何永捍，博士生导师，中科院昆明动物研究所
电子邮件： heyonghan@mail.kiz.ac.cn
通讯地址： 云南省昆明市盘龙区龙欣路17号
邮政编码： 650201
研究领域
衰老及老年疾病的机制、调控与干预
招生信息
招生专业
071009-细胞生物学
招生方向
衰老机制与调控
细胞衰老与代谢疾病
抗衰老活性小分子研发
细胞衰老与代谢疾病
抗衰老活性小分子研发
教育背景
2011-09--2012-09 加拿大国家研究委员会 (NRC) 联合培养博士研究生
2007-09--2012-12 哈尔滨医科大学 医学博士
2002-09--2007-07 哈尔滨医科大学 医学学士
2007-09--2012-12 哈尔滨医科大学 医学博士
2002-09--2007-07 哈尔滨医科大学 医学学士
学历
研究生
学位
医学博士
工作经历
工作简历
2020-10~现在, 中国科学院昆明动物研究所, 研究员
2018-06~2020-09,佛罗里达大学, 博士后
2016-10~2018-05,阿肯色大学医学部, 博士后
2015-01~2016-09,中国科学院昆明动物研究所, 副研究员
2013-01~2014-12,中国科学院昆明动物研究所, 助理研究员
2018-06~2020-09,佛罗里达大学, 博士后
2016-10~2018-05,阿肯色大学医学部, 博士后
2015-01~2016-09,中国科学院昆明动物研究所, 副研究员
2013-01~2014-12,中国科学院昆明动物研究所, 助理研究员
社会兼职
2021-06-01-今,中国生物物理学会-衰老生物学分会, 委员
2020-12-31-今,中国老年医学学会-基础与转化医学分会, 委员
2020-09-30-今,中国营养协会-营养与组学分会, 常务会员
2019-01-01-今,肿瘤学SCI期刊《Current Cancer Drug Targets》, 客座编委
2018-12-31-今,美国血液病协会（The American Society of Hematology, ASH）, 会员
2017-12-31-2018-12-31,遗传学SCI期刊《Frontiers in Genetics》, 客座编委
2017-12-31-今,美国衰老协会（The Gerontological Society of America, GSA）, 会员
2020-12-31-今,中国老年医学学会-基础与转化医学分会, 委员
2020-09-30-今,中国营养协会-营养与组学分会, 常务会员
2019-01-01-今,肿瘤学SCI期刊《Current Cancer Drug Targets》, 客座编委
2018-12-31-今,美国血液病协会（The American Society of Hematology, ASH）, 会员
2017-12-31-2018-12-31,遗传学SCI期刊《Frontiers in Genetics》, 客座编委
2017-12-31-今,美国衰老协会（The Gerontological Society of America, GSA）, 会员
专利与奖励
奖励信息
（1） 黑龙江省高校科学技术奖, 一等奖, 省级, 2013
（2） 黑龙江省科技进步奖, 二等奖, 省级, 2013
（3） 优秀博士毕业论文, 一等奖, 研究所（学校）, 2013
（2） 黑龙江省科技进步奖, 二等奖, 省级, 2013
（3） 优秀博士毕业论文, 一等奖, 研究所（学校）, 2013
专利成果
[1] 何永捍. 一种靶向衰老细胞的近红外生物探针及其制备方法与用途. 202211569064.4, 2023-03-02.
[2] ZHOU, DAOHONG, ZHENG, GUANGRONG, 何永捍, PI, LIYA. Methods of treating diseases associated with senescent cell accumulation. WO2023064326A1, 2023-01-01.
[3] 何永捍. BCL-2 proteins degraders for cancer treatment. WO/2019/1441172019, 2019-06-01.
[2] ZHOU, DAOHONG, ZHENG, GUANGRONG, 何永捍, PI, LIYA. Methods of treating diseases associated with senescent cell accumulation. WO2023064326A1, 2023-01-01.
[3] 何永捍. BCL-2 proteins degraders for cancer treatment. WO/2019/1441172019, 2019-06-01.
出版信息
发表论文
[1] AGING AND DISEASE. 2024, 通讯作者
[2] Xuan Zhang, Yonghan He, Xingui Liu, Xin Zhang, Peizhong Shi, Yingying Wang, Daohong Zhou, Guangrong Zheng. Design and optimization of piperlongumine analogs as potent senolytics. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2024, 第 2 作者98: http://dx.doi.org/10.1016/j.bmcl.2023.129593.
[3] Li Hu, Chanjuan Dong, Zhe Wang, Shengyuan He, Yiwen Yang, Meiting Zi, Huiqin Li, Yanghuan Zhang, Chuanjie Chen, Runzi Zheng, Shuting Jia, Jing Liu, Xuan Zhang, Yonghan He. A rationally designed fluorescence probe achieves highly specific and long-term detection of senescence in vitro and in vivo. Aging Cell[J]. 2023, 第 14 作者 通讯作者 https://onlinelibrary.wiley.com/doi/10.1111/acel.13896.
[4] AGING CELL. 2023, 通讯作者
[5] Jiahua Liu, Runzi Zheng, Yanghuan Zhang, Shuting Jia, Yonghan He, Jing Liu, Nicolas Dumaz, Celeste Lebbe. The Cross Talk between Cellular Senescence and Melanoma: From Molecular Pathogenesis to Target Therapies. CANCERS[J]. 2023, 第 5 作者 通讯作者 15(9): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10177054/.
[6] Xiao, Fu-Hui, Wang, Hao-Tian, Chen, Xiao-Qiong, Ge, Ming-Xia, Yan, Dongjing, Yang, Xing-Li, Yang, Li-Qin, Lin, Rong, Guo, Rong-Hui, Zhang, Wen, Tang, Nelson, He, Yonghan, Zhou, Jumin, Cai, Wang-Wei, Kong, Qing-Peng. Hypermethylation in H3K9me3 regions characterizes the centenarian methylomes in healthy aging. National Science Review[J]. 2023, 第 12 作者10(6): https://doi.org/10.1093/nsr/nwad067.
[7] Huang, Yaqun, Ge, MingXia, Li, YuHong, Li, JingLin, Yu, Qin, Xiao, FuHui, Ao, HongShun, Yang, LiQin, Li, Ji, He, Yonghan, Kong, QingPeng. Longevity-Associated Transcription Factor ATF7 Promotes Healthspan by Suppressing Cellular Senescence and Systematic Inflammation. Aging and Disease[J]. 2023, 第 10 作者 通讯作者 http://dx.doi.org/10.14336/AD.2022.1217.
[8] AGING AND DISEASE. 2023, 通讯作者
[9] Guo, Liyun, Chen, Yajuan, Li, Huiqin, Yin, Fanqian, Ge, Mingxia, Hu, Li, Zi, Meiting, Qin, Zhenghong, He, Yonghan. Telomere length is maternally inherited and associated with lipid metabolism in Chinese population. AGING-US[J]. 2022, 第 9 作者 通讯作者 14(1): 354-367,
[10] Ge, Mingxia, Jiang, Jianjun, Yang, Liqin, Yang, Xingli, He, Yonghan, Li, Gonghua, Kong, Qingpeng. Specific Gain and Loss of Co-Expression Modules in Long-Lived Individuals Indicate a Role of circRNAs in Human Longevity. GENES[J]. 2022, 第 5 作者13(5): 749,
[11] Ge, MingXia, Yu, Qin, Li, GongHua, Yang, LiQin, He, Yonghan, Li, Ji, Kong, QingPeng. Multiple time-series expression trajectories imply dynamic functional changes during cellular senescence. Computational and Structural Biotechnology Journal[J]. 2022, 第 5 作者20: 4131-4137, http://dx.doi.org/10.1016/j.csbj.2022.08.005.
[12] Xiao, Fu-Hui, Yu, Qin, Deng, Zhili, Yang, Ke, Ye, Yunshuang, Ge, Mingxia, Yan, Dongjing, Wang, Haotian, Chen, Xiaoxiong, Yang, Liqin, Yang, Binyu, Lin, Rong, Zhang, Wen, Yang, Xingli, Dong, Lei, He, Yonghan, Zhou, Jumin, Cai, Wangwei, Li, Ji, Kong, Qingpeng. ETS1 acts as a regulator of human healthy aging via decreasing ribosomal activity. Science Advances[J]. 2022, 第 16 作者8(17): https://www.science.org/doi/10.1126/sciadv.abf2017.
[13] Xin Zhang, Huiqin Li, Qiupeng Lv, Li Hu, Wen Li, Meiting Zi, Yonghan He. Impact of Diets on Response to Immune Checkpoint Inhibitors (ICIs) Therapy against Tumors. LIFE[J]. 2022, 第 7 作者 通讯作者 https://www.mdpi.com/2075-1729/12/3/409.
[14] Li Hu, Huiqin Li, Meiting Zi, Wen Li, Jing Liu, Yang Yang, Daohong Zhou, QingPeng Kong, Yunxia Zhang, Yonghan He. Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2022, 第 10 作者 通讯作者 10: https://doaj.org/article/de94d62fc43e4a11a546707feb73f965.
[15] Hu, Guangrong, He, Yonghan, Li, Yaozong, Hu, Xiao, Liu, Sida, Liao, Chang, Zhang, Rui, Zhou, Xinyao, Sun, Hui. Effect of HIF1 alpha on the TRPC6 channel of glomerular podocytes under chronic hypoxia. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2021, 第 2 作者541: 1-7, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000615714500001.
[16] Budamagunta, Vivekananda, ManoharSindhu, Sahana, Yang, Yang, He, Yonghan, Traktuev, Dmitry O, Foster, Thomas C, Zhou, Daohong. Senescence-associated hyper-activation to inflammatory stimuli in vitro. AGING-US[J]. 2021, 第 4 作者13(15): 19088-19107, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000685362600004.
[17] Ge, Mingxia, Hu, Li, Ao, Hongshun, Zi, Meiting, Kong, Qingpeng, He, Yonghan. Senolytic targets and new strategies for clearing senescent cells. MECHANISMS OF AGEING AND DEVELOPMENT[J]. 2021, 第 6 作者 通讯作者 195: http://dx.doi.org/10.1016/j.mad.2021.111468.
[18] Ji, Xiao Ning, Huang, Min, Yao, Si Han, Qi, Jia Yue, Onwuka, Justina Ucheojor, Wang, Yan, Wang, Xue Mei, Chen, Yang, Wu, Xiao Yan, Liu, Li Yan, Wang, Si Han, Zhou, Meng, He, Yong Han, Feng, Ren Nan. Refined grains intake in high fat, high protein, low carbohydrate and low energy levels subgroups and higher likelihood of abdominal obesity in Chinese population. INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION[J]. 2020, 第 13 作者71(8): 979-990, http://dx.doi.org/10.1080/09637486.2020.1746956.
[19] He, Yonghan, Li, Wen, Lv, Dongwen, Zhang, Xin, Zhang, Xuan, Ortiz, Yuma T, Budamagunta, Vivekananda, Campisi, Judith, Zheng, Guangrong, Zhou, Daohong. Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. AGING CELL[J]. 2020, 第 1 作者19(3): http://dx.doi.org/10.1111/acel.13117.
[20] Yonghan He, Xuan Zhang, Jianhui Chang, HaNeui Kim, Peiyi Zhang, Yingying Wang, Sajid Khan, Xingui Liu, Xin Zhang, Dongwen Lv, Lin Song, Wen Li, Dinesh Thummuri, Yaxia Yuan, Janet S Wiegand, Yuma T Ortiz, Vivekananda Budamagunta, Jennifer H Elisseeff, Judith Campisi, Maria Almeida, Guangrong Zheng, Daohong Zhou. Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity. NATURE COMMUNICATIONS[J]. 2020, 第 1 作者11(1): http://dx.doi.org/10.1038/s41467-020-15838-0.
[21] Kim, Ha-Neui, Xiong, Jinhu, MacLeod, Ryan S, IYER, SRIVIDHYA, Fujiwara, Yuko, Cawley, Keisha M, Han, Li, He, Yonghan, Thostenson, Jeff D, Ferreira, Elisabeth, Jilka, Robert L, Zhou, Daohong, Almeida, Maria, O'Brien, Charles A. Osteocyte RANKL is required for loss of bone with age and is induced by cellular senescence. JCI INSIGHT[J]. 2020, 第 8 作者5(19):
[22] Khan, Sajid, He, Yonghan, Zhang, Xuan, Yuan, Yaxia, Pu, Shaoyan, Kong, Qingpeng, Zheng, Guangrong, Zhou, Daohong. PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics. ONCOGENE[J]. 2020, 第 2 作者39(26): 4909-4924, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319888/.
[23] He, Yonghan, Koch, Raphael, Budamagunta, Vivekananda, Zhang, Peiyi, Zhang, Xuan, Khan, Sajid, Thummuri, Dinesh, Ortiz, Yuma T, Zhang, Xin, Lv, Dongwen, Wiegand, Janet S, Li, Wen, Palmer, Adam C, Zheng, Guangrong, Weinstock, David M, Zhou, Daohong. DT2216-a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas. JOURNAL OF HEMATOLOGY & ONCOLOGY[J]. 2020, 第 1 作者13(1): http://dx.doi.org/10.1186/s13045-020-00928-9.
[24] He, Yonghan, Khan, Sajid, Huo, Zhiguang, Lv, Dongwen, Zhang, Xuan, Liu, Xingui, Yuan, Yaxia, Hromas, Robert, Xu, Mingjiang, Zheng, Guangrong, Zhou, Daohong. Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies. JOURNAL OF HEMATOLOGY & ONCOLOGY. 2020, 第 1 作者13(1): https://doaj.org/article/d50c64223d3741a28884e3b3aee78b69.
[25] Xuan Zhang, Dinesh Thummuri, Yonghan He, Xingui Liu, Peiyi Zhang, Daohong Zhou, Guangrong Zheng. Utilizing PROTAC technology to address the on-target platelet toxicity associated with inhibition of BCL-XL. CHEMICAL COMMUNICATIONS[J]. 2020, 第 3 作者55(98): 14765-14768, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057339/.
[26] Zhang, Xuan, He, Yonghan, Zhang, Peiyi, Budamagunta, Vivekananda, Lv, Dongwen, Thummuri, Dinesh, Yang, Yang, Pei, Jing, Yuan, Yaxia, Zhou, Daohong, Zheng, Guangrong. Discovery of IAP-recruiting BCL-X-L PROTACs as potent degraders across multiple cancer cell lines. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2020, 第 2 作者199: http://dx.doi.org/10.1016/j.ejmech.2020.112397.
[27] Khan, Sajid, Zhang, Xuan, Lv, Dongwen, Zhang, Qi, He, Yonghan, Zhang, Peiyi, Liu, Xingui, Thummuri, Dinesh, Yuan, Yaxia, Wiegand, Janet S, Pei, Jing, Zhang, Weizhou, Sharma, Abhisheak, McCurdy, Christopher R, Kuruvilla, Vinitha M, Baran, Natalia, Ferrando, Adolfo A, Kim, Yongmi, Rogojina, Anna, Houghton, Peter J, Huang, Guangcun, Hromas, Robert, Konopleva, Marina, Zheng, Guangrong, Zhou, Daohong. A selective BCL-X-L PROTAC degrader achieves safe and potent antitumor activity. NATURE MEDICINE[J]. 2019, 第 5 作者25(12): 1938-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000500824900037.
[28] Li, Wen, He, Yonghan, Zhang, Rongping, Zheng, Guangrong, Zhou, Daohong. The curcumin analog EF24 is a novel senolytic agent. AGING-US[J]. 2019, 第 2 作者11(2): 771-782,
[29] Yu, Qin, Pu, ShaoYan, Wu, Huan, Chen, XiaoQiong, Jiang, JianJun, Gu, KangShuyun, He, YongHan, Kong, QingPeng. TICRR Contributes to Tumorigenesis Through Accelerating DNA Replication in Cancers. FRONTIERS IN ONCOLOGY[J]. 2019, 第 7 作者 通讯作者 9: https://doaj.org/article/88d599c7796d48d794445e9b787373f6.
[30] He, Yonghan, Thummuri, Dinesh, Zheng, Guangrong, Okunieff, Paul, Citrin, Deborah E, Vujaskovic, Zeljko, Zhou, Daohong. Cellular senescence and radiation-induced pulmonary fibrosis. TRANSLATIONAL RESEARCH. 2019, 第 1 作者209: 14-21, http://dx.doi.org/10.1016/j.trsl.2019.03.006.
[31] Zhang, Xuan, Thummuri, Dinesh, He, Yonghan, Liu, Xingui, Zhang, Peiyi, Zhou, Daohong, Zheng, Guangrong. Utilizing PROTAC technology to address the on-target platelet toxicity associated with inhibition of BCL-XL. CHEMICAL COMMUNICATIONS[J]. 2019, 第 3 作者55(98): 14765-14768, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7057339/.
[32] 孙辉, 马凌波, 董飞, 胡光荣, 何永捍, 邓颖. 乳酸堆积对肝星状细胞增殖、分化、凋亡的影响. 重庆医学[J]. 2019, 第 5 作者48(16): 2743-2746, http://lib.cqvip.com/Qikan/Article/Detail?id=7002723537.
[33] Li, Wen, Qin, Lin, Feng, Rennan, Hu, Guangrong, Sun, Hui, He, Yonghan, Zhang, Rongping. Emerging senolytic agents derived from natural products. MECHANISMS OF AGEING AND DEVELOPMENT[J]. 2019, 第 6 作者 通讯作者 181: 1-6, http://dx.doi.org/10.1016/j.mad.2019.05.001.
[34] He, YongHan, Li, Wen, Hu, Guangrong, Sun, Hui, Kong, Qingpeng. Bioactivities of EF24, a novel curcumin analog: A review. Frontiers in Oncology. FRONTIERS IN ONCOLOGY[J]. 2018, 第 1 作者8: https://www.frontiersin.org/articles/10.3389/fonc.2018.00614/full.
[35] He, Yonghan, Li, Wen, Hu, Guangrong, Sun, Hui, Kong, Qingpeng. Bioactivities of EF24, a Novel Curcumin Analog: A Review. FRONTIERS IN ONCOLOGY[J]. 2018, 第 1 作者 通讯作者 8: https://doaj.org/article/2063e82609d24a1aba0b92070365cc1c.
[36] Zhang, Xin, Zhang, Suping, Liu, Xingui, Wang, Yingying, Chang, Jianhui, Zhang, Xuan, Mackintosh, Samuel G, Tackett, Alan J, He, Yonghan, Lv, Dongwen, Laberge, RemiMartin, Campisi, Judith, Wang, Jianrong, Zheng, Guangrong, Zhou, Daohong. Oxidation resistance 1 is a novel senolytic target. AGING CELL[J]. 2018, 第 9 作者17(4): https://www.webofscience.com/wos/woscc/full-record/WOS:000439767700025.
[37] Yuan, Lifeng, Zhai, Linhui, Qian, Lili, Huang, De, Ding, Yi, Xiang, Handan, Liu, Xiaojing, Thompson, J Will, Liu, Juan, He, YongHan, Chen, XiaoQiong, Hu, Jing, Kong, QingPeng, Tan, Minjia, Wang, XiaoFan. Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death. CELL RESEARCH[J]. 2018, 第 10 作者28(6): 625-643, http://lib.cqvip.com/Qikan/Article/Detail?id=675655257.
[38] Xiao, Fu-Hui, Chen, Xiao-Qiong, He, Yong-Han, Kong, Qing-Peng. Accelerated DNA methylation changes in middle-aged men define sexual dimorphism in human lifespans. CLINICAL EPIGENETICS[J]. 2018, 第 3 作者10(1): https://doaj.org/article/822c60a451f54c71b8bbeabd320dcb85.
[39] Xiao, Fu-Hui, Chen, Xiao-Qiong, Yu, Qin, Ye, Yunshuang, Liu, Yao-Wen, Yan, Dongjing, Yang, Li-Qin, Chen, Guijun, Lin, Rong, Yang, Liping, Liao, Xiaoping, Zhang, Wen, Zhang, Wei, Tang, Nelson-Leung-Sang, Wang, XiaoFan, Zhou, Jumin, Cai, Wang-Wei, He, Yong-Han, Kong, Qing-Peng. Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians. GENOME RESEARCH[J]. 2018, 第 18 作者 通讯作者 28(11): 1601-1610, https://www.webofscience.com/wos/woscc/full-record/WOS:000448950400001.
[40] Wang, Xiao-Xiong, Xiao, Fu-Hui, Li, Qi-Gang, Liu, Jia, He, Yong-Han, Kong, Qing-Peng. Large-scale DNA methylation expression analysis across 12 solid cancers reveals hypermethylation in the calcium-signaling pathway. ONCOTARGET[J]. 2017, 第 5 作者 通讯作者 8(7): 11868-11876, http://www.irgrid.ac.cn/handle/1471x/1151618.
[41] Li, QiGang, He, YongHan, Wu, Huan, Yang, CuiPing, Pu, ShaoYan, Fan, SongQing, Jiang, LiPing, Shen, QiuShuo, Wang, XiaoXiong, Chen, XiaoQiong, Yu, Qin, Li, Ying, Sun, Chang, Wang, Xiangting, Zhou, Jumin, Li, HaiPeng, Chen, YongBin, Kong, QingPeng. A Normalization-Free and Nonparametric Method Sharpens Large-Scale Transcriptome Analysis and Reveals Common Gene Alteration Patterns in Cancers. THERANOSTICS[J]. 2017, 第 2 作者7(11): 2888-2899, http://159.226.149.26:8080/handle/152453/11821.
[42] Pu, ShaoYan, Yu, Qin, Wu, Huan, Jiang, JianJun, Chen, XiaoQiong, He, YongHan, Kong, QingPeng. ERCC6L, a DNA helicase, is involved in cell proliferation and associated with survival and progress in breast and kidney cancers. ONCOTARGET[J]. 2017, 第 6 作者 通讯作者 8(26): 42116-42124, https://www.webofscience.com/wos/woscc/full-record/WOS:000405493400032.
[43] He, Yong-Han, Pu, Shao-Yan, Li, Wen, Chen, Xiao-Qiong, Xiao, Fu-Hui, Yan, Dong-Jing, Liu, Yao-Wen, Lin, Rong, Liao, Xiao-Ping, Yang, Xing-Li, Ge, Ming-Xia, Cai, Wang-Wei, Kong, Qing-Peng. DECLINE IN BLOOD HEMOGLOBIN CONCENTRATION IS ASSOCIATED WITH FAMILIAL LONGEVITY. ARCHIVES OF BIOLOGICAL SCIENCES[J]. 2016, 第 1 作者68(3): 533-540, https://www.webofscience.com/wos/woscc/full-record/WOS:000384908900007.
[44] He, YongHan, Chen, XiaoQiong, Yan, DongJing, Xiao, FuHui, Lin, Rong, Liao, XiaoPing, Liu, YaoWen, Pu, ShaoYan, Yu, Qin, Sun, HongPeng, Jiang, JianJun, Cai, WangWei, Kong, QingPeng. Familial longevity study reveals a significant association of mitochondrial DNA copy number between centenarians and their offspring. NEUROBIOLOGY OF AGING[J]. 2016, 第 1 作者47(X): 218.e11-218.e18, http://dx.doi.org/10.1016/j.neurobiolaging.2016.07.026.
[45] Jiang, JianJun, Cheng, LeHua, Wu, Huan, He, YongHan, Kong, QingPeng. Insights into long noncoding RNAs of naked mole rat (Heterocephalus glaber) and their potential association with cancer resistance. EPIGENETICS & CHROMATIN[J]. 2016, 第 4 作者 通讯作者 9(X): http://dx.doi.org/10.1186/s13072-016-0101-5.
[46] Han, Liyuan, Liu, Yanfen, Duan, Shiwei, Perry, Benjamin, Li, Wen, He, Yonghan. DNA methylation and hypertension: emerging evidence and challenges. BRIEFINGS IN FUNCTIONAL GENOMICS[J]. 2016, 第 6 作者 通讯作者 15(6): 460-469, http://159.226.149.26:8080/handle/152453/10960.
[47] Xiao, Fu-Hui, Kong, Qing-Peng, Perry, Benjamin, He, Yong-Han. Progress on the role of DNA methylation in aging and longevity. BRIEFINGS IN FUNCTIONAL GENOMICS[J]. 2016, 第 4 作者 通讯作者 15(6): 454-459, https://www.webofscience.com/wos/woscc/full-record/WOS:000392717700007.
[48] He, YongHan, Lu, Xiang, Tian, JiaoYang, Yan, DongJing, Li, YuChun, Lin, Rong, Perry, Benjamin, Chen, XiaoQiong, Yu, Qin, Cai, WangWei, Kong, QingPeng. Mitochondrial DNA plays an equal role in influencing female and male longevity in centenarians. EXPERIMENTAL GERONTOLOGY[J]. 2016, 第 1 作者83(X): 94-96, http://dx.doi.org/10.1016/j.exger.2016.07.010.
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[35] He, Yonghan, Li, Wen, Hu, Guangrong, Sun, Hui, Kong, Qingpeng. Bioactivities of EF24, a Novel Curcumin Analog: A Review. FRONTIERS IN ONCOLOGY[J]. 2018, 第 1 作者 通讯作者 8: https://doaj.org/article/2063e82609d24a1aba0b92070365cc1c.
[36] Zhang, Xin, Zhang, Suping, Liu, Xingui, Wang, Yingying, Chang, Jianhui, Zhang, Xuan, Mackintosh, Samuel G, Tackett, Alan J, He, Yonghan, Lv, Dongwen, Laberge, RemiMartin, Campisi, Judith, Wang, Jianrong, Zheng, Guangrong, Zhou, Daohong. Oxidation resistance 1 is a novel senolytic target. AGING CELL[J]. 2018, 第 9 作者17(4): https://www.webofscience.com/wos/woscc/full-record/WOS:000439767700025.
[37] Yuan, Lifeng, Zhai, Linhui, Qian, Lili, Huang, De, Ding, Yi, Xiang, Handan, Liu, Xiaojing, Thompson, J Will, Liu, Juan, He, YongHan, Chen, XiaoQiong, Hu, Jing, Kong, QingPeng, Tan, Minjia, Wang, XiaoFan. Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death. CELL RESEARCH[J]. 2018, 第 10 作者28(6): 625-643, http://lib.cqvip.com/Qikan/Article/Detail?id=675655257.
[38] Xiao, Fu-Hui, Chen, Xiao-Qiong, He, Yong-Han, Kong, Qing-Peng. Accelerated DNA methylation changes in middle-aged men define sexual dimorphism in human lifespans. CLINICAL EPIGENETICS[J]. 2018, 第 3 作者10(1): https://doaj.org/article/822c60a451f54c71b8bbeabd320dcb85.
[39] Xiao, Fu-Hui, Chen, Xiao-Qiong, Yu, Qin, Ye, Yunshuang, Liu, Yao-Wen, Yan, Dongjing, Yang, Li-Qin, Chen, Guijun, Lin, Rong, Yang, Liping, Liao, Xiaoping, Zhang, Wen, Zhang, Wei, Tang, Nelson-Leung-Sang, Wang, XiaoFan, Zhou, Jumin, Cai, Wang-Wei, He, Yong-Han, Kong, Qing-Peng. Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians. GENOME RESEARCH[J]. 2018, 第 18 作者 通讯作者 28(11): 1601-1610, https://www.webofscience.com/wos/woscc/full-record/WOS:000448950400001.
[40] Wang, Xiao-Xiong, Xiao, Fu-Hui, Li, Qi-Gang, Liu, Jia, He, Yong-Han, Kong, Qing-Peng. Large-scale DNA methylation expression analysis across 12 solid cancers reveals hypermethylation in the calcium-signaling pathway. ONCOTARGET[J]. 2017, 第 5 作者 通讯作者 8(7): 11868-11876, http://www.irgrid.ac.cn/handle/1471x/1151618.
[41] Li, QiGang, He, YongHan, Wu, Huan, Yang, CuiPing, Pu, ShaoYan, Fan, SongQing, Jiang, LiPing, Shen, QiuShuo, Wang, XiaoXiong, Chen, XiaoQiong, Yu, Qin, Li, Ying, Sun, Chang, Wang, Xiangting, Zhou, Jumin, Li, HaiPeng, Chen, YongBin, Kong, QingPeng. A Normalization-Free and Nonparametric Method Sharpens Large-Scale Transcriptome Analysis and Reveals Common Gene Alteration Patterns in Cancers. THERANOSTICS[J]. 2017, 第 2 作者7(11): 2888-2899, http://159.226.149.26:8080/handle/152453/11821.
[42] Pu, ShaoYan, Yu, Qin, Wu, Huan, Jiang, JianJun, Chen, XiaoQiong, He, YongHan, Kong, QingPeng. ERCC6L, a DNA helicase, is involved in cell proliferation and associated with survival and progress in breast and kidney cancers. ONCOTARGET[J]. 2017, 第 6 作者 通讯作者 8(26): 42116-42124, https://www.webofscience.com/wos/woscc/full-record/WOS:000405493400032.
[43] He, Yong-Han, Pu, Shao-Yan, Li, Wen, Chen, Xiao-Qiong, Xiao, Fu-Hui, Yan, Dong-Jing, Liu, Yao-Wen, Lin, Rong, Liao, Xiao-Ping, Yang, Xing-Li, Ge, Ming-Xia, Cai, Wang-Wei, Kong, Qing-Peng. DECLINE IN BLOOD HEMOGLOBIN CONCENTRATION IS ASSOCIATED WITH FAMILIAL LONGEVITY. ARCHIVES OF BIOLOGICAL SCIENCES[J]. 2016, 第 1 作者68(3): 533-540, https://www.webofscience.com/wos/woscc/full-record/WOS:000384908900007.
[44] He, YongHan, Chen, XiaoQiong, Yan, DongJing, Xiao, FuHui, Lin, Rong, Liao, XiaoPing, Liu, YaoWen, Pu, ShaoYan, Yu, Qin, Sun, HongPeng, Jiang, JianJun, Cai, WangWei, Kong, QingPeng. Familial longevity study reveals a significant association of mitochondrial DNA copy number between centenarians and their offspring. NEUROBIOLOGY OF AGING[J]. 2016, 第 1 作者47(X): 218.e11-218.e18, http://dx.doi.org/10.1016/j.neurobiolaging.2016.07.026.
[45] Jiang, JianJun, Cheng, LeHua, Wu, Huan, He, YongHan, Kong, QingPeng. Insights into long noncoding RNAs of naked mole rat (Heterocephalus glaber) and their potential association with cancer resistance. EPIGENETICS & CHROMATIN[J]. 2016, 第 4 作者 通讯作者 9(X): http://dx.doi.org/10.1186/s13072-016-0101-5.
[46] Han, Liyuan, Liu, Yanfen, Duan, Shiwei, Perry, Benjamin, Li, Wen, He, Yonghan. DNA methylation and hypertension: emerging evidence and challenges. BRIEFINGS IN FUNCTIONAL GENOMICS[J]. 2016, 第 6 作者 通讯作者 15(6): 460-469, http://159.226.149.26:8080/handle/152453/10960.
[47] Xiao, Fu-Hui, Kong, Qing-Peng, Perry, Benjamin, He, Yong-Han. Progress on the role of DNA methylation in aging and longevity. BRIEFINGS IN FUNCTIONAL GENOMICS[J]. 2016, 第 4 作者 通讯作者 15(6): 454-459, https://www.webofscience.com/wos/woscc/full-record/WOS:000392717700007.
[48] He, YongHan, Lu, Xiang, Tian, JiaoYang, Yan, DongJing, Li, YuChun, Lin, Rong, Perry, Benjamin, Chen, XiaoQiong, Yu, Qin, Cai, WangWei, Kong, QingPeng. Mitochondrial DNA plays an equal role in influencing female and male longevity in centenarians. EXPERIMENTAL GERONTOLOGY[J]. 2016, 第 1 作者83(X): 94-96, http://dx.doi.org/10.1016/j.exger.2016.07.010.
[49] He, Yong-Han, Pu, Shao-Yan, Xiao, Fu-Hui, Chen, Xiao-Qiong, Yan, Dong-Jing, Liu, Yao-Wen, Lin, Rong, Liao, Xiao-Ping, Yu, Qin, Yang, Li-Qin, Yang, Xing-Li, Ge, Ming-Xia, Li, Ying, Jiang, Jian-Jun, Cai, Wang-Wei, Kong, Qing-Peng. Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families. SCIENTIFIC REPORTS[J]. 2016, 第 1 作者6(X): https://www.webofscience.com/wos/woscc/full-record/WOS:000370783700002.
[50] He YongHan, Pu ShaoYan, Li Wen, Chen XiaoQiong, Xiao FuHui, Yan DongJing, Liu YaoWen, Lin Rong, Liao XiaoPing, Yang XingLi, Ge MingXia, Cai WangWei, Kong QingPeng. Decline in blood hemoglobin concentrations is associated with familial longevity. ARCHIVES OF BIOLOGICAL SCIENCES[J]. 2016, 第 1 作者68(3): 533-540, https://doaj.org/article/a79a0006e9974c26b3d70ac8437c7e67.
[51] He, YongHan, Lu, Xiang, Tian, Jiaoyang, Yan, Dongjing, Li, Yuchun, Lin, Rong, Perry, Benjamin, Chen, Xiaoqiong, Yu, Qin, Cai, Wangwei, Kong, Qingpeng. Mitochondrial DNA contributes equally to female and male longevity in Chinese centenarians. EXPERIMENTAL GERONTOLOGY[J]. 2016, 第 1 作者83: 94-96,
[52] Xiao, Fu-Hui, He, Yong-Han, Li, Qi-Gang, Wu, Huan, Luo, Long-Hai, Kong, Qing-Peng. A Genome-Wide Scan Reveals Important Roles of DNA Methylation in Human Longevity by Regulating Age-Related Disease Genes. PLOS ONE[J]. 2015, 第 2 作者10(3): http://159.226.149.42:8080:8088/handle/152453/8328.
[53] He, Yong-Han, Chen, Xiao-Qiong, Yan, Dong-Jing, Xiao, Fu-Hui, Liu, Yao-Wen, Lin, Rong, Liao, Xiao-Ping, Cai, Wang-Wei, Kong, Qing-Peng. Thyroid Function Decreases with Age and May Contribute to Longevity in Chinese Centenarians' Families. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY[J]. 2015, 第 1 作者 通讯作者 63(7): 1474-1476, https://www.webofscience.com/wos/woscc/full-record/WOS:000358254200033.
[54] Yu, Qin, Sun, HongPeng, Chen, WanQun, Chen, XiaoQiong, Xu, Yong, He, YongHan, Kong, QingPeng. Sex-specific association of rs4746172 of VCL gene with hypertension in two Han populations from Southern China. SCIENTIFIC REPORTS[J]. 2015, 第 6 作者 通讯作者 5(X): http://dx.doi.org/10.1038/srep15245.
[55] Huan WU, YongHan HE, TianRui XU, QingPeng KONG. Absence of mutation in miR-34a gene in a Chinese longevity population. ZOOLOGICAL RESEARCH[J]. 2015, 第 2 作者36(2): 112-114, http://www.irgrid.ac.cn/handle/1471x/1151602.
[56] He, YongHan, Lu, Xiang, Yang, LiQin, Xu, LiangYou, Kong, QingPeng. Association of the insulin-like growth factor binding protein 3 (IGFBP-3) polymorphism with longevity in Chinese nonagenarians and centenarians. AGING-US[J]. 2014, 第 1 作者6(11): 944-956,
[57] He, Yonghan, Kong, Weilan, Wang, Guan, Zhao, Yue, Bi, Mingxin, Na, Lixin, Wang, Maoqing, Perry, Ben, Li, Ying. The calcium-sensing receptor R990G polymorphism is associated with increased risk of hypertriglyceridemia in obese Chinese. GENE[J]. 2014, 第 1 作者533(1): 67-71, http://dx.doi.org/10.1016/j.gene.2013.09.122.
[58] He YH, Lu X, Bi MX, Yang LQ, Xu LY, Kong QP. The reduction of vascular disease risk mutations contributes to longevity in the Chinese population. META GENE[J]. 2014, 2(X): 761-768, http://dx.doi.org/10.1016/j.mgene.2014.09.010.
[59] He, Yonghan, Li, Wen, Li, Ying, Zhang, Shuocheng, Wang, Yanwen, Sun, Changhao. Ursolic Acid Increases Glucose Uptake through the PI3K Signaling Pathway in Adipocytes. PLOS ONE[J]. 2014, 第 1 作者9(10): http://159.226.149.42:8080:8088/handle/152453/8189.
[60] Liu, YaoWen, He, YongHan, Zhang, YunXia, Cai, WangWei, Yang, LiQin, Xu, LiangYou, Kong, QingPeng. Absence of A673T variant in APP gene indicates an alternative protective mechanism contributing to longevity in Chinese individuals. NEUROBIOLOGY OF AGING[J]. 2014, 第 2 作者35(4): 935.e11-935.e12, http://dx.doi.org/10.1016/j.neurobiolaging.2013.09.023.
[61] He, YongHan, Lu, Xiang, Wu, Huan, Cai, WangWei, Yang, LiQin, Xu, LiangYou, Sun, HongPeng, Kong, QingPeng. Mitochondrial DNA content contributes to healthy aging in Chinese: a study from nonagenarians and centenarians. NEUROBIOLOGY OF AGING[J]. 2014, 第 1 作者35(7): 1779.e1-1779.e4, http://dx.doi.org/10.1016/j.neurobiolaging.2014.01.015.
[62] He, YongHan, Zhang, YunXia, Yang, LiQin, Liao, XiaoPing, Zhang, QingYing, Cai, WangWei, Kong, QingPeng. Assessment of the health status of centenarians in the south of China: a cross-sectional study. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY[J]. 2014, 第 1 作者 通讯作者 62(7): 1402-1404, http://159.226.149.42:8080:8088/handle/152453/7977.
[63] Huang, Yifan, He, Yonghan, Sun, Xiaowei, He, Yujie, Li, Ying, Sun, Changhao. Maternal High Folic Acid Supplement Promotes Glucose Intolerance and Insulin Resistance in Male Mouse Offspring Fed a High-Fat Diet. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2014, 第 2 作者15(4): 6298-6313, http://dx.doi.org/10.3390/ijms15046298.
[64] Zhang, Huaqi, Teng, Jianhua, Li, Ying, Li, Xiaoxia, He, Yonghan, He, Xuan, Sun, Changhao. Vitamin D status and its association with adiposity and oxidative stress in schoolchildren. NUTRITION[J]. 2014, 第 5 作者30(9): 1040-1044, http://dx.doi.org/10.1016/j.nut.2014.02.024.
[65] He, Yonghan, Li, Ying, Zhao, Tiantian, Wang, Yanwen, Sun, Changhao. Ursolic Acid Inhibits Adipogenesis in 3T3-L1 Adipocytes through LKB1/AMPK Pathway. PLOS ONE[J]. 2013, 第 1 作者8(7): https://doaj.org/article/3820c6fd43594814a5f06eed69f18c30.
[66] He, Yonghan, Perry, Ben, Bi, Mingxin, Sun, Hui, Zhao, Tiantian, Li, Ying, Sun, Changhao. Allosteric regulation of the calcium-sensing receptor in obese individuals. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE[J]. 2013, 第 1 作者32(2): 511-518, http://www.irgrid.ac.cn/handle/1471x/680413.
[67] Songtao Li, Ying Li, Hua Ning, Lixin Na, Yucun Niu, Maoqing Wang, Rennan Feng, Liyan Liu, Fuchuan Guo, Shaoying Hou, Xia Chu, Yemei Wang, Yunbo Zhang, Huaqi Zhang, Lina Huang, Mingxin Bi, Yifan Huang, Liuyi Hao, Yan Zhao, Cheng Wang, Yanwen Wang, Yonghan He, Changhao Sun. Calcium supplementation increases circulating cholesterol by reducing its catabolism via GPER and TRPC1-dependent pathway in estrogen deficient women. INTERNATIONAL JOURNAL OF CARDIOLOGY. 2013, 第 22 作者168(3): 2548-2560, http://dx.doi.org/10.1016/j.ijcard.2013.03.057.
[68] He, Yonghan, Li, Ying, Zhang, Shuocheng, Perry, Ben, Zhao, Tiantian, Wang, Yanwen, Sun, Changhao. Radicicol, a heat shock protein 90 inhibitor, inhibits differentiation and adipogenesis in 3T3-L1 preadipocytes. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2013, 第 1 作者436(2): 169-174, http://www.irgrid.ac.cn/handle/1471x/680414.
[69] He, Yonghan, Han, Liyuan, Li, Wen, Shu, Xiang, Zhao, Chen, He, Ying, Bi, Mingxin, Li, Ying, Sun, Changhao. Effects of the calcium-sensing receptor A986S polymorphism on serum calcium and parathyroid hormone levels in healthy individuals: A meta-analysis. GENE[J]. 2012, 第 1 作者491(2): 110-115, http://dx.doi.org/10.1016/j.gene.2011.10.017.
[70] He, YongHan, Li, SongTao, Wang, YanYan, Wang, Guan, He, Ying, Liao, XiLu, Sun, ChangHao, Li, Ying. Postweaning low-calcium diet promotes later-life obesity induced by a high-fat diet. JOURNAL OF NUTRITIONAL BIOCHEMISTRY[J]. 2012, 第 1 作者23(10): 1238-1244, http://dx.doi.org/10.1016/j.jnutbio.2011.07.004.
[71] He, YongHan, He, Ying, Liao, XiLu, Niu, YuCun, Wang, Guan, Zhao, Chen, Wang, Liang, Tian, MingJie, Li, Ying, Sun, ChangHao. The calcium-sensing receptor promotes adipocyte differentiation and adipogenesis through PPAR gamma pathway. MOLECULAR AND CELLULAR BIOCHEMISTRY[J]. 2012, 第 1 作者361(1-2): 321-328, https://www.webofscience.com/wos/woscc/full-record/WOS:000298607600037.
[72] He, Yonghan, Zhang, Huaqi, Teng, Jianghua, Huang, Lina, Li, Ying, Sun, Changhao. Involvement of calcium-sensing receptor in inhibition of lipolysis through intracellular cAMP and calcium pathways in human adipocytes. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2011, 第 1 作者404(1): 393-399, https://www.webofscience.com/wos/woscc/full-record/WOS:000286487700070.
[73] He, YongHan, Song, Yue, Liao, XiLu, Wang, Liang, Li, Gang, Alima, Li, Ying, Sun, ChangHao. The Calcium-Sensing Receptor Affects Fat Accumulation via Effects on Antilipolytic Pathways in Adipose Tissue of Rats Fed Low-Calcium Diets. JOURNAL OF NUTRITION[J]. 2011, 第 1 作者141(11): 1938-1946, https://www.webofscience.com/wos/woscc/full-record/WOS:000296214800004.
[74] Huang, Lina, Xue, Jingyi, He, Ying, Wang, Jian, Sun, Changhao, Feng, Rennan, Teng, Jianhua, He, Yonghan, Li, Ying. Dietary Calcium but Not Elemental Calcium from Supplements Is Associated with Body Composition and Obesity in Chinese Women. PLOS ONE[J]. 2011, 第 8 作者6(12): https://doaj.org/article/4dbfc135592b46469649b6c2300de5a6.
发表著作
（1） Healthy Ageing and Longevity, Springer, Cham, 2020-01, 第 1 作者
科研活动
科研项目
（ 1 ） “泛第三极环境变化与绿色丝绸之路建设”项目子课题, 主持, 部委级, 2018-03--2023-02
（ 2 ） 甲状腺素单羧酸转运蛋白10 影响衰老/寿命的作用及机制研究, 主持, 省级, 2017-06--2020-05
（ 3 ） 长寿人群特异低表达基因-甲状腺素转运蛋白MCT10调控衰老的作用机制研究, 主持, 国家级, 2017-01--2020-12
（ 4 ） 中国科学院青年创新促进会, 主持, 部委级, 2016-01--2019-12
（ 5 ） 热休克蛋白 70（HSP-70）在肥胖发生中的作用和机制研究, 主持, 国家级, 2016-01--2018-12
（ 6 ） 中科院西部之光“西部博士”项目, 主持, 部委级, 2014-01--2017-06
（ 7 ） 基于长寿人群甲基化模式筛查和研究老年疾病的表观遗传因子, 主持, 市地级, 2014-01--2015-12
（ 8 ） 新成立学科组项目启动经费, 主持, 部委级, 2020-10--2025-10
（ 9 ） 衰老细胞特异高表达lncRNA调控衰老的作用和机制研究, 主持, 国家级, 2022-01--2025-12
（ 10 ） 动物能量代谢系统创新与重塑的进化发育机制, 参与, 部委级, 2021-06--2022-05
（ 11 ） 内脏器官衰老与相关老年疾病防治的基础研究, 参与, 国家级, 2013-01--2017-08
（ 12 ） 中国人群长寿相关DNA甲基化调控位点的筛查和功能研究, 主持, 省级, 2013-10--2016-09
（ 13 ） 中国科学院引进海外高层次人才计划, 主持, 部委级, 2022-01--2024-12
（ 2 ） 甲状腺素单羧酸转运蛋白10 影响衰老/寿命的作用及机制研究, 主持, 省级, 2017-06--2020-05
（ 3 ） 长寿人群特异低表达基因-甲状腺素转运蛋白MCT10调控衰老的作用机制研究, 主持, 国家级, 2017-01--2020-12
（ 4 ） 中国科学院青年创新促进会, 主持, 部委级, 2016-01--2019-12
（ 5 ） 热休克蛋白 70（HSP-70）在肥胖发生中的作用和机制研究, 主持, 国家级, 2016-01--2018-12
（ 6 ） 中科院西部之光“西部博士”项目, 主持, 部委级, 2014-01--2017-06
（ 7 ） 基于长寿人群甲基化模式筛查和研究老年疾病的表观遗传因子, 主持, 市地级, 2014-01--2015-12
（ 8 ） 新成立学科组项目启动经费, 主持, 部委级, 2020-10--2025-10
（ 9 ） 衰老细胞特异高表达lncRNA调控衰老的作用和机制研究, 主持, 国家级, 2022-01--2025-12
（ 10 ） 动物能量代谢系统创新与重塑的进化发育机制, 参与, 部委级, 2021-06--2022-05
（ 11 ） 内脏器官衰老与相关老年疾病防治的基础研究, 参与, 国家级, 2013-01--2017-08
（ 12 ） 中国人群长寿相关DNA甲基化调控位点的筛查和功能研究, 主持, 省级, 2013-10--2016-09
（ 13 ） 中国科学院引进海外高层次人才计划, 主持, 部委级, 2022-01--2024-12
参与会议
（1）衰老细胞senolytic靶点挖掘及PROTAC小分子的应用 2022中国衰老科学大会（CASC） 2022-04-22
（2）衰老细胞和选择性清除衰老细胞 --新的衰老干预靶点和策略 中国营养学会营养与组学技术分会第二届学术会议 2021-11-13
（3）Long-Term Clearance of Senescent Cells Prevents the Hematopoietic Stem Cell Aging in Naturally Aged Mice 2019-12-07
（4）DT2216, a BCL-XL Proteolysis Targeting Chimera (PROTAC), Is a Potent Anti T-Cell Lymphoma Agent That Does Not Induce Significant Thrombocytopenia 2019-12-07
（5）DT2216, a Synthetic Proteolytic Selectively Targeting Bcl-XL for Ubiquitination and Degradation in Tumor Cells but Not in Platelets, Is a Safer and More Potent Antitumor Agent Than Navitoclax 2018-11-29
（6）Inhibition of USP7 activity selectively eliminates senescent cells in a p53-dependent manner 2018-11-14
（2）衰老细胞和选择性清除衰老细胞 --新的衰老干预靶点和策略 中国营养学会营养与组学技术分会第二届学术会议 2021-11-13
（3）Long-Term Clearance of Senescent Cells Prevents the Hematopoietic Stem Cell Aging in Naturally Aged Mice 2019-12-07
（4）DT2216, a BCL-XL Proteolysis Targeting Chimera (PROTAC), Is a Potent Anti T-Cell Lymphoma Agent That Does Not Induce Significant Thrombocytopenia 2019-12-07
（5）DT2216, a Synthetic Proteolytic Selectively Targeting Bcl-XL for Ubiquitination and Degradation in Tumor Cells but Not in Platelets, Is a Safer and More Potent Antitumor Agent Than Navitoclax 2018-11-29
（6）Inhibition of USP7 activity selectively eliminates senescent cells in a p53-dependent manner 2018-11-14