My expertise is in the pathogenesis and molecular biology of RNA viruses. The long-term goal of my laboratory is to understand how viruses interact with the host, microbiome, and environment to cause disease at mucosal barrier surfaces. We employ genome-wide CRISPR screening, organoid culture, single-cell RNA sequencing, and mouse models to study virus-host interactions of human coronaviruses and norovirus, and reveal novel therapeutic targets for infectious disease. 

2012 Wuhan University. BS. in Biological Sciences

2017 Wuhan University. Ph.D. in Cell Biology

2022.11-Present Wuhan Institute of Virology, Principal Investigator

2018.08-2022.11 Yale University, Postdoctoral Associate

2018.03-2018.08 UT Health, Postdoctoral Fellow

（1） Antagonistic Ubiquitin Switching by USP7 and RNF40 Orchestrates KDM6A Homeostasis to License Coronavirus Susceptibility, ADVANCED SCIENCE, 2026

（2） Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection, NATURE GENETICS, 2023

（3） The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression, PLOS PATHOGENS, 2023

（4） DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner, PLoS Biology, 2023, 

（5） Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer, CANCER CELL, 2023

（6） Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53, CELL REPORTS, 2023,

（7） High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells, SCIENCE IMMUNOLOGY, 2022

（8） Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection, NATURE GENETICS, 2022

（9） Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617, NATURE COMMUNICATIONS, 2022

（10） Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection, CELL, 2021

（11） Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes, PLOS BIOLOGY, 2021

（12） CD300lf Conditional Knockout Mouse Reveals Strain-Specific Cellular Tropism of Murine Norovirus, JOURNAL OF VIROLOGY, 2021

（13） Nonsteroidal Anti-inflammatory Drugs Dampen the Cytokine and Antibody Response to SARS-CoV-2 Infection, JOURNAL OF VIROLOGY, 2021

（14） Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions, CELL, 2021

（15） CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus, PLOS PATHOGENS, 2020

（16） Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling, JOURNAL OF EXPERIMENTAL MEDICINE, 2020

（17） SNX8 modulates the innate immune response to RNA viruses by regulating the aggregation of VISA, CELLULAR AND MOLECULAR IMMUNOLOGY, 2019

（18） Norovirus Attachment and Entry, VIRUSESBASEL, 2019

（19） MARCH3 attenuates IL-1β–triggered inflammation by mediating K48-linked polyubiquitination and degradation of IL-1RI, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018

（20） The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors, IMMUNITY, 2018

（21） SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA, PLOS PATHOGENS, 2018

（22） ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response, NATURE COMMUNICATIONS, 2018

（23） TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses., PLOS PATHOGENS, 2017

（24） SNX8 mediates IFNγ-triggered noncanonical signaling pathway and host defense against Listeria monocytogenes, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017

（25） Parafibromin Is a Component of IFN-gamma-Triggered Signaling Pathways That Facilitates JAK1/2-Mediated Tyrosine Phosphorylation of STAT1, JOURNAL OF IMMUNOLOGY, 2015

（26） Transmembrane Protein 214 (TMEM214) Mediates Endoplasmic Reticulum Stress-induced Caspase 4 Enzyme Activation and Apoptosis, JOURNAL OF BIOLOGICAL CHEMISTRY, 2013

（27） RAVER1 is a coactivator of MDA5-mediated cellular antiviral response, JOURNAL OF MOLECULAR CELL BIOLOGY, 2013

(1) COMPOUNDS AND COMPOSITIONS FOR TREATING, AMELIORATING, AND/OR PREVENTING SARS-COV-2 INFECTION AND/OR COMPLICATIONS THEREOF, 2021, Patent No. : WO2021247367-A1

（1）A chemically-targetable transcription factor-chromatin remodeler interaction underlies SARS-CoV-2 susceptibility, American Society for Virology's 41th Annual Meeting. Jin Wei 2022-07-16
（2）Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection, American Society for Virology's 40th Annual Meeting. Jin Wei 2021-07-19
（3）Establishment and characterization of a tuft cell line for murine norovirus infection, American Society for Virology's 39th Annual Meeting. Jin Wei 2020-06-13

已指导学生

葛研  硕士研究生  086000-生物与医药  

现指导学生

王诗  博士研究生  100102-免疫学  

黄梦卓  博士研究生  100102-免疫学  

宋宛遥  硕士研究生  071005-微生物学  

杨中元  博士研究生  071005-微生物学  

孔明珠  博士研究生  071005-微生物学  

(1) Outstanding Reviewer Award (Signal Transduction and Targeted Therapy), 2023

(2) Postdoctoral Scholar Registration Award (American Society for Virology), 2021

(3) Postdoctoral Scholar Travel Award (American Society for Virology), 2020

(4) Rudolph J. Anderson Postdoctoral Fellowship (Yale University), 2019