Di Chen

Associate Professor

Biomolecules Function & Molecular Mechanism Research Group

Dalian Institute of Chemical Physics, CAS.


Research Areas

  • Multi-omics integration and analysis

  • Network-based molecular interaction prediction


2011.09-2016.07, Institute of Automation, Chinese Academy of Sciences, PhD, Computer Applications Technology;

2007.09-2011.07, Beijing Technology and Business University, Master, Automation


Work Experience

2021.07-present, Associate Professor, Dalian Institute of Chemical and Physics, Chinese Academy of Sciences

2021.02-2021.06, Research Assistant, Dalian Institute of Chemical and Physics, Chinese Academy of Sciences

2016.08-2021.01, Postdoctor, Dalian Institute of Chemical and Physics, Chinese Academy of Sciences



Chen D, Zhang Y, Wang W, Chen H, Ling T, Yang R, Wang Y, Duan C, Liu Y, Guo X, Fang L, Liu W, Liu X, Liu J, Otkur W, Qi H, Liu X, Xia T, Liu HX, Piao HL. Identification and Characterization of Robust Hepatocellular Carcinoma Prognostic Subtypes Based on an Integrative Metabolite-Protein Interaction Network. Adv Sci (Weinh). 2021 Sep;8(17):e2100311.

Chen D, Zhao X, Sui Z, Niu H, Chen L, Hu C, Xuan Q, Hou X, Zhang R, Zhou L, Li Y, Yuan H, Zhang Y, Wu J, Zhang L, Wu R, Piao HL, Xu G, Jia W. A multi-omics investigation of the molecular characteristics and classification of six metabolic syndrome relevant diseases. Theranostics. 2020;10(5):2029-2046.

Chen D, Ning Z, Chen H, Lu C, Liu X, Xia T, Qi H, Wang W, Ling T, Guo X, Tekcham DS, Liu X, Liu J, Wang A, Yan Q, Liu JW, Tan G, Piao HL. An integrative pan-cancer analysis of biological and clinical impacts underlying ubiquitin-specific-processing proteases. Oncogene. 2020 Jan;39(3):587-602.

Chen D, Liu X, Xia T, Tekcham DS, Wang W, Chen H, Li T, Lu C, Ning Z, Liu X, Liu J, Qi H, He H, Piao HL. A Multidimensional Characterization of E3 Ubiquitin Ligase and Substrate Interaction Network. iScience. 2019 Jun 28;16:177-191.

Xia T, Chen D, Liu X, Qi H, Wang W, Chen H, Ling T, Otkur W, Zhang CS, Kim J, Lin SC, Piao HL. Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex. Cell Death Dis. 2022 Apr 29;13(4):414.

Liu X, Chen D, Chen H, Wang W, Liu Y, Wang Y, Duan C, Ning Z, Guo X, Otkur W, Liu J, Qi H, Liu X, Lin A, Xia T, Liu HX, Piao HL. YB1 regulates miR-205/200b-ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma. Cancer Commun (Lond). 2021 Jul;41(7):576-595.

Ning Z, Guo X, Liu X, Lu C, Wang A, Wang X, Wang W, Chen H, Qin W, Liu X, Zhou L, Ma C, Du J, Lin Z, Luo H, Otkur W, Qi H, Chen D, Xia T, Liu J, Tan G, Xu G, Piao HL. USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma. Nat Commun. 2022 Apr 21;13(1):2187.

Wang W, Chen D, Piao H. [Identification of LAMTOR1-regulated metabolites using ultra-performance liquid chromatography coupled with time-of-flight mass spectrometry in malignant transformation of liver inflammation]. Se Pu. 2021 Oct;39(10):1118-1127.

Zang B, Wang W, Wang Y, Li P, Xia T, Liu X, Chen D, Piao HL, Qi H, Ma Y. Metabolomic Characterization Reveals ILF2 and ILF3 Affected Metabolic Adaptions in Esophageal Squamous Cell Carcinoma. Front Mol Biosci. 2021;8:721990.

Wang Y, Chen D, Liu Y, Zhang Y, Duan C, Otkur W, Chen H, Liu X, Xia T, Qi H, Piao HL, Liu HX. AQP3-mediated H2 O2 uptake inhibits LUAD autophagy by inactivating PTEN. Cancer Sci. 2021 Aug;112(8):3278-3292.

Wang Y, Qi H, Liu Y, Duan C, Liu X, Xia T, Chen D, Piao HL, Liu HX. The double-edged roles of ROS in cancer prevention and therapy. Theranostics. 2021;11(10):4839-4857.

Guo X, Wang A, Wang W, Wang Y, Chen H, Liu X, Xia T, Zhang A, Chen D, Qi H, Ling T, Piao HL, Wang HJ. HRD1 inhibits fatty acid oxidation and tumorigenesis by ubiquitinating CPT2 in triple-negative breast cancer. Mol Oncol. 2021 Feb;15(2):642-656.

He H, Chen D, Cui S, Wu G, Piao H, Wang X, Ye P, Jin S. HDNA methylation data-based molecular subtype classification related to the prognosis of patients with hepatocellular carcinoma. BMC Med Genomics. 2020 Aug 24;13(1):118.

Tekcham DS, Chen D, Liu Y, Ling T, Zhang Y, Chen H, Wang W, Otkur W, Qi H, Xia T, Liu X, Piao HL, Liu H. F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects. Theranostics. 2020;10(9):4150-4167.

He H, Chen D, Cui S, Piao H, Tang H, Wang X, Ye P, Jin S. Identification of a long noncoding RNAmediated competitive endogenous RNA network in hepatocellular carcinoma. Oncol Rep. 2019 Aug;42(2):745-752.

Yan M, Qi H, Xia T, Zhao X, Wang W, Wang Z, Lu C, Ning Z, Chen H, Li T, Tekcham DS, Liu X, Liu J, Chen D, Liu X, Xu G, Piao HL. Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPKα. Metabolism. 2019 Feb;91:18-29.

Lu C, Ning Z, Wang A, Chen D, Liu X, Xia T, Tekcham DS, Wang W, Li T, Liu X, Liu J, Qi H, Luo H, Du J, Ma C, Yan Q, Liu J, Xu G, Piao HL, Tan G. USP10 suppresses tumor progression by inhibiting mTOR activation in hepatocellular carcinoma. Cancer Lett. 2018 Nov 1;436:139-148.


Research Interests

Multi-omics integration

Single-cell omics


Molecular interactions