org.cn/handle/1471x/2177858.
[19] Liu, Yi, Li, Heping, Xie, Jin, Zhou, Mengxue, Huang, Hui, Lu, Huiru, Chai, Zhifang, Chen, Jun, Hu, Yi. Facile construction of mitochondria-targeting nanoparticles for enhanced phototherapeutic effects. BIOMATERIALS SCIENCE[J]. 2017, 5(5): 1022-1031, http://www.corc.org.cn/handle/1471x/2177189.
[20] Zhou, Mengxue, Wen, Kaikai, Bi, Ying, Lu, Huiru, Chen, Jun, Hu, Yi, Chai, Zhifang. The Application of Stimuli-responsive Nanocarriers for Targeted Drug Delivery. CURRENT TOPICS IN MEDICINAL CHEMISTRYnull. 2017, 17(20): 2319-2334, http://www.corc.org.cn/handle/1471x/2177248.
[21] Chen, Ganchao, Xie, Yusheng, Peltier, Raoul, Lei, Haipeng, Wang, Ping, Chen, Jun, Hu, Yi, Wang, Feng, Yao, Xi, Sun, Hongyan. Peptide-Decorated Gold Nanoparticles as Functional Nano-Capping Agent of Mesoporous Silica Container for Targeting Drug Delivery. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 8(18): 11204-11209, http://ir.ihep.ac.cn/handle/311005/247864.
[22] Gao, Hui, Bi, Ying, Chen, Jun, Peng, Lirong, Wen, Kaikai, Ji, Pan, Ren, Weifeng, Li, Xiaoqing, Zhang, Ning, Gao, Jimin, Chai, Zhifang, Hu, Yi. Near-Infrared Light-Triggered Switchable Nanoparticles for Targeted Chemo/Photothermal Cancer Therapy. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 8(24): 15103-15112, https://www.webofscience.com/wos/woscc/full-record/WOS:000378584800025.
[23] 赵宇亮. Near-infrared light remote-controlled intracellular anti-cancer drug delivery using thermo/pH sensitive nanovehicle. Acta biomaterialia[J]. 2015, 17: 201-209, http://dx.doi.org/10.1016/j.actbio.2015.01.026.
[24] Chen, Jun, Shi, Min, Liu, Pengmin, Ko, Alex, Zhong, Wen, Liao, WangJun, Xing, Malcolm M Q. Reducible polyamidoamine-magnetic iron oxide self-assembled nanoparticles for doxorubicin delivery. BIOMATERIALS[J]. 2014, 35(4): 1240-1248, http://dx.doi.org/10.1016/j.biomaterials.2013.10.057.
[25] Chen, Jun, Qiu, Xiaozhong, Wang, Leyu, Zhong, Wen, Kong, Jiming, Xing, Malcolm M Q. Free-Standing Cell Sheet Assembled with Ultrathin Extracellular Matrix as an Innovative Approach for Biomimetic Tissues. ADVANCED FUNCTIONAL MATERIALS[J]. 2014, 24(15): 2216-2223, https://www.webofscience.com/wos/woscc/full-record/WOS:000334281400010.
[26] Li, Xia, Zhou, Jin, Liu, Zhiqiang, Chen, Jun, Lu, Shuanghong, Sun, Hongyu, Li, Junjie, Lin, Qiuxia, Yang, Boguang, Duan, Cuimi, Xing, Malcolm Mengqiu, Wang, Changyong. A PNIPAAm-based thermosensitive hydrogel containing SWCNTs for stem cell transplantation in myocardial repair. BIOMATERIALS[J]. 2014, 35(22): 5679-5688, http://dx.doi.org/10.1016/j.biomaterials.2014.03.067.
[27] Zhou, Jin, Chen, Jun, Sun, Hongyu, Qiu, Xiaozhong, Mou, Yongchao, Liu, Zhiqiang, Zhao, Yuwei, Li, Xia, Han, Yao, Duan, Cuimi, Tang, Rongyu, Wang, Chunlan, Zhong, Wen, Liu, Jie, Luo, Ying, Xing, Malcolm Mengqiu, Wang, Changyong. Engineering the heart: Evaluation of conductive nanomaterials for improving implant integration and cardiac function. SCIENTIFIC REPORTS[J]. 2014, 4: https://www.webofscience.com/wos/woscc/full-record/WOS:000329848100023.
[28] Chen, Jun, Ouyang, Jun, Kong, Jiming, Zhong, Wen, Xing, Malcolm Mq. Photo-cross-linked and pH-Sensitive Biodegradable Micelles for Doxorubicin Delivery. ACS APPLIED MATERIALS & INTERFACES[J]. 2013, 5(8): 3108-3117, http://ir.ihep.ac.cn/handle/311005/224224.
[29] Wu, Chao, Li, Jing, Zhu, Yu, Chen, Jun, Oupicky, David. Opposing influence of intracellular and membrane thiols on the toxicity of reducible polycations. BIOMATERIALS[J]. 2013, 34(34): 8843-8850, http://dx.doi.org/10.1016/j.biomaterials.2013.07.095.
[30] Chen, Jun, Zehtabi, Fatemeh, Ouyang, Jun, Kong, Jiming, Zhong, Wen, Xing, Malcolm M Q. Reducible self-assembled micelles for enhanced intracellular delivery of doxorubicin. JOURNAL OF MATERIALS CHEMISTRY[J]. 2012, 22(15): 7121-7129, https://www.webofscience.com/wos/woscc/full-record/WOS:000301957300008.
[31] Chen, Jun, Xing, Malcolm M Q, Zhong, Wen. Degradable micelles based on hydrolytically degradable amphiphilic graft copolymers for doxorubicin delivery. POLYMER[J]. 2011, 52(4): 933-941, http://dx.doi.org/10.1016/j.polymer.2010.12.056.
[32] Chen Jun. Multifunctional Nanofibrous Scaffolds Based on Poly(L-lactic acid) and Poly(L-lactic acid)-Poly(ethylene glycol) for Tissue Engineering. International Journal of Nanomedicine. 2011, [33] Chen, Jun, Qiu, Xiaozhong, Ouyang, Jun, Kong, Jiming, Zhong, Wen, Xing, Malcolm M Q. pH and Reduction Dual-Sensitive Copolymeric Micelles for Intracellular Doxorubicin Delivery. BIOMACROMOLECULES[J]. 2011, 12(10): 3601-3611, https://www.webofscience.com/wos/woscc/full-record/WOS:000295602600027.
[34] Liu, Min, Chen, Jun, Xue, YaNan, Liu, WenMing, Zhuo, RenXi, Huang, ShiWen. Poly(beta-aminoester)s with Pendant Primary Amines for Efficient Gene Delivery. BIOCONJUGATE CHEMISTRY[J]. 2009, 20(12): 2317-2323, https://www.webofscience.com/wos/woscc/full-record/WOS:000272690100015.
[35] Chen, Jun, Wu, Chao, Oupicky, David. Bioreducible Hyperbranched Poly(amido amine)s for Gene Delivery. BIOMACROMOLECULES[J]. 2009, 10(10): 2921-2927, https://www.webofscience.com/wos/woscc/full-record/WOS:000270548700027.
[36] Chen, Jun, Huang, ShiWen, Lin, WenHai, Zhuo, RenXi. Tunable film degradation and sustained release of plasmid DNA from cleavable polycation/plasmid DNA multilayers under reductive conditions. SMALL[J]. 2007, 3(4): 636-643, https://www.webofscience.com/wos/woscc/full-record/WOS:000245560200016.
[37] Chen, Jun, Huang, ShiWen, Liu, Min, Zhuo, RenXi. Synthesis and degradation of poly(beta-aminoester) with pendant primary amine. POLYMER[J]. 2007, 48(3): 675-681, http://dx.doi.org/10.1016/j.polymer.2006.12.008.
[38] Chen, Jun, Xia, XiMing, Huang, ShiWen, Zhuo, RenXi. A cleavable-polycation template method for the fabrication of noncrosslinked, porous polyelectrolyte multilayered films. ADVANCED MATERIALS[J]. 2007, 19(7): 979-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000245720200017.

   

（ 1 ） 用于癌症诊断治疗的纳米载体的研究, 主持, 市地级, 2013-02--2016-01
（ 2 ） 近红外光敏多功能纳米载体的构建及药物靶向传递和成像研究, 主持, 国家级, 2014-01--2016-12
（ 3 ） 肝癌早期诊断用新型纳米材料的设计和构筑, 参与, 国家级, 2012-09--2015-08
（ 4 ） 基于胞内多种生物活性分子同时识别的荧光探针研究, 参与, 国家级, 2014-01--2018-12
（ 5 ） 中国科学院青年创新促进会, 主持, 部委级, 2015-01--2018-12
（ 6 ） 多重刺激响应性纳米药物的光热治疗与化疗的协同抗肿瘤研究, 主持, 国家级, 2016-01--2019-12

（1）光热/化疗联合免疫治疗纳米复合药物的抗肿瘤研究   2017 中国生物材料大会   2017-10-27
（2）Near-Infrared Guided Switchable Nanoparticles for Enhanced Targeted Therapy againstSubcutaneous and Orthotopic Bladder Cancer   美国材料学会2016秋季年会（Materials Research Society 2016 Fall Meeting）   2016-11-27
（3）In Vivo Evaluation of Near-Infrared Mediated Nanoplatforms for Targeted Chemo-Photothermal Therapy and Photothermo-Immunotherapy   第二届国际纳米药物大会   2016-10-18
（4）独立细胞膜片与层层组装细胞外基质制备仿生组织   2015 中国生物材料大会暨中美生物材料学会第三次专题论坛   2015-11-19
（5）还原降解性聚阳离子的细胞毒性的机理研究   中国毒理学会第七次全国毒理学大会   2015-10-25
（6）光致尺寸变换型纳米载体用于膀胱癌的靶向热化疗研究   2015年全国高分子学术论文报告会   2015-10-17
（7）Photothermally Size-Switchable Nanocarriers for Near Infrared Laser Guided Tumor Targeted Chemo/Photothermal Therapy    中国化学会第十五届胶体与界面化学会议   2015-07-17
（8）Photothermally Switchable Nanocarriers for Near Infrared Laser Guided Tumor Targeted Chemo/Photothermal Therapy    第10届中美纳米论坛   Ying Bi, Hui Gao, Yi Hu, Jun Chen,*   2015-06-26
（9）Preparation of Thermal/pH Dual Responsive Nanocarriers for Near Infrared Laser Guided Tumor Targeted Chemo/Photothermal Therapy    2015年美国生物材料学会年会（2015 Annual Meeting of Society for Biomaterials）   Ying Bi, Hui Gao, Aiping Lan, Yi Hu, Jun Chen*   2015-04-19
（10）Free-Standing Cell Sheet Assembled with Ultrathin Extracellular Matrix as an Innovative Approach for Biomimetic Tissues   第五届中欧生物材料大会   Peng Chen, Ying Bi, Xiaozhong Qiu, Yi Hu, Malcolm M. Q. Xing, Jun Chen*   2015-04-14
（11）Redution Sensitive Micellar Magnatic Nanoparticles for Cancer Targeted Chemotherapy   2015年纳米药物与纳米生物技术国际会议   Hui Zhou, Ying Bi, Jun Chen*, Yi Hu   2015-04-13
（12）Near-infrared light remote-enhanced tumor targeting chemo-photothermal co-therapy using thermo/pH sensitive nanovehicle   2015转化纳米医学国际学术研讨会   Ying Bi, Yi Hu*, Yuliang Zhao, Jimin Gao, Jun Chen*   2015-01-12
（13）同步辐射技术检测甲基汞在水稻中的转运   2014年北京同步辐射装置用户学术年会暨专家会   赵甲亭，陈俊，胡毅，高愈希    2014-08-12
（14）Preparation of Biocompatible Conductive Nanomaterials for Improving Myocardial Repair   2014年国际高分子化学学术研讨会   Ying Bi, Xiaohan Xu, Yanping Qin, Hui Zhou, Yi Hu, Jun Chen,   2014-06-04
（15）Controlled release of Doxorubicin from pH and reducing agents dual responsive PEG-Reducible Poly(beta-amino ester)s-PEG micelles   239届美国化学学会年会   Jun Chen, Shufei Zhou and Wen Zhong   2010-05-20
（16）Effect of intracellular glutathione levels on the cytotoxicity of bioreducible polycations   20届美国基因治疗学会年会   Chao Wu, Jun Chen, Jing Li, David Oupicky   2009-05-27
（17）Synthesis and characterization of hyperbranched poly(amido amine)s for gene delivery   第35届美国控制释放学会年会   Ye-Zi You, Jun Chen, Devika S Manickam, Qing-Hui Zhou, Lei Wan, Guangzhao Mao and David Oupicky   2008-07-12
（18）聚酯-胺阳离子/质粒DNA 多层膜的构建及其控制释放DNA   2005 全国高分子学术论文报告会   陈俊，黄世文，林文海，卓仁禧   2005-10-18

动物体内实验合作单位：

温州医科大学检验医学院 高基民 教授
哈尔滨医科大学第一附属医院 刘宏宇 院长
天津医科大学 张宁教授
南方医科大学 欧阳均 教授


材料实验合作单位：

中国科学院大学材料科学与光电技术学院 黄辉 教授
美国德州农工大学化学系 方磊 助理教授
中国科学院宁波材料技术与工程研究所 黄又举 副研究员

已指导学生

周梦雪  博士研究生  070301-无机化学