基本信息
邸迎彤  男  博导  中国科学院昆明植物研究所
办公电话: 0871-65223070
电子邮件: diyt@mail.kib.ac.cn
通信地址: 昆明市蓝黑路134号中国科学院昆明植物研究所

邮政编码: 650201

研究领域

主要研究方向为天然产物的化学生物学,综合运用有机化学、生物信息学、分子生物学、生物化学、分析化学、基因工程及代谢工程等学科知识与实验技术手段,进行以下三个方面研究:  

1、真菌活性次生代谢产物生物合成途径及酶催化机制研究; 

2、针对天然产物研究中的关键原始创新点----靶标/药物新结合位点的发现展开研究,阐明活性天然产物的作用靶标及其作用机制; 

3、活性天然产物的合成生物学研究。


招生信息

   
招生专业
100701-药物化学
071010-生物化学与分子生物学
100705-微生物与生化药学
招生方向
药物化学
化学生物学
天然产物化学

教育背景

2011-04--2012-04 加利福尼亚大学洛杉矶分校 访问学者
2004-03--2007-03 中国科学院昆明植物研究所 理学博士
2000-09--2003-07 中国科学院成都生物研究所 理学硕士
1992-09--1996-06 兰州大学生物系 理学学士

工作经历

   
工作简历
2009-01--今 中国科学院昆明植物研究所 副研究员
2007-04--2008-12 中国科学院昆明植物研究所 助理研究员
2003-07--2003-12 贵州省中国科学院天然产物重点实验室 研究实习员
1996-07--2000-08 太原瑞丰制药有限公司 开发部业务主管

专利与奖励

   
奖励信息
(1) 植物化学防御 物质与新农药先导物的研究,一等奖,省级,2013
(2) 虎皮楠中新颖结构生物碱的研究,一等奖,省级,2009
(3) 中国科学院院长奖优秀奖,院级级,2007
专利成果
[1] 郝小江, 姚永刚, 邸迎彤, 罗荣灿, 唐小涵. 牛筋果三内酯A、治疗抗阿尔兹海默症的药物及制备方法和应用. CN: CN112592351A, 2021-04-02.

[2] 杨崇林, 郝小江, 李洋, 徐猛, 丁骁, 晏晨, 邸迎彤, 穆淑珍, 蹇友理, 宋智琴, 郭伟翔. 巨大戟醇及其衍生物在增强溶酶体生成中的应用. CN: CN106619600B, 2019-10-18.

[3] 郝小江, 蔡洁云, 何红平, 黎胜红, 骆世洪, 邸迎彤, 景树溪, 李顺林. 四降三萜类化合物及其制备方法与应用. 中国: CN103788078A, 2014-05-14.

[4] 郝小江, 陈铎之, 尹俊林, 彭宗根, 何红平, 蒋建东, 邸迎彤, 张于, 李顺林. 菲啶类衍生物及其药物组合物和其制备方法与应用. 中国: CN103145617A, 2013.06.12.

[5] 郝小江, 张于, 何红平, 李艳, 郭伶俐, 邸迎彤. 抗肿瘤生物碱类化合物,其药物组合物及其制备方法和应用. 中国: CN102225937A, 2011-10-26.

[6] 郝小江, 郑永唐, 何红平, 黄宁, 谭承建, 李春燕, 邸迎彤, 王睿睿. 三宝木内酯A-D,其药物组合物,制备方法和应用. 中国: CN102101864A, 2011-06-22.

[7] 郝小江, 陈全, 刘海洋, 赵丽霞, 邸迎彤, 金海京, 何红平, 乐雯, 高锁, 王晓慧, 杜蕾. 15-氧代绣线菊内酯,其药物组合物和其制备方法及其应用. CN: CN101239964A, 2008-08-13.

出版信息

   
发表论文
[1] Qing-Yun Lu, Jia-Hui Zhang, Ying-Yao Li, Xue-Xue Pu, Cui-Shan Zhang, Shuai Liu, Jia-Jia Wan, Ying-Tong Di, Xiao-Jiang Hao. New Secodaphnane-Type Alkaloids with Cytotoxic Activities from Daphniphyllum angustifolium Hutch. Natural Products and Bioprospecting. 2021, 11(4): 453-457, http://dx.doi.org/10.1007/s13659-021-00309-w.
[2] Chen, YanNi, Ding, Xiao, Li, DongMei, Sun, Mao, Yang, Lei, Zhang, Yu, Di, YingTong, Fang, Xin, Hao, XiaoJiang. Diterpenoids with an unprecedented ring system from Euphorbia peplus and their activities in the lysosomal-autophagy pathway. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2021, 19(7): 1541-1545, https://www.webofscience.com/wos/woscc/full-record/WOS:000621563000010.
[3] 姚永刚. Harpertrioate A, an A,B,D-seco-limonoid with promising biological activity against Alzheimer's disease from twigs of Harrisonia perforata (Blanco) Merr.. Organic Letters, 23: 262 - 267. 2021, [4] Yuan, WenJuan, Gao, WenFen, Zhao, JiangYu, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. Diterpenes with potential treatment of vitiligo from the aerials parts of Euphorbia antiquorum L. FITOTERAPIA[J]. 2020, 144: http://ir.kib.ac.cn/handle/151853/72049, http://www.irgrid.ac.cn/handle/1471x/6927915, http://ir.kib.ac.cn/handle/151853/72050, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000537596000004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab.
[5] Gui, PengYan, Yan, XiaoHui, Yuan, WenJuan, Ma, YuanLiang, Ding, Xiao, Liu, Shuai, Di, YingTong, Zhu, WeiMing, Hao, XiaoJiang. 12 beta-Acetyloxyperforatin, a New Limonoid from Harrisonia Perforata. NATURAL PRODUCT RESEARCH[J]. 2019, 33(19): 2830-2836, http://dx.doi.org/10.1080/14786419.2018.1508139.
[6] Zhang, Jiahui, Cao, Pei, Ma, Yuanliang, Fang, Xin, Yang, Jing, Zhang, Yu, Chen, Duozhi, Gu, Yucheng, Di, Yingtong, Hao, Xiaojiang. Structural Revision of Macropodumine A and Structure of 2-Deoxymacropodumine A, Daphniphyllum Alkaloids with 11-Membered Macrolactone Rings. JOURNAL OF NATURAL PRODUCTS[J]. 2019, 82(3): 427-430, http://dx.doi.org/10.1021/acs.jnatprod.8b00232.
[7] YuanLiang Ma, XiaoHan Tang, WenJuan Yuan, Xiao Ding, YingTong Di, XiaoJiang Hao. Abietane Diterpernoids from the Roots of Euphorbia ebracteolata. NATURAL PRODUCTS AND BIOPROSPECTING[J]. 2018, 8(2): 131-135, http://ir.kib.ac.cn/handle/151853/64821.
[8] Yi, Wenfang, Chen, Duozhi, Ding, Xiao, Li, Xiaonian, Li, Shunlin, Di, Yingtong, Zhang, Yu, Hao, Xiaojiang. Cytotoxic indole alkaloids from Melodinus khasianus and Melodinus tenuicaudatus. FITOTERAPIA[J]. 2018, 128: 162-168, http://dx.doi.org/10.1016/j.fitote.2018.05.015.
[9] Bian, Guangkai, Hou, Anwei, Yuan, Yujie, Hu, Ben, Cheng, Shu, Ye, Ziling, Di, Yingtong, Deng, Zixin, Liu, Tiangang. Metabolic Engineering-Based Rapid Characterization of a Sesquiterpene Cyclase and the Skeletons of Fusariumdiene and Fusagramineol from Fusarium graminearum. ORGANIC LETTERS[J]. 2018, 20(6): 1626-1629, https://www.webofscience.com/wos/woscc/full-record/WOS:000428003600036.
[10] Zhao, NingDong, Ding, Xiao, Song, Yu, Yang, DongQiong, Adelakun, Tiwalade Adegoke, Qian, WenDan, Zhang, Yu, Di, YingTong, Gao, Fang, Hao, XiaoJiang, Li, ShunLin. Identification of Ingol and Rhamnofolane Diterpenoids from Euphorbia resinifera and Their Abilities to Induce Lysosomal Biosynthesis. JOURNAL OF NATURAL PRODUCTS[J]. 2018, 81(5): 1209-1218, https://www.webofscience.com/wos/woscc/full-record/WOS:000433635500010.
[11] Liu, Shuai, Zhang, Jiahui, Di, Yingtong, Dong, Jinyan, Hao, Xiaojiang. Daphniphyllum alkaloids with cytotoxic activity from Daphniphyllum angustifolium. NATURAL PRODUCT RESEARCH[J]. 2018, 32(18): 2165-2170, https://www.webofscience.com/wos/woscc/full-record/WOS:000441057100007.
[12] 杨智, 孙国太, 邸迎彤, 王跃虎, 胡旭佳. 茶褐牛肝菌化学成分研究. 热带亚热带植物学报. 2018, 26(3): 309-316, http://lib.cqvip.com/Qikan/Article/Detail?id=675282225.
[13] Yuan, WenJuan, Gao, WenFen, Zhang, JiaHui, Cao, Pei, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. (+/-)-Perforison A, A Pair of New Chromone Enantiomers from Harrisonia perforata. NATURAL PRODUCT COMMUNICATIONS[J]. 2017, 12(1): 63-65, http://ir.kib.ac.cn/handle/151853/41892.
[14] Yuan, WenJuan, Ding, Xiao, Wang, Zhe, Yang, BiJuan, Li, XiaoNian, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Chen, Quan, Di, YingTong, Aisa, Haji Akber, Hao, XiaoJiang. Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/e37a28dc25a9453b84cb871969fa2f32.
[15] XiaoHui Yan, Ping Yi, Pei Cao, ShiYing Yang, Xin Fang, Yu Zhang, Bin Wu, Ying Leng, YingTong Di, Yang Lv, XiaoJiang Hao. 16-nor Limonoids from Harrisonia perforata as promising selective 11 β -HSD1 inhibitors. Scientific Reports. 2016, 6: [16] Li, XiaoHui, Zhang, Yu, Zhang, JiaHui, Li, XiaoNian, Cao, MingMing, Di, YingTong, Peng, ZongGen, Jiang, JianDong, Hao, XiaoJiang. Myritonines A-C, Alkaloids from Myrioneuron tonkinensis Based on a Novel Hexacyclic Skeleton. JOURNAL OF NATURAL PRODUCTS[J]. 2016, 79(4): 1203-1207, http://ir.kib.ac.cn/handle/151853/26223.
[17] Yuan, WenJuan, Yang, GuoPing, Zhang, JiaHui, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. Three new diterpenes with cytotoxic activity from the roots of Euphorbia ebracteolata Hayata. PHYTOCHEMISTRY LETTERS[J]. 2016, 18(1): 176-179, http://dx.doi.org/10.1016/j.phytol.2016.10.008.
[18] Li, Yang, Xu, Meng, Ding, Xiao, Yan, Chen, Song, Zhiqin, Chen, Lianwan, Huang, Xiahe, Wang, Xin, Jian, Youli, Tang, Guihua, Tang, Changyong, Di, Yingtong, Mu, Shuzhen, Liu, Xuezhao, Liu, Kai, Li, Ting, Wang, Yingchun, Miao, Long, Guo, Weixiang, Hao, Xiaojiang, Yang, Chonglin. Protein kinase C controls lysosome biogenesis independently of mTORC1. NATURE CELL BIOLOGY[J]. 2016, 18(10): 1065-1077, http://www.irgrid.ac.cn/handle/1471x/1140918.
[19] Zhang, JiaHui, JingGuo, Jing, Yuan, Yu Xi, Fu, YanHui, Gu, YuCheng, Zhang, Yu, Chen, DuoZhi, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. Four new tetracyclic alkaloids with cis-decahydroquinoline motif from Myrioneuron effusum. FITOTERAPIA[J]. 2016, 112: 217-221, http://dx.doi.org/10.1016/j.fitote.2016.06.006.
[20] Qin, XuJie, Yan, Huan, Ni, Wei, Yu, MuYuan, Khan, Afsar, Liu, Hui, Zhang, HongXia, He, Li, Hao, XiaoJiang, Di, YingTong, Liu, HaiYang. Cytotoxic Meroterpenoids with Rare Skeletons from Psidium guajava Cultivated in Temperate Zone. SCIENTIFIC REPORTS[J]. 2016, 6: http://www.irgrid.ac.cn/handle/1471x/1109614.
[21] Chang, YaoWen, Yuan, ChunMao, Zhang, Jing, Liu, Shuai, Cao, Pei, Hua, HuiMing, Di, YingTong, Hao, XiaoJiang. Speramides A-B, two new prenylated indole alkaloids from the freshwater-derived fungus Aspergillus ochraceus KM007. TETRAHEDRON LETTERS[J]. 2016, 57(45): 4952-4955, http://dx.doi.org/10.1016/j.tetlet.2016.09.071.
[22] Wang, Chunxiang, Ding, Xiao, Feng, ShiXiu, Guan, Qiunong, Zhang, XiaoPing, Du, Caigan, Di, YingTong, Chen, Tao. Seven New Tetrahydroanthraquinones from the Root of Prismatomeris connata and Their Cytotoxicity against Lung Tumor Cell Growth. Molecules[J]. 2015, 20(12): 22565-22577, https://doaj.org/article/d07fda9194324dccba0c4834ca82a821.
[23] 郝小江, 谭承建, 邸迎彤. 虎皮楠中1个新的环戊二烯负离子结构生物碱. 中草药. 2015, 46(20): 2989-2991, http://lib.cqvip.com/Qikan/Article/Detail?id=666527428.
[24] Tan, ChengJian, Zhang, Yu, Kong, NingChuan, Di, YingTong, Hao, XiaoJiang. Further Alkaloids from the Leaves of Trigonostemon lii. HELVETICA CHIMICA ACTA[J]. 2015, 98(1): 72-77, http://ir.kib.ac.cn/handle/151853/20606.
[25] Yan, Ying, Yuan, ChunMao, Di, YingTong, Huang, Tao, Fan, YiMin, Ma, Yuan, Zhang, JianXin, Hao, XiaoJiang. Limonoids from Munronia henryi and their anti-tobacco mosaic virus activity. FITOTERAPIA[J]. 2015, 107: 29-35, http://www.irgrid.ac.cn/handle/1471x/1029017.
[26] Fang, Xin, Di, Ying Tong, Zhang, Yu, Xu, Zhi Ping, Lu, Yang, Chen, Qian Qian, Zheng, Qi Tai, Hao, Xiao Jiang. Unprecedented Quassinoids with Promising Biological Activity from Harrisonia perforata. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2015, 54(19): 5592-5595, http://www.irgrid.ac.cn/handle/1471x/963666.
[27] 赵伟, 邸迎彤, 李岑, 吕庆银, 张于, 张振. 臭常山喹啉生物碱化学成分及活性研究. 江苏农业科学. 2015, 43(6): 283-285, http://lib.cqvip.com/Qikan/Article/Detail?id=665352757.
[28] Chang YaoWen, Yuan ChunMao, Zhang Jing, Zhang Yu, Hua HuiMing, Di YingTong, Hao XiaoJiang. A novel γ-lactone derivative from the twigs of Turraea pubescens. Zeitschrift für Naturforschung B[J]. 2015, [29] Wang, KaiBo, Yuan, ChunMao, Xue, ChunMei, Li, DaHong, Jing, YongKui, He, HongPing, Hao, XiaoJiang, Di, YingTong, Li, ZhanLin, Hua, HuiMing. Pegaharmalines A and B, two novel beta-carboline alkaloids with unprecedented carbon skeletons from Peganum harmala. RSC ADVANCES[J]. 2014, 4(96): 53725-53729, http://www.irgrid.ac.cn/handle/1471x/929659.
[30] Li, XiaoHui, Cao, MingMing, Zhang, Yu, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. Fluevirines A-D, four new securinega-type alkaloids from Flueggea virosa. TETRAHEDRON LETTERS[J]. 2014, 55(44): 6101-6104, http://dx.doi.org/10.1016/j.tetlet.2014.09.046.
[31] Cao, MingMing, Huang, ShengDian, Di, YingTong, Yuan, ChunMao, Zuo, GuoYing, Gu, YuCheng, Zhang, Yu, Hao, XiaoJiang. Myrifabine, the First Dimeric Myrioneuron Alkaloid from Myrioneuron faberi. ORGANIC LETTERS[J]. 2014, 16(2): 528-531, http://dx.doi.org/10.1021/ol403408m.
[32] Fu, Yanhui, Di, Yingtong, He, Hongping, Li, Shunlin, Zhang, Yu, Hao, Xiaojiang. Angustifonines A and B, Cytotoxic Bisindole Alkaloids from Bousigonia angustifolia. JOURNAL OF NATURAL PRODUCTS[J]. 2014, 77(1): 57-62, http://www.irgrid.ac.cn/handle/1471x/832445.
[33] 廖金华, 胡旭佳, 苑春茂, 何红平, 邸迎彤. 马槟榔果实的化学成分研究(英文). 天然产物研究与开发[J]. 2014, 1780-1784, http://www.irgrid.ac.cn/handle/1471x/929696.
[34] Di, YingTong, Wee, ChorngShin, Li, ChunShun, Kong, NingChuan, Wang, JunSong, Fang, Xin, Zhu, HuaJie, Wu, YunDong, Hao, XiaoJiang. Longphyllinesides A and B: natural Diels-Alder adducts from Daphniphyllum longeracemosum?. TETRAHEDRON[J]. 2014, 70(26): 4017-4021, http://dx.doi.org/10.1016/j.tet.2014.04.073.
[35] Ding, JiaYin, Yuan, ChunMao, Cao, MingMing, Liu, WeiWei, Yu, Chun, Zhang, HaiYuan, Zhang, Yu, Di, YingTong, He, HongPing, Li, ShunLin, Hao, XiaoJiang. Antimicrobial Constituents of the Mature Carpels of Manglietiastrum sinicum. JOURNAL OF NATURAL PRODUCTS[J]. 2014, 77(8): 1800-1805, http://www.irgrid.ac.cn/handle/1471x/877326.
[36] Yin, JunLin, Fang, Xin, Liu, EnDe, Yuan, ChunMao, Li, ShiFei, Zhang, Yu, He, HongPing, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. Phragmalin Limonoids from the Stem Barks of Chukrasia tabularis var. velutina. PLANTA MEDICA[J]. 2014, 80(15): 1304-1309, http://www.irgrid.ac.cn/handle/1471x/915851.
[37] Cao, MingMing, Zhang, Yu, Li, XiaoHui, Peng, ZongGen, Jiang, JianDong, Gu, YuCheng, Di, YingTong, Li, XiaoNian, Chen, DuoZhi, Xia, ChengFeng, He, HongPing, Li, ShunLin, Hao, XiaoJiang. Cyclohexane-Fused Octahydroquinolizine Alkaloids from Myrioneuron faberi with Activity against Hepatitis C Virus. JOURNAL OF ORGANIC CHEMISTRY[J]. 2014, 79(17): 7945-7950, http://dx.doi.org/10.1021/jo501076x.
[38] Huang ShengDian, Zhang Yu, He HongPing, Li ShiFei, Tang GuiHua, Chen DuoZhi, Cao MingMing, Di YingTong, Hao XiaoJiang. A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata. CHINESE JOURNAL OF NATURAL MEDICINES[J]. 2013, 11(4): 406-410, http://dx.doi.org/10.1016/S1875-5364(13)60060-6.
[39] Zhang, Qiang, Zhang, Yu, Yang, TingQuan, Di, YingTong, Hao, XiaoJiang. Longeracemine, an unprecedented C-7/C-9 bonding alkaloid from Daphniphyllum longeracemosum. RSC ADVANCES[J]. 2013, 3(25): 9658-9661, http://www.irgrid.ac.cn/handle/1471x/660272.
[40] 张振, 杨小生, 邸迎彤, 何红平, 郝小江. 钩吻(Gelsemium elegans)生物碱结构类型增补探讨. 广西植物. 2013, 33(2): 143-147, http://lib.cqvip.com/Qikan/Article/Detail?id=45747841.
[41] Huang, ShengDian, Zhang, Yu, Cao, MingMing, Di, YingTong, Tang, GuiHua, Peng, ZongGen, Jiang, JianDong, He, HongPing, Hao, XiaoJiang. Myriberine A, a New Alkaloid with an Unprecedented Heteropentacyclic Skeleton from Myrioneuron faberi. ORGANIC LETTERS[J]. 2013, 15(3): 590-593, http://www.irgrid.ac.cn/handle/1471x/596090.
[42] Li, ShiFei, Zhang, Yu, Huang, Ning, Zheng, YongTang, Di, YingTong, Li, ShunLin, Cheng, YuanYuan, He, HongPing, Hao, XiaoJiang. Daphnane diterpenoids from the stems of Trigonostemon lii and their anti-HIV-1 activity. PHYTOCHEMISTRY[J]. 2013, 93(X): 216-221, http://dx.doi.org/10.1016/j.phytochem.2013.03.003.
[43] Cao, MingMing, Wang, Lei, Zhang, Yu, He, HongPing, Gu, YuCheng, Zhang, Qiang, Li, Yan, Yuan, ChunMao, Li, ShunLin, Di, YingTong, Hao, XiaoJiang. Daphmacromines K-O, alkaloids from Daphniphyllum macropodum. FITOTERAPIA[J]. 2013, 89: 205-209, http://dx.doi.org/10.1016/j.fitote.2013.06.005.
[44] 张荣, 曹明明, 何红平, 张于, 邸迎彤, 郝小江. 大叶桃花心木中的柠檬苦素成分(英文). 天然产物研究与开发[J]. 2013, 581-584,633, http://www.irgrid.ac.cn/handle/1471x/832420.
[45] 黄升殿, 张于, 何红平, 李石飞, 唐贵华, 陈铎之, 曹明明, 邸迎彤, 郝小江. 红花石蒜中的一个新石蒜生物碱(英文). 中国天然药物[J]. 2013, 406-410, http://www.irgrid.ac.cn/handle/1471x/832399.
[46] Zhang, Yu, He, HongPing, Guo, LingLi, Li, ShiFei, Di, YingTong, Hao, XiaoJiang. Daphhimalenines C and D. New Alkaloids from Daphniphyllum himalense. ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES[J]. 2012, 67(5): 407-410, http://dx.doi.org/10.5560/ZNB.2012-0004.
[47] Fu, Yanhui, He, Hongping, Di, Yingtong, Li, Shunlin, Zhang, Yu, Hao, Xiaojiang. Mekongenines A and B, two new alkaloids from Bousigonia mekongensis. TETRAHEDRON LETTERS[J]. 2012, 53(28): 3642-3646, http://dx.doi.org/10.1016/j.tetlet.2012.05.026.
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科研活动

   
科研项目
( 1 ) penamycin 生物合成途径的研究, 主持, 部委级, 2014-03--2017-02
( 2 ) 基于自噬—溶酶体通路的抗肿瘤先导化合物川楝素构效关系及其作用靶点的研究, 主持, 省级, 2015-01--2017-12
( 3 ) 南欧大戟中巨大戟醇生物合成基因簇初探, 主持, 部委级, 2015-01--2015-12
( 4 ) 生物活性分子的发现、修饰及应用, 参与, 国家级, 2015-01--2019-12
( 5 ) 中亚地区中药资源评价及活性, 参与, 国家级, 2014-01--2017-03
( 6 ) 真菌中二聚烯化吲哚生物碱生物的生物合成机制与其药用功能导向的 生物合成途径理性改造, 主持, 国家级, 2016-01--2019-12