基本信息
范广益 男 硕导 其他
电子邮件： fanguangyi@genomics.cn
通信地址： 广东省深圳市盐田区综合楼
邮政编码：
电子邮件： fanguangyi@genomics.cn
通信地址： 广东省深圳市盐田区综合楼
邮政编码：
招生信息
招生专业
0710Z1-基因组学
0710J3-生物信息学
0710J3-生物信息学
招生方向
基因组学
生物信息学
分子遗传学
生物信息学
分子遗传学
教育背景
2014-09--2020-01 澳门大学 博士
2005-09--2010-07 哈尔滨医科大学 学士
2005-09--2010-07 哈尔滨医科大学 学士
工作经历
工作简历
2016-09~现在, 深圳华大生命科学研究院, 分院执行院长
2010-07~2016-09,深圳华大生命科学研究院, 信息分析工程师
2010-07~2016-09,深圳华大生命科学研究院, 信息分析工程师
专利与奖励
专利成果
[1] 齐彦伟, 邓礼, 张跃, 古盛强, 郭立东, 范广益, 徐梦阳, 陈建威. 确定宏基因组菌种数据集及组装菌种基因组的方法和系统. CN: CN116417067A, 2023-07-11.
[2] 任丙昭, 欧阳冰洁, 于颖佳, 范广益, 王媚娘, 李新洋, 杨乃波, 刘心. 一种基于噬菌体展示技术开发的ALK纳米抗体及其应用. CN: CN112794914A, 2021-05-14.
[3] 邓礼, 郭立东, 王文超, 徐梦阳, 范广益. 基于单管长片段测序数据进行骨架组装的方法和装置. CN: CN112133371A, 2020-12-25.
[4] 王晨, 黎瀚博, 刘田宾, 刘姗姗, 范广益, 顾颖, 刘心, 徐讯. 一种两栖类动物细胞解离试剂盒. CN: CN111378613A, 2020-07-07.
[2] 任丙昭, 欧阳冰洁, 于颖佳, 范广益, 王媚娘, 李新洋, 杨乃波, 刘心. 一种基于噬菌体展示技术开发的ALK纳米抗体及其应用. CN: CN112794914A, 2021-05-14.
[3] 邓礼, 郭立东, 王文超, 徐梦阳, 范广益. 基于单管长片段测序数据进行骨架组装的方法和装置. CN: CN112133371A, 2020-12-25.
[4] 王晨, 黎瀚博, 刘田宾, 刘姗姗, 范广益, 顾颖, 刘心, 徐讯. 一种两栖类动物细胞解离试剂盒. CN: CN111378613A, 2020-07-07.
出版信息
发表论文
[1] Nat Ecol Evol.. 2024, 通讯作者
[2] Sci Adv.. 2024, 通讯作者
[3] Kang, Hui, Liu, Qun, Seim, Inge, Zhang, Wenwei, Li, Hanbo, Gao, Haiyu, Lin, Wenzhi, Lin, Mingli, Zhang, Peijun, Zhang, Yaolei, Gao, Haoyang, Wang, Yang, Qin, Yating, Liu, Mingming, Dong, Lijun, Yang, Zixin, Zhang, Yingying, Han, Lei, Fan, Guangyi, Li, Songhai. A genome and single-nucleus cerebral cortex transcriptome atlas of the short-finned pilot whale Globicephala macrorhynchus. MOLECULAR ECOLOGY RESOURCES[J]. 2023, 第 11 作者23(5): 1108-1123, http://dx.doi.org/10.1111/1755-0998.13775.
[4] Marty Kardos, Yaolei Zhang, Kim M. Parsons, Yunga A, Hui Kang, Xun Xu, Xin Liu, Craig O. Matkin, Peijun Zhang, Eric J. Ward, M. Bradley Hanson, Candice Emmons, Michael J. Ford, Guangyi Fan, Songhai Li. Inbreeding depression explains killer whale population dynamics. Nature Ecology & Evolution[J]. 2023, 第 14 作者 通讯作者
[5] Guo, Yang, Meng, Lingfeng, Wang, Minxiao, Zhong, Zhaoshan, Li, Denghui, Zhang, Yaolei, Li, Hanbo, Zhang, Huan, Seim, Inge, Li, Yuli, Jiang, Aijun, Ji, Qianyue, Su, Xiaoshan, Chen, Jianwei, Fan, Guangyi, Li, Chaolun, Liu, Shanshan. Hologenome analysis reveals independent evolution to chemosymbiosis by deep-sea bivalves. BMC BIOLOGY[J]. 2023, 第 15 作者 通讯作者 21(1): http://dx.doi.org/10.1186/s12915-023-01551-z.
[6] Changwei Shao, Shuai Sun, Kaiqiang Liu, Jiahao Wang, Shuo Li, Qun Liu, Bruce E Deagle, Inge Seim, Alberto Biscontin, Qian Wang, Xin Liu, So Kawaguchi, Yalin Liu, Simon Jarman, Yue Wang, HongYan Wang, Guodong Huang, Jiang Hu, Bo Feng, Cristiano De Pitt, Shanshan Liu, Rui Wang, Kailong Ma, Yiping Ying, Gabrielle Sales, Tao Sun, Xinliang Wang, Yaolei Zhang, Yunxia Zhao, Shanshan Pan, Xiancai Hao, Yang Wang, Jiakun Xu, Bowen Yue, Yanxu Sun, He Zhang, Mengyang Xu, Yuyan Liu, Xiaodong Jia, Jiancheng Zhu, Shufang Liu, Jue Ruan, Guojie Zhang, Huanming Yang, Xun Xu, Jun Wang, Xianyong Zhao, Bettina Meyer, Guangyi Fan. The enormous repetitive Antarctic krill genome reveals environmental adaptations and population insights. CELL[J]. 2023, 第 49 作者 通讯作者 186(6): 1279-1294.e19, http://dx.doi.org/10.1016/j.cell.2023.02.005.
[7] Wang, HongYan, Liu, Xiang, Chen, JianYang, Huang, Yingyi, Lu, Yifang, Tan, Fujian, Liu, Qun, Yang, Mingming, Li, Shuo, Zhang, Xianghui, Qin, Yating, Ma, Wenxiu, Yang, Yingming, Meng, Liang, Liu, Kaiqiang, Wang, Qian, Fan, Guangyi, Nobrega, Rafael H, Liu, Shanshan, Piferrer, Francesc, Shao, Changwei. Single-cell-resolution transcriptome map revealed novel genes involved in testicular germ cell progression and somatic cells specification in Chinese tongue sole with sex reversal. SCIENCE CHINA-LIFE SCIENCES. 2022, 第 17 作者
[8] Jiang, Dianhang, Liu, Qun, Sun, Jin, Liu, Shikai, Fan, Guangyi, Wang, Lihua, Zhang, Yaolei, Seim, Inge, An, Shucai, Liu, Xin, Li, Qi, Zheng, Xiaodong. The gold-ringed octopus (Amphioctopus fangsiao) genome and cerebral single-nucleus transcriptomes provide insights into the evolution of karyotype and neural novelties. BMC BIOLOGY[J]. 2022, 第 5 作者20(1): http://dx.doi.org/10.1186/s12915-022-01500-2.
[9] Li, Ming, Zhang, Rui, Fan, Guangyi, Xu, Wenteng, Zhou, Qian, Wang, Lei, Li, Wensheng, Pang, Zunfang, Yu, Mengjun, Liu, Qun, Liu, Xin, Schartl, Manfred, Chen, Songlin. Reconstruction of the Origin of a Neo-Y Sex Chromosome and Its Evolution in the Spotted Knifejaw, Oplegnathus punctatus. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2021, 第 3 作者38(6): 2615-2626, http://dx.doi.org/10.1093/molbev/msab056.
[10] Wang, Kun, Wang, Jun, Zhu, Chenglong, Yang, Liandong, Ren, Yandong, Ruan, Jue, Fan, Guangyi, Hu, Jiang, Xu, Wenjie, Bi, Xupeng, Zhu, Youan, Song, Yue, Chen, Huatao, Ma, Tiantian, Zhao, Ruoping, Jiang, Haifeng, Zhang, Bin, Feng, Chenguang, Yuan, Yuan, Gan, Xiaoni, Li, Yongxin, Zeng, Honghui, Liu, Qun, Zhang, Yaolei, Shao, Feng, Hao, Shijie, Zhang, He, Xu, Xun, Liu, Xin, Wang, Depeng, Zhu, Min, Zhang, Guojie, Zhao, Wenming, Qiu, Qiang, He, Shunping, Wang, Wen. African lungfish genome sheds light on the vertebrate water-to-land transition. CELL[J]. 2021, 第 7 作者184(5): 1362-1376, http://dx.doi.org/10.1016/j.cell.2021.01.047.
[11] Xu, Mengyang, Guo, Lidong, Du, Xiao, Li, Lei, Peters, Brock A, Deng, Li, Wang, Ou, Chen, Fang, Wang, Jun, Jiang, Zhesheng, Han, Jinglin, Ni, Ming, Yang, Huanming, Xu, Xun, Liu, Xin, Huang, Jie, Fan, Guangyi. Accurate haplotype-resolved assembly reveals the origin of structural variants for human trios. BIOINFORMATICS[J]. 2021, 第 17 作者 通讯作者 37(15): 2095-2102, http://dx.doi.org/10.1093/bioinformatics/btab068.
[12] Fan, Guangyi, Song, Yue, Yang, Liandong, Huang, Xiaoyun, Zhang, Suyu, Zhang, Mengqi, Yang, Xianwei, Chang, Yue, Zhang, He, Li, Yongxin, Liu, Shanshan, Yu, Lili, Chu, Jeffery, Seim, Inge, Feng, Chenguang, Near, Thomas J, Wing, Rod A, Wang, Wen, Wang, Kun, Wang, Jing, Xu, Xun, Yang, Huanming, Liu, Xin, Chen, Nansheng, He, Shunping. Initial data release and announcement of the 10,000 Fish Genomes Project (Fish10K). GIGASCIENCE[J]. 2020, 第 1 作者9(8): https://www.webofscience.com/wos/woscc/full-record/WOS:000569172100003.
[13] YunPeng Zhao, Guangyi Fan, PingPing Yin, Shuai Sun, Ning Li, Xiaoning Hong, Gang Hu, He Zhang, FuMin Zhang, JingDan Han, YaJun Hao, Qiwu Xu, Xianwei Yang, Wenjie Xia, Wenbin Chen, HanYang Lin, Rui Zhang, Jiang Chen, XiaoMing Zheng, Simon MingYuen Lee, Joongku Lee, Koichi Uehara, Jian Wang, Huanming Yang, ChengXin Fu, Xin Liu, Xun Xu, Song Ge, 张富民. Resequencing 545 ginkgo genomes across the world reveals the evolutionary history of the living fossil. NATURE COMMUNICATIONS[J]. 2019, 第 2 作者10(1): 1-10, http://dx.doi.org/10.1038/s41467-019-12133-5.
[14] Qixiang Zhang, He Zhang, Lidan Sun, Guangyi Fan, Meixia Ye, Libo Jiang, Xin Liu, Kaifeng Ma, Chengcheng Shi, Fei Bao, Rui Guan, Yu Han, Yuanyuan Fu, Huitang Pan, Zhaozhe Chen, Liangwei Li, Jia Wang, Meiqi Lv, Tangchun Zheng, Cunquan Yuan, Yuzhen Zhou, Simon MingYuen Lee, Xiaolan Yan, Xun Xu, Rongling Wu, Wenbin Chen, Tangren Cheng. The genetic architecture of floral traits in the woody plant Prunus mume. NATURE COMMUNICATIONS[J]. 2018, 第 4 作者9(1): https://doaj.org/article/710256fe335b41ad9ec8cb604cf4e3cc.
[15] Lidong Guo, Yao Li, Yanwei Qi, Zhi Huang, Kai Han, Xiaobin Liu, Xin Liu, Mengyang Xu, Guangyi Fan. VT3D: a visualization toolbox for 3D transcriptomic data. JOURNAL OF GENETICS AND GENOMICS. 第 9 作者http://dx.doi.org/10.1016/j.jgg.2023.04.001.
[2] Sci Adv.. 2024, 通讯作者
[3] Kang, Hui, Liu, Qun, Seim, Inge, Zhang, Wenwei, Li, Hanbo, Gao, Haiyu, Lin, Wenzhi, Lin, Mingli, Zhang, Peijun, Zhang, Yaolei, Gao, Haoyang, Wang, Yang, Qin, Yating, Liu, Mingming, Dong, Lijun, Yang, Zixin, Zhang, Yingying, Han, Lei, Fan, Guangyi, Li, Songhai. A genome and single-nucleus cerebral cortex transcriptome atlas of the short-finned pilot whale Globicephala macrorhynchus. MOLECULAR ECOLOGY RESOURCES[J]. 2023, 第 11 作者23(5): 1108-1123, http://dx.doi.org/10.1111/1755-0998.13775.
[4] Marty Kardos, Yaolei Zhang, Kim M. Parsons, Yunga A, Hui Kang, Xun Xu, Xin Liu, Craig O. Matkin, Peijun Zhang, Eric J. Ward, M. Bradley Hanson, Candice Emmons, Michael J. Ford, Guangyi Fan, Songhai Li. Inbreeding depression explains killer whale population dynamics. Nature Ecology & Evolution[J]. 2023, 第 14 作者 通讯作者
[5] Guo, Yang, Meng, Lingfeng, Wang, Minxiao, Zhong, Zhaoshan, Li, Denghui, Zhang, Yaolei, Li, Hanbo, Zhang, Huan, Seim, Inge, Li, Yuli, Jiang, Aijun, Ji, Qianyue, Su, Xiaoshan, Chen, Jianwei, Fan, Guangyi, Li, Chaolun, Liu, Shanshan. Hologenome analysis reveals independent evolution to chemosymbiosis by deep-sea bivalves. BMC BIOLOGY[J]. 2023, 第 15 作者 通讯作者 21(1): http://dx.doi.org/10.1186/s12915-023-01551-z.
[6] Changwei Shao, Shuai Sun, Kaiqiang Liu, Jiahao Wang, Shuo Li, Qun Liu, Bruce E Deagle, Inge Seim, Alberto Biscontin, Qian Wang, Xin Liu, So Kawaguchi, Yalin Liu, Simon Jarman, Yue Wang, HongYan Wang, Guodong Huang, Jiang Hu, Bo Feng, Cristiano De Pitt, Shanshan Liu, Rui Wang, Kailong Ma, Yiping Ying, Gabrielle Sales, Tao Sun, Xinliang Wang, Yaolei Zhang, Yunxia Zhao, Shanshan Pan, Xiancai Hao, Yang Wang, Jiakun Xu, Bowen Yue, Yanxu Sun, He Zhang, Mengyang Xu, Yuyan Liu, Xiaodong Jia, Jiancheng Zhu, Shufang Liu, Jue Ruan, Guojie Zhang, Huanming Yang, Xun Xu, Jun Wang, Xianyong Zhao, Bettina Meyer, Guangyi Fan. The enormous repetitive Antarctic krill genome reveals environmental adaptations and population insights. CELL[J]. 2023, 第 49 作者 通讯作者 186(6): 1279-1294.e19, http://dx.doi.org/10.1016/j.cell.2023.02.005.
[7] Wang, HongYan, Liu, Xiang, Chen, JianYang, Huang, Yingyi, Lu, Yifang, Tan, Fujian, Liu, Qun, Yang, Mingming, Li, Shuo, Zhang, Xianghui, Qin, Yating, Ma, Wenxiu, Yang, Yingming, Meng, Liang, Liu, Kaiqiang, Wang, Qian, Fan, Guangyi, Nobrega, Rafael H, Liu, Shanshan, Piferrer, Francesc, Shao, Changwei. Single-cell-resolution transcriptome map revealed novel genes involved in testicular germ cell progression and somatic cells specification in Chinese tongue sole with sex reversal. SCIENCE CHINA-LIFE SCIENCES. 2022, 第 17 作者
[8] Jiang, Dianhang, Liu, Qun, Sun, Jin, Liu, Shikai, Fan, Guangyi, Wang, Lihua, Zhang, Yaolei, Seim, Inge, An, Shucai, Liu, Xin, Li, Qi, Zheng, Xiaodong. The gold-ringed octopus (Amphioctopus fangsiao) genome and cerebral single-nucleus transcriptomes provide insights into the evolution of karyotype and neural novelties. BMC BIOLOGY[J]. 2022, 第 5 作者20(1): http://dx.doi.org/10.1186/s12915-022-01500-2.
[9] Li, Ming, Zhang, Rui, Fan, Guangyi, Xu, Wenteng, Zhou, Qian, Wang, Lei, Li, Wensheng, Pang, Zunfang, Yu, Mengjun, Liu, Qun, Liu, Xin, Schartl, Manfred, Chen, Songlin. Reconstruction of the Origin of a Neo-Y Sex Chromosome and Its Evolution in the Spotted Knifejaw, Oplegnathus punctatus. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2021, 第 3 作者38(6): 2615-2626, http://dx.doi.org/10.1093/molbev/msab056.
[10] Wang, Kun, Wang, Jun, Zhu, Chenglong, Yang, Liandong, Ren, Yandong, Ruan, Jue, Fan, Guangyi, Hu, Jiang, Xu, Wenjie, Bi, Xupeng, Zhu, Youan, Song, Yue, Chen, Huatao, Ma, Tiantian, Zhao, Ruoping, Jiang, Haifeng, Zhang, Bin, Feng, Chenguang, Yuan, Yuan, Gan, Xiaoni, Li, Yongxin, Zeng, Honghui, Liu, Qun, Zhang, Yaolei, Shao, Feng, Hao, Shijie, Zhang, He, Xu, Xun, Liu, Xin, Wang, Depeng, Zhu, Min, Zhang, Guojie, Zhao, Wenming, Qiu, Qiang, He, Shunping, Wang, Wen. African lungfish genome sheds light on the vertebrate water-to-land transition. CELL[J]. 2021, 第 7 作者184(5): 1362-1376, http://dx.doi.org/10.1016/j.cell.2021.01.047.
[11] Xu, Mengyang, Guo, Lidong, Du, Xiao, Li, Lei, Peters, Brock A, Deng, Li, Wang, Ou, Chen, Fang, Wang, Jun, Jiang, Zhesheng, Han, Jinglin, Ni, Ming, Yang, Huanming, Xu, Xun, Liu, Xin, Huang, Jie, Fan, Guangyi. Accurate haplotype-resolved assembly reveals the origin of structural variants for human trios. BIOINFORMATICS[J]. 2021, 第 17 作者 通讯作者 37(15): 2095-2102, http://dx.doi.org/10.1093/bioinformatics/btab068.
[12] Fan, Guangyi, Song, Yue, Yang, Liandong, Huang, Xiaoyun, Zhang, Suyu, Zhang, Mengqi, Yang, Xianwei, Chang, Yue, Zhang, He, Li, Yongxin, Liu, Shanshan, Yu, Lili, Chu, Jeffery, Seim, Inge, Feng, Chenguang, Near, Thomas J, Wing, Rod A, Wang, Wen, Wang, Kun, Wang, Jing, Xu, Xun, Yang, Huanming, Liu, Xin, Chen, Nansheng, He, Shunping. Initial data release and announcement of the 10,000 Fish Genomes Project (Fish10K). GIGASCIENCE[J]. 2020, 第 1 作者9(8): https://www.webofscience.com/wos/woscc/full-record/WOS:000569172100003.
[13] YunPeng Zhao, Guangyi Fan, PingPing Yin, Shuai Sun, Ning Li, Xiaoning Hong, Gang Hu, He Zhang, FuMin Zhang, JingDan Han, YaJun Hao, Qiwu Xu, Xianwei Yang, Wenjie Xia, Wenbin Chen, HanYang Lin, Rui Zhang, Jiang Chen, XiaoMing Zheng, Simon MingYuen Lee, Joongku Lee, Koichi Uehara, Jian Wang, Huanming Yang, ChengXin Fu, Xin Liu, Xun Xu, Song Ge, 张富民. Resequencing 545 ginkgo genomes across the world reveals the evolutionary history of the living fossil. NATURE COMMUNICATIONS[J]. 2019, 第 2 作者10(1): 1-10, http://dx.doi.org/10.1038/s41467-019-12133-5.
[14] Qixiang Zhang, He Zhang, Lidan Sun, Guangyi Fan, Meixia Ye, Libo Jiang, Xin Liu, Kaifeng Ma, Chengcheng Shi, Fei Bao, Rui Guan, Yu Han, Yuanyuan Fu, Huitang Pan, Zhaozhe Chen, Liangwei Li, Jia Wang, Meiqi Lv, Tangchun Zheng, Cunquan Yuan, Yuzhen Zhou, Simon MingYuen Lee, Xiaolan Yan, Xun Xu, Rongling Wu, Wenbin Chen, Tangren Cheng. The genetic architecture of floral traits in the woody plant Prunus mume. NATURE COMMUNICATIONS[J]. 2018, 第 4 作者9(1): https://doaj.org/article/710256fe335b41ad9ec8cb604cf4e3cc.
[15] Lidong Guo, Yao Li, Yanwei Qi, Zhi Huang, Kai Han, Xiaobin Liu, Xin Liu, Mengyang Xu, Guangyi Fan. VT3D: a visualization toolbox for 3D transcriptomic data. JOURNAL OF GENETICS AND GENOMICS. 第 9 作者http://dx.doi.org/10.1016/j.jgg.2023.04.001.
科研活动
科研项目
（ 1 ） 海水鱼类耐盐性状与肠道菌群的遗传关系, 负责人, 国家任务, 2018-12--2022-12
（ 2 ） 对澳门红树林植物内生菌多样性及其代谢物的研究, 参与, 国家任务, 2017-01--2019-12
（ 2 ） 对澳门红树林植物内生菌多样性及其代谢物的研究, 参与, 国家任务, 2017-01--2019-12
指导学生
现指导学生
刘承训 硕士研究生 086000-生物与医药
贾利敏 硕士研究生 086000-生物与医药
范洁 硕士研究生 086000-生物与医药