Jinyong Wang, Ph.D., joined Institute of Zoology, Chinese Academy of Sciences in July 2021 as principal investigator (Full Professor), member of 100-talents Program of Chinese Academy of Sciences. Dr. Wang obtained his doctoral degree at Zhejiang University, China. He successively took postdoctoral training at Medical College of Wisconsin (MCW), and University of Wisconsin-Madison (UW-Madison). His lab is interested in stem cell biology, hematopoietic/immune cell regeneration, and cell therapy.
Email: wangjinyong AT ioz.ac.cn
Research Areas
Regeneration of Blood and immune lineages from pluripotent stem cells for translational purpose.
Experience
Work Experience
2021.7-, Institute of Zoology, CAS, Principal Investigator
2012.03-2021.6, Guangzhou Insititutes of Biomedicine and Health，CAS, Principal Investigator
2007.09-2012.02, Medical College of Wisconsin &Univeristy of Wisconsin-Madison, Research Associate(Post Doc), Assistant Scientist
Publications
1. Huang D, Li J, Hu F, Xia C, Weng Q, Wang T, Peng H, Wu B, Wu H, Xiong J, Lin Y, Wang Y, Zhang Q, Liu X, Liu L, Zheng X, Geng Y, Du X, Zhu X, Wang L, Hao J, Wang J. Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells. Cell Discov. 2022 Nov 8;8(1):121. doi: 10.1038/s41421-022-00467-2.
2. Huang D, Zhao Q, Zhang M, Weng Q, Zhang Q, Wang K, Dong F, Cheng H, Hu F, Wang J. Hoxb5 reprogrammes murine multipotent blood progenitors into haematopoietic stem cell-like cells. Cell Prolif. 2022 Jun;55(6):e13235. doi: 10.1111/cpr.13235. Epub 2022 May 17.
3. Zhang,Q., Wu, B., Weng, Q., Hu, F., Lin, Y., Xia, C., Peng,H., Wang, Y., Liu,X., Liu, L., Xiong, J., Geng, Y., Zhao,Y., Zhang, M., Du,J., Wang, J. (2021) Regeneration of immunocompetent B lymphopoiesis from pluripotent stem cells guided by transcription factors.Cellular & Molecular Immunology, 2022 Apr;19(4):492-503
4. Wang, T., Xia, C., Weng, Q., Wang, K., Dong, Y., Hao, S., Dong, F., Liu, X., Liu, L., Geng, Y., Guan, Y., Du, J., Cheng, T., Cheng, H., Wang, J. Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathway. Haematologica, 2022 Jan 1;107(1):154-166.
5. Wang, T., Lv, C., Hu, F., Liu, L., Wang, J. (2020) Two-step protocol for regeneration of immunocompetent T cells from mouse pluripotent stem cells. Blood Science 2, 79-88.
6. Guo, R., Wu, H., Du, J., Wang, J. (2020) T cell regeneration: an update on progress and challenges. Blood Science 2, 22-26.
7. Hu, F., Huang, D., Luo, Y., Zhou, P., LV, C., Wang, K., Weng, Q., Liu, X., Guan Y., Geng, Y., Du, J., Chen J., Wang, J., and Wu, H. (2020) Haematopoietic lineage-converted T cells carrying tumour associated antigen-recognizing TCRs effectively kill tumour cells. Journal for ImmunoTherapy of Cancer, DOI: 10.1136/jitc-2019-000498.
8. LV, C., Chen, S., Hu, F., Huang, D., Wang, T., Du, J., Wang, J., and Wu, H. (2020) Pluripotent stem cell-derived CD19-CAR iT cells effectively eradicate B-cell lymphoma in vivo. Cellular & Molecular Immunology, DOI: 10.1038/s41423-020-0429-4.
9. Xia, C., Wang, T., Cheng, H., Dong, Y., Weng, Q., Sun, G., Zhou, P., Wang, K., Liu, X., Geng, Y., Ma, S., Hao, S., Xu, L., Guan, Y., Du, J., Du, X., Li, Y., Zhu, X., Shi, Y., Xu, S., Wang, D., Cheng, T., and Wang, J. (2020) Mesenchymal stem cells suppress leukemia via macrophage-mediated functional restoration of bone marrow microenvironment. Leukemia, 34(9):2375-2383.
10. Guo, R., Hu, F., Weng, Q., Lv, C., Wu, H., Liu, L., Li, Z., Zeng, Y., Bai, Z., Zhang, M., Liu, Y., Liu, X., Xia, C., Wang, T., Zhou, P., Wang, K., Dong, Y., Luo, Y., Zhang, X., Guan, Y., Geng, Y., Du, J., Li, Y., Lan, Y., Chen, J., Liu, B., and Wang, J. (2020) Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors. Cell Research 30, 21-33.
11. Weng, Q., Hu, F., Zhang, M., Dong, Y., Lv, C., Wang, Y., Liu, X., Wang, J. (2018) A protocol for generating induced T cells by reprogramming B cells in vivo. Cell Regeneration 7, 7-15.
12. Zhang, M., Dong, Y., Hu, F., Yang, D., Zhao, Q., Lv, C., Wang, Y., Xia, C., Weng, Q., Liu, X., Li, C., Zhou, P., Wang, T., Guan, Y., Guo, R., Liu, L., Geng, Y., Wu, H., Du, J., Hu, Z., Xu, S., Chen, J., He, A., Liu, B., Wang, D., Yang, Y. G., and Wang, J. (2018) Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes. Nat Immunology 19, 279-290.
13. Li, X., Xia, C., Wang, T., Liu, L., Zhao, Q., Yang, D., Hu, F., Zhang, M., Huang, K., Geng, Y., Zheng, Y., Guan, Y., Wu, H., Chen, X., Pan, G., Chen, J., Du, J., and Wang, J. (2017) Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells. Stem Cell Research 21, 32-39.
14. Chen, X., Zhao, Q., Li, C., Geng, Y., Huang, K., Zhang, J., Wang, X., Yang, J., Wang, T., Xia, C., Liu, X., Meng, M., Yang, D., Zheng, Y., Du, J., Zhang, X., Chen, J., Pan, G., and Wang, J. (2015) OP9-Lhx2 stromal cells facilitate derivation of hematopoietic progenitors both in vitro and in vivo. Stem Cell Research 15, 395-402.
15. Yang, D., Zhang, X., Dong, Y., Liu, X., Wang, T., Wang, X., Geng, Y., Fang, S., Zheng, Y., Chen, X., Chen, J., Pan, G., and Wang, J. (2015) Enforced expression of Hoxa5 in haematopoietic stem cells leads to aberrant erythropoiesis in vivo. Cell Cycle 14, 612-620.
Research Interests
Stem cell biology,
Blood and Immune cell biology,
Immune cell theray
Students
已指导学生
李学家 博士研究生 071009-细胞生物学
董勇 博士研究生 071009-细胞生物学
张梦云 博士研究生 071009-细胞生物学
郭荣群 博士研究生 071009-细胞生物学
夏成祥 博士研究生 071009-细胞生物学
汪颖 硕士研究生 071009-细胞生物学
翁启童 硕士研究生 085238-生物工程
周培青 博士研究生 071009-细胞生物学
翁启童 博士研究生 071009-细胞生物学
张琪 博士研究生 071009-细胞生物学
黄德浩 博士研究生 071009-细胞生物学
现指导学生
熊加品 博士研究生 071009-细胞生物学
吴冰燕 博士研究生 071009-细胞生物学
彭欢 博士研究生 071009-细胞生物学
李剑焕 博士研究生 071009-细胞生物学
王瑶 博士研究生 071009-细胞生物学