基本信息

陈俊  男  博导  中国科学院高能物理研究所
电子邮件: chenjun@ihep.ac.cn
通信地址: 北京市石景山区玉泉路19号(乙)中国科学院高能物理研究所
邮政编码: 100049

研究领域

围绕生物医学关键问题,发展基于高分子的生物医用新策略。重点关注生物医用材料的可控合成,其中多个聚合物已经商业化并广泛用于生物医用研究;首创性证明肿瘤细胞线粒体的高温特性,并以此发展响应性药物靶向递送策略。目前的研究兴趣集中于:(1)肿瘤诊疗中纳米技术的基础研究与应用; (2)基于生物医用材料的基础研究及应用。


招生信息

博士生每年一名

硕士生每年一名


招生专业
070301-无机化学
070305-高分子化学与物理
0703J1-纳米科学与技术
招生方向
纳米材料,生物材料
抗肿瘤治疗,基因治疗

教育背景

2001-09--2007-06   武汉大学   理学博士
1997-09--2001-06   武汉大学   理学学士
学位

Ph.D

工作经历

陈俊,博士,中国共产党党员。研究员,博士生导师。2007年于武汉大学获理学博士学位,师从卓仁禧院士(中国科学院院士)、黄世文教授;2007-2012年作为博士后或助理研究员在美国韦恩州立大学、加拿大曼尼托巴大学工作,合作导师分别是David Oupicky教授(长江学者),Malcolm Xing教授(加拿大工程院院士),Wen Zhong教授;2013年加入中国科学院高能物理研究所,工作至今。一直致力于开发新型生物医用材料的研究,已有多个材料商业化并在药物递送、组织工程等领域得到初步应用。在生物材料领域重要学术期刊,如Adv. Mater., Nano Lett., Nano Today, Adv. Funct. Mater., Small, Biomaterials等,共发表SCI论文60余篇,研究工作引起国际国内同行的广泛关注和评价,被引2000余次。近五年主持和参与国家自然科学基金及其他省部级项目6项。以第一发明人身份,已获授权中国发明专利5项。中国科学院青年创新促进会(中科院青促会)会员,中科院青促会数理学会第二届委员会委员,中科院青促会北京分会第二届委员会委员,中科院高能所优秀青年人才,高能所多学科中心学术委员会成员。



工作简历
2021-10~现在, 中国科学院高能物理研究所, 研究员
2013-02~2021-09,中国科学院高能物理研究所, 副研究员
2012-02~2013-01,University of Manitoba, 助理研究员
2009-02~2012-01,University of Manitoba, 博士后
2007-09~2008-11,Wayne State University, 博士后

专利与奖励

   
奖励信息
(1) 中科院高能物理研究优秀青年, 研究所(学校), 2018
(2) 中科院青年创新促进会, 特等奖, 部委级, 2015
专利成果
[1] 陈俊, 毕颖, 胡毅. 一种电荷转换纳米颗粒及其制备方法. CN: CN106511298A, 2017-03-22.

[2] 陈俊, 周晖, 齐荣翔, 胡毅. 一种两亲性聚合物以及由其形成的磁性胶束纳米载体和其用途. CN: CN106519211A, 2017-03-22.

[3] 陈俊, 谢进, 胡毅. 一种粒径可控的阿霉素纳米颗粒及其制备方法. CN: CN106511297A, 2017-03-22.

[4] 陈俊, 温凯凯, 胡毅. 一种近红外光触发释放化疗药物的纳米载体及其制备方法. CN: CN106512000A, 2017-03-22.

[5] 陈俊, 刘毅, 胡毅. 一种聚乙二醇/聚酰胺胺共聚物、其制备方法及包含该共聚物的两亲性siRNA载体. CN: CN106519221A, 2017-03-22.

出版信息

   
发表论文
[1] Zhang, Jiayu, Song, Xiaofang, Xia, Miaoren, Xue, Yanan, Zhou, Mengxue, Ruan, Lifo, Lu, Huiru, Chen, Jun, Wang, Dongqi, Chai, Zhifang, Hu, Yi. The proximity of the G-quadruplex to hemin impacts the intrinsic DNAzyme activity in mitochondria. CHEMICAL COMMUNICATIONS[J]. 2021, 57(24): 3038-3041, https://www.webofscience.com/wos/woscc/full-record/WOS:000631568300013.
[2] Geng, Huan, Zhou, Mengxue, Li, Bin, Liu, Liang, Yang, Xu, Wen, Yinxian, Yu, Haijun, Wang, Hui, Chen, Jun, Chen, Liaobin. Metal-drug nanoparticles-mediated osteolytic microenvironment regulation for enhanced radiotherapy of orthotopic osteosarcoma. CHEMICAL ENGINEERING JOURNAL[J]. 2021, 417: http://dx.doi.org/10.1016/j.cej.2020.128103.
[3] Du, Chuanchao, Zhou, Mengxue, Jia, Fei, Ruan, Lifo, Lu, Huiru, Zhang, Jiayu, Zhu, Bin, Liu, Xiaoguang, Chen, Jun, Chai, Zhifang, Hu, Yi. D-arginine-loaded metal-organic frameworks nanoparticles sensitize osteosarcoma to radiotherapy. BIOMATERIALS[J]. 2021, 269: http://dx.doi.org/10.1016/j.biomaterials.2020.120642.
[4] Ju, Xiaoyan, Chen, Jun, Zhou, Mengxue, Zhu, Meng, Li, Zhuang, Gao, Sijia, Ou, Jinzhao, Xu, Dandan, Wu, Man, Jiang, Shidong, Hu, Yi, Tian, Ye, Niu, Zhongwei. Combating Pseudomonas aeruginosa Biofilms by a Chitosan-PEG-Peptide Conjugate via Changes in Assembled Structure. ACS APPLIED MATERIALS & INTERFACES[J]. 2020, 12(12): 13731-13738, https://www.webofscience.com/wos/woscc/full-record/WOS:000526552100014.
[5] Bi, Ying, Wang, Miao, Peng, Lirong, Ruan, Lifo, Zhou, Mengxue, Hu, Yi, Chen, Jun, Gao, Jimin. Photo/thermo-responsive and size-switchable nanoparticles for chemo-photothermal therapy against orthotopic breast cancer. NANOSCALE ADVANCES[J]. 2020, 2(1): 210-213, http://dx.doi.org/10.1039/c9na00652d.
[6] Wang, Miao, Ruan, Lifo, Zheng, Tianyu, Wang, Dongqing, Zhou, Mengxue, Lu, Huiru, Gao, Jimin, Chen, Jun, Hu, Yi. A surface convertible nanoplatform with enhanced mitochondrial targeting for tumor photothermal therapy. COLLOIDS AND SURFACES B-BIOINTERFACES[J]. 2020, 189: http://dx.doi.org/10.1016/j.colsurfb.2020.110854.
[7] Ruan, Lifo, Zhou, Mengxue, Chen, Jun, Huang, Hui, Zhang, Jiayu, Sun, Hongyan, Chai, Zhifang, Hu, Yi. Thermoresponsive drug delivery to mitochondria in vivo. CHEMICAL COMMUNICATIONS[J]. 2019, 55(97): 14645-14648, http://dx.doi.org/10.1039/c9cc07538k.
[8] Zhou, Mengxue, Huang, Hui, Wang, Dongqing, Lu, Huiru, Chen, Jun, Chai, Zhifang, Yao, Shao Q, Hu, Yi. Light-Triggered PEGylation/dePEGylation of the Nanocarriers for Enhanced Tumor Penetration. NANO LETTERS[J]. 2019, 19(6): 3671-3675, https://www.webofscience.com/wos/woscc/full-record/WOS:000471834900036.
[9] Wang, Dongqing, Zhou, Mengxue, Huang, Hui, Ruan, Lifo, Lu, Huiru, Zhang, Jiayu, Chen, Jun, Gao, Jimin, Chai, Zhifang, Hu, Yi. Gold Nanoparticle-Based Probe for Analyzing Mitochondrial Temperature in Living Cells. ACS APPLIED BIO MATERIALS[J]. 2019, 2(8): 3178-3182, [10] Huang, Hui, Zhou, Mengxue, Ruan, Lifo, Wang, Dongqing, Lu, Huiru, Zhang, Jiayu, Chen, Jun, Hu, Yi, Chai, Zhifang. AMPK mediates the neurotoxicity of iron oxide nanoparticles retained in mitochondria or lysosomes. METALLOMICS[J]. 2019, 11(7): 1200-1206, https://www.webofscience.com/wos/woscc/full-record/WOS:000475799400001.
[11] Ruan, Lifo, Wang, Miao, Zhou, Mengxue, Lu, Huiru, Zhang, Jiayu, Gao, Jimin, Chen, Jun, Hu, Yi. Doxorubicin-Metal Coordinated Micellar Nanoparticles for Intracellular Codelivery and Chemo/Chemodynamic Therapy in Vitro. ACS APPLIED BIO MATERIALS[J]. 2019, 2(11): 4703-4707, [12] Wen, Kaikai, Xu, Xiaozhou, Chen, Jun, Lv, Lei, Wu, Lifen, Hu, Yi, Wu, Xiaoxi, Liu, Guozhen, Peng, Aidong, Huang, Hui. Triplet Tellurophene-Based Semiconducting Polymer Nanoparticles for Near-Infrared-Mediated Cancer Theranostics. ACS APPLIED MATERIALS & INTERFACES[J]. 2019, 11(19): 17884-17893, https://www.webofscience.com/wos/woscc/full-record/WOS:000468364500084.
[13] Wang, Dongqing, Huang, Hui, Zhou, Mengxue, Lu, Huiru, Chen, Jun, Chang, YoungTae, Gao, Jimin, Chai, Zhifang, Hu, Yi. A thermoresponsive nanocarrier for mitochondria-targeted drug delivery. CHEMICAL COMMUNICATIONS[J]. 2019, 55(28): 4051-4054, [14] Chen, Jun. Photo/chemo/immunotherapy of primary tumor and remission of metastasis by using cascade upconversion nanoparticles. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETYnull. 2018, 255: http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000435539902328.
[15] Chen Jun, Gao Hui, Bi Ying, Zhou Mengxue, Hu Yi, Zhou MengXue. In vivo evaluation of near-infrared mediated nanoplatforms for targeted chemo-photothermal therapy and photothermo-immunotherapy. NANOMEDICINE: NANOTECHNOLOGY, BIOLOGY AND MEDICINE[J]. 2018, 14(5): 1807-1808, http://dx.doi.org/10.1016/j.nano.2017.11.188.
[16] Dong, Tao, Wen, Kaikai, Chen, Jun, Xie, Jin, Fan, Weili, Ma, Han, Yang, Lei, Wu, Xiaoxi, Xu, Fujian, Peng, Aidong, Huang, Hui. Significant Enhancement of Photothermal and Photoacoustic Efficiencies for Semiconducting Polymer Nanoparticles through Simply Molecular Engineering. ADVANCED FUNCTIONAL MATERIALS[J]. 2018, 28(23): http://www.corc.org.cn/handle/1471x/2177504.
[17] Tian, Ye, Zhou, Mengxue, Shi, Haigang, Gao, Sijia, Xie, Guocheng, Zhu, Meng, Wu, Man, Chen, Jun, Niu, Zhongwei. Integration of Cell-Penetrating Peptides with Rod-like Bionanoparticles: Virus-Inspired Gene-Silencing Technology. NANO LETTERS[J]. 2018, 18(9): 5453-5460, https://www.webofscience.com/wos/woscc/full-record/WOS:000444793500016.
[18] Mengxue Zhou, Xingcai Zhang, Jin Xie, Rongxiang Qi, Huiru Lu, Stefano Leporatti, Jun Chen, Yi Hu. pH-Sensitive Poly(β-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells. Nanomaterials[J]. 2018, 8(11): https://doaj.org/article/7bbc1c41ab954409afef1dcd520f1ca7.
[19] Huang, Hui, Chen, Jun, Lu, Huiru, Zhou, Mengxue, Hu, Yi, Chai, Zhifang. Neurotoxicity of Key Metals in Parkinson's Disease. PROGRESS IN CHEMISTRY[J]. 2018, 30(10): 1592-1600, https://www.webofscience.com/wos/woscc/full-record/WOS:000451113600013.
[20] 黄辉, 陈俊, 卢会茹, 周梦雪, 胡毅, 柴之芳. 帕金森病中的关键金属元素. 化学进展[J]. 2018, 30(10): 1592-1600, http://lib.cqvip.com/Qikan/Article/Detail?id=676692954.
[21] Zhou, Mengxue, Zhang, Xingcai, Xie, Jin, Qi, Rongxiang, Lu, Huiru, Leporatti, Stefano, Chen, Jun, Hu, Yi. pH-Sensitive Poly(beta-amino ester)s Nanocarriers Facilitate the Inhibition of Drug Resistance in Breast Cancer Cells. NANOMATERIALS[J]. 2018, 8(11): https://www.webofscience.com/wos/woscc/full-record/WOS:000451316100087.
[22] Chen, Jun. Near-infrared enhanced Fenton reaction mediated by cascade upconversion nanoparticles in combination with immunotherapy for elimination of primary tumor and remission of metastasis. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETYnull. 2018, 256: https://www.webofscience.com/wos/woscc/full-record/WOS:000447609105015.
[23] Wen, Kaikai, Zhou, Mengxue, Lu, Huiru, Bi, Ying, Ruan, Lifo, Chen, Jun, Hu, Yi. Near-Infrared/pH Dual-Sensitive Nanocarriers for Enhanced Intracellular Delivery of Doxorubicin. ACS BIOMATERIALS SCIENCE & ENGINEERING[J]. 2018, 4(12): 4244-4254, [24] Xie, Jin, Fang, Xingxing, Zhou, Mengxue, Hu, Yi, Ouyang, Jun, Chen, Jun. A facile construction of pH-sensitive shell-sheddable supramolecular nanoassembly codelivery anticancer drugs to combat drug resistance. JOURNAL OF CONTROLLED RELEASE[J]. 2017, 259: E64-E64, http://dx.doi.org/10.1016/j.jconrel.2017.03.148.
[25] Huang, Hui, Chen, Jun, Lu, Huiru, Zhou, Mengxue, Chai, Zhifang, Hu, Yi. Two mTOR inhibitors, rapamycin and Torin 1, differentially regulate iron-induced generation of mitochondrial ROS. BIOMETALS[J]. 2017, 30(6): 975-980, http://www.corc.org.cn/handle/1471x/2176915.
[26] Gao, Hui, Bi, Ying, Wang, Xin, Wang, Miao, Zhou, Mengxue, Lu, Huiru, Gao, Jimin, Chen, Jun, Hu, Yi. Near-Infrared Guided Thermal-Responsive Nanomedicine against Orthotopic Superficial Bladder Cancer. ACS BIOMATERIALS SCIENCE & ENGINEERING[J]. 2017, 3(12): 3628-3634, http://www.corc.org.cn/handle/1471x/2177858.
[27] Lu, Huiru, Chen, Jun, Huang, Hui, Zhou, Mengxue, Zhu, Qing, Yao, Shao Q, Chai, Zhifang, Hu, Yi. Iron modulates the activity of monoamine oxidase B in SH-SY5Y cells. BIOMETALS[J]. 2017, 30(4): 599-607, http://www.corc.org.cn/handle/1471x/2177242.
[28] 赵宇亮. mTOR signaling in Parkinson’s disease. Neuromolecular medicine[J]. 2017, 19(1): 1-10, http://www.corc.org.cn/handle/1471x/2176739.
[29] Liu, Yi, Li, Heping, Xie, Jin, Zhou, Mengxue, Huang, Hui, Lu, Huiru, Chai, Zhifang, Chen, Jun, Hu, Yi. Facile construction of mitochondria-targeting nanoparticles for enhanced phototherapeutic effects. BIOMATERIALS SCIENCE[J]. 2017, 5(5): 1022-1031, http://www.corc.org.cn/handle/1471x/2177189.
[30] Liu, Yi, Lu, Huiru, Lan, Aiping, Hu, Yi, Li, Heping, Chen, Jun. Mitochondria-targeted nanocarriers using hyperbranched polycations wrapped carbon nanotubes for augment photodynamic therapeutic effects. JOURNAL OF CONTROLLED RELEASE[J]. 2017, 259: E170-E171, http://www.corc.org.cn/handle/1471x/2176997.
[31] Huang, Hui, Chen, Jun, Lu, Huiru, Zhou, Mengxue, Chai, Zhifang, Hu, Yi. Iron-induced generation of mitochondrial ROS depends on AMPK activity. BIOMETALS[J]. 2017, 30(4): 623-628, http://www.corc.org.cn/handle/1471x/2177245.
[32] Zhou, Mengxue, Gao, Hui, Bi, Ying, Lu, Huiru, Lan, Aiping, Hu, Yi, Chen, Jun. In vivo chemo/photothermal therapy using near-infrared light triggered switchable nanoparticles against subcutaneous and orthotopic superficial bladder cancer. JOURNAL OF CONTROLLED RELEASE[J]. 2017, 259: E92-E93, http://www.corc.org.cn/handle/1471x/2177018.
[33] Zhou, Mengxue, Wen, Kaikai, Bi, Ying, Lu, Huiru, Chen, Jun, Hu, Yi, Chai, Zhifang. The Application of Stimuli-responsive Nanocarriers for Targeted Drug Delivery. CURRENT TOPICS IN MEDICINAL CHEMISTRY[J]. 2017, 17(20): 2319-2334, http://www.corc.org.cn/handle/1471x/2177248.
[34] Chen, Ganchao, Xie, Yusheng, Peltier, Raoul, Lei, Haipeng, Wang, Ping, Chen, Jun, Hu, Yi, Wang, Feng, Yao, Xi, Sun, Hongyan. Peptide-Decorated Gold Nanoparticles as Functional Nano-Capping Agent of Mesoporous Silica Container for Targeting Drug Delivery. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 8(18): 11204-11209, http://ir.ihep.ac.cn/handle/311005/247864.
[35] Lan, Aiping, Xiong, Xianjia, Chen, Jun, Wang, Xi, Chai, Zhifang, Hu, Yi. AMPK Inhibition Enhances the Neurotoxicity of Cu(II) in SH-SY5Y Cells. NEUROTOXICITY RESEARCH[J]. 2016, 30(3): 499-509, https://www.webofscience.com/wos/woscc/full-record/WOS:000383727300015.
[36] 赵宇亮. A thiol fluorescent probe reveals the intricate modulation of cysteine's reactivity by Cu (II). Talanta[J]. 2016, 146: 477-482, http://dx.doi.org/10.1016/j.talanta.2015.09.014.
[37] Gao, Liqian, Chen, Jun, Hu, Yi, Sun, Hongyan, Ong, Yong Siang, Zhang, Jingxin, Chai, Zhifang, Lee, Su Seong. Characterization and Preclinical Perspectives of Organic Small Molecule Drug Metabolites in Drug-drug Interactions. CURRENT ORGANIC CHEMISTRY[J]. 2016, 20(17): 1827-1834, https://www.webofscience.com/wos/woscc/full-record/WOS:000380833700008.
[38] Zhou, Hui, Bi, Ying, Gao, Hui, Chen, Peng, Chen, Jun, Hu, Yi. Reduction sensitive micellar magnetic nanoparticles for cancer targeted chemotherapy. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE[J]. 2016, 12(2): 547-547, http://dx.doi.org/10.1016/j.nano.2015.12.281.
[39] Gao, Hui, Bi, Ying, Chen, Jun, Peng, Lirong, Wen, Kaikai, Ji, Pan, Ren, Weifeng, Li, Xiaoqing, Zhang, Ning, Gao, Jimin, Chai, Zhifang, Hu, Yi. Near-Infrared Light-Triggered Switchable Nanoparticles for Targeted Chemo/Photothermal Cancer Therapy. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 8(24): 15103-15112, https://www.webofscience.com/wos/woscc/full-record/WOS:000378584800025.
[40] 赵宇亮. Near-infrared light remote-controlled intracellular anti-cancer drug delivery using thermo/pH sensitive nanovehicle. Acta biomaterialia[J]. 2015, 17: 201-209, http://dx.doi.org/10.1016/j.actbio.2015.01.026.
[41] 赵宇亮. Metal ions modulate the conformation and stability of a G-quadruplex with or without a small-molecule ligand. Metallomics[J]. 2015, 7(11): 1508-1514, http://ir.ihep.ac.cn/handle/311005/228874.
[42] Chen, Jun, Shi, Min, Liu, Pengmin, Ko, Alex, Zhong, Wen, Liao, WangJun, Xing, Malcolm M Q. Reducible polyamidoamine-magnetic iron oxide self-assembled nanoparticles for doxorubicin delivery. BIOMATERIALS[J]. 2014, 35(4): 1240-1248, http://dx.doi.org/10.1016/j.biomaterials.2013.10.057.
[43] Chen, Jun, Qiu, Xiaozhong, Wang, Leyu, Zhong, Wen, Kong, Jiming, Xing, Malcolm M Q. Free-Standing Cell Sheet Assembled with Ultrathin Extracellular Matrix as an Innovative Approach for Biomimetic Tissues. ADVANCED FUNCTIONAL MATERIALS[J]. 2014, 24(15): 2216-2223, https://www.webofscience.com/wos/woscc/full-record/WOS:000334281400010.
[44] Li, Xia, Zhou, Jin, Liu, Zhiqiang, Chen, Jun, Lu, Shuanghong, Sun, Hongyu, Li, Junjie, Lin, Qiuxia, Yang, Boguang, Duan, Cuimi, Xing, Malcolm Mengqiu, Wang, Changyong. A PNIPAAm-based thermosensitive hydrogel containing SWCNTs for stem cell transplantation in myocardial repair. BIOMATERIALS[J]. 2014, 35(22): 5679-5688, http://dx.doi.org/10.1016/j.biomaterials.2014.03.067.
[45] Hu, Yi, Lu, Huiru, Zhang, Jinchao, Chen, Jun, Chai, Zhifang, Zhang, Jingxin. Essential role of AKT in tumor cells addicted to FGFR. ANTI-CANCER DRUGS[J]. 2014, 25(2): 183-188, http://ir.ihep.ac.cn/handle/311005/224814.
[46] Zhou, Jin, Chen, Jun, Sun, Hongyu, Qiu, Xiaozhong, Mou, Yongchao, Liu, Zhiqiang, Zhao, Yuwei, Li, Xia, Han, Yao, Duan, Cuimi, Tang, Rongyu, Wang, Chunlan, Zhong, Wen, Liu, Jie, Luo, Ying, Xing, Malcolm Mengqiu, Wang, Changyong. Engineering the heart: Evaluation of conductive nanomaterials for improving implant integration and cardiac function. SCIENTIFIC REPORTS[J]. 2014, 4: https://www.webofscience.com/wos/woscc/full-record/WOS:000329848100023.
[47] Chen, Jun, Ouyang, Jun, Kong, Jiming, Zhong, Wen, Xing, Malcolm Mq. Photo-cross-linked and pH-Sensitive Biodegradable Micelles for Doxorubicin Delivery. ACS APPLIED MATERIALS & INTERFACES[J]. 2013, 5(8): 3108-3117, http://ir.ihep.ac.cn/handle/311005/224224.
[48] Wu, Chao, Li, Jing, Zhu, Yu, Chen, Jun, Oupicky, David. Opposing influence of intracellular and membrane thiols on the toxicity of reducible polycations. BIOMATERIALS[J]. 2013, 34(34): 8843-8850, http://dx.doi.org/10.1016/j.biomaterials.2013.07.095.
[49] Chen, Jun, Zehtabi, Fatemeh, Ouyang, Jun, Kong, Jiming, Zhong, Wen, Xing, Malcolm M Q. Reducible self-assembled micelles for enhanced intracellular delivery of doxorubicin. JOURNAL OF MATERIALS CHEMISTRY[J]. 2012, 22(15): 7121-7129, https://www.webofscience.com/wos/woscc/full-record/WOS:000301957300008.
[50] Chen, Jun, Xing, Malcolm M Q, Zhong, Wen. Degradable micelles based on hydrolytically degradable amphiphilic graft copolymers for doxorubicin delivery. POLYMER[J]. 2011, 52(4): 933-941, http://dx.doi.org/10.1016/j.polymer.2010.12.056.
[51] Chen Jun. Multifunctional Nanofibrous Scaffolds Based on Poly(L-lactic acid) and Poly(L-lactic acid)-Poly(ethylene glycol) for Tissue Engineering. International Journal of Nanomedicine. 2011, [52] Chen, Jun, Qiu, Xiaozhong, Ouyang, Jun, Kong, Jiming, Zhong, Wen, Xing, Malcolm M Q. pH and Reduction Dual-Sensitive Copolymeric Micelles for Intracellular Doxorubicin Delivery. BIOMACROMOLECULES[J]. 2011, 12(10): 3601-3611, https://www.webofscience.com/wos/woscc/full-record/WOS:000295602600027.
[53] Liu, Min, Chen, Jun, Xue, YaNan, Liu, WenMing, Zhuo, RenXi, Huang, ShiWen. Poly(beta-aminoester)s with Pendant Primary Amines for Efficient Gene Delivery. BIOCONJUGATE CHEMISTRY[J]. 2009, 20(12): 2317-2323, https://www.webofscience.com/wos/woscc/full-record/WOS:000272690100015.
[54] Chen, Jun, Wu, Chao, Oupicky, David. Bioreducible Hyperbranched Poly(amido amine)s for Gene Delivery. BIOMACROMOLECULES[J]. 2009, 10(10): 2921-2927, https://www.webofscience.com/wos/woscc/full-record/WOS:000270548700027.
[55] Chen, Jun, Huang, ShiWen, Lin, WenHai, Zhuo, RenXi. Tunable film degradation and sustained release of plasmid DNA from cleavable polycation/plasmid DNA multilayers under reductive conditions. SMALL[J]. 2007, 3(4): 636-643, https://www.webofscience.com/wos/woscc/full-record/WOS:000245560200016.
[56] Chen, Jun, Huang, ShiWen, Liu, Min, Zhuo, RenXi. Synthesis and degradation of poly(beta-aminoester) with pendant primary amine. POLYMER[J]. 2007, 48(3): 675-681, http://dx.doi.org/10.1016/j.polymer.2006.12.008.
[57] Chen, Jun, Xia, XiMing, Huang, ShiWen, Zhuo, RenXi. A cleavable-polycation template method for the fabrication of noncrosslinked, porous polyelectrolyte multilayered films. ADVANCED MATERIALS[J]. 2007, 19(7): 979-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000245720200017.

科研活动

   
科研项目
( 1 ) 用于癌症诊断治疗的纳米载体的研究, 负责人, 研究所自选, 2013-02--2016-01
( 2 ) 近红外光敏多功能纳米载体的构建及药物靶向传递和成像研究, 负责人, 国家任务, 2014-01--2016-12
( 3 ) 肝癌早期诊断用新型纳米材料的设计和构筑, 参与, 国家任务, 2012-09--2015-08
( 4 ) 基于胞内多种生物活性分子同时识别的荧光探针研究, 参与, 国家任务, 2014-01--2018-12
( 5 ) 中国科学院青年创新促进会, 负责人, 中国科学院计划, 2015-01--2018-12
( 6 ) 多重刺激响应性纳米药物的光热治疗与化疗的协同抗肿瘤研究, 负责人, 国家任务, 2016-01--2019-12
( 7 ) 基于趋化因子受体阻断剂的多功能纳米药物用于光动力抗肿瘤研究, 参与, 地方任务, 2021-01--2023-12
( 8 ) 构筑分级靶向型纳米递送载体用于肿瘤硼中子俘获治疗研究, 负责人, 地方任务, 2022-10--2025-09
参与会议
(1)光热/化疗联合免疫治疗纳米复合药物的抗肿瘤研究   2017 中国生物材料大会   2017-10-27
(2)Near-Infrared Guided Switchable Nanoparticles for Enhanced Targeted Therapy against Subcutaneous and Orthotopic Bladder Cancer   美国材料学会2016秋季年会(Materials Research Society 2016 Fall Meeting)   2016-11-27
(3)In Vivo Evaluation of Near-Infrared Mediated Nanoplatforms for Targeted Chemo-Photothermal Therapy and Photothermo-Immunotherapy   第二届国际纳米药物大会   2016-10-18
(4)独立细胞膜片与层层组装细胞外基质制备仿生组织   2015 中国生物材料大会暨中美生物材料学会第三次专题论坛   2015-11-19
(5)还原降解性聚阳离子的细胞毒性的机理研究   中国毒理学会第七次全国毒理学大会   2015-10-25
(6)光致尺寸变换型纳米载体用于膀胱癌的靶向热化疗研究   2015年全国高分子学术论文报告会   2015-10-17
(7)Photothermally Size-Switchable Nanocarriers for Near Infrared Laser Guided Tumor Targeted Chemo/Photothermal Therapy    中国化学会第十五届胶体与界面化学会议   2015-07-17
(8)Photothermally Switchable Nanocarriers for Near Infrared Laser Guided Tumor Targeted Chemo/Photothermal Therapy    第10届中美纳米论坛   Ying Bi, Hui Gao, Yi Hu, Jun Chen,*   2015-06-26
(9)Preparation of Thermal/pH Dual Responsive Nanocarriers for Near Infrared Laser Guided Tumor Targeted Chemo/Photothermal Therapy    2015年美国生物材料学会年会(2015 Annual Meeting of Society for Biomaterials)   Ying Bi, Hui Gao, Aiping Lan, Yi Hu, Jun Chen*   2015-04-19
(10)Free-Standing Cell Sheet Assembled with Ultrathin Extracellular Matrix as an Innovative Approach for Biomimetic Tissues   第五届中欧生物材料大会   Peng Chen, Ying Bi, Xiaozhong Qiu, Yi Hu, Malcolm M. Q. Xing, Jun Chen*   2015-04-14
(11)Redution Sensitive Micellar Magnatic Nanoparticles for Cancer Targeted Chemotherapy   2015年纳米药物与纳米生物技术国际会议   Hui Zhou, Ying Bi, Jun Chen*, Yi Hu   2015-04-13
(12)Near-infrared light remote-enhanced tumor targeting chemo-photothermal co-therapy using thermo/pH sensitive nanovehicle   2015转化纳米医学国际学术研讨会   Ying Bi, Yi Hu*, Yuliang Zhao, Jimin Gao, Jun Chen*   2015-01-12
(13)同步辐射技术检测甲基汞在水稻中的转运   2014年北京同步辐射装置用户学术年会暨专家会   赵甲亭,陈俊,胡毅,高愈希    2014-08-12
(14)Preparation of Biocompatible Conductive Nanomaterials for Improving Myocardial Repair   2014年国际高分子化学学术研讨会   Ying Bi, Xiaohan Xu, Yanping Qin, Hui Zhou, Yi Hu, Jun Chen,   2014-06-04
(15)Controlled release of Doxorubicin from pH and reducing agents dual responsive PEG-Reducible Poly(beta-amino ester)s-PEG micelles   239届美国化学学会年会   Jun Chen, Shufei Zhou and Wen Zhong   2010-05-20
(16)Effect of intracellular glutathione levels on the cytotoxicity of bioreducible polycations   20届美国基因治疗学会年会   Chao Wu, Jun Chen, Jing Li, David Oupicky   2009-05-27
(17)Synthesis and characterization of hyperbranched poly(amido amine)s for gene delivery   第35届美国控制释放学会年会   Ye-Zi You, Jun Chen, Devika S Manickam, Qing-Hui Zhou, Lei Wan, Guangzhao Mao and David Oupicky   2008-07-12
(18)聚酯-胺阳离子/质粒DNA 多层膜的构建及其控制释放DNA   2005 全国高分子学术论文报告会   陈俊,黄世文,林文海,卓仁禧   2005-10-18

合作情况

动物体内实验合作单位:

温州医科大学检验医学院 高基民 教授
哈尔滨医科大学第一附属医院 刘宏宇 院长
天津医科大学 张宁教授
南方医科大学 欧阳均 教授


材料实验合作单位:

中国科学院大学材料科学与光电技术学院 黄辉 教授
美国德州农工大学化学系 方磊 助理教授
中国科学院宁波材料技术与工程研究所 黄又举 副研究员

指导学生

已指导学生

周梦雪  博士研究生  070301-无机化学