电子邮件: jfyin@rcees.ac.cn
通信地址: 北京市海淀区双清路18号
邮政编码: 100085
研究领域
主要从事环境化学和分析化学领域的研究。近年来的研究包括:DNA损伤的高选择性和高灵敏度检测;功能性分子识别材料及环境纳米材料的研制及应用等。
招生信息
欢迎有分析化学、材料化学和生物化学专业背景的同学报考。
招生专业
招生方向
教育背景
学历
研究生
学位
专利与奖励
( 1 ) 一种用于DNA酶切为单核苷的级联酶反应器, 发明专利, 2016, 第 2 作者, 专利号: 201610544434.7
( 2 ) 脂蛋白毛细管涂层及其制备方法, 发明专利, 2008, 第 2 作者, 专利号: 200810240105.9
( 3 ) 一种毛细管和微流控芯片电泳通道中蛋白质的荧光成像表征方法, 发明专利, 2008, 第 2 作者, 专利号: 200810240104.4
代表性论著
(1) Citrate-functionalized osmium nanoparticles with peroxidase-like specific activity for highly efficient degradation of phenolic pollutants, CHEMICAL ENGINEERING JOURNAL, 2023, 通讯作者
(2) Magnetic multi-enzyme cascade combined with liquid chromatography tandem mass spectrometry for fast DNA digestion and quantitative analysis of 5-hydroxymethylcytosine in genome of human bladder cancer T24 cells induced by tetrachlorobenzoquinone, JOURNAL OF CHROMATOGRAPHY A, 2022, 通讯作者
(3) Selective extraction and detection of beta-agonists in swine urine for monitoring illegal use in livestock breeding, FOOD CHEMISTRY, 2020, 第 3 作者
(4) Immobilized Multi-Enzyme Cascade Reactor, PROGRESS IN CHEMISTRY, 2020, 通讯作者
(5) 固定化多酶级联反应器, Immobilized Multi-Enzyme Cascade Reactor, 化学进展, 2020, 第 5 作者
(6) Bioaccumulation and transfer characteristics of dechlorane plus in human adipose tissue and blood stream and the underlying mechanisms, SCIENCE OF THE TOTAL ENVIRONMENT, 2020, 第 1 作者
(7) Fluorescent imaging of cytoplasmic nucleolin in live cells by a functionalized-engineered aptamer, CHEMICAL COMMUNICATIONS, 2020, 第 1 作者
(8) Profiling of epigenetic DNA modifications by advanced liquid chromatography-mass spectrometry technologies, TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2019, 第 3 作者
(9) Liquid chromatography- mass spectrometry for analysis of DNA damages induced by environmental exposure, TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2019, 第 1 作者
(10) Profiling of epigenetic DNA modifications by advanced liquid chromatography-mass spectrometry technologies, TRENDS IN ANALYTICAL CHEMISTRY, 2019, 第 3 作者
(11) Chemical etching of pH- sensitive aggregationinduced emission- active gold nanoclusters for ultra- sensitive detection of cysteine, NANOSCALE, 2019, 第 4 作者
(12) Elevated 8-oxo-7,8-dihydro-2 '-deoxyguanosine in genome of T24 bladder cancer cells induced by halobenzoquinones, JOURNAL OF ENVIRONMENTAL SCIENCES, 2018, 第 2 作者
(13) Multienzyme cascade bioreactor for a 10 min digestion of genomic dna into single nucleosides and quantitative detection of structural dna modifications in cellular genomic dna, ACS APPLIED MATERIALS & INTERFACES, 2018, 第 1 作者
(14) A multi-enzyme cascade bioreactor for ten-minute digestion of genomic DNA into single nucleosides and quantitative detection of structural DNA modifications in cellular genomic DNA, ACS Applied Materials & Interfaces, 2018, 第 1 作者
(15) Detection of 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker of oxidative damage in peripheral leukocyte DNA by UHPLC–MS/MS, JOURNAL OF CHROMATOGRAPHY B, 2017, 第 3 作者
(16) 级联固定化酶反应器的制备及在核酸修饰分析中的应用, 第21届全国色谱学术报告会及仪器展览会会议论文集, 2017, 第 1 作者
(17) Oxidative stress and immunotoxicity induced by graphene oxide in zebrafish, AQUATIC TOXICOLOGY, 2016, 第 2 作者
(18) 高效液相色谱法测定细胞内的三种能量代谢物, 中国化学会第十一届全国生物医药色谱及相关技术学术交流会(大会特邀报告及墙报)论文摘要集, 2016, 第 3 作者
(19) Three-Enzyme Cascade Bioreactor for Rapid Digestion of Genomic DNA into Single Nucleosides, ANALYTICAL CHEMISTRY, 2016, 第 1 作者
(20) 分子印迹纳米材料用于DNA损伤的荧光成像分析, 第二十届全国色谱学术报告会及仪器展览会, 2015, 第 1 作者
(21) 级联固定化酶微反应器的制备及用于DNA损伤分析, 第二十届全国色谱学术报告会及仪器展览会, 2015, 第 5 作者
(22) 有机-无机杂化毛细管整体基质DNA微酶反应器的制备与应用, 第二十届全国色谱学术报告会及仪器展览会, 2015, 第 3 作者
(23) A fluorophore-conjugated ascorbic acid functions for the visualization of sodium vitamin C transporters in living cells, ANALYTICAL METHODS, 2015, 第 1 作者
(24) 荧光修饰抗坏血酸酯的合成及细胞中SVCTs成像分析, 第二十届全国色谱学术报告会及仪器展览会, 2015, 第 4 作者
(25) Plastic antibody for DNA damages: Fluorescent imaging of BPDE-dG adducts in genomic DNA, Analyst, 2013, 第 1 作者
(26) Study of cytotoxic effects of single-walled carbon nanotubes functionalized with different chemical groups on human MCF7 cells, CHEMOSPHERE, 2013, 第 4 作者
(27) 在线MISPE-HPLC技术用于河水中双酚A类污染物的测定, 第七届全国环境化学学术大会, 2013, 第 1 作者
(28) Polyvinyl Pyrrolidone Promotes DNA Cleavage by a ROS-Independent and Depurination Mechanism, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2013, 第 5 作者
(29) Capillary Monolithic Bioreactor of Immobilized Snake Venom Phosphodiesterase for Mass Spectrometry Based Oligodeoxynucleotide Sequencing, ANALYTICAL CHEMISTRY, 2012, 第 3 作者
(30) 基于整体柱微酶反应器的DNA测序方法研究, 中国化学会第28届学术年会, 2012, 第 3 作者
(31) 分子印迹纳米材料用于BPDE-DNA加合物的高灵敏检测, 全国生物医药色谱及相关技术学术交流会, 2012, 第 1 作者
(32) Size-dependent toxicity of nano-C60 aggregates: More sensitive indication by apoptosis-related Bax translocation in cultured human cells., Environm. Sci. & Technol., 2012,
(33) Size-Dependent Toxicity of Nano-C-60 Aggregates: More Sensitive Indication by Apoptosis-Related Bax Translocation in Cultured Human Cell, ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2012, 第 3 作者
(34) Interaction of Human Serum Album and C-60 Aggregates in Solution, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2011, 第 3 作者
(35) 基于适配体的有机聚合物HPLC整体柱对靶蛋白的提取, 第六届全国环境化学学术大会论文集, 2011, 第 2 作者
(36) 基于固定化微酶反应器的DNA测序方法的研究, 第六届全国环境化学学术大会论文集, 2011, 第 2 作者
(37) MISPE-HPLC法用于水中痕量阿特拉津的测定, 第六届全国环境化学学术大会论文集, 2011, 第 1 作者
(38) Dummy molecularly imprinted polymer for selective screening of trace bisphenols in river water, ANALYTICAL METHODS, 2011, 第 1 作者
(39) Molecularly imprinted nanotubes for enantioselective drug delivery and controlled release, CHEMICALCOMMUNICATIONS, 2010, 通讯作者
(40) Inhibition of polymerase activity by pristine fullerene nanoparticles can be mitigated by abundant proteins, CHEMICAL COMMUNICATIONS, 2010, 第 3 作者
(41) 替代模板分子印迹技术在环境污染物痕量分析中的应用, 2010年全国生物医药色谱学术交流会论文集, 2010, 第 1 作者
(42) Molecularly imprinted nanotubes for enantio-selective drug delivery and controlled release (Cover), Chemical Communications, 2010, 第 1 作者
(43) Fluorescently Imaged Particle Counting Immunoassay for Sensitive Detection of DNA Modifications, ANALYTICAL CHEMISTRY, 2010, 第 4 作者
(44) Pseudo-template molecularly imprinted polymer for selective screening of trace beta-lactam antibiotics in river and tap water, JOURNAL OF CHROMATOGRAPHY A, 2010, 第 1 作者
(45) Fabrication and fluorescence imaging of human low-density lipoprotein coatings for highly efficient capillary electrophoresis separation of basic proteins, ELECTROPHORESIS, 2009, 第 1 作者
(46) Improved preparation and identification of aristolochic acid-DNA adducts by solid-phase extraction with liquid chromatography-tandem mass spectrometry, JOURNAL OF ENVIRONMENTAL SCIENCES, 2009, 第 4 作者
(47) Interaction Between Water-soluble Hydroxylated Single-wall Carbon Nanotubes and Human Serum Albumin, CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2009, 第 2 作者
(48) Highly sensitive detection of human thrombin in serum by affinity capillary electrophoresis/laser-induced fluorescence polarization using aptamers as probes, JOURNAL OF CHROMATOGRAPHY A, 2009, 第 5 作者
(49) 水溶性羟基化单壁碳纳米管与人血清白蛋白之间的相互作用研究, Interaction Between Water-soluble Hydroxylated Single-wall Carbon Nanotubes and Human Serum Albumin, 高等学校化学学报, 2009, 第 2 作者
(50) Improved preparation and identification of aristolochic acid-DNA adducts by solid-phase extraction with liquid chromatography-tandem mass spectrometry, JOURNAL OF ENVIRONMENTAL SCIENCES-CHINA, 2009, 第 4 作者
(51) p- tert-Butylcalix8arene-bonded silica monoliths for liquid chromatography, JOURNAL OF CHROMATOGRAPHY A, 2008, 第 1 作者
(52) Focusing and stabilization of bis-intercalating dye-DNA complexes for high-sensitive CE-LIF DNA analysis, ELECTROPHORESIS, 2008, 第 3 作者
(53) Preparation, identification and analysis of stereoisomeric anti-benzo apyrene diol epoxide–deoxyguanosine adducts using phenyl liquid chromatography with diode array, fluorescence and tandem mass spectrometry detection, JOURNAL OF CHROMATOGRAPHY A, 2008, 第 2 作者
(54) 脂蛋白涂层毛细管电色谱法的应用, 2008年全国生物医药色谱交流会论文集, 2008, 第 1 作者
(55) Macroporous polymer monoliths fabricated by using a metal-organic coordination gel template, CHEMICAL COMMUNICATIONS, 2007, 第 1 作者
(56) Molecularly imprinted solid-phase extraction for rapid screening of mycophenolic acid in human plasma, JOURNAL OF CHROMATOGRAPHY B, 2006, 第 1 作者
(57) Purification and determination of stachyose in Chinese artichoke ( Stachys Sieboldii Miq.) by high-performance liquid chromatography with evaporative light scattering detection, TALANTA, 2006, 第 1 作者
(58) Rapid and efficient chiral separation of nateglinide and its l-enantiomer on monolithic molecularly imprinted polymers, JOURNAL OF CHROMATOGRAPHY A, 2005,
科研项目情况
(1) 国家自然科学基金面上项目“遗传毒性效应导向的大气细颗粒物诱导DNA损伤敏感标志物的筛查”,批准号:22174156,2022.01 - 2025.12, 主持, 60万
(2)国家自然科学基金面上项目“级联酶反应器的研制及高灵敏DNA损伤分析新方法的研究”,批准号:21974148,2020.01-2013.12,主持,70万
(3)国家自然科学基金面上项目“特异性识别DNA损伤的新型分子印迹纳米材料的设计合成及应用”,批准号:21375142,2014.01 - 2017.12,主持,80万
(4)国家自然科学基金青年基金“原子转移自由基聚合法制备新型分子印迹纳米膜包覆型毛细管整体柱”,批准号:20805057,2009.01-2011.12,主持,18万
(5)中科院战略性先导专项B子课题“污染物诱发核酸损伤类型的鉴定”(XDB14030302),2014.07-2019.06,主持,158万
(6)国家重点研发计划“纳米材料治理水体复合污染的应用基础研究及工程示范”课题“水处理过程中纳米材料和污染物的转化与归趋”,批准号:2016YFA0203102,2016.01-2020.12,子课题负责人,80万
(7)973项目“典型人工纳米材料的水环境过程、生物效应及其调控研究”之子课题“理化性质/赋存状态对纳米材料损伤DNA效应的影响机制”,批准号:2014CB932003,2014,01-2018.12,子课题负责人,40万
(8)863计划项目“重大环境污染事件应急技术系统研究开发与应用示范”课题“重大环境污染事件特征污染物实验室检测技术系统”,批准号:No. 2007AA06A407,2008.03-2011.03,子课题负责人,85万
(9)中国科学院重大科研装备研制项目“DNA损伤单分子偏振成像检测装置研制”,批准号:YZ200749,2007.09-2010.10,参加,30万
(10)环保公益性行业科研专项“典型水体污染区环境与健康综合监测关键技术及案例研究”,批准号:201309045,2013.01-2015.12,参加,56万
(11)环境化学与生态毒理学国家重点实验室青年创新基金“在线分子印迹固相萃取-纳流液相色谱法分析水体中酚类环境雌激素”,批准号:QN200810,2008.09-2010.09,主持,8万
指导学生
已指导学生
宋媛媛 硕士研究生 070302-分析化学
徐田 硕士研究生 077601-环境科学
陈少坤 硕士研究生 085229-环境工程
现指导学生
贾蒙 硕士研究生 085700-资源与环境