围绕生物医学关键问题，发展基于高分子的生物医用新策略。重点关注生物医用材料的可控合成，其中多个聚合物已经商业化并广泛用于生物医用研究；首创性证明肿瘤细胞线粒体的高温特性，并以此发展响应性药物靶向递送策略。目前的研究兴趣集中于：（1）肿瘤诊疗中纳米技术的基础研究与应用; （2）基于生物医用材料的基础研究及应用。

博士生每年一名

硕士生每年一名

070301-无机化学
070305-高分子化学与物理
0703J1-纳米科学与技术

纳米材料，生物材料
抗肿瘤治疗，基因治疗

2001-09--2007-06   武汉大学   理学博士
1997-09--2001-06   武汉大学   理学学士

Ph.D

陈俊，博士，中国共产党党员。研究员，博士生导师。2007年于武汉大学获理学博士学位，师从卓仁禧院士（中国科学院院士）、黄世文教授；2007-2012年作为博士后或助理研究员在美国韦恩州立大学、加拿大曼尼托巴大学工作，合作导师分别是David Oupicky教授（长江学者），Malcolm Xing教授（加拿大工程院院士），Wen Zhong教授；2013年加入中国科学院高能物理研究所，工作至今。一直致力于开发新型生物医用材料的研究，已有多个材料商业化并在药物递送、组织工程等领域得到初步应用。在生物材料领域重要学术期刊，如Adv. Mater., Nano Lett., Nano Today, Adv. Funct. Mater., Small, Biomaterials等，共发表SCI论文60余篇，研究工作引起国际国内同行的广泛关注和评价，被引2000余次。近五年主持和参与国家自然科学基金及其他省部级项目6项。以第一发明人身份，已获授权中国发明专利5项。中国科学院青年创新促进会（中科院青促会）会员，中科院青促会数理学会第二届委员会委员，中科院青促会北京分会第二届委员会委员，中科院高能所优秀青年人才，高能所多学科中心学术委员会成员。

2021-10~现在, 中国科学院高能物理研究所, 研究员
2013-02~2021-09,中国科学院高能物理研究所, 副研究员
2012-02~2013-01,University of Manitoba, 助理研究员
2009-02~2012-01,University of Manitoba, 博士后
2007-09~2008-11,Wayne State University, 博士后

   

（1） 中科院高能物理研究优秀青年, 研究所（学校）, 2018
（2） 中科院青年创新促进会, 特等奖, 部委级, 2015

[1] 陈俊, 毕颖, 胡毅. 一种电荷转换纳米颗粒及其制备方法. CN: CN106511298A, 2017-03-22.

[2] 陈俊, 周晖, 齐荣翔, 胡毅. 一种两亲性聚合物以及由其形成的磁性胶束纳米载体和其用途. CN: CN106519211A, 2017-03-22.

[3] 陈俊, 谢进, 胡毅. 一种粒径可控的阿霉素纳米颗粒及其制备方法. CN: CN106511297A, 2017-03-22.

[4] 陈俊, 温凯凯, 胡毅. 一种近红外光触发释放化疗药物的纳米载体及其制备方法. CN: CN106512000A, 2017-03-22.

[5] 陈俊, 刘毅, 胡毅. 一种聚乙二醇/聚酰胺胺共聚物、其制备方法及包含该共聚物的两亲性siRNA载体. CN: CN106519221A, 2017-03-22.

   

[1] Zhang, Jiayu, Song, Xiaofang, Xia, Miaoren, Xue, Yanan, Zhou, Mengxue, Ruan, Lifo, Lu, Huiru, Chen, Jun, Wang, Dongqi, Chai, Zhifang, Hu, Yi. The proximity of the G-quadruplex to hemin impacts the intrinsic DNAzyme activity in mitochondria. CHEMICAL COMMUNICATIONS[J]. 2021, 57(24): 3038-3041, https://www.webofscience.com/wos/woscc/full-record/WOS:000631568300013.
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[13] Wang, Dongqing, Huang, Hui, Zhou, Mengxue, Lu, Huiru, Chen, Jun, Chang, YoungTae, Gao, Jimin, Chai, Zhifang, Hu, Yi. A thermoresponsive nanocarrier for mitochondria-targeted drug delivery. CHEMICAL COMMUNICATIONS[J]. 2019, 55(28): 4051-4054, [14] Chen, Jun. Photo/chemo/immunotherapy of primary tumor and remission of metastasis by using cascade upconversion nanoparticles. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETYnull. 2018, 255: http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000435539902328.
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[18] Mengxue Zhou, Xingcai Zhang, Jin Xie, Rongxiang Qi, Huiru Lu, Stefano Leporatti, Jun Chen, Yi Hu. pH-Sensitive Poly(β-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells. Nanomaterials[J]. 2018, 8(11): https://doaj.org/article/7bbc1c41ab954409afef1dcd520f1ca7.
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[20] 黄辉, 陈俊, 卢会茹, 周梦雪, 胡毅, 柴之芳. 帕金森病中的关键金属元素. 化学进展[J]. 2018, 30(10): 1592-1600, http://lib.cqvip.com/Qikan/Article/Detail?id=676692954.
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[57] Chen, Jun, Xia, XiMing, Huang, ShiWen, Zhuo, RenXi. A cleavable-polycation template method for the fabrication of noncrosslinked, porous polyelectrolyte multilayered films. ADVANCED MATERIALS[J]. 2007, 19(7): 979-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000245720200017.

   

（ 1 ） 用于癌症诊断治疗的纳米载体的研究, 负责人, 研究所自选, 2013-02--2016-01
（ 2 ） 近红外光敏多功能纳米载体的构建及药物靶向传递和成像研究, 负责人, 国家任务, 2014-01--2016-12
（ 3 ） 肝癌早期诊断用新型纳米材料的设计和构筑, 参与, 国家任务, 2012-09--2015-08
（ 4 ） 基于胞内多种生物活性分子同时识别的荧光探针研究, 参与, 国家任务, 2014-01--2018-12
（ 5 ） 中国科学院青年创新促进会, 负责人, 中国科学院计划, 2015-01--2018-12
（ 6 ） 多重刺激响应性纳米药物的光热治疗与化疗的协同抗肿瘤研究, 负责人, 国家任务, 2016-01--2019-12
（ 7 ） 基于趋化因子受体阻断剂的多功能纳米药物用于光动力抗肿瘤研究, 参与, 地方任务, 2021-01--2023-12
（ 8 ） 构筑分级靶向型纳米递送载体用于肿瘤硼中子俘获治疗研究, 负责人, 地方任务, 2022-10--2025-09

（1）光热/化疗联合免疫治疗纳米复合药物的抗肿瘤研究   2017 中国生物材料大会   2017-10-27
（2）Near-Infrared Guided Switchable Nanoparticles for Enhanced Targeted Therapy againstSubcutaneous and Orthotopic Bladder Cancer   美国材料学会2016秋季年会（Materials Research Society 2016 Fall Meeting）   2016-11-27
（3）In Vivo Evaluation of Near-Infrared Mediated Nanoplatforms for Targeted Chemo-Photothermal Therapy and Photothermo-Immunotherapy   第二届国际纳米药物大会   2016-10-18
（4）独立细胞膜片与层层组装细胞外基质制备仿生组织   2015 中国生物材料大会暨中美生物材料学会第三次专题论坛   2015-11-19
（5）还原降解性聚阳离子的细胞毒性的机理研究   中国毒理学会第七次全国毒理学大会   2015-10-25
（6）光致尺寸变换型纳米载体用于膀胱癌的靶向热化疗研究   2015年全国高分子学术论文报告会   2015-10-17
（7）Photothermally Size-Switchable Nanocarriers for Near Infrared Laser Guided Tumor Targeted Chemo/Photothermal Therapy    中国化学会第十五届胶体与界面化学会议   2015-07-17
（8）Photothermally Switchable Nanocarriers for Near Infrared Laser Guided Tumor Targeted Chemo/Photothermal Therapy    第10届中美纳米论坛   Ying Bi, Hui Gao, Yi Hu, Jun Chen,*   2015-06-26
（9）Preparation of Thermal/pH Dual Responsive Nanocarriers for Near Infrared Laser Guided Tumor Targeted Chemo/Photothermal Therapy    2015年美国生物材料学会年会（2015 Annual Meeting of Society for Biomaterials）   Ying Bi, Hui Gao, Aiping Lan, Yi Hu, Jun Chen*   2015-04-19
（10）Free-Standing Cell Sheet Assembled with Ultrathin Extracellular Matrix as an Innovative Approach for Biomimetic Tissues   第五届中欧生物材料大会   Peng Chen, Ying Bi, Xiaozhong Qiu, Yi Hu, Malcolm M. Q. Xing, Jun Chen*   2015-04-14
（11）Redution Sensitive Micellar Magnatic Nanoparticles for Cancer Targeted Chemotherapy   2015年纳米药物与纳米生物技术国际会议   Hui Zhou, Ying Bi, Jun Chen*, Yi Hu   2015-04-13
（12）Near-infrared light remote-enhanced tumor targeting chemo-photothermal co-therapy using thermo/pH sensitive nanovehicle   2015转化纳米医学国际学术研讨会   Ying Bi, Yi Hu*, Yuliang Zhao, Jimin Gao, Jun Chen*   2015-01-12
（13）同步辐射技术检测甲基汞在水稻中的转运   2014年北京同步辐射装置用户学术年会暨专家会   赵甲亭，陈俊，胡毅，高愈希    2014-08-12
（14）Preparation of Biocompatible Conductive Nanomaterials for Improving Myocardial Repair   2014年国际高分子化学学术研讨会   Ying Bi, Xiaohan Xu, Yanping Qin, Hui Zhou, Yi Hu, Jun Chen,   2014-06-04
（15）Controlled release of Doxorubicin from pH and reducing agents dual responsive PEG-Reducible Poly(beta-amino ester)s-PEG micelles   239届美国化学学会年会   Jun Chen, Shufei Zhou and Wen Zhong   2010-05-20
（16）Effect of intracellular glutathione levels on the cytotoxicity of bioreducible polycations   20届美国基因治疗学会年会   Chao Wu, Jun Chen, Jing Li, David Oupicky   2009-05-27
（17）Synthesis and characterization of hyperbranched poly(amido amine)s for gene delivery   第35届美国控制释放学会年会   Ye-Zi You, Jun Chen, Devika S Manickam, Qing-Hui Zhou, Lei Wan, Guangzhao Mao and David Oupicky   2008-07-12
（18）聚酯-胺阳离子/质粒DNA 多层膜的构建及其控制释放DNA   2005 全国高分子学术论文报告会   陈俊，黄世文，林文海，卓仁禧   2005-10-18

动物体内实验合作单位：

温州医科大学检验医学院 高基民 教授
哈尔滨医科大学第一附属医院 刘宏宇 院长
天津医科大学 张宁教授
南方医科大学 欧阳均 教授


材料实验合作单位：

中国科学院大学材料科学与光电技术学院 黄辉 教授
美国德州农工大学化学系 方磊 助理教授
中国科学院宁波材料技术与工程研究所 黄又举 副研究员

已指导学生

周梦雪  博士研究生  070301-无机化学