基本信息

魏进 男 博导 中国科学院武汉病毒研究所
电子邮件: jin.wei@wh.iov.cn
通信地址: 湖北省武汉市江夏区郑店街道黄金工业园金龙大街262号
邮政编码: 430207
电子邮件: jin.wei@wh.iov.cn
通信地址: 湖北省武汉市江夏区郑店街道黄金工业园金龙大街262号
邮政编码: 430207
研究领域
实验室主要从事病毒与宿主相互作用的分子机制研究,利用 CRISPR 基因编辑技术,高通量测序技术(RNA-seq、scRNA-seq、ATAC-seq和CUT&TAG等),类器官培养(Organoid culture)和气-液界面(Air-Liquid Interface)细胞培养等,在全基因组范围内筛选调控RNA病毒感染、复制与致病的关键宿主分子,开发基于宿主的抗病毒疗法。主要包括:
1. RNA病毒(如冠状病毒,肠道病毒等),分子病毒学、病毒感染与致病机制研究;
2. 病毒与宿主相互作用及免疫逃逸的机制研究;
3. 开发基于宿主的抗病毒药物。
招生信息
硕士研究生、博士研究生
招生专业
071005-微生物学071009-细胞生物学071010-生物化学与分子生物学
招生方向
病毒与宿主相互作用、免疫逃逸、感染与致病机制、抗病毒药物
教育背景
2012-09--2017-07 武汉大学 博士学位2008-09--2012-07 武汉大学 学士学位
工作经历
2022.11-至今 中国科学院武汉病毒研究所, 研究员
2018.08-2022.11 耶鲁大学, 博士后
2018.03-2018.08 UT Health, 博士后
专利与奖励
奖励信息
(1) Postdoctoral Scholar Registration Award (American Society for Virology), , 国家级, 2021(2) Postdoctoral Scholar Travel Award (American Society for Virology), , 国家级, 2020(3) Rudolph J. Anderson Postdoctoral Fellowship (Yale University), , 研究所(学校), 2019(4) 武汉大学学术创新奖, 二等奖, 研究所(学校), 2019(5) 武汉大学学术创新奖, 一等奖, 研究所(学校), 2018
专利成果
( 1 ) COMPOUNDS AND COMPOSITIONS FOR TREATING, AMELIORATING, AND/OR PREVENTING SARS-COV-2 INFECTION AND/OR COMPLICATIONS THEREOF, 发明专利, 2021, 专利号: WO2021247367-A1
出版信息
发表论文
[1] Wei, Jin, Patil, Ajinkya, Collings, Clayton K, Alfajaro, Mia Madel, Liang, Yu, Cai, Wesley L, Strine, Madison S, Filler, Renata B, DeWeirdt, Peter C, Hanna, Ruth E, Menasche, Bridget L, Okten, Arya, PenaHernandez, Mario A, Klein, Jon, McNamara, Andrew, Rosales, Romel, McGovern, Briana L, Rodriguez, M Luis, GarciaSastre, Adolfo, White, Kris M, Qin, Yiren, Doench, John G, Yan, Qin, Iwasaki, Akiko, Zwaka, Thomas P, Qi, Jun, Kadoch, Cigall, Wilen, Craig B. Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection. NATURE GENETICS[J]. 2023, 第 1 作者http://dx.doi.org/10.1038/s41588-023-01307-z.[2] Jin Wei, Mia Madel Alfajaro, Wesley L Cai, Vincent R Graziano, Madison S Strine, Renata B Filler, Scott B Biering, Sylvia A Sarnik, Sonam Patel, Bridget L Menasche, Susan R Compton, Silvana Konermann, Patrick D Hsu, Robert C Orchard, Qin Yan, Craig B Wilen, Jacob S Yount. The KDM6A-KMT2D-p300 axis regulates susceptibility to diverse coronaviruses by mediating viral receptor expression. PLOS PATHOGENS[J]. 2023, 第 1 作者 通讯作者 19(7): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10325096/.[3] Madison S. Strine,Wesley L. Cai,Jin Wei,Mia Madel Alfajaro,Renata B. Filler,Scott B. Biering,Sylvia Sarnik,Ryan D. Chow,Ajinkya Patil,Kasey S. Cervantes,Clayton K. Collings,Peter C. DeWeirdt,Ruth E. Hanna,Kevin Schofield,Christopher Hulme,Silvana Konermann,John G. Doench,Patrick D. Hsu,Cigall Kadoch,Qin Yan,Craig B. Wilen. DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner. PLoS Biology[J]. 2023, 21(6): e3002097, https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002097.[4] Fernando J de Miguel, Claudia Gentile, William W Feng, Shannon J Silva, Akshay Sankar, Francisco Exposito, Wesley L Cai, Mary Ann Melnick, Camila RoblesOteiza, Madeline M Hinkley, Jeanelle A Tsai, AntjaVoy Hartley, Jin Wei, Anna Wurtz, Fangyong Li, Maria I Toki, David L Rimm, Robert Homer, Craig B Wilen, Andrew Z Xiao, Jun Qi, Qin Yan, Don X Nguyen, Pasi A Jnne, Cigall Kadoch, Katerina A Politi. Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer. CANCER CELL. 2023, 第 13 作者41(8): 1516-1534.e9, http://dx.doi.org/10.1016/j.ccell.2023.07.005.[5] Lee, Jonathan D, Menasche, Bridget L, Mavrikaki, Maria, Uyemura, Madison M, Hong, Su Min, Kozlova, Nina, Wei, Jin, Alfajaro, Mia M, Filler, Renata B, Muller, Arne, Saxena, Tanvi, Posey, Ryan R, Cheung, Priscilla, Muranen, Taru, Heng, Yujing J, Paulo, Joao A, Wilen, Craig B, Slack, Frank J. Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53. CELL REPORTS[J]. 2023, 第 7 作者42(12): http://dx.doi.org/10.1016/j.celrep.2023.113478.[6] Chen, Jennifer S, Chow, Ryan D, Song, Eric, Mao, Tianyang, Israelow, Benjamin, Kamath, Kathy, Bozekowski, Joel, Haynes, Winston A, Filler, Renata B, Menasche, Bridget L, Wei, Jin, Alfajaro, Mia Madel, Song, Wenzhi, Peng, Lei, Carter, Lauren, Weinstein, Jason S, Gowthaman, Uthaman, Chen, Sidi, Craft, Joe, Shon, John C, Iwasaki, Akiko, Wilen, Craig B, Eisenbarth, Stephanie C. High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells. SCIENCE IMMUNOLOGY[J]. 2022, 第 11 作者7(68): http://dx.doi.org/10.1126/sciimmunol.abl5652.[7] Biering, Scott B, Sarnik, Sylvia A, Wang, Eleanor, Zengel, James R, Leist, Sarah R, Schafer, Alexandra, Sathyan, Varun, Hawkins, Padraig, Okuda, Kenichi, Tau, Cyrus, Jangid, Aditya R, Duffy, Connor, V, Wei, Jin, Gilmore, Rodney C, Alfajaro, Mia Madel, Strine, Madison S, Nguyenla, Xammy, Van Dis, Erik, Catamura, Carmelle, Yamashiro, Livia H, Belk, Julia A, Begeman, Adam, Stark, Jessica C, Shon, D Judy, Fox, Douglas M, Ezzatpour, Shahrzad, Huang, Emily, Olegario, Nico, Rustagi, Arjun, Volmer, Allison S, LivraghiButrico, Alessandra, Wehri, Eddie, Behringer, Richard R, Cheon, DongJoo, Schaletzky, Julia, Aguilar, Hector C, Puschnik, Andreas S, Button, Brian, Pinsky, Benjamin A, Blish, Catherine A, Baric, Ralph S, ONeal, Wanda K, Bertozzi, Carolyn R, Wilen, Craig B, Boucher, Richard C, Carette, Jan E, Stanley, Sarah A, Harris, Eva, Konermann, Silvana, Hsu, Patrick D. Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection. NATURE GENETICS[J]. 2022, 第 13 作者54(8): 1078-+, http://dx.doi.org/10.1038/s41588-022-01131-x.[8] Peng, Lei, Hu, Yingxia, Mankowski, Madeleine C, Ren, Ping, Chen, Rita E, Wei, Jin, Zhao, Min, Li, Tongqing, Tripler, Therese, Ye, Lupeng, Chow, Ryan D, Fang, Zhenhao, Wu, Chunxiang, Dong, Matthew B, Cook, Matthew, Wang, Guilin, Clark, Paul, Nelson, Bryce, Klein, Daryl, Sutton, Richard, Diamond, Michael S, Wilen, Craig B, Xiong, Yong, Chen, Sidi. Monospecific and bispecific monoclonal SARS-CoV-2 neutralizing antibodies that maintain potency against B.1.617. NATURE COMMUNICATIONS[J]. 2022, 第 6 作者13(1): https://doaj.org/article/3c2da467436042e1868fd384b454c96c.[9] Wei, Jin, Alfajaro, Mia Madel, DeWeirdt, Peter C, Hanna, Ruth E, LuCulligan, William J, Cai, Wesley L, Strine, Madison S, Zhang, ShangMin, Graziano, Vincent R, Schmitz, Cameron O, Chen, Jennifer S, Mankowski, Madeleine C, Filler, Renata B, Ravindra, Neal G, Gasque, Victor, de Miguel, Fernando J, Patil, Ajinkya, Chen, Huacui, Oguntuyo, Kasopefoluwa Y, Abriola, Laura, Surovtseva, Yulia, V, Orchard, Robert C, Lee, Benhur, Lindenbach, Brett D, Politi, Katerina, van Dijk, David, Kadoch, Cigall, Simon, Matthew D, Yan, Qin, Doench, John G, Wilen, Craig B. Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection. CELL[J]. 2021, 第 1 作者184(1): 76-+, http://dx.doi.org/10.1016/j.cell.2020.10.028.[10] Ravindra, Neal G, Alfajaro, Mia Madel, Gasque, Victor, Huston, Nicholas C, Wan, Han, SzigetiBuck, Klara, Yasumoto, Yuki, Greaney, Allison M, Habet, Victoria, Chow, Ryan D, Chen, Jennifer S, Wei, Jin, Filler, Renata B, Wang, Bao, Wang, Guilin, Niklason, Laura E, Montgomery, Ruth R, Eisenbarth, Stephanie C, Chen, Sidi, Williams, Adam, Iwasaki, Akiko, Horvath, Tamas L, Foxman, Ellen F, Pierce, Richard W, Pyle, Anna Marie, van Dijk, David, Wilen, Craig B. Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium identifies target cells, alterations in gene expression, and cell state changes. PLOS BIOLOGY[J]. 2021, 第 12 作者19(3): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007021/.[11] Graziano, Vincent R, Alfajaro, Mia Madel, Schmitz, Cameron O, Filler, Renata B, Strine, Madison S, Wei, Jin, Hsieh, Leon L, Baldridge, Megan T, Nice, Timothy J, Lee, Sanghyun, Orchard, Robert C, Wilen, Craig B. CD300lf Conditional Knockout Mouse Reveals Strain-Specific Cellular Tropism of Murine Norovirus. JOURNAL OF VIROLOGY[J]. 2021, 第 6 作者95(3): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7925115/.[12] Chen, Jennifer S, Alfajaro, Mia Madel, Chow, Ryan D, Wei, Jin, Filler, Renata B, Eisenbarth, Stephanie C, Wilen, Craig B. Nonsteroidal Anti-inflammatory Drugs Dampen the Cytokine and Antibody Response to SARS-CoV-2 Infection. JOURNAL OF VIROLOGY[J]. 2021, 第 4 作者95(7): http://dx.doi.org/10.1128/JVI.00014-21.[13] Flynn, Ryan A, Belk, Julia A, Qi, Yanyan, Yasumoto, Yuki, Wei, Jin, Alfajaro, Mia Madel, Shi, Quanming, Mumbach, Maxwell R, Limaye, Aditi, DeWeirdt, Peter C, Schmitz, Cameron O, Parker, Kevin R, Woo, Elizabeth, Chang, Howard Y, Horvath, Tamas L, Carette, Jan E, Bertozzi, Carolyn R, Wilen, Craig B, Satpathy, Ansuman T. Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions. CELL[J]. 2021, 第 5 作者184(9): 2394-+, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7951565/.[14] Graziano, Vincent R, Walker, Forrest C, Kennedy, Elizabeth A, Wei, Jin, Ettayebi, Khalil, Strine, Madison S, Filler, Renata B, Hassan, Ebrahim, Hsieh, Leon L, Kim, Arthur S, Kolawole, Abimbola O, Wobus, Christiane E, Lindesmith, Lisa C, Baric, Ralph S, Estes, Mary K, Orchard, Robert C, Baldridge, Megan T, Wilen, Craig B. CD300lf is the primary physiologic receptor of murine norovirus but not human norovirus. PLOS PATHOGENS[J]. 2020, 第 4 作者16(4): https://doaj.org/article/c2674dd032554c20845ee5f10d202eda.[15] Israelow, Benjamin, Song, Eric, Mao, Tianyang, Lu, Peiwen, Meir, Amit, Liu, Feimei, Alfajaro, Mia Madel, Wei, Jin, Dong, Huiping, Homer, Robert J, Ring, Aaron, Wilen, Craig B, Iwasaki, Akiko. Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling. JOURNAL OF EXPERIMENTAL MEDICINE[J]. 2020, 第 8 作者217(12): http://dx.doi.org/10.1084/jem.20201241.[16] Wei Guo, Jin Wei, Xuan Zhong, Ru Zang, Huan Lian, MingMing Hu, Shu Li, HongBing Shu, Qing Yang. SNX8 modulates the innate immune response to RNA viruses by regulating the aggregation of VISA. CELLULAR AND MOLECULAR IMMUNOLOGY. 2019, 第 2 作者17(11): 1126-1135, [17] Graziano, Vincent R, Wei, Jin, Wilen, Craig B. Norovirus Attachment and Entry. VIRUSESBASEL[J]. 2019, 第 2 作者11(6): https://doaj.org/article/b22324fbe64e4b338fb9195f7a32c485.[18] Heng Lin, Deng Gao, MingMing Hu, Man Zhang, XiaoXia Wu, Lu Feng, WenHua Xu, Qing Yang, Xuan Zhong, Jin Wei, ZhiSheng Xu, HongXia Zhang, ZeMin Song, Qian Zhou, Wen Ye, Ying Liu, Shu Li, HongBing Shu. MARCH3 attenuates IL-1β–triggered inflammation by mediating K48-linked polyubiquitination and degradation of IL-1RI. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018, 第 10 作者115(49): 12483-12488, [19] Lian, Huan, Zang, Ru, Wei, Jin, Ye, Wen, Hu, MingMing, Chen, YunDa, Zhang, XiaNan, Guo, Yi, Lei, CaoQi, Yang, Qing, Luo, WeiWei, Li, Shu, Shu, HongBing. The Zinc-Finger Protein ZCCHC3 Binds RNA and Facilitates Viral RNA Sensing and Activation of the RIG-I-like Receptors. IMMUNITY[J]. 2018, 第 3 作者49(3): 438-+, http://www.corc.org.cn/handle/1471x/2373240.[20] Wei, Jin, Lian, Huan, Guo, Wei, Chen, YunDa, Zhang, XiaNan, Zang, Ru, Zhong, Li, Yang, Qing, Hu, MingMing, Luo, WeiWei, Shu, HongBing, Li, Shu. SNX8 modulates innate immune response to DNA virus by mediating trafficking and activation of MITA. PLOSPATHOGENS[J]. 2018, 第 1 作者14(10): http://202.127.146.157/handle/2RYDP1HH/4011.[21] Huan Lian, Jin Wei, Ru Zang, Wen Ye, Qing Yang, XiaNan Zhang, YunDa Chen, YuZhi Fu, MingMing Hu, CaoQi Lei, WeiWei Luo, Shu Li, HongBing Shu. ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response. NATURE COMMUNICATIONS[J]. 2018, 第 2 作者9(1): http://www.corc.org.cn/handle/1471x/2373248.[22] Yang, Qing, Liu, TianTian, Lin, Heng, Zhang, Man, Wei, Jin, Luo, WeiWei, Hu, YunHong, Zhong, Bo, Hu, MingMing, Shu, HongBing. TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses. PLOS PATHOGENS[J]. 2017, 第 5 作者13(9): http://dx.doi.org/10.1371/journal.ppat.1006600.[23] Jin Wei, Wei Guo, Huan Lian, Qing Yang, Heng Lin, Shu Li, HongBing Shu. SNX8 mediates IFNγ-triggered noncanonical signaling pathway and host defense against Listeria monocytogenes. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017, 第 1 作者114(49): 13000-13005, [24] Wei, Jin, Lian, Huan, Zhong, Bo, Shu, HongBing. Parafibromin Is a Component of IFN-gamma-Triggered Signaling Pathways That Facilitates JAK1/2-Mediated Tyrosine Phosphorylation of STAT1. JOURNAL OF IMMUNOLOGY[J]. 2015, 第 1 作者195(6): 2870-2878, http://dx.doi.org/10.4049/jimmunol.1501111.[25] Li, Chao, Wei, Jin, Li, Ying, He, Xiao, Zhou, Qian, Yan, Jie, Zhang, Jing, Liu, Ying, Liu, Yu, Shu, HongBing. Transmembrane Protein 214 (TMEM214) Mediates Endoplasmic Reticulum Stress-induced Caspase 4 Enzyme Activation and Apoptosis. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2013, 第 2 作者288(24): 17908-17917, http://dx.doi.org/10.1074/jbc.M113.458836.[26] Chen, He, Li, Ying, Zhang, Jing, Ran, Yong, Wei, Jin, Yang, Yan, Shu, HongBing. RAVER1 is a coactivator of MDA5-mediated cellular antiviral response. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2013, 第 5 作者5(2): 111-119, http://dx.doi.org/10.1093/jmcb/mjt006.
科研活动
科研项目
( 1 ) KDM6A-KMT2D-p300信号轴调节多种冠状病毒感染的分子机制, 负责人, 国家任务, 2024-01--2027-12( 2 ) RNA病毒与宿主相互作用, 负责人, 国家任务, 2024-01--2026-12( 3 ) 病毒感染的宿主辅助因子及限制因子, 负责人, 国家任务, 2023-12--2026-11
参与会议
(1)A chemically-targetable transcription factor-chromatin remodeler interaction underlies SARS-CoV-2 susceptibility 美国病毒学学会第41届年会 Jin Wei 2022-07-16(2)A chemically-targetable transcription factor-chromatin remodeler interaction underlies SARS-CoV-2 susceptibility Signal Transduction and Targeted Therapy 学术沙龙(第八期)之SARS-COV-2感染与复制新见解 Jin Wei 2022-06-22(3)Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection 美国病毒学学会第40届年会 Jin Wei 2021-07-19(4)Establishment and characterization of a tuft cell line for murine norovirus infection 美国病毒学学会第39届年会 Jin Wei 2020-06-13
指导学生
现指导学生
葛研 硕士研究生 086000-生物与医药
王诗 博士研究生 100102-免疫学
黄梦卓 博士研究生 100102-免疫学
宋宛遥 硕士研究生 071005-微生物学
孔明珠 硕士研究生 100103-病原生物学