王金勇 男 博导 中国科学院动物研究所
电子邮件： wangjinyong@ioz.ac.cn
通信地址： 中国科学院动物研究所
邮政编码：
研究领域
1. 干细胞与血液细胞再生（单核、粒系等白细胞）
基于多能干细胞(ESC/iPSC)谱系分化原理，结合基因编辑，获得可移植的造血干祖细胞种子，探索代替骨髓移植、治疗肿瘤、遗传病、感染、器官退行衰老、病理炎症等目的。
2. 干细胞与免疫细胞再生（T, B, NK等免疫细胞）
基于多能干细胞（ESC/iPSC)谱系分化原理，结合基因编辑，获得可移植的淋巴细胞祖细胞，模拟淋巴细胞发育微环境，进一步制备成熟的B, T, NK细胞。结合细胞疗法原理，探索治疗肿瘤和相关免疫疾病。
招生信息
生物学一级学科，方向是再生医学，每年招生名额2-3人（倾向招收国科大硕博连读学生）。
常年招收具有人类多能干细胞（hESC/iPSC）生物学、实验血液学、免疫学、生物材料科学背景的博士后。具有类器官培养、器官芯片、细胞永生化经验的优先。
招生专业
招生方向
出版信息
1. Huan Peng, Yunqing Lin, Fangxiao Hu, Cui Lv, Bingyan Wu, Qitong Weng, Lijuan Liu, Chengxiang Xia, Xiaofei Liu, Yalan Zhao, Qi Zhang, Yang Geng, Mengyun Zhang, Jinyong Wang.Prolonged generation of multi-lineage blood cells in wild-type animals from pluripotent stem cells. Stem Cell Reports. 2023 Feb 6;S2213-6711(23)00012-7. doi:10.1016/j.stemcr.2023.01.009.
2. Bingyan Wu, Qi Zhang, Pingshan Hong, Lijuan Liu, Huan Peng, Chengxiang Xia, Tongjie Wang, Yao Wang, Qitong Weng, Xiaofei Liu, Yang Geng, Jinyong Wang, Hongling Wu. Antigen-specific TCR-T cells from Rag2 gene-deleted pluripotent stem cells impede solid tumour growth in a mouse model.Cell Prolif. 2023 Jan 2;e13389. doi: 10.1111/cpr.13389. Online ahead of print.
3.Jiapin Xiong, Yalan Zhao, Yunqing Lin, Lebei Chen, Qitong Weng, Chuanping Shi, Xiaofei Liu, Yang Geng, Lijuan Liu, Jinyong Wang, Mengyun Zhang. Identification and characterization of innate lymphoid cells generated from pluripotent stem cells. Cell Rep. 2022 Nov 1;41(5):111569. doi: 10.1016/j.celrep.2022.111569.
4.Huang D, Li J, Hu F, Xia C, Weng Q, Wang T, Peng H, Wu B, Wu H, Xiong J, Lin Y, Wang Y, Zhang Q, Liu X, Liu L, Zheng X, Geng Y, Du X, Zhu X, Wang L, Hao J, Wang J. Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells. Cell Discov. 2022 Nov 8;8(1):121. doi: 10.1038/s41421-022-00467-2.
5. Huang D, Zhao Q, Zhang M, Weng Q, Zhang Q, Wang K, Dong F, Cheng H, Hu F, Wang J. Hoxb5 reprogrammes murine multipotent blood progenitors into haematopoietic stem cell-like cells. Cell Prolif. 2022 Jun;55(6):e13235. doi: 10.1111/cpr.13235. Epub 2022 May 17.
6. Zhang,Q., Wu, B., Weng, Q., Hu, F., Lin, Y., Xia, C., Peng,H., Wang, Y., Liu,X., Liu, L., Xiong, J., Geng, Y., Zhao,Y., Zhang, M., Du,J., Wang, J. (2021) Regeneration of immunocompetent B lymphopoiesis from pluripotent stem cells guided by transcription factors.Cellular & Molecular Immunology, 2022 Apr;19(4):492-503.
7. Wang, T., Xia, C., Weng, Q., Wang, K., Dong, Y., Hao, S., Dong, F., Liu, X., Liu, L., Geng, Y., Guan, Y., Du, J., Cheng, T., Cheng, H., Wang, J. Loss of Nupr1 promotes engraftment by tuning the quiescence threshold of hematopoietic stem cell repository via regulating p53-checkpoint pathway. Haematologica, 2022 Jan 1;107(1):154-166.
8. Xia, C., Wang, T., Cheng, H., Dong, Y., Weng, Q., Sun, G., Zhou, P., Wang, K., Liu, X., Geng, Y., Ma, S., Hao, S., Xu, L., Guan, Y., Du, J., Du, X., Li, Y., Zhu, X., Shi, Y., Xu, S., Wang, D., Cheng, T., and Wang, J. (2020) Mesenchymal stem cells suppress leukemia via macrophage-mediated functional restoration of bone marrow microenvironment. Leukemia, 34(9):2375-2383.
9. Guo, R., Hu, F., Weng, Q., Lv, C., Wu, H., Liu, L., Li, Z., Zeng, Y., Bai, Z., Zhang, M., Liu, Y., Liu, X., Xia, C., Wang, T., Zhou, P., Wang, K., Dong, Y., Luo, Y., Zhang, X., Guan, Y., Geng, Y., Du, J., Li, Y., Lan, Y., Chen, J., Liu, B., and Wang, J. (2020) Guiding T lymphopoiesis from pluripotent stem cells by defined transcription factors. Cell Research 30, 21-33.
10. Zhang, M., Dong, Y., Hu, F., Yang, D., Zhao, Q., Lv, C., Wang, Y., Xia, C., Weng, Q., Liu, X., Li, C., Zhou, P., Wang, T., Guan, Y., Guo, R., Liu, L., Geng, Y., Wu, H., Du, J., Hu, Z., Xu, S., Chen, J., He, A., Liu, B., Wang, D., Yang, Y. G., and Wang, J. (2018) Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes. Nat Immunology 19, 279-290.