生物医用材料开发与疾病智能诊疗技术研究，聚焦：

1、生物医用高分子。

2、智能生物材料设计与精准递送系统。

3、基于多组学（基因组、代谢组、影像组）分析的纳米生物效应研究。

博士生每年一名

硕士生每年一名

070301-无机化学
070305-高分子化学与物理
0703J1-纳米科学与技术

纳米材料，生物材料
抗肿瘤治疗，基因治疗

2001-09--2007-06   武汉大学   理学博士
1997-09--2001-06   武汉大学   理学学士

Ph.D

陈俊，博士，中国共产党党员。研究员，博士生导师。2007年于武汉大学获理学博士学位，师从卓仁禧院士（中国科学院院士）、黄世文教授；2007-2012年作为博士后或助理研究员在美国韦恩州立大学、加拿大曼尼托巴大学工作，合作导师分别是David Oupicky教授（长江学者），Malcolm Xing教授（加拿大工程院院士），Wen Zhong教授；2013年加入中国科学院高能物理研究所，工作至今。一直致力于开发新型生物医用材料的研究，已有多个材料商业化并在药物递送、组织工程等领域得到初步应用。在生物材料领域重要学术期刊，如Adv. Mater., Nano Lett., Nano Today, Adv. Funct. Mater., Small, Biomaterials等，共发表SCI论文60余篇，研究工作引起国际国内同行的广泛关注和评价，被引2000余次。近五年主持和参与国家自然科学基金及其他省部级项目6项。以第一发明人身份，已获授权中国发明专利5项。中国科学院青年创新促进会（中科院青促会）会员，中科院青促会数理学会第二届委员会委员，中科院青促会北京分会第二届委员会委员，中科院高能所优秀青年人才，高能所多学科中心学术委员会成员。

2021-10~现在, 中国科学院高能物理研究所, 研究员
2013-02~2021-09,中国科学院高能物理研究所, 副研究员
2012-02~2013-01,University of Manitoba, 助理研究员
2009-02~2012-01,University of Manitoba, 博士后
2007-09~2008-11,Wayne State University, 博士后

   

（1） Protocol for forming G-quadruplexes from double-stranded DNA during transcription, Star Protocols, 2025, 
（2） A metal-drug self-delivery nanomedicine alleviates tumor immunosuppression to potentiate synergistic chemo/chemodynamic therapy against hepatocellular carcinoma, Fundamental Research, 2025, 
（3） Reversing Photodynamic Therapy-Induced Tumor Metabolic Symbiosis and Immune Evasion Delivers a Two-Punch Attack on Tumors, Small, 2025, 
（4） Mitochondria-targeted piezoelectric catalyst regulate pyroptosis and efferocytosis for enhancing the osteosarcoma immunogenic death, Chemical Engineering Journal, 2025, 
（5） Activated Dendritic Cell Membrane-Engineered Nanoformulation of Metallo-Immunomodulators as Lysosome-Targeted Adjuvants for Synergistic Cancer Immunotherapy, Advanced Healthcare Materials, 2025, 
（6） Boosting chemotherapy of bladder cancer cells by ferroptosis using intelligent magnetic targeting nanoparticles, Colloids and Surfaces B: Biointerfaces, 2024, 
（7） Emerging nanomedicine strategies for hepatocellular carcinoma therapy, iMetaOmics, 2024, 
（8） The potential of collagen-based materials for wound management, Materials Today Chemistry, 2024, 
（9） Poly(b-amino ester)s-based nanovehicles: Structural regulation and gene delivery, MOLECULAR THERAPY - NUCLEIC ACIDS, 2023, 第 8 作者  通讯作者
（10） Oversized liposomes boost macrophage-targeted RNA delivery to regulate macrophage polarity, MOLECULAR THERAPY - NUCLEIC ACIDS, 2023, 第 3 作者  通讯作者
（11） The nanoformula of zoledronic acid and calcium carbonate targets osteoclasts and reverses osteoporosis, BIOMATERIALS, 2023, 第 9 作者  通讯作者
（12） A GM-CSF and DOX co-delivery nanoplatform modulates macrophage polarization to promote tumor suppression, JCIS OPEN, 2023, 第 8 作者  通讯作者
（13） Chemical transformation and cytotoxicity of iron oxide nanoparticles (IONPs) accumulated in mitochondria, TALANTA, 2023, 第 10 作者
（14） Colostrum-derived exosome based system: The next-generation nucleic acid delivery system with enhanced biosafety?, MOLECULAR THERAPY-NUCLEIC ACIDS, 2022, 第 3 作者  通讯作者
（15） Circular mRNAs: More stable RNAs lead to more persistent protein expression, MOLECULAR THERAPY NUCLEIC ACIDS, 2022, 第 2 作者  通讯作者
（16） Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer, BIOACTIVE MATERIALS, 2022, 第 2 作者
（17） Tumor-Penetrating and Mitochondria-Targeted Drug Delivery Overcomes Doxorubicin Resistance in Lung Cancer, CHINESE JOURNAL OF POLYMER SCIENCE, 2022, 第 8 作者  通讯作者
（18） Bi-based visible light-driven nano-photocatalyst: the design, synthesis, and its application in pollutant governance and energy development, NANO TODAY, 2022, 第 6 作者
（19） The proximity of the G-quadruplex to hemin impacts the intrinsic DNAzyme activity in mitochondria, CHEMICAL COMMUNICATIONS, 2021, 第 8 作者  通讯作者
（20） Metal-drug nanoparticles-mediated osteolytic microenvironment regulation for enhanced radiotherapy of orthotopic osteosarcoma, CHEMICAL ENGINEERING JOURNAL, 2021, 第 9 作者  通讯作者
（21） D-arginine-loaded metal-organic frameworks nanoparticles sensitize osteosarcoma to radiotherapy, BIOMATERIALS, 2021, 第 9 作者  通讯作者
（22） Combating Pseudomonas aeruginosa Biofilms by a Chitosan-PEG-Peptide Conjugate via Changes in Assembled Structure, ACS APPLIED MATERIALS & INTERFACES, 2020, 第 2 作者
（23） Photo/thermo-responsive and size-switchable nanoparticles for chemo-photothermal therapy against orthotopic breast cancer, NANOSCALE ADVANCES, 2020, 第 7 作者  通讯作者
（24） A surface convertible nanoplatform with enhanced mitochondrial targeting for tumor photothermal therapy, COLLOIDS AND SURFACES B-BIOINTERFACES, 2020, 第 8 作者  通讯作者
（25） Thermoresponsive drug delivery to mitochondria in vivo, CHEMICAL COMMUNICATIONS, 2019, 第 3 作者
（26） Light-Triggered PEGylation/dePEGylation of the Nanocarriers for Enhanced Tumor Penetration, NANO LETTERS, 2019, 第 5 作者  通讯作者
（27） Gold Nanoparticle-Based Probe for Analyzing Mitochondrial Temperature in Living Cells, ACS APPLIED BIO MATERIALS, 2019, 第 7 作者  通讯作者
（28） AMPK mediates the neurotoxicity of iron oxide nanoparticles retained in mitochondria or lysosomes, METALLOMICS, 2019, 第 7 作者  通讯作者
（29） Doxorubicin-Metal Coordinated Micellar Nanoparticles for Intracellular Codelivery and Chemo/Chemodynamic Therapy in Vitro, ACS APPLIED BIO MATERIALS, 2019, 第 7 作者  通讯作者
（30） Triplet Tellurophene-Based Semiconducting Polymer Nanoparticles for Near-Infrared-Mediated Cancer Theranostics, ACS APPLIED MATERIALS & INTERFACES, 2019, 第 3 作者
（31） A thermoresponsive nanocarrier for mitochondria-targeted drug delivery, CHEMICAL COMMUNICATIONS, 2019, 第 5 作者  通讯作者
（32） Photo/chemo/immunotherapy of primary tumor and remission of metastasis by using cascade upconversion nanoparticles, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 第 1 作者
（33） In vivo evaluation of near-infrared mediated nanoplatforms for targeted chemo-photothermal therapy and photothermo-immunotherapy, NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY AND MEDICINE, 2018, 第 1 作者
（34） Significant Enhancement of Photothermal and Photoacoustic Efficiencies for Semiconducting Polymer Nanoparticles through Simply Molecular Engineering, ADVANCED FUNCTIONAL MATERIALS, 2018, 第 3 作者
（35） Integration of Cell-Penetrating Peptides with Rod-like Bionanoparticles: Virus-Inspired Gene-Silencing Technology, NANO LETTERS, 2018, 第 8 作者
（36） pH-Sensitive Poly(��-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells, NANOMATERIALS, 2018, 第 7 作者  通讯作者
（37） Neurotoxicity of Key Metals in Parkinson's Disease, PROGRESS IN CHEMISTRY, 2018, 第 2 作者
（38） 帕金森病中的关键金属元素, Neurotoxicity of Key Metals in Parkinson��� s Disease, 化学进展, 2018, 第 2 作者
（39） pH-Sensitive Poly(beta-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells, NANOMATERIALS, 2018, 第 7 作者  通讯作者
（40） Near-infrared enhanced Fenton reaction mediated by cascade upconversion nanoparticles in combination with immunotherapy for elimination of primary tumor and remission of metastasis, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 第 1 作者
（41） Near-Infrared/pH Dual-Sensitive Nanocarriers for Enhanced Intracellular Delivery of Doxorubicin, ACS BIOMATERIALS SCIENCE & ENGINEERING, 2018, 第 6 作者  通讯作者
（42） A facile construction of pH-sensitive shell-sheddable supramolecular nanoassembly codelivery anticancer drugs to combat drug resistance, JOURNAL OF CONTROLLED RELEASE, 2017, 第 6 作者
（43） Two mtor inhibitors, rapamycin and torin 1, differentially regulate iron-induced generation of mitochondrial ros, BIOMETALS, 2017, 第 2 作者
（44） Near-infrared guided thermal-responsive nanomedicine against orthotopic superficial bladder cancer, ACS BIOMATERIALS SCIENCE & ENGINEERING, 2017, 第 8 作者  通讯作者
（45） Iron modulates the activity of monoamine oxidase b in sh-sy5y cells, BIOMETALS, 2017, 第 2 作者
（46） Mtor signaling in parkinson's disease, NEUROMOLECULAR MEDICINE, 2017, 
（47） Mitochondria-targeted nanocarriers using hyperbranched polycations wrapped carbon nanotubes for augment photodynamic therapeutic effects, JOURNAL OF CONTROLLED RELEASE, 2017, 第 6 作者
（48） Facile construction of mitochondria-targeting nanoparticles for enhanced phototherapeutic effects, BIOMATERIALS SCIENCE, 2017, 第 8 作者  通讯作者
（49） Iron-induced generation of mitochondrial ROS depends on AMPK activity, BIOMETALS, 2017, 第 2 作者
（50） In vivo chemo/photothermal therapy using near-infrared light triggered switchable nanoparticles against subcutaneous and orthotopic superficial bladder cancer, JOURNAL OF CONTROLLED RELEASE, 2017, 第 7 作者
（51） The Application of Stimuli-responsive Nanocarriers for Targeted Drug Delivery, CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2017, 第 5 作者  通讯作者
（52） Peptide-Decorated Gold Nanoparticles as Functional Nano-Capping Agent of Mesoporous Silica Container for Targeting Drug Delivery, ACS APPLIED MATERIALS & INTERFACES, 2016, 第 6 作者
（53） AMPK Inhibition Enhances the Neurotoxicity of Cu(II) in SH-SY5Y Cells, NEUROTOXICITY RESEARCH, 2016, 第 3 作者
（54） A thiol fluorescent probe reveals the intricate modulation of cysteine's reactivity by Cu(II), TALANTA, 2016, 第 3 作者
（55） Characterization and Preclinical Perspectives of Organic Small Molecule Drug Metabolites in Drug-drug Interactions, CURRENT ORGANIC CHEMISTRY, 2016, 第 2 作者
（56） Reduction sensitive micellar magnetic nanoparticles for cancer targeted chemotherapy, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2016, 第 5 作者
（57） Near-Infrared Light-Triggered Switchable Nanoparticles for Targeted Chemo/Photothermal Cancer Therapy, ACS APPLIED MATERIALS & INTERFACES, 2016, 第 3 作者  通讯作者
（58） Near-infrared light remote-controlled intracellular anti-cancer drug delivery using thermo/pH sensitive nanovehicle, ACTA BIOMATERIALIA, 2015, 
（59） Metal ions modulate the conformation and stability of a G-quadruplex with or without a small-molecule ligand, METALLOMICS, 2015, 第 3 作者
（60） Reducible polyamidoamine-magnetic iron oxide self-assembled nanoparticles for doxorubicin delivery, BIOMATERIALS, 2014, 第 1 作者
（61） A PNIPAAm-based thermosensitive hydrogel containing SWCNTs for stem cell transplantation in myocardial repair, BIOMATERIALS, 2014, 第 4 作者
（62） Free-Standing Cell Sheet Assembled with Ultrathin Extracellular Matrix as an Innovative Approach for Biomimetic Tissues, ADVANCED FUNCTIONAL MATERIALS, 2014, 第 1 作者  通讯作者
（63） Essential role of AKT in tumor cells addicted to FGFR, ANTI-CANCER DRUGS, 2014, 第 4 作者
（64） Engineering the heart: Evaluation of conductive nanomaterials for improving implant integration and cardiac function, SCIENTIFIC REPORTS, 2014, 第 2 作者
（65） Photo-cross-linked and pH-Sensitive Biodegradable Micelles for Doxorubicin Delivery, ACS APPLIED MATERIALS & INTERFACES, 2013, 第 1 作者
（66） Opposing influence of intracellular and membrane thiols on the toxicity of reducible polycations, BIOMATERIALS, 2013, 第 4 作者
（67） Reducible self-assembled micelles for enhanced intracellular delivery of doxorubicin, JOURNAL OF MATERIALS CHEMISTRY, 2012, 第 1 作者
（68） Degradable micelles based on hydrolytically degradable amphiphilic graft copolymers for doxorubicin delivery, POLYMER, 2011, 第 1 作者
（69） Multifunctional Nanofibrous Scaffolds Based on Poly(L-lactic acid) and Poly(L-lactic acid)-Poly(ethylene glycol) for Tissue Engineering, International Journal of Nanomedicine, 2011, 第 1 作者
（70） pH and Reduction Dual-Sensitive Copolymeric Micelles for Intracellular Doxorubicin Delivery, BIOMACROMOLECULES, 2011, 第 1 作者
（71） Poly(beta-aminoester)s with Pendant Primary Amines for Efficient Gene Delivery, BIOCONJUGATE CHEMISTRY, 2009, 第 2 作者
（72） Bioreducible Hyperbranched Poly(amido amine)s for Gene Delivery, BIOMACROMOLECULES, 2009, 第 1 作者
（73） Tunable film degradation and sustained release of plasmid DNA from cleavable polycation/plasmid DNA multilayers under reductive conditions, SMALL, 2007, 第 1 作者
（74） Synthesis and degradation of poly(beta-aminoester) with pendant primary amine, POLYMER, 2007, 第 1 作者
（75） A cleavable-polycation template method for the fabrication of noncrosslinked, porous polyelectrolyte multilayered films, ADVANCED MATERIALS, 2007, 第 1 作者

动物体内实验合作单位：

温州医科大学检验医学院 高基民 教授
哈尔滨医科大学第一附属医院 刘宏宇 院长
天津医科大学 张宁教授
南方医科大学 欧阳均 教授


材料实验合作单位：

中国科学院大学材料科学与光电技术学院 黄辉 教授
美国德州农工大学化学系 方磊 助理教授
中国科学院宁波材料技术与工程研究所 黄又举 副研究员

已指导学生

周梦雪  博士研究生  070301-无机化学  

蔡霄梦  博士研究生  0703Z2-生物无机化学  

窦瑞  博士研究生  0703Z2-生物无机化学  

现指导学生

唐嘉若  博士研究生  070301-无机化学