土壤环境化学/土壤污染生物过程与生物效应研究

   

083001-环境科学

环境化学与污染控制
理论环境化学，计算毒理学

[1]. 国家自然科学基金青年项目-土壤中PCBs生物有效性的QSARs模型预测与分子机制研究（41001335），2011.01-2013.12，主持

[2]. 国家自然科学基金面上项目-PBDEs微生物酶促降解的分子作用机制及其构效关系（21377138），2014.01-2017.12，80万元，主持

[3]. 国家自然科学基金面上项目-土壤中酞酸酯类污染物生物有效性的微观作用机制与定量构效关系研究（41977356），2020.01-2023.12，主持

[4]. 国家自然科学基金面上项目-土壤酞酸酯类污染物的蚯蚓代谢转化及其关键酶促分子机制与构效关系（42377406），2024.01-2027.12，主持

[5]. 江苏省自然科学基金面上项目-土壤中多氯联苯生物有效性的定量构效关系及影响机制（BK2011886），2011.07-2014.07，主持

[6]. 中国科学院 A 类战略性先导科技专项“黑土地保护与利用科技创新工程”子课题-黑土农药污染生物防控技术（XDA28030501），2021.09-2026.08，主持

[7]. 中国科学院研究所 “一三五”计划与领域前沿项目-土壤中酞酸酯生物富集途径对其生物有效性的影响及定量构效关系（ISSASIP1618），2016.01-2018.12，主持

[8]. 中国科学院研究所知识创新工程领域前沿项目-土壤中典型有机污染物生物有效性的模型估算与分子机制理论阐释（ISSASIP1108），2012.01-2014.12，主持

[9]. 国家重点研发计划项目子课题-场地土壤-地下水-地表水污染演化与风险评价模型研究（2023YFC3706702），2023.12-2027.11, 主持

[10].国家重点研发计划项目子课题-场地表层低成本、强富集复合净化材料的可控制备与示范验证（2020YFC1808602），2020.11-2024.10，主持

[11].国家重点研发计划项目子课题-场地土壤污染物形态和生物有效性时空变异特征与主控因子（2018YFC1801005），2018.12-2022.11，主持

[12].国家重点研发计划项目子课题-设施菜地酞酸酯和激素的多界面迁移转化机制与效应（2016YFD0800204），2016.01-2020.12，主持

[13].农业部公益性行业专项子课题-农产品产地环境保障技术政策研究（201203045），2012.01-2016.12，主持

[14].第42批中国博士后科学基金面上资助项目（一等）-基于配/受体作用的POPs致毒机制与三维构效关系研究（20070420191），2007.10-2009.08，主持

[15].江苏省博士后科研资助计划项目-基于配/受体作用的POPs致毒机制与三维构效关系研究（0702014C），2007.10-2009.08，主持

已指导学生

程吟文  硕士研究生  077601-环境科学  

朱梦荣  硕士研究生  077601-环境科学  

刘畅  硕士研究生  077601-环境科学  

提清清  硕士研究生  077601-环境科学  

蔡君  硕士研究生  077601-环境科学  

范秀丽  硕士研究生  077601-环境科学  

金志华  硕士研究生  077601-环境科学  

现指导学生

沈乐祖  硕士研究生  077601-环境科学  

张如静  硕士研究生  077601-环境科学  

近五年主要发表论文情况

[1].   Chenggang Gu*, Lezu Shen, Zhengyuan Gao, Xiuli Fan, Xinglun Yang, Zunyao Wang, Cheng Sun, Fang Wang, Xin Jiang. Unveiling the structural requirements for congener-specific biodegradation of polybrominated diphenyl ethers by Burkholderia xenovorans LB400: A combined QSAR study. Environmental Research 2026, 302: 124632.

[2].   Lezu Shen, Chenggang Gu*, Zhengyuan Gao, Xiuli Fan, Xinglun Yang, Dongyun Yan, Zunyao Wang, Cheng Sun, Huan He, Shaogui Yang, Xin Jiang. Computational mapping of CYP450 metabolism for Benzotriazole UV absorbers: Biotransformation pathways, mechanisms and environmental implications demonstrated with UV-P. Ecotoxicology and Environmental Safety 2026, 314: 120052.

[3].   Xiuli Fan, Chenggang Gu*, Zhengyuan Gao, Lezu Shen, Dongyun Yan, Huan He, Xinglun Yang, Yang Song, Mao Ye, Fang Wang, Xin Jiang. Novel regulatory mechanisms of carboxylesterase by soil organic matter: Correlative insights into enzymatic activation and pollutant degradation via multi-spectral and molecular dynamics approaches. J. Hazard. Mater. 2025, 499: 140315.

[4].   Xiuli Fan, Chenggang Gu*, Zhengyuan Gao, Lezu Shen, Xinglun Yang, Yang Song, Yongrong Bian, Qingfeng Xu, Fang Wang, Xin Jiang. Active binding mechanism to superoxide dismutase and toxicological implication for environmentally prevalent phthalates and their hydrolytic products: Coupling in vitro bioassay with molecular dynamics simulation. Int. J. Biol. Macromol. 2025, 311: 143607.

[5].   Xiuli Fan, Chenggang Gu*, Lezu Shen, Zhengyuan Gao, Xinglun Yang, Yongrong Bian, Fang Wang, Xin Jiang. Theoretical insights into the binding of mono/di-ethyl phthalates to superoxide dismutase and associated structural changes impairing antioxidant activity: A coupled molecular docking and dynamics simulation approach. Sci. Total Environ. 2025, 983: 179667.

[6].   Gao ZY, Gu CG*, Fan XL, Shen LZ, Jin ZH, Wang F, Jiang X. Biochemical insights into the biodegradation mechanism of typical sulfonylureas herbicides and association with active enzymes and physiological response of fungal microbes: A multi-omics approach. Environ. Int. 2024, 190: 108906.

[7].   Fan X.L., Gu C.G.*, Jin Z.H., Cai J., Bian Y.R., Wang F., Chen H., Jiang X. Major biotransformation of phthalic acid esters in Eisenia fetida: Mechanistic insights and association with catalytic enzymes and intestinal symbionts. Environ. Int. 2023, 171: 107712.

[8].   Gu C.G.*, Wang L., Jin Z.H., Fan X.L., Gao Z.Y., Yang X.L., Sun C., Jiang X. Congener-specificity, dioxygenation dependency and association with enzyme binding for biodegradation of polybrominated diphenyl ethers by typical aerobic bacteria: Experimental and theoretical studies. Chemosphere 2023, 314: 137697.

[9].   Gu C.G.*, Jin Z.H., Fan X.L., Ti Q.Q., Yang X.L., Sun C., Jiang X.^* Comparative evaluation and prioritization of key influences on biodegradation of 2,2′,4,4′-tetrabrominated diphenyl ether by bacterial isolate B.xenovorans LB400. J. Environ. Manage. 2023 331:117320

[10].Jin Z.H., Gu C.G. *, Fan X.L., Cai J., Bian Y.R., Song Y., Sun C., Jiang X. Novel insights into the predominant factors affecting the bioavailability of polycyclic aromatic hydrocarbons in industrial contaminated areas using PLS-developed model. Chemosphere 2023, 319: 138033.

[11].Yang L.F., Han W.J., Zhao W.*, Gu C.G.*, Xu Z.H., Jiang X. Mono-/multiadsorption of chlorobenzene compounds on biochar: influence of the properties of the chlorobenzene molecules and biochar. J. Soils Sediments 2023, 23: 2120-2135.

[12].Fan X.L., Gu C.G.*, Cai J., Zhong M., Bian Y.R., Jiang X. Mechanistic insights into primary biotransformation of diethyl phthalate in earthworm and significant SOD inhibitory effect of esterolytic products. Chemosphere 2022, 288: 132491.

[13].Gu C.G.*, Fan X.L., Ti Q.Q., Yang X.L., Bian Y.R., Sun C., Jiang X. Mechanistic insight into hydroxylation of 2,2',4,4'-tetrabromodiphenyl ether during biodegradation by typical aerobic bacteria: Experimental and computational studies. J. Hazard. Mater. 2021, 416: 126132.

[14].Gu C.G., Cai J., Fan X.L., Bian Y.R., Yang X.L., Xia Q.Y., Sun C., Jiang X.* Theoretical investigation of AhR binding property with relevant structural requirements for AhR-mediated toxicity of polybrominated diphenyl ethers. Chemosphere 2020, 249: 126554.

[15].Fan X.L., Gu C.G.*, Cai J., Bian Y.R., Yang X.L., Sun C., Jiang X. Study on active response of superoxide dismutase and relevant binding interaction with bioaccumulated phthalates and key metabolites in Eisenia fetida. Ecotoxicol. Environ. Safe. 2021, 223: 112559.

[16].Ti Q.Q., Gu C.G.*, Cai J., Fan X.L., Zhang Y.P., Bian Y.R., Sun C., Jiang X. Understanding the role of bacterial cellular adsorption, accumulation and bioavailability regulation by biosurfactant in affecting biodegradation efficacy of polybrominated diphenyl ethers. J. Hazard. Mater. 2020, 393: 122382.

[17].Tang J.P., Rong X., Jin D.C., Gu C.G.*, Chen A.W., Luo, S. Biodegradation of phthalate esters in four agricultural soils: Main influencing factors and mechanisms. Int. Biodeterior. Biodegrad. 2020, 147: 104867.

[18].Cai J., Gu C.G.*, Ti Q.Q., Liu C., Bian Y.R., Sun C., Jiang X. Mechanistic studies of congener-specific adsorption and bioaccumulation of polycyclic aromatic hydrocarbons and phthalates in soil by novel QSARs. Environ. Res. 2019, 179: 108838.

[19].Ti Q.Q., Gu C.G.*, Liu C., Cai J., Bian Y.R., Yang X.L., Song Y., Wang F., Sun C., Jiang X. Comparative evaluation of influence of aging, soil properties and structural characteristics on bioaccessibility of polychlorinated biphenyls in soil. Chemosphere 2018, 210: 941-948.

[20].Wang Y., Wang F., Xiang L.L., Gu C.G.,  Redmile-Gordon M.,  Sheng H.J., Wang Z.Q.,  Fu Y.H.,  Bian Y.R., Jiang X. Risk Assessment of Agricultural Plastic Films Based on Release Kinetics of Phthalate Acid Esters. Environ. Sci. Technol. 2021, 55(6): 3676-3685.

[21].Li X.N., Song Y., Bian Y.R., Gu C.G., Yang X.L., Wang F., Jiang X. Insights into the mechanisms underlying efficient Rhizodegradation of PAHs in biochar-amended soil: From microbial communities to soil metabolomics. Environ. Int. 2020, 144: 105995.