单细胞组学是目前生物学研究的前沿技术。本课题组主要通过高通量单细胞转录组测序和表观基因组测序技术，绘制常见细胞系模型的异质性图谱、主要器官的跨物种单细胞图谱以及人体重要器官的单细胞图谱，同时通过生物信息学分析，揭示细胞水平基因表达调控的异质性，特别是选择性剪接、RNA编辑等转录后调控过程在细胞谱系分化、重大疾病如癌症、神经退行性疾病等发生发展过程中的作用机制。

   

070321-化学生物学
070322-生物无机化学
071022-基因组学

单细胞组学分析

2014-09--2017-03   丹麦哥本哈根大学生物系   博士
2011-07--2014-01   东南大学生物科学与医学工程学院   硕士
2007-08--2011-06   东南大学生物科学与医学工程学院   本科

   

2018-06~现在, 深圳华大生命科学研究院, 执行院长
2014-07~2018-06,深圳华大基因研究院, 执行副院长
2010-03~2014-07,深圳华大基因研究院, 生物信息分析工程师

2017-10-09-今,深圳市盐田区田东中学科技副校长,
2017-09-01-今,深圳市盐田区团委副书记,

单细胞组学分析

   

（1） 血液肿瘤及相关疾病发病的分子机理和诊疗新技术研究, 二等奖, 省级, 2019
（2） 中华医学科技二等奖, 二等奖, 其他, 2014

（ 1 ） 功能水平调解肠道菌群, 发明, 2016, 第 3 作者, 专利号: 201610976999.2
（ 2 ） 一种新的肿瘤特异性多肽及其应用, 发明, 2016, 第 1 作者, 专利号: 16/326,659
（ 3 ） 一种新的肿瘤特异性多肽及其应用, 发明, 2016, 第 1 作者, 专利号: 201680086580.8
（ 4 ） 一种新的肿瘤特异性多肽及其应用, 发明, 2016, 第 1 作者, 专利号: PCT/CN2016/096020
（ 5 ） 多肽及其应用, 发明, 2016, 第 3 作者, 专利号: 201680088999.7
（ 6 ） 多肽及其应用, 发明, 2016, 第 3 作者, 专利号: 16/295,653
（ 7 ） 多肽及其应用, 发明, 2016, 第 3 作者, 专利号: PCT/CN2016/098328
（ 8 ） 多肽及其应用, 发明, 2016, 第 5 作者, 专利号: PCT/CN2016/098329
（ 9 ） CACNA1H衍生的肿瘤抗原多肽及其应用, 发明, 2016, 第 2 作者, 专利号: PCT/CN2016/100978
（ 10 ） 多肽及其应用, 发明, 2016, 第 5 作者, 专利号: PCT/CN2016/106140
（ 11 ） 多肽及其应用, 发明, 2016, 第 3 作者, 专利号: PCT/CN2016/106797
（ 12 ） 多肽及其应用, 发明, 2016, 第 3 作者, 专利号: PCT/CN2016/106796
（ 13 ） 多肽及其应用, 发明, 2016, 第 3 作者, 专利号: PCT/CN2016/107751
（ 14 ） 多肽及其应用, 发明, 2016, 第 3 作者, 专利号: PCT/CN2016/108102
（ 15 ） 多肽及其应用, 发明, 2016, 第 3 作者, 专利号: PCT/CN2016/109308
（ 16 ） 一种基于体细胞新序列特异识别的疾病治疗技术, 发明, 2016, 第 2 作者, 专利号: 201611156438.4
（ 17 ） 一种基于CRISPR技术治疗KRAS突变恶性肿瘤的sgRNA及其应用, 发明, 2017, 第 4 作者, 专利号: 201711115396.4
（ 18 ） 细胞改造的方法, 发明, 2017, 第 2 作者, 专利号: 18113564.9
（ 19 ） 细胞改造的方法, 发明, 2017, 第 2 作者, 专利号: 201711340125.9
（ 20 ） 一种扩增特异性CAR-T细胞的培养方法, 发明, 2017, 第 5 作者, 专利号: 201711458709.6
（ 21 ） 一种small RNA的文库构建及测序方法, 发明, 2018, 第 4 作者, 专利号: 201810045361.6
（ 22 ） MART-1(27-35)表位特异性T细胞受体, 发明, 2018, 第 4 作者, 专利号: PCT/CN2018/095395
（ 23 ） 肠道宏基因组在筛选PD-1抗体阻断剂疗效方面的用途, 发明, 2019, 第 3 作者, 专利号: PCT/CN2019/075825
（ 24 ） POLYPEPTIDE AND USE THEREOF, 发明, 2020, 第 3 作者, 专利号: US Patent App. 16/417,579
（ 25 ） Cacna1h-derived tumor antigen polypeptide and use thereof, 发明, 2020, 第 2 作者, 专利号: US Patent App. 16/338,126

   

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（1） Nanoparticles in Biology and Medicine, Humana Press, 2012-06, 第 3 作者
（2） Single Cell Biomedicine, Spring Nature, 2018-05, 第 5 作者

   

（ 1 ） 基于单细胞转录组数据检测RNA编辑位点的生物信息学方法研究, 主持, 省级, 2018-05--2021-04
（ 2 ） 基于肠道菌群及HLA的鼻咽癌免疫疗法精准治疗研究, 主持, 省级, 2019-03--2021-03
（ 3 ） 基于多位点微克隆和单细胞多组学的乳腺癌异质性与个体化治疗研究, 参与, 省级, 2017-01--2020-12
（ 4 ） 基于分子影像和影像组学的乳腺癌早诊、疗效评价与预后预测新技术研发, 参与, 国家级, 2017-07--2020-12
（ 5 ） 基于单细胞基因测序的新型抗体靶向药物研发平台, 参与, 省级, 2016-07--2019-06
（ 6 ） 血液单细胞基因选择性剪接谱的特征分析及其在预测细胞亚群上的应用, 主持, 国家级, 2019-01--2021-12
（ 7 ） 单细胞组学重点实验室, 主持, 省级, 2020-01--2025-01

（1）cost effecitve accurate genome sequencing by DNB-SEQ   2019-06-15
（2）Single Cell Sequencing in Cancer   2016-11-01
（3）Single cell sequencing towards precision medicine   2016-06-13

本课题组与美国国立癌症研究所Michael Dean教授，丹麦哥本哈根大学Karsten Kristiansen教授，美国斯坦福大学Andreas Keller教授等建立了长期的合作与交流关系，包括互访、学生交换等。