主要研究方向为天然产物的化学生物学，综合运用有机化学、生物信息学、分子生物学、生物化学、分析化学、基因工程及代谢工程等学科知识与实验技术手段，进行以下三个方面研究：  

1、真菌活性次生代谢产物生物合成途径及酶催化机制研究； 

2、针对天然产物研究中的关键原始创新点----靶标/药物新结合位点的发现展开研究，阐明活性天然产物的作用靶标及其作用机制； 

3、活性天然产物的合成生物学研究。

​

100701-药物化学
071010-生物化学与分子生物学
100705-微生物与生化药学

（1） 植物化学防御 物质与新农药先导物的研究，一等奖，省级，2013
（2） 虎皮楠中新颖结构生物碱的研究，一等奖，省级，2009
（3） 中国科学院院长奖优秀奖，院级级，2007

   

[1] QingYun Lu, JiaHui Zhang, YingYao Li, XueXue Pu, CuiShan Zhang, Shuai Liu, JiaJia Wan, YingTong Di, XiaoJiang Hao. New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch.. Natural products and bioprospecting[J]. 2021, 11(4): 453-457, http://lib.cqvip.com/Qikan/Article/Detail?id=7105833936.

[2] Chen, YanNi, Ding, Xiao, Li, DongMei, Sun, Mao, Yang, Lei, Zhang, Yu, Di, YingTong, Fang, Xin, Hao, XiaoJiang. Diterpenoids with an unprecedented ring system from Euphorbia peplus and their activities in the lysosomal-autophagy pathway. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2021, 19(7): 1541-1545, https://www.webofscience.com/wos/woscc/full-record/WOS:000621563000010.

[3] 姚永刚. Harpertrioate A， an A，B，D-seco-limonoid with promising biological activity against Alzheimer's disease from twigs of Harrisonia perforata （Blanco） Merr （共同一作）. Organic Letters[J]. 2021, 23(2): 262-267, 
[4] Yuan, WenJuan, Gao, WenFen, Zhao, JiangYu, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. Diterpenes with potential treatment of vitiligo from the aerials parts of Euphorbia antiquorum L. FITOTERAPIA[J]. 2020, 144(7): http://ir.kib.ac.cn/handle/151853/72049,

[5] Gui, PengYan, Yan, XiaoHui, Yuan, WenJuan, Ma, YuanLiang, Ding, Xiao, Liu, Shuai, Di, YingTong, Zhu, WeiMing, Hao, XiaoJiang. 12 beta-Acetyloxyperforatin, a New Limonoid from Harrisonia Perforata. NATURAL PRODUCT RESEARCH[J]. 2019, 33(19): 2830-2836, http://dx.doi.org/10.1080/14786419.2018.1508139.

[6] Zhang, Jiahui, Cao, Pei, Ma, Yuanliang, Fang, Xin, Yang, Jing, Zhang, Yu, Chen, Duozhi, Gu, Yucheng, Di, Yingtong, Hao, Xiaojiang. Structural Revision of Macropodumine A and Structure of 2-Deoxymacropodumine A, Daphniphyllum Alkaloids with 11-Membered Macrolactone Rings. JOURNAL OF NATURAL PRODUCTS[J]. 2019, 82(3): 427-430, http://dx.doi.org/10.1021/acs.jnatprod.8b00232.

[7] YuanLiang Ma, XiaoHan Tang, WenJuan Yuan, Xiao Ding, YingTong Di, XiaoJiang Hao. Abietane Diterpernoids from the Roots of Euphorbia ebracteolata. NATURAL PRODUCTS AND BIOPROSPECTING[J]. 2018, 8(2): 131-135, http://ir.kib.ac.cn/handle/151853/64821.

[8] Yi, Wenfang, Chen, Duozhi, Ding, Xiao, Li, Xiaonian, Li, Shunlin, Di, Yingtong, Zhang, Yu, Hao, Xiaojiang. Cytotoxic indole alkaloids from Melodinus khasianus and Melodinus tenuicaudatus. FITOTERAPIA[J]. 2018, 128: 162-168, http://dx.doi.org/10.1016/j.fitote.2018.05.015.

[9] Bian, Guangkai, Hou, Anwei, Yuan, Yujie, Hu, Ben, Cheng, Shu, Ye, Ziling, Di, Yingtong, Deng, Zixin, Liu, Tiangang. Metabolic Engineering-Based Rapid Characterization of a Sesquiterpene Cyclase and the Skeletons of Fusariumdiene and Fusagramineol from Fusarium graminearum. ORGANIC LETTERS[J]. 2018, 20(6): 1626-1629, https://www.webofscience.com/wos/woscc/full-record/WOS:000428003600036.

[10] Zhao, NingDong, Ding, Xiao, Song, Yu, Yang, DongQiong, Adelakun, Tiwalade Adegoke, Qian, WenDan, Zhang, Yu, Di, YingTong, Gao, Fang, Hao, XiaoJiang, Li, ShunLin. Identification of Ingol and Rhamnofolane Diterpenoids from Euphorbia resinifera and Their Abilities to Induce Lysosomal Biosynthesis. JOURNAL OF NATURAL PRODUCTS[J]. 2018, 81(5): 1209-1218, https://www.webofscience.com/wos/woscc/full-record/WOS:000433635500010.

[11] Liu, Shuai, Zhang, Jiahui, Di, Yingtong, Dong, Jinyan, Hao, Xiaojiang. Daphniphyllum alkaloids with cytotoxic activity from Daphniphyllum angustifolium. NATURAL PRODUCT RESEARCH[J]. 2018, 32(18): 2165-2170, https://www.webofscience.com/wos/woscc/full-record/WOS:000441057100007.

[12] 杨智, 孙国太, 邸迎彤, 王跃虎, 胡旭佳. 茶褐牛肝菌化学成分研究. 热带亚热带植物学报[J]. 2018, 26(3): 309-316, http://lib.cqvip.com/Qikan/Article/Detail?id=675282225.

[13] Yuan, WenJuan, Gao, WenFen, Zhang, JiaHui, Cao, Pei, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. (+/-)-Perforison A, A Pair of New Chromone Enantiomers from Harrisonia perforata. NATURAL PRODUCT COMMUNICATIONS[J]. 2017, 12(1): 63-65, http://ir.kib.ac.cn/handle/151853/41892.

[14] Yuan, WenJuan, Ding, Xiao, Wang, Zhe, Yang, BiJuan, Li, XiaoNian, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Chen, Quan, Di, YingTong, Aisa, Haji Akber, Hao, XiaoJiang. Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/e37a28dc25a9453b84cb871969fa2f32.

[15] XiaoHui Yan, Ping Yi, Pei Cao, ShiYing Yang, Xin Fang, Yu Zhang, Bin Wu, Ying Leng, YingTong Di, Yang Lv, XiaoJiang Hao. 16-nor Limonoids from Harrisonia perforata as promising selective 11 β -HSD1 inhibitors. Scientific Reports. 2016, 6: 
[16] Li, XiaoHui, Zhang, Yu, Zhang, JiaHui, Li, XiaoNian, Cao, MingMing, Di, YingTong, Peng, ZongGen, Jiang, JianDong, Hao, XiaoJiang. Myritonines A-C, Alkaloids from Myrioneuron tonkinensis Based on a Novel Hexacyclic Skeleton. JOURNAL OF NATURAL PRODUCTS[J]. 2016, 79(4): 1203-1207, http://ir.kib.ac.cn/handle/151853/26223.

[17] Yuan, WenJuan, Yang, GuoPing, Zhang, JiaHui, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. Three new diterpenes with cytotoxic activity from the roots of Euphorbia ebracteolata Hayata. PHYTOCHEMISTRY LETTERS[J]. 2016, 18(1): 176-179, http://dx.doi.org/10.1016/j.phytol.2016.10.008.

[18] Li, Yang, Xu, Meng, Ding, Xiao, Yan, Chen, Song, Zhiqin, Chen, Lianwan, Huang, Xiahe, Wang, Xin, Jian, Youli, Tang, Guihua, Tang, Changyong, Di, Yingtong, Mu, Shuzhen, Liu, Xuezhao, Liu, Kai, Li, Ting, Wang, Yingchun, Miao, Long, Guo, Weixiang, Hao, Xiaojiang, Yang, Chonglin. Protein kinase C controls lysosome biogenesis independently of mTORC1. NATURE CELL BIOLOGY[J]. 2016, 18(10): 1065-1077, http://www.irgrid.ac.cn/handle/1471x/1140918.

[19] Zhang, JiaHui, JingGuo, Jing, Yuan, Yu Xi, Fu, YanHui, Gu, YuCheng, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. Four new tetracyclic alkaloids with cis-decahydroquinoline motif from Myrioneuron effusum. FITOTERAPIA[J]. 2016, 112: 217-221, http://dx.doi.org/10.1016/j.fitote.2016.06.006.

[20] Qin, XuJie, Yan, Huan, Ni, Wei, Yu, MuYuan, Khan, Afsar, Liu, Hui, Zhang, HongXia, He, Li, Hao, XiaoJiang, Di, YingTong, Liu, HaiYang. Cytotoxic Meroterpenoids with Rare Skeletons from Psidium guajava Cultivated in Temperate Zone. SCIENTIFIC REPORTS[J]. 2016, 6: http://www.irgrid.ac.cn/handle/1471x/1109614.

[21] Chang, YaoWen, Yuan, ChunMao, Zhang, Jing, Liu, Shuai, Cao, Pei, Hua, HuiMing, Di, YingTong, Hao, XiaoJiang. Speramides A-B, two new prenylated indole alkaloids from the freshwater-derived fungus Aspergillus ochraceus KM007. TETRAHEDRON LETTERS[J]. 2016, 57(45): 4952-4955, http://dx.doi.org/10.1016/j.tetlet.2016.09.071.

[1] 郝小江, 姚永刚, 邸迎彤, 罗荣灿, 唐小涵. 牛筋果三内酯A、治疗抗阿尔兹海默症的药物及制备方法和应用. CN: CN112592351A, 2021-04-02.

[2] 杨崇林, 郝小江, 李洋, 徐猛, 丁骁, 晏晨, 邸迎彤, 穆淑珍, 蹇友理, 宋智琴, 郭伟翔. 巨大戟醇及其衍生物在增强溶酶体生成中的应用. CN: CN106619600B, 2019-10-18.

[3] 郝小江, 蔡洁云, 何红平, 黎胜红, 骆世洪, 邸迎彤, 景树溪, 李顺林. 四降三萜类化合物及其制备方法与应用. CN: CN103788078A, 2014-05-14.

[4] 郝小江, 陈铎之, 尹俊林, 彭宗根, 何红平, 蒋建东, 邸迎彤, 张于, 李顺林. 菲啶类衍生物及其药物组合物和其制备方法与应用. CN: CN103145617A, 2013-06-12.

[5] 郝小江, 张于, 何红平, 李艳, 郭伶俐, 邸迎彤. 抗肿瘤生物碱类化合物,其药物组合物及其制备方法和应用. CN: CN102225937A, 2011-10-26.

[6] 郝小江, 郑永唐, 何红平, 黄宁, 谭承建, 李春燕, 邸迎彤, 王睿睿. 三宝木内酯A-D,其药物组合物,制备方法和应用. CN: CN102101864A, 2011-06-22.

[7] 郝小江, 陈全, 刘海洋, 赵丽霞, 邸迎彤, 金海京, 何红平, 乐雯, 高锁, 王晓慧, 杜蕾. 15－氧代绣线菊内酯，其药物组合物和其制备方法及其应用. CN: CN101239964A, 2008-08-13.

药物化学
化学生物学
天然产物化学

已指导学生

马元良  硕士研究生  078001-药物化学  

陆庆云  硕士研究生  078001-药物化学  

张翠珊  硕士研究生  078001-药物化学  

刘帅  博士研究生  100701-药物化学  

现指导学生

周琪  硕士研究生  078001-药物化学  

袁名睿  博士研究生  100701-药物化学  

刘林  硕士研究生  078001-药物化学  

郭峰  硕士研究生  105500-药学  

姚佩彤  硕士研究生  105500-药学  

梁弘  博士研究生  100701-药物化学