研究领域：细胞周期调控机制研究；天然多肽药物抗肿瘤机制研究；纳米材料抗肿瘤机制研究

2022-2023年度拟招收硕士研究生和博士研究生1-3名，学科方向为细胞生物学，纳米生物学

071010-生物化学与分子生物学
071009-细胞生物学
0703Z1-化学生物学

细胞增殖与细胞周期
纳米生物效应
多肽药物

1999-09--2006-06   中国科学院遗传与发育生物学研究所   博士
1995-09--1999-07   北京师范大学生物系   学士

博士：中国科学院遗传与发育生物学研究所，分子遗传学，2006

博士：分子遗传学

   

2011-11~现在, 中国科学院深圳先进技术研究院, 研究员
2006-07~2010-08,美国普度大学生物化学系, 博士后

化学生物学进展
神经生物学基础
生命科学综合实验

   

（ 1 ） 在Hela细胞系中稳定敲低Syntaxin7的方法, 发明专利, 2013, 第 3 作者, 专利号: 201310745250.3

（ 2 ） 利用siRNA技术在Hela细胞系敲低Syntaxin8, 发明专利, 2013, 第 3 作者, 专利号: 201310746152.1

（ 3 ） 稳定敲低Syntaxin6 的Hela细胞系, 发明专利, 2013, 第 3 作者, 专利号: 201310746166.3

（ 4 ）  Syntaxin16表达量稳定降低的Hela细胞系的构建方法, 发明专利, 2013, 第 3 作者, 专利号: 201310744339.8

（ 5 ） 稳定敲低VPS11 的Hela细胞系, 发明专利, 2013, 第 3 作者, 专利号: 201310746080.0

（ 6 ） 稳定敲低Delta-like 4 的人脐静脉内皮细胞系, 发明专利, 2013, 第 3 作者, 专利号: 201310744174.4

（ 7 ） 带HA标签的LAMP1真核表达载体及其在溶酶体分离中的应用, 发明专利, 2013, 第 2 作者, 专利号: 201310560452.0

（ 8 ） 带MYC标签的LAMP1真核表达载体及其在溶酶体分离中的应用 , 发明专利, 2013, 第 2 作者, 专利号: 201310561630.1

（ 9 ） LAMP1绿色荧光表达载体、其制备方法及应用 , 发明专利, 2013, 第 2 作者, 专利号: 201310675953.3

（ 10 ） LAMP1红色荧光表达载体、其制备方法及应用 , 发明专利, 2013, 第 2 作者, 专利号: 201310674877.4

（ 11 ） 带Flag标签的LAMP1真核表达载体及其在溶酶体分离中的应用 , 发明专利, 2013, 第 2 作者, 专利号: 201310560532.6

（ 12 ） 带Strep标签的LAMP1真核表达载体及其在溶酶体分离中的应用, 发明专利, 2013, 第 2 作者, 专利号: 201310561628.4

   

[1] Jiwei Zheng, Wanyi He, Jing Li, Hongchang Li, Liang Chen, Lijing Fang. Bifunctional Compounds as Molecular Degraders for Integrin-facilitated Targeted Protein Degradation. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2023, 第 4 作者  通讯作者  144: 21831-21836, 
[2] Guofang Zhang, Hongchang Li, Liming Wang, Yang Li. A nanomaterial targeting the spike protein captures SARS-CoV-2 variants and promotes viral elimination. Nature Nanotechnology[J]. 2022, 第 2 作者  通讯作者  17(9): 993-1003, 
[3] Wu, Chunlei, Hongchang Li, Fang, Lijing. Cell-penetrating riboflavin conjugate for antitumor photodynamic therapy. Chinese Chemical Letters[J]. 2022, 第 2 作者  通讯作者  
[4] Shao, Ximing, Ding, Zhihao, Zhou, Wenhua, Li, Yanyan, Li, Zhibin, Cui, Haodong, Lin, Xian, Cao, Guoli, Cheng, Binghua, Sun, Haiyan, Li, Meiqing, Liu, Ke, Lu, Danyi, Geng, Shengyong, Shi, Wenli, Zhang, Guofang, Song, Qingle, Chen, Liang, Wang, Guocheng, Su, Wu, Cai, Lintao, Fang, Lijing, Leong, David Tai, Li, Yang, Yu, XueFeng, Li, Hongchang. Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinase. NATURE NANOTECHNOLOGY[J]. 2021, 第 26 作者  通讯作者  16(10): 1150-+, http://dx.doi.org/10.1038/s41565-021-00952-x.
[5] Wu, Chunlei, Hongchang Li, Lijing Fang. A Novel N-methylated Cyclodepsipeptide Prodrug for Targeted Cancer Therapy. Journal of Medicinal Chemistry[J]. 2021, 第 2 作者  通讯作者  
[6] Shi, Wenli, Lu, Danyi, Wu, Chunlei, Li, Meiqing, Ding, Zhihao, Li, Yanyan, Chen, Binghua, Lin, Xian, Su, Wu, Shao, Ximing, Xia, Zhihui, Fang, Lijing, Liu, Ke, Li, Hongchang. Coibamide A kills cancer cells through inhibiting autophagy. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2021, 第 14 作者  通讯作者  547: 52-58, http://dx.doi.org/10.1016/j.bbrc.2021.01.112.
[7] Wu, Chunlei, Cheng, Zhehong, Lu, Danyi, Liu, Ke, Cheng, Yulian, Wang, Pengxin, Zhou, Yimin, Li, Meiqing, Shao, Ximing, Li, Hongchang, Su, Wu, Fang, Lijing. Novel N-Methylated Cyclodepsipeptide Prodrugs for Targeted Cancer Therapy. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2021, 第 10 作者  通讯作者  64(2): 991-1000, http://dx.doi.org/10.1021/acs.jmedchem.0c01387.
[8] Liu, Ke, Zou, Rongfeng, Cui, Wenqiang, Li, Meiqing, Wang, Xueying, Dong, Junlin, Li, Hongchun, Li, Hongpei, Wang, Peihui, Shao, Ximing, Su, Wu, Chan, H C Stephen, Li, Hongchang, Yuan, Shuguang. Clinical HDAC Inhibitors Are Effective Drugs to Prevent the Entry of SARS-CoV2. ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE[J]. 2020, 第 13 作者  通讯作者  3(6): 1361-1370, http://dx.doi.org/10.1021/acsptsci.0c00163.
[9] Li, Meiqing, Shao, Ximing, Wu, Chunlei, Lu, Danyi, Liu, Ke, Wang, Wei, Liu, Jiakai, Li, Hongchang, Su, Wu, Fang, Lijing. Chlorotoxin-derived bicyclic peptides for targeted imaging of glioblastomas. CHEMICAL COMMUNICATIONS[J]. 2020, 第 8 作者  通讯作者  56(66): 9537-9540, http://dx.doi.org/10.1039/d0cc01089h.
[10] Liu, Yanfeng, Tao, Shishi, Liao, Lijuan, Li, Yang, Li, Hongchang, Li, Zhihuan, Lin, Lilong, Wan, Xiaochun, Yang, Xiaolu, Chen, Liang. TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway. NATURE COMMUNICATIONS[J]. 2020, 第 5 作者11(1): https://doaj.org/article/8a113faa8cad44bca1e2d4948f32e7c0.
[11] Haishan Zhang, Ximing Shao, Yin Peng, Yanning Teng, Konda Mani Saravanan, Huiling Zhang, Hongchang Li, Yanjie Wei. A novel machine learning based approach for iPS progenitor cell identification.. PLOS COMPUTATIONAL BIOLOGY[J]. 2019, 第 7 作者  通讯作者  15(12): 19, https://doaj.org/article/82dcaa32c6a14e979f24cd2db4a2f804.
[12] Yao, Guiyang, Wang, Wei, Ao, Lijiao, Cheng, Zhehong, Wu, Chunlei, Pang, Zhengyin, Liu, Ke, Li, Hongchang, Su, Wu, Fang, Lijing. Improved Total Synthesis and Biological Evaluation of Coibamide A Analogues. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 第 8 作者61(19): 8908-8916, http://ir.siat.ac.cn:8080/handle/172644/14615.
[13] Liu, Ke, Fang, Lijing, Sun, Haiyan, Pan, Zhengyin, Zhang, Jianchao, Chen, Juntao, Shao, Ximing, Wang, Wei, Tan, Yuanyan, Ding, Zhihao, Ao, Lijiao, Wu, Chunlei, Liu, Xiaoqi, Li, Huashun, Wang, Rui, Su, Wu, Li, Hongchang. Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide-Hoechst Conjugate Suppresses Tumor Growth In Vivo. MOLECULAR CANCER THERAPEUTICS[J]. 2018, 第 17 作者  通讯作者  17(5): 988-1002, http://ir.siat.ac.cn:8080/handle/172644/14593.
[14] Li, Hongchang, Ji, Guobiao, Wang, Yun, Qian, Qian, Xu, Jichen, Sodmergen, Liu, Guozhen, Zhao, Xianfeng, Chen, Mingsheng, Zhai, Wenxue, Li, Dayong, Zhu, Lihuang. WHITE PANICLE3, a Novel Nucleus-Encoded Mitochondrial Protein, Is Essential for Proper Development and Maintenance of Chloroplasts and Mitochondria in Rice. FRONTIERS IN PLANT SCIENCE[J]. 2018, 第 1 作者9: http://ir.siat.ac.cn:8080/handle/172644/14605.
[15] Yao, Guiyang, Wang, Wei, Ao, Lijiao, Cheng, Zhehong, Wu, Chunlei, Pang, Zhengyin, Liu, Ke, Li, Hongchang, Su, Wu, Fang, Lijing. Improved Total Synthesis and Biological Evaluation of Coibamide A Analogues. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 第 8 作者61(19): 8908-8916, http://ir.siat.ac.cn:8080/handle/172644/14615.
[16] Pan, Zhengyin, Wu, Chunlei, Wang, Wei, Cheng, Zhehong, Yao, Guiyang, Liu, Ke, Li, Hongchang, Fang, Lijing, Su, Wu. Total Synthesis and Stereochemical Assignment of Gymnopeptides A and B. ORGANIC LETTERS[J]. 2017, 第 7 作者19(17): 4420-4423, https://www.webofscience.com/wos/woscc/full-record/WOS:000409566400003.
[17] Shao, Ximing, Ding, Zhihao, Zhao, Ming, Liu, Ke, Sun, Haiyan, Chen, Juntao, Liu, Xianming, Zhang, Yuzhen, Hong, Yang, Li, Huashun, Li, Hongchang. Mammalian Numb protein antagonizes Notch by controlling postendocytic trafficking of the Notch ligand Delta-like 4. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2017, 第 11 作者  通讯作者  292(50): 20628-20643, http://dx.doi.org/10.1074/jbc.M117.800946.
[18] Sun, Haiyan, Liu, Yi, Zhang, Lei, Shao, Ximing, Liu, Ke, Ding, Zhihao, Liu, Xianming, Jiang, Changan, Li, Huashun, Li, Hongchang. Numb positively regulates autophagic flux via regulating lysosomal function. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2017, 第 10 作者  通讯作者  491(3): 780-786, http://dx.doi.org/10.1016/j.bbrc.2017.07.084.
[19] 陈俊涛, 张建超, 李红昌. Aurora 蛋白激酶抑制剂研究综述. 集成技术[J]. 2017, 第 3 作者6(2): 49-58, https://jcjs.siat.ac.cn/jcjs/article/abstract/201702006?st=article_issue.
[20] Wang, Ce, Li, Ping, Liu, Lanlan, Pan, Hong, Li, Hongchang, Cai, Lintao, Ma, Yifan. Self-adjuvanted nanovaccine for cancer immunotherapy: Role of lysosomal rupture-induced ROS in MHC class I antigen presentation. BIOMATERIALS[J]. 2016, 第 5 作者79: 88-100, http://dx.doi.org/10.1016/j.biomaterials.2015.11.040.
[21] Liu, Ke, Lei, Run, Li, Qiong, Wang, XinXin, Wu, Qian, An, Peng, Zhang, Jianchao, Zhu, Minyan, Xu, Zhiheng, Hong, Yang, Wang, Fudi, Shen, Ying, Li, Hongchang, Li, Huashun. Transferrin Receptor Controls AMPA Receptor Trafficking Efficiency and Synaptic Plasticity. SCIENTIFIC REPORTS[J]. 2016, 第 13 作者  通讯作者  6: https://www.webofscience.com/wos/woscc/full-record/WOS:000370296600001.
[22] Shao, Ximing, Liu, Yi, Yu, Qian, Ding, Zhihao, Qian, Wenyu, Zhang, Lei, Zhang, Jianchao, Jiang, Nan, Gui, Linfei, Xu, Zhiheng, Hong, Yang, Ma, Yifan, Wei, Yanjie, Liu, Xiaoqing, Jiang, Changan, Zhu, Minyan, Li, Hongchang, Li, Huashun. Numb regulates vesicular docking for homotypic fusion of early endosomes via membrane recruitment of Mon1b. CELL RESEARCH[J]. 2016, 第 17 作者  通讯作者  26(5): 593-612, http://dx.doi.org/10.1038/cr.2016.34.
[23] Shao Ximing, Liu Ke, Fan Yi, Zhihao Ding, Chen Min, Zhu Minyan, Weinstein Lee S, Li Hongchang, Li Huashun. Gαs Relays Sphingosine-1-Phosphate Receptor 1 Signaling to Stabilize Vascular Endothelial-Cadherin at Endothelial Junctions to Control Mouse Embryonic Vascular Integrity. JOURNAL OF GENETICS AND GENOMICS[J]. 2015, 第 8 作者42(11): 613-624, http://dx.doi.org/10.1016/j.jgg.2015.08.006.
[24] 张建超, 李红昌. EMT 的表观遗传调控在癌症进程中的研究进展. 集成技术[J]. 2015, 第 2 作者4(4): 55-63, https://jcjs.siat.ac.cn/jcjs/article/abstract/201504006?st=article_issue.
[25] Pan, Hong, Zhang, Yijuan, Luo, Zichao, Li, Ping, Liu, Lanlan, Wang, Ce, Wang, Hanzhong, Li, Hongchang, Ma, Yifan. Autophagy mediates avian influenza H5N1 pseudotyped particle-induced lung inflammation through NF-kappa B and p38 MAPK signaling pathways. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY[J]. 2014, 第 8 作者306(2): L183-L195, http://dx.doi.org/10.1152/ajplung.00147.2013.

   

（ 1 ） 干细胞分裂模式和干细胞干性维持的机制研究, 参与, 国家任务, 2012-01--2016-12
（ 2 ） 深圳市神经发育分子生物学重点实验室建设项目, 负责人, 地方任务, 2012-08--2014-08
（ 3 ） 成体干细胞的命运决定机制与功能研究, 参与, 国家任务, 2014-01--2018-12
（ 4 ） Gas蛋白在哺乳动物细胞有丝分裂过程中的功能研究, 负责人, 国家任务, 2014-01--2016-12
（ 5 ） 神经退行性疾病自噬机制研究, 负责人, 地方任务, 2013-12--2015-12
（ 6 ） 癌症相关激酶Plk1新型抑制剂及其对乳腺肿瘤的抑制作用研究, 负责人, 地方任务, 2016-06--2019-06
（ 7 ） Mon1b 协同NSF调控早期内吞体膜融合的机制研究, 负责人, 国家任务, 2017-01--2020-12
（ 8 ） 靶向细胞周期激酶的新型抗肿瘤药物研究, 参与, 地方任务, 2018-03--2021-03
（ 9 ） Numb磷酸化决定细胞分裂早期物理形态和生物信号通路紧密协同的机制研究, 负责人, 国家任务, 2019-01--2022-12
（ 10 ） 细胞形态变化和细胞周期紧密协同的分子机制研究, 负责人, 地方任务, 2018-05--2022-04
（ 11 ） 乙肝病毒导致肝癌病变的肿瘤微环境机制研究, 负责人, 地方任务, 2021-07--2024-06
（ 12 ） SIAT优秀青年基金A档, 负责人, 研究所自选, 2022-03--2024-02

已指导学生

孙海燕  博士研究生  071010-生物化学与分子生物学  

李梅青  博士研究生  071010-生物化学与分子生物学  

张海山  硕士研究生  085211-计算机技术  

现指导学生

李艳艳  博士研究生  071010-生物化学与分子生物学  

程冰华  博士研究生  071010-生物化学与分子生物学  

朱燕  硕士研究生  086000-生物与医药