General

Guangwei Si

Principal Investigator

Institute of Biophysics, Chinese Academy of Science

email: si@ibp.ac.cn

Phone: +86 10 64888474

Address: Room 2315, 25 Datun Road, Chaoyang District, Beijing, China, 100101

Research Areas

Systems neuroscience, neural coding, olfaction

Education

2008-2013 Ph.D in Physics, Peking University, Center for quantitative biology. Thesis with Qi Ouyang & Yuhai Tu.

2004-2008 B.S. in Physics, Jilin University, School of Physics.

Experience

   
Work Experience

2020-          Principal Investigator, Institute of Biophysics, Chinese Academy of Science.

2013-2020, Postdoctoral Fellow, Harvard University, Department of Physics and Center for Brain Science.

Teaching Experience
2020 Fall, Fundamental Biomedical Signal Processing


Publications

   
Papers

  • "Structured odorant response patterns across a complete olfactory receptor neuron population" Neuron, (2019).

  • "Escape band in Escherichia coli chemotaxis in opposing attractant and nutrient gradients." PNAS., (2019).

  • "Mechanical regulation of stem cell differentiation through stretch-activated Piezo channel." Nature. (2018).

  • "Barrier crossing in Escherichia coli chemotaxis." Phys. Rev. Lett., (2017).

  • "The wiring diagram of a glomerular olfactory system." eLife, (2016).

  • "Reverse-correlation analysis of navigation dynamics in Drosophila larva using optogenetics." eLife, (2015).

  • "A pathway-based mean-field model for E. coli chemotaxis: mathematical derivation and its hyperbolic and parabolic limits." Multiscale Modeling & Simulation, (2014).

  • "Discovery of novel chemoeffectors and rational design of Escherichia coli chemoreceptor specificity." PNAS, (2013).

  • "Frequency dependent Escherichia coli chemotaxis behavior." Phys. Rev. Lett (2012).

  • "Pathway-based mean-field model for Escherichia coli chemotaxis." Phys. Rev. Lett., (2012).

  • "A parallel diffusion-based microfluidic device for bacterial chemotaxis analysis." Lab Chip, (2012).

  • "Diffusion-based concentration control in microcavities during long time period by programmed syringe pumps." Microelectronic Engineering, (2010).

Research Interests

We are interested in searching quantitative principles governing the population coding, dynamic wiring, and development of biological neural circuits. 
Our lab uses Drosophila larval olfactory system as the model system, which combined many unique advantages for systems neuroscience studies: small brain, complete connectome, transparent body, and rich genetic resources. Specifically, we focus on following questions: how the external and internal information encoded by neuronal activities; how the codes propagate and transform across layers of the network; how the corresponding network structures adapt to the experience; how these improve animal’s discrimination and learning behavior. We combine quantitative behavior, calcium imaging, optogenetics, and microfluidics, along with computation and modeling methods to tackle questions.
The lab is committing to creating a collaborative and supportive environment for members with diverse backgrounds. We welcome students with strong interest contact and join us.

Students

现指导学生

张露涵  博士研究生  071006-神经生物学  

李月白  硕士研究生  071006-神经生物学  

叶琛  博士研究生  071006-神经生物学  

陈叶无霜  硕士研究生  0771Z2-认知神经科学  

纪潇航  博士研究生  071006-神经生物学  

陈诗瀚  硕士研究生  071006-神经生物学  

杨瑞初  博士研究生  071006-神经生物学  

李维汉  博士研究生  071006-神经生物学