• Mechanisms and regulation of cellular senescence
• Development of small anti-aging molecules  
• Pathology and intervention of age-related diseases

2007/09–2012/12   M.D., Public Health College, Harbin Medical University (HMU), Harbin, China
2011/09–2012/09   Joint Training M.D. student, Institute for Nutrisciences and Health, National Research Council Canada, Charlottetown, PE, Canada
2002/09–2007/07   Bachelor of Preventive Medicine, Public Health College, Harbin Medical University (HMU), Harbin, China

   

2020/10– now         Professor, Kunming Institute of Zoology, Chinese Academy of Sciences, China
2018/06–2020-09 Post-doctoral Associate, University of Florida (UF), USA
2016/10–2018/05 Post-doctoral fellow, University of Arkansas for Medical University (UAMS), USA
2015/01–2016/09 Associate professor, Kunming Institute of Zoology, Chinese Academy of Sciences, China
2013/01–2014/12  Assistant professor, Kunming Institute of Zoology, Chinese Academy of Sciences, China

Experience of Mentoring
1. Vivek Budamagunta, PhD candidate, University of Florida, College of Pharmacy, 2019.3-2020.9
2. Yuma T Ortiz, PhD candidate, University of Florida, College of Pharmacy, 2019.3-2020.9
3. Yang Yang, PhD candidate, University of Florida, College of Pharmacy, 2020.1-2020.9
4. Qin Yu, PhD, Kunming Institute of Zoololgy, Chinese Academy of Sciences, 2013.9-2016.09

   

2021

[1] Ge MX, Hu L, Ao HS, Zi MT, Kong QP*, He YH*. Senolytic targets and new strategies for clearing senescent cells. Mechanisms of Ageing and Development. 2021; 195:111468.
[2] He YH*^,#, Li W*, Zhang JL, Yang Y, Qian YW, Zhou DH. The curcumin analog EF24 is highly active against chemotherapy-resistant melanoma cells. Current Cancer Drug Targets. 2021. Doi: 10.2174/1568009621666210303092921.
[3] Budamagunta V, Manohar-Sindhu S, Yang Y, He YH, Traktuev D, Foster T, Zhou D*. Senescence-associated hyper-activation to inflammatory stimuli in vitro. Aging. 2021;13(15):19088-19107.
[4] Hu GR, He YH, Li YZ, Hu X, Liu SD, Liao C, Zhang R, Zhou XY, Sun H*. Effect of HIF1α on the TRPC6 channel of glomerular podocytes under chronic hypoxia. Biochemical and Biophysical Research Communications. 2021;541:1-7.

 

2020
[1] He YH^#, Zhang X(uan)^#, Chang JH^#, Kim H^#, Zhang PY, Wang YY, Khan Sajid, Liu XG, Zhang X(in), Lv DW, Li W, Thummuri Dinesh, Yuan YX, Elisseeff Jennifer, Campisi Judith, Almeida Maria, Song L, Zheng GR*, Zhou DH*. Using Proteolysis-Targeting Chimera Technology to Reduce Navitoclax Platelet Toxicity and Improve Its Senolytic Activity. Nature Communications. 2020;11(1):1996.
[2] He YH, Koch R, Budamagunta V, Zhang PY, Zhang X(uan), Khan S, Thummuri D, Ortiz Y. T, Zhang X(in), Lv DW, Wiegand J. S, Li W, Palmer A. C, Zheng GR, Weinstock D. M*, Zhou DH*. DT2216–a Bcl-xL specific degrader is highly active against Bcl-xL-dependent T-cell lymphomas. Journal of Hematology & Oncology. 2020;13(1):95.
[3] He YH, Wen Li, Lv DW, Zhang Xin, Zhang X, Campisi Judith, Zheng GR, Zhou DH*. Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. Aging Cell. 2020;19(3):e13117.
[4] He YH^#, Khan S^#, Huo ZG, Lv DW, Zhang X, Liu XG, Yuan YX, Hromas R, Xu MJ, Zheng GR, Zhou DH. Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies. Journal of Hematology & Oncology. 2020;13(1):103.
[5] He YH, Zheng GR, Zhou DH. Senolytic Drug Development. In: Senolytics in Disease, Ageing and Longevity. Healthy Ageing and Longevity. Springer, Cham. 2020; 11. Doi: 10.1007/978-3-030-44903-2_1.
[6] Khan S^#, He YH^# , Zhang X, Yuan YX, Pu SY, Kong QP, Zheng GR, Zhou DH*. PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics. Oncogene. 2020;39(26):4909-4924.
[7] Zhang X^#, He YH^# , Zhang PY^#, Budamagunta V, Lv DW, Thummuri D, Yang Y, Pei J, Yuan YX, Zhou DH*, Zheng GR*. Discovery of IAP-Recruiting BCL-XL PROTACs as Potent Degraders across Multiple Cancer Cell Lines. European Journal of Medicinal Chemistry. 2020;199:112397.
[8] Ji XN^#, Huang M^#, Yao SH^#, Qi JY^#, Onwuka JU, Wang Y, Wang XM, Chen Y, Wu XY, Liu LY, Wang SH, Zhou M, He YH, Feng RN*. Refined grains intake in high fat, high protein, low carbohydrate and low energy levels subgroups and higher likelihood of abdominal obesity in Chinese population. International Journal of Food Sciences and Nutrition. 2020:1-12.
 
2019
[1] Khan Sajid^#, Zhang X^#, Lv DW^#, Zhang Q, He YH, Zhang PY, Yuan YX, Liu XG, Thummuri Dinesh, Wiegand Janet, Ferrando Adolfo, Hromas Robert, Konopleva Maria, Zheng GR*, Zhou DH*. A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity. Nature Medicine. 2019;25(12):1938-1947.
[2] He YH, Thummuri D, Zheng GR, Okunieff P, Citrin DE, Vujaskovic Z, Zhou DH*. Cellular Senescence and Radiation-induced Pulmonary Fibrosis. Translational Research. 2019;209:14-21.
[3] Yu Q, Pu SY, Wu H, Chen XQ, Jiang JJ, Gu KS, He YH*, Kong QP*. TICRR Contributes to Tumorigenesis through Accelerating DNA Replication in Cancers. Frontiers in Oncology. 2019;9:516.
[4] Li W^#, Qin L^#, Feng RN, Hu GR, Sun H, He YH*, RP Zhang*. Emerging senolytic agents derived from natural products. Mechanisms of Ageing and Development. 2019;181:1-6.
[5] Zhang X^#, Thummuri Dinesh^#, He YH, Liu XG, Zhang PY, Zhou DH, Zheng GR*. Utilizing PROTAC technology to address the on-target platelet toxicity associated with inhibition of BCL-XL. Chemical Communications. 2019;55(98):14765-14768.
[6] Li W, He YH, Zhang RP, Zheng GR, Zhou DH*. The curcumin analog EF24 is a novel senolytic agent. Aging-US. 2019;28;11(2):771-782.
 
2018
[1] Xiao FH^#, Chen XQ^#, Yu Q^#, Ye YS^#, Liu YW, Yan DJ, Yang LQ, Chen GJ, Lin R, Yang LP, Liao XP, Zhang W, Zhang W, Wang XF, Zhou JM*, Cai WW*, He YH*, Kong QP*. Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians. Genome Research. 2018;28(11):1601-1610.
[2] He YH*, Li Wen, Hu GR, Kong QP. Bioactivities of EF24, a novel curcumin analog: A review. Frontiers in Oncology. Frontiers in Oncology. 2018;11(8):614.
[3] Xiao FH, Chen XQ, He YH, Kong QP*. Accelerated DNA methylation changes in middle-aged men define sexual dimorphism in human lifespans. Clinical Epigenetics. 2018;10(1):133.
[4] Yuan LF, Zhai LH, Qian LL, Huang D, Ding Y, Xiang HD, Dr. Liu XJ, Thompson W, Liu J, He YH, Chen XQ, Hu J, Kong QP, Tan MJ, Wang XF*. Switching off IMMP2L Signaling Drives Senescence via Simultaneous Metabolic Alteration and Blockage of Cell Death. Cell Research. 2018;28(6):625-643.
[5] Zhang X, Zhang SP, Liu XG, Wang YY, Chang JH, Zhang X, Mackintosh S, Tackett A, He YH, Lv DW, Laberge RM, Campisi J, Wang JR, Zheng GR, Zhou DH*. Oxidation resistance 1 is a novel senolytic target. Aging Cell. 2018;17(4):e12780.
 
2017
[1] Li QG^#, He YH^#, Wu H^#, Yang CP, Pu SY, Fan SQ, Jiang LP, Shen QS, Wang XX, Chen XQ, Yu Q, Li Y, Sun C, Wang XT, Zhou JM, Li HP, Chen YB*, Kong QP*. A normalization-free and nonparametric method sharpens pan-cancer expression analysis. Theranostics. 2017;7(11):2888-2899.
[2] Pu SY^#, Yu Q^#, Wu H, Jiang JJ, Chen XQ, He YH*, Kong QP*. ERCC6L, a DNA helicase, is involved in cell proliferation and associated with survival and progress in breast and kidney cancers. Oncotarget. 2017;8(26):42116-42124.
[3] Wang XX, Xiao FH, Li QG, He YH*, Kong QP*. Large-scale DNA methylation expression analysis across 12 solid cancers reveals hypermethylation in the calcium-signaling pathway. Oncotarget. 2017;8(7):11868-11876.
 
2016
[1] He YH^#, Chen XQ^#, Yan DJ, Xiao FH, Lin R, Liao XP, Liu YW, Pu SY, Yu Q, Sun HP, Jiang JJ, Cai WW*, Kong QP*. Familial longevity study reveals a significant association of mitochondrial DNA copy number between centenarians and their offspring. Neurobiology of Aging. 2016;47:218.e11-218.e18.
[2] He YH, Pu SY, Xiao FH, Chen XQ, Yan DJ, Liu YW, Lin R, Liao XP, Yu Q, Yang LQ, Yang XL, Ge MX, Li Y, Jiang JJ, Cai WW*, Kong QP*. Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families. Scientific Reports. 2016;25;6:21962.
[3] He YH^#, Lu X^#, Tian JY, DJ Yan, Li YC, Lin R, Perry B, Chen XQ, Yu Q, Cai WW*, Kong QP*. Mitochondrial DNA contributes equally to female and male longevity in Chinese centenarians. Experimental Gerontology. 2016;83:94-96.
[4] He YH, Pu SY, Li W, Chen XQ, Xiao FH, Yan DJ, Liu YW, Lin R, Liao XP, Yang XL, Ge MX, Cai WW*, Kong QP*. Decline in blood hemoglobin concentrations is associated with familial longevity. Archives of Biological Sciences. 2016;68(3):533-540.
[5] Xiao FH, Kong QP, Perry B, He YH*. Progress on the role of DNA methylation in aging and longevity. Briefings in Functional Genomics. 2016;15(6):454-459.
[6] Han LY, Liu YF, Duan SW, Perry B, Li W*, He YH*. DNA methylation and hypertension: emerging evidence and challenges. Briefings in Functional Genomics. 2016;15(6):460-469.
[7] Jiang JJ, Cheng LH, Wu H, He YH*, Kong QP*. Insights into long noncoding RNAs of naked mole rat (Heterocephalus glaber) and their potential association with cancer resistance. Epigenetics & Chromatin. 2016;9:51.
 
2015
[1] He YH, Chen XQ, Yan DJ, Xiao FH, Liu YW, Lin R, Liao XP, Cai WW*, Kong QP*. Thyroid function decreases with age and may contribute to longevity in Chinese centenarians’ families. Journal of the American Geriatrics Society. 2015;63(7) 1474-1476.
[2] Yu Q, Sun HP, Chen WQ, Chen XQ, Xu Y*, He YH*, Kong QP*. Sex-specific association of rs4746172 of VCL gene with hypertension in two Chinese Han populations. Scientific Reports. 2015;5:15245.
[3] Xiao FH^#, He YH^#, Li QG, Wu H, Luo LH, Kong QP*. A genome-wide scan reveals important roles of DNA methylation in human longevity by regulating age-related disease genes. PLoS One. 2015;10(3):e0120388.
[4] Wu H, He YH, Xu TR*, Kong QP*. Absence of mutation in MiR-34a gene in a Chinese longevity population. Zoological Research. 2015;36(2):112-114.
 
2014
[1] He YH, Lu X, Wu H, Cai WW*, Yang LQ, Sun HP, Kong QP*. MtDNA content contributes to healthy aging in Chinese: a study from nonagenarians and centenarians. Neurobiology of Aging. 2014;35(7):1779.e1-1779.e14.
[2] He YH, Zhang YX, Yang LQ, Liao XP, Cai WW*, Kong QP*. Assessment of the health status of centenarians in the South of China: A cross-sectional study. Journal of the American Geriatrics Society. 2014;62(7):1402-1404.
[3] He YH, Lu X, Yang LQ, Xu LY, Kong QP*. Association of the insulin-like growth factor binding protein 3 (IGFBP-3) polymorphism with longevity in Chinese nonagenarians and centenarians. Aging-US. 2014;6(11):944-56.
[4] He YH, Kong WL, Wang G, Zhao Y, Bi MX, Na LX, Wang MQ, Perry B, Li Y*. The calcium-sensing receptor R990G polymorphism is associated with increased risk of hypertriglyceridemia in obese Chinese. Gene. 2014;533:67-71.
[5] He YH, Li W, Li Y, Zhang SC, Wang YW*, Sun CH*. Ursolic acid increases glucose uptake through the PI3K signaling pathway in adipocytes. PLoS One. 2014;9 (10):e110711.
[6] He YH, Lu X, Bi MX, Yang LQ, Xu LY, Kong QP*. The reduction of vascular disease risk mutations contributes to longevity in Chinese. Meta Gene. 2014;2:761-768.
[7] Liu YW, He YH, Zhang YX, Cai WW*, Yang LQ, Xu LY, Kong QP*. Absence of A673T variant in APP gene indicates an alternative protective mechanism contributing to longevity in Chinese individuals. Neurobiology of Aging. 2014;35(4):935.e11-2.
[8] Huang YF, He YH, Sun XW, He YJ, Li Y, Sun CH*. Maternal high folic acid supplement promotes the glucose intolerance and insulin resistance in male mice offspring fed high fat diet. International Journal of Molecular Sciences. 2014;15(4):6298-6313.
[9] Zhang HQ, Teng JH, Li Y, Li XX, He YH, He X, Sun CH*. Vitamin D status and its association with adiposity and oxidative stress in school children. Nutrition. 2014;30(9):1040-1044.
 
2013
[1] He YH, Li Y, Zhang SC, Perry B, Zhao TT, Wang YW*, Sun CH*. Radicicol, a heat shock protein 90 inhibitor, inhibits differentiation and adipogenesis in 3T3-L1 preadipocytes. Biochemical and Biophysical Research Communications. 2013;436:169-174.
[2] He YH, Perry B, Bi MX, Sun H, Zhao TT, Li Y*, Sun CH*. Allosteric regulation of the calcium-sensing receptor in obese individuals. International Journal of Molecular Medicine. 2013;32:511-518.
[3] He YH, Li Y, Zhao TT, Wang YW*, Sun CH*. Ursolic acid inhibits adipogenesis in 3T3-L1 adipocytes through LKB1/AMPK pathway. PLoS One. 2013;8: 8(7):e70135.
[4] Li ST, Li Y, Ning H, Na LX, Niu YC, Wang MQ, Feng RN, Liu LY, Guo FC, Hou SY, Chu X, Wang YM, Zhang YB, Zhang HQ, Huang LN, Bi MX, Huang YF, Hao LY, Zhao Y, Wang C, Wang YW, He YH, Sun CH*. Calcium supplementation increases circulating cholesterol by reducing its catabolism via GPER and TRPC1-dependent pathway in estrogen deficient women. International Journal of Cardiology. 2013;168:2548-2560.
 
2012
[1] He YH, Han LY, Li W, Shu X, Zhao C, Bi MX, Li Y*, Sun CH*. Effects of the calcium-sensing receptor A986S polymorphism on serum calcium and parathyroid hormone levels in healthy individuals: a meta-analysis. Gene. 2012;491:110-115.
[2] He YH, He Y, Liao XL, Niu YC, Wang G, Zhao C, Wang L, Tian MJ, Li Y*, Sun CH*. The calcium-sensing receptor promotes adipocyte differentiation and adipogenesis through PPARgamma pathway. Molecular and Cellular Biochemistry. 2012;361:321-328.
 
2011
[1] He YH, Song Y, Liao XL, Wang L, Li G, Alima, Li Y*, Sun CH*. The calcium-sensing receptor affects fat accumulation via effects on antilipolytic pathways in adipose tissue of rats fed low-calcium diets. Journal of Nutrition. 2011;141(11):1938-46.
[2] He YH, Li ST, Wang YY, Wang G, He Y, Liao XL, Sun CH*, Li Y*. Postweaning low-calcium diet promotes later-life obesity induced by a high-fat diet. Journal of Nutritional Biochemistry. 2011;23:1238-1244.
[3] He YH, Zhang HQ, Teng JH, Huang LN, Li Y*, Sun CH*. Involvement of calcium-sensing receptor in inhibition of lipolysis through intracellular cAMP and calcium pathways in human adipocytes. Biochemical and Biophysical Research Communications. 2011;404:393-399.
[4] Huang LN, Xue JY, He Y, Wang J, Sun CH, Feng RN, Teng JH, He YH, Li Y*. Dietary calcium but not elemental calcium from supplements is associated with body composition and obesity in Chinese women. PLoS One. 2011;6(12):e27703.

Zheng GR, Zhou DH, Zhang X, Khan S, He YH, Zhang PY. BCL-2 proteins degraders for cancer treatment. Pub. No. WO/2019/1441172019. 2019.

Conference Abstracts
1. He YH, Koch Raphael, Budamagunta Vivekananda, Khan Sajid, Lv Dongwen, Wiegand Janet S, Zheng GR, David Weinstock, Zhou DH*. DT2216, a BCL-XL proteolysis targeting chimera (PROTAC), is a potent anti T-cell lymphoma agent that does not induce significant thrombocytopenia. Blood.2019;134 (Supplement 1):303. Doi: 10.1182/blood-2019-125820.
2. He YH^#, Chang JH^#, Lv DW, Kim H, Almeida M, Zhang X, Mao XJ, Zhao XH, Li LH, Campisi J, Liang Y, Zhou DH*. Long-term clearance of senescent cells prevents the hematopoietic stem cell aging in naturally aged mice. Blood.2019;134 (Supplement 1):1204. Doi: 10.1182/blood-2019-123159.
3. He YH, Li W, Lyu DW, Zhang X, Campisi J, Zheng GR, Zhou DH*. Inhibition of USP7 activity selectively eliminates senescent cells in a p53-dependent manner. Innovation in Aging. 2018;2(Suppl 1):883. Doi: 10.1093/geroni/igy031.3295.
4. Khan S, Zhang X, Lv DW, He YH, Zhang PY, Liu XG, Thummuri D, Zhang Q, Konopleva MY, Hromas R, Zheng GR, Zhou DH*. DT2216, a Synthetic Proteolytic Selectively Targeting Bcl-XL for Ubiquitination and Degradation in Tumor Cells but Not in Platelets, Is a Safer and More Potent Antitumor Agent Than Navitoclax. Blood. 2018;132 (Suppl 1):2698.Doi: 10.1182/blood-2018-99-114762. 

1. He YH. ASH Abstract Achievement Award. 2019 ASH Annual Meeting.
2. He YH. NRC-MOE Research and Post-doctoral Fellowship Program. 2011/09-2012/09.
3. Li Y, Niu YC, Liu LY, He YH, Guo FC. Association study of calcium and obesity. First level, Science and Technology Award of Heilongjiang Province 2013.2.
4. Li Y, Niu YC, Liu LY, He YH, Guo FC. Association study of calcium and obesity, Second level, Award of Progress in Science and Technology of Heilongjiang Province. 2013.11.
5. He YH. Effect and mechanisms of CaSR on fat accumulation under low calcium intake. Outstanding Doctoral Thesis of Harbin Medical University. 2013.