1. 干细胞与造血干祖细胞再生

基于多能干细胞(ESC/iPSC)谱系分化原理，结合基因编辑，诱导获得可移植的造血干祖细胞种子，探索代替传统骨髓移植细胞来源，实现治疗肿瘤、遗传病、感染、器官退行衰老、病理炎症等适应症的目的。

2. 干细胞与免疫细胞再生（T, B, NK等免疫细胞）

基于多能干细胞（ESC/iPSC)谱系分化原理，结合基因编辑，获得可移植的淋巴细胞祖细胞，模拟淋巴细胞发育微环境，进一步制备成熟的B, T, NK细胞。结合细胞疗法原理，探索治疗肿瘤和相关免疫疾病。

生物学一级学科，方向是再生医学，每年招生名额2-3人（倾向招收国科大硕博连读学生）。

常年招收具有人类多能干细胞（hESC/iPSC）生物学、实验血液学、免疫学、生物材料科学背景的博士后。具有类器官培养、器官芯片、细胞永生化经验的优先。

1001J6-再生医学

血液/免疫细胞再生与细胞治疗
造血调控
白血病

1. Zhang, M., Z. Wang, Y. Liu, L. Zhang, F. Hu, C. Xia, M. Zhang, T. Wang, Q. Weng, H. Qi, Y. Zhu, L. Liu, D. Huang, H. H. Zhu and J. Wang (2026). "iPSC‐Derived iNK Progenitors Engraft and Generate NK Cells in Unconditioned and Autologous Immune Humanized Mice." Cell Prolif. e70261.
2. Wang, Z., L. Zhang, D. Huang, C. Xia, Q. Weng, Y. Lin, Y. Liu, Z. Liu, R. Yi, F. Zhang, Y. Zhao, J. Wu, H. Qi, L. Liu, Y. Shen, Y. Chen, Y. Zhu, T. Wang, M. Zhang, F. Hu and J. Wang (2026). "Pluripotent stem cell-derived CAR-NK progenitor therapy targets minimal residual disease and prevents relapse in leukemia models." Cell Stem Cell.
3. Hu, F., J. Li, Y. Wang, Y. Lin, J. Zhang, J. Xu, X. Zheng, Q. Weng, X. Liu, Y. Geng, H. Wu, L. Liu, H. Peng, B. Wu, D. Huang, C. Xia, T. Wang, X. Du, H. Zeng, F. Dong, Y. Zhang, X. Zhu, M. Zhang and J. Wang (2025). “Large-scale generation of iNK and CAR-iNK cells from CD34+ hematopoietic stem and progenitor cells for adoptive immunotherapy.” Nature Biomedical Engineering.
4. Wang, Y., X. Zheng, Z. Wang, Z. Xiao, Y. Lin, F. Zhang, Y. Liu, P. Liu, Q. Weng, L. Zhang, C. Xia, D. Huang, L. Liu, Y. Zhu, Q. Zhang, H. Qi, Y. Chen, Y. Shen, C. Zhang, J. Xu, Y. Zhao, J. Wu, T. Wang, M. Zhang, M. Li, W. Qian, A. Liang, X. Du, W. Yang, T. Hu, Q. Chen, X. Zhu, F. Hu and J. Wang (2025). "CD33(KO)-CD33-mesothelin Loop CAR design avoids fratricide and improves efficacy of iNK cells against acute myeloid leukemia." J Immunother Cancer 13(9).
5. Lin, Y., Z. Xiao, F. Hu, X. Zheng, C. Zhang, Y. Wang, Y. Liu, D. Huang, Z. Wang, C. Xia, Q. Weng, L. Zhang, Y. Zhao, H. Qi, Y. Shen, Y. Chen, F. Zhang, J. Wu, P. Liu, J. Xu, L. Liu, Y. Zhu, J. Zhang, W. Qian, A. Liang, X. Zhu, T. Wang, M. Zhang and J. Wang (2025). "Engineered CRO-CD7 CAR-NK cells derived from pluripotent stem cells avoid fratricide and efficiently suppress human T-cell malignancies." J Hematol Oncol 18(1): 57.
6. Zhang, Q., C. Xia, Q. Weng, L. Zhang, Y. Wang, Y. Liu, X. Zheng, Y. Lin, Y. Chen, Y. Shen, H. Qi, L. Liu, Y. Zhu, M. Zhang, D. Huang, F. Hu, M. Zhang, H. Zeng, J. Wang and T. Wang (2024). "Hypoimmunogenic CD19 CAR-NK cells derived from embryonic stem cells suppress the progression of human B-cell malignancies in xenograft animals." Front Immunol 15: 1504459.
7. Liu, Y., M. Zhang, X. Shen, C. Xia, F. Hu, D. Huang, Q. Weng, Q. Zhang, L. Liu, Y. Zhu, L. Wang, J. Hao, M. Zhang, T. Wang and J. Wang (2024). "Mesothelin CAR-engineered NK cells derived from human embryonic stem cells suppress the progression of human ovarian cancer in animals." Cell Prolif: e13727.
8. Wang, Y., J. Li, Z. Wang, Y. Liu, T. Wang, M. Zhang, C. Xia, F. Zhang, D. Huang, L. Zhang, Y. Zhao, L. Liu, Y. Zhu, H. Qi, X. Zhu, W. Qian, F. Hu and J. Wang (2024). "Comparison of seven CD19 CAR designs in engineering NK cells for enhancing anti-tumour activity." Cell Prolif: e13683.
9. Peng, H., Y. Lin, F. Hu, C. Lv, B. Wu, Q. Weng, L. Liu, C. Xia, X. Liu, Y. Zhao, Q. Zhang, Y. Geng, M. Zhang and J. Wang (2023). "Prolonged generation of multi-lineage blood cells in wild-type animals from pluripotent stem cells." Stem Cell Reports 18(3): 720-735.
10. Wu, B., Q. Zhang, P. Hong, L. Liu, H. Peng, C. Xia, T. Wang, Y. Wang, Q. Weng, X. Liu, Y. Geng, J. Wang and H. Wu (2023). "Antigen-specific TCR-T cells from Rag2 gene-deleted pluripotent stem cells impede solid tumour growth in a mouse model." Cell Prolif: e13389.
11. Xiong, J., Y. Zhao, Y. Lin, L. Chen, Q. Weng, C. Shi, X. Liu, Y. Geng, L. Liu, J. Wang and M. Zhang (2022). "Identification and characterization of innate lymphoid cells generated from pluripotent stem cells." Cell Rep 41(5): 111569.
12. Huang, D., J. Li, F. Hu, C. Xia, Q. Weng, T. Wang, H. Peng, B. Wu, H. Wu, J. Xiong, Y. Lin, Y. Wang, Q. Zhang, X. Liu, L. Liu, X. Zheng, Y. Geng, X. Du, X. Zhu, L. Wang, J. Hao and J. Wang (2022). "Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells." Cell Discov 8(1): 121.
13. Huang, D., Q. Zhao, M. Zhang, Q. Weng, Q. Zhang, K. Wang, F. Dong, H. Cheng, F. Hu and J. Wang (2022). "Hoxb5 reprogrammes murine multipotent blood progenitors into haematopoietic stem cell-like cells." Cell Prolif 55(6): e13235.
14. Yu, B., B. Wu, P. Hong, H. Peng, M. Zhang, Q. Zhang, L. Liu, X. Liu, Y. Geng, J. Wang and Y. Lan (2022). "Co-Expression of Runx1, Hoxa9, Hlf, and Hoxa7 Confers Multi-Lineage Potential on Hematopoietic Progenitors Derived From Pluripotent Stem Cells." Front Cell Dev Biol 10: 859769.
15. Zhang, Q., B. Wu, Q. Weng, F. Hu, Y. Lin, C. Xia, H. Peng, Y. Wang, X. Liu, L. Liu, J. Xiong, Y. Geng, Y. Zhao, M. Zhang, J. Du and J. Wang (2022). "Regeneration of immunocompetent B lymphopoiesis from pluripotent stem cells guided by transcription factors." Cell Mol Immunol 19(4): 492-503.
16. Wang, T., C. Xia, Q. Weng, K. Wang, Y. Dong, S. Hao, F. Dong, X. Liu, L. Liu, Y. Geng, Y. Guan, J. Du, T. Cheng, H. Cheng and J. Wang (2022). "Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathway." Haematologica 107(1): 154-166.
17. Zhou, P., C. Xia, T. Wang, Y. Dong, Q. Weng, X. Liu, Y. Geng, J. Wang and J. Du (2021). "Senescent bone marrow microenvironment promotes Nras-mutant leukemia." J Mol Cell Biol 13(1): 72-74.
18. Lv, C., S. Chen, F. Hu, D. Huang, T. Wang, J. Du, J. Wang and H. Wu (2021). "Pluripotent stem cell-derived CD19-CAR iT cells effectively eradicate B-cell lymphoma in vivo." Cell Mol Immunol 18(3): 773-775.
19. Xia, C., T. Wang, H. Cheng, Y. Dong, Q. Weng, G. Sun, P. Zhou, K. Wang, X. Liu, Y. Geng, S. Ma, S. Hao, L. Xu, Y. Guan, J. Du, X. Du, Y. Li, X. Zhu, Y. Shi, S. Xu, D. Wang, T. Cheng and J. Wang (2020). "Mesenchymal stem cells suppress leukemia via macrophage-mediated functional restoration of bone marrow microenvironment." Leukemia 34(9): 2375-2383.
20. Guo, R., F. Hu, Q. Weng, C. Lv, H. Wu, L. Liu, Z. Li, Y. Zeng, Z. Bai, M. Zhang, Y. Liu, X. Liu, C. Xia, T. Wang, P. Zhou, K. Wang, Y. Dong, Y. Luo, X. Zhang, Y. Guan, Y. Geng, J. Du, Y. Li, Y. Lan, J. Chen, B. Liu and J. Wang (2020). "Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors." Cell Res 30(1): 21-33.
21. Guo, R., H. Wu, J. Du and J. Wang (2020). "T cell regeneration: an update on progress and challenges." Blood Sci 2(1): 22-26.
22. Hu, F., D. Huang, Y. Luo, P. Zhou, C. Lv, K. Wang, Q. Weng, X. Liu, Y. Guan, Y. Geng, J. Du, J. Chen, J. Wang and H. Wu (2020). "Hematopoietic lineage-converted T cells carrying tumor-associated antigen-recognizing TCRs effectively kill tumor cells." J Immunother Cancer 8(2).
23. Wang, T., C. Lv, F. Hu, L. Liu and J. Wang (2020). "Two-step protocol for regeneration of immunocompetent T cells from mouse pluripotent stem cells." Blood Sci 2(3): 79-88.
24. Dong, Y., K. Wang, Q. Weng, T. Wang, P. Zhou, X. Liu, Y. Geng, L. Liu, H. Wu, J. Wang and J. Du (2020). "NUP98-HOXA10hd fusion protein sustains multi-lineage haematopoiesis of lineage-committed progenitors in transplant setting." Cell Prolif 53(9): e12885.
25. Zhang, M., Y. Dong, F. Hu, D. Yang, Q. Zhao, C. Lv, Y. Wang, C. Xia, Q. Weng, X. Liu, C. Li, P. Zhou, T. Wang, Y. Guan, R. Guo, L. Liu, Y. Geng, H. Wu, J. Du, Z. Hu, S. Xu, J. Chen, A. He, B. Liu, D. Wang, Y. G. Yang and J. Wang (2018). "Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes." Nat Immunol 19(3): 279-290.
26. Weng, Q., F. Hu, M. Zhang, Y. Dong, C. Lv, Y. Wang, X. Liu and J. Wang (2018). "A protocol for generating induced T cells by reprogramming B cells in vivo." Cell Regen 7(1): 7-15.
27. Wang, T., C. Xia, Y. Dong, X. Chen, J. Wang and J. Du (2018). "Trim27 confers myeloid hematopoiesis competitiveness by up-regulating myeloid master genes." J Leukoc Biol 104(4): 799-809.
28. Li, X., C. Xia, T. Wang, L. Liu, Q. Zhao, D. Yang, F. Hu, M. Zhang, K. Huang, Y. Geng, Y. Zheng, Y. Guan, H. Wu, X. Chen, G. Pan, J. Chen, J. Du and J. Wang (2017). "Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells." Stem Cell Res 21: 32-39.
29. Wang, T., C. Li, C. Xia, Y. Dong, D. Yang, Y. Geng, J. Cai, J. Zhang, X. Zhang and J. Wang (2015). "Oncogenic NRAS hyper-activates multiple pathways in human cord blood stem/progenitor cells and promotes myelomonocytic proliferation in vivo." Am J Transl Res 7(10): 1963-1973.
30. Chen, X., Q. Zhao, C. Li, Y. Geng, K. Huang, J. Zhang, X. Wang, J. Yang, T. Wang, C. Xia, X. Liu, M. Meng, D. Yang, Y. Zheng, J. Du, X. Zhang, J. Chen, G. Pan and J. Wang (2015). "OP9-Lhx2 stromal cells facilitate derivation of hematopoietic progenitors both in vitro and in vivo." Stem Cell Res 15(2): 395-402.
31. Yang, D., X. Zhang, Y. Dong, X. Liu, T. Wang, X. Wang, Y. Geng, S. Fang, Y. Zheng, X. Chen, J. Chen, G. Pan and J. Wang (2015). "Enforced expression of Hoxa5 in haematopoietic stem cells leads to aberrant erythropoiesis in vivo." Cell Cycle 14(4): 612-620.
32. Wang, J., G. Kong, Y. Liu, J. Du, Y. I. Chang, S. R. Tey, X. Zhang, E. A. Ranheim, M. K. Saba-El-Leil, S. Meloche, A. Damnernsawad, J. Zhang and J. Zhang (2013). "Nras(G12D/+) promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions." Blood 121(26): 5203-5207.
33. Wang, J., Y. Liu, Z. Li, Z. Wang, L. X. Tan, M. J. Ryu, B. Meline, J. Du, K. H. Young, E. Ranheim, Q. Chang and J. Zhang (2011). "Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner." Blood 118(2): 368-379.
34. Wang, J., Y. Liu, Z. Li, J. Du, M. J. Ryu, P. R. Taylor, M. D. Fleming, K. H. Young, H. Pitot and J. Zhang (2010). "Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia." Blood 116(26): 5991-6002.

（ 1 ） 新型 iNKP细胞疗法策略开发与抗血液肿瘤研究, 负责人, 国家任务, 2025-01--2027-12
（ 2 ） 多能干细胞源性免疫细胞诱导技术建立, 负责人, 国家任务, 2024-11--2027-11
（ 3 ） 基于中胚层特异干细胞获得功能性血液及免疫细胞研究, 负责人, 国家任务, 2020-10--2024-12
（ 4 ） 血液细胞再生与抗白血病研究, 负责人, 国家任务, 2020-01--2024-12
（ 5 ） 血液系统再生及应用, 负责人, 其他国际合作项目, 2018-12--2021-12
（ 6 ） 造血再生与重建技术, 负责人, 中国科学院计划, 2018-08--2022-12
（ 7 ） 再生T细胞新技术及临床转化研究, 负责人, 地方任务, 2018-04--2021-03
（ 8 ） MSC治疗MDS/MPN的临床应用研究, 参与, 地方任务, 2017-07--2020-06
（ 9 ） 体内转分化再生功能性T细胞研究, 负责人, 中国科学院计划, 2017-05--2019-04
（ 10 ） 体内转分化再生功能性T细胞研究, 负责人, 中国科学院计划, 2017-05--2022-12
（ 11 ） 多能干细胞分化来源HSC的获取及移植后造血生成、诱导免疫耐受的研究(后3年), 负责人, 国家任务, 2017-02--2019-08
（ 12 ） 造血干细胞体外维持、诱导获得技术研究, 负责人, 地方任务, 2015-07--2018-06
（ 13 ） ND融合基因促进造血干细胞扩增的机制研究, 负责人, 国家任务, 2015-01--2018-12
（ 14 ） 多能干细胞分化来源HSC的获取及移植后造血生成、诱导免疫耐受的研究, 负责人, 国家任务, 2015-01--2017-01
（ 15 ） Nras肿瘤突变扰乱造血干细胞自我更新与分化功能的机制研究, 负责人, 国家任务, 2013-01--2016-12
（ 16 ） 院启动, 负责人, 研究所自主部署, 2012-02--2017-02

   

已指导学生

李学家  博士研究生  071009-细胞生物学  

董勇  博士研究生  071009-细胞生物学  

张梦云  博士研究生  071009-细胞生物学  

郭荣群  博士研究生  071009-细胞生物学  

夏成祥  博士研究生  071009-细胞生物学  

汪颖  硕士研究生  071009-细胞生物学  

翁启童  硕士研究生  085238-生物工程  

周培青  博士研究生  071009-细胞生物学  

翁启童  博士研究生  071009-细胞生物学  

张琪  博士研究生  071009-细胞生物学  

黄德浩  博士研究生  071009-细胞生物学  

熊加品  博士研究生  071009-细胞生物学  

吴冰燕  博士研究生  071009-细胞生物学  

彭欢  博士研究生  071009-细胞生物学  

李剑焕  博士研究生  071009-细胞生物学  

王瑶  博士研究生  071009-细胞生物学  

吴嘉欣  硕士研究生  0710J6-再生医学  

林云轻  博士研究生  0710J6-再生医学  

郑秀娟  博士研究生  071009-细胞生物学  

现指导学生

肖子芸  博士研究生  0710J6-再生医学  

王智乾  博士研究生  1001J6-再生医学  

刘鹏程  博士研究生  1001J6-再生医学  

冯琴琴  硕士研究生  0710J6-再生医学  

伊若文  硕士研究生  0710J6-再生医学  

张乐强  博士研究生  1001J6-再生医学  

赵瑶琴  博士研究生  1001J6-再生医学  

张帆  博士研究生  1001J6-再生医学  

邓晓洪  硕士研究生  0710J6-再生医学  

杨雅茗  硕士研究生  0710J6-再生医学  

张辰圆  博士研究生  1001J6-再生医学  

徐嘉诚  博士研究生  1001J6-再生医学