cancer signaling pathways，cell cycle control，endocytic trafficking, chemical biology

1995-1999  Beijing Normal University, Bachelor

1999-2006  Institutes of Genetics and Developmental Biology, CAS, Ph.D

   

2006-2010, Biochemistry Department, Purdue University, USA, Postdoc 

2010-2011, Sichuan University, Professor

2011-      Shenzhen Institutes of Advanced Technology, CAS

Experiment in Biochemistry

Progression in Chemical Biology

1) Haishan Zhang , Ximing Shao, Yin Peng, Yanning Teng, Konda Mani Saravanan, Huiling Zhang, Hongchang Li, Yanjie Wei.(2019) A novel machine learning based approach for iPS progenitor cell identification, Plos Comput Biol, 15 (12), e1007351 

 

2) Ke Liu, Lijing Fang, Haiyan Sun, Zhengyin Pan, Jianchao Zhang, Juntao Chen, Ximing Shao, Wei Wang, Yuanyan Tan, Zhihao Ding, Lijiao Ao, Chunlei, Wu, Xiaoqi Liu, Huashun Li, Rui Wang, Wu Su1, and Hongchang Li* (2018)Targeting Polo-like Kinase 1 by a Novel Pyrrole-imidazole Polyamide-Hoechst Conjugate Suppresses Tumor Growth in vivo­. Mol Cancer Ther.17(5) 988-1002 

3）Ximing Shao, Zhihao Ding, Ming Zhao, Ke Liu, Haiyan Sun, Juntao Chen, Xianming Liu, Yuzhen Zhang, Yang Hong, Huashun Li* & Hongchang Li*. (2017) Mammalian Numb protein antagonizes Notch by controlling postendocytic trafficking of the Notch ligand Delta-like 4. J Biol Chem.  2017 Dec 15;292(50):20628-20643

4)Haiyan Sun, Yi Liu, Lei Zhang, Ximing Shao, Ke Liu, Zhihao Ding, Xianming Liu, Changan Jiang , Huashun Li, Hongchang Li. (2017) Numb positively regulates autophagic flux via regulating lysosomal Function. Biochem Biophys Res Commun. 2017 Sep 23;491(3):780-786.

5)Zhenyin Pan, Chunlei Wu, Wei Wang, Zhehong Cheng，Ke Liu, Hongchang Li, Lijin Fang, Wu Su. (2017)Total Synthesis and Stereochemical Assignment of Gymnopeptides A and B. Org Lett. 2017 Sep 1;19(17):4420-4423.

6).Wenyu Qian, Yang Hong, Minyan Zhu, Liang Zhou, Hongchang Li, Huashun Li. (2017)  Deletion of Numb/Numblike in glutamatergic neurons leads to anxiety-like behavior in mice. Brain Research 1665 (2017) 36–49

7）Jianchao Zhang, Ximing Shao, Haiyan Sun, Ke Liu, Zhihao Ding, Juntao Chen, Lijing Fang, Wu Su, Yang Hong, Huashun Li* and Hongchang Li*. (2016) NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling. Oncotarget, 2016, 2016, , 7(38):61036-53  

8）Run Lei , Ke Zhang , Ke Liu, Ximing Shao, Zhihao Ding, Fudi Wang, Yang Hong, Minyan Zhu, Hongchang Li,* and Huashun Li*. (2016) Transferrin Receptor Facilitates TGF- and BMP Signaling Activation to Control Craniofacial Morphogenesis. Cell death and Disease, 2016, Jun 30;7(6):e2282

9）Ximing Shao,　Yi Liu, Qian Yu, Zhihao Ding, Wenyu Qian, Lei Zhang, Jianchao Zhang, Nan Jiang, Linfei Gui, Zhiheng Xu, Yang Hong, Yifan Ma, Yanjie Wei, Xiaoqing Liu, Changan Jiang, Minyan Zhu, Hongchang Li* & Huashun Li*. (2016) Numb Regulates Vesicular Docking for Homotypic Fusion of Early Endosomes via Membrane Recruitment of Mon1b. Cell Research, 26(5):593-612

　

10）Run Lei, Ke Zhang,Yanxia Wei,Min Chen,LeeS.Weinstein,Yang Hong, Minyan Zhu, Hongchang Li*,Huashun Li*. (2016) G-Protein α-Subunit Gsα Is Required for Craniofacial Morphogenesis. PLoS ONE  9;11(2):e0147535

 

11）Ke Liu, Run Lei, Qiong Li, Xin-Xin Wang, Qian Wu, Peng An, Jianchao Zhang, Minyan Zhu, Zhiheng Xu, Yang Hong, Fudi Wang, Ying Shen, Hongchang Li,* & Huashun Li*. (2016) Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity.  Scientific Reports， 16;6:21019.

 

12）Ximing Shao, Ke Liu, Yi Fan, Zhihao Ding, Min Chen, Minyan Zhu, Lee S Weinstein, Hongchang Li*, Huashun Li*. (2015)　Gαs Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize VE-cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity. Journal of genetics and Genomics, 42（11）：613-624．

 

13）Ke Liu, Quan Lin, Yanxia Wei, Renbing He, Ximing Shao, Zhihao Ding, Jianchao Zhang, Minyan Zhu, Lee S. Weinstein, Yang Hong, Hongchang Li *, Huashun Li*. (2015) Gas regulates asymmetric cell division of cortical progenitors by controlling Numb mediated Notch signaling suppression. Neuroscience Letters 597， 97–103

 

14）Hongchang Li, Shawn Liu, Xiaoming Yang, Yun Wang, Bing Song, and Xiaoqi Liu. (2010) Plk1 phosphorylation of p150Glued facilitates nuclear envelope breakdown during prophase. Proc Natl Acad Sci USA. 107 (33), 14633-14638.(Featured in faculty of 1000,  http://f1000.com/prime/4916968; Incorporated in the book, Intracellular Membranes: Advances in Research and application:2011 Edition Scholarly Brief, 59-60)

 

15）Hongchang Li, Shawn Liu, Xiaoming Yang, Yingmin Wang, Yun Wang, Jerrold R. Turner, and Xiaoqi Liu. (2010) Phosphorylation of CLIP-170 by Plk1 and CK2 promotes timely formation of kinetochore-microtubule attachments. Embo J. 29, 2953-2965.

 

16）Xiaoming Yang*, Hongchang Li*, X.Shawn Liu, Anping Deng, and Xiaoqi Liu. (2009) CDC2-mediated phosphorylation of CLIP-170 is essential for its inhibition of centrosome reduplication. J. Biol. Chem. 284, 28775-28782 (*, contributed equally)

 

17）Hongchang Li, Yun Wang, and Xiaoqi Liu. (2008) Plk1-dependent phosphorylation regulates functions of DNA Topoisomerase IIa in cell cycle progression. J. Biol. Chem. 283, 6209-6221 

Molecular mechanisms of carcinogenesis and tumor drug development 

已指导学生

孙海燕  博士研究生  071010-生物化学与分子生物学  

李梅青  博士研究生  071010-生物化学与分子生物学  

张海山  硕士研究生  085211-计算机技术  

现指导学生

李艳艳  博士研究生  071010-生物化学与分子生物学  

程冰华  博士研究生  071010-生物化学与分子生物学  

朱燕  硕士研究生  086000-生物与医药  

Selected as “Shenzhen Peacock Plan Talents” in 2012