1. 多组学整合研究

研究基因组、转录组、代谢组及蛋白质组学等多类型的组学以及单细胞组学数据及空间转录组等多层次、高通量组学数据的整合分析方法；通过对多组学数据的整合分析，挖掘对于癌症等复杂疾病发生发展具有重要意义的多层次分子调控网络机制，同时基于多组学整合识别全新的疾病分子分型，助力疾病精准医疗。

2. 生物分子相互作用研究

利用机器学习、复杂网络等数据科学领域的计算方法，开发生物大小分子相互作用预测模型，对复杂生物体系内发挥重要作用的分子间相互作用，例如蛋白质-蛋白质相互作用，蛋白质-代谢物相互作用进行高效预测，构建生物分子相互作用图谱，并基于复杂网络拓扑特征及具体生物学功能等系统性揭示疾病发生发展过程中核心生物分子相互作用网络。

   

070302-分析化学

多组学整合挖掘

2011-09--2016-07   中国科学院自动化研究所   博士
2007-09--2011-07   北京工商大学   学士

博士研究生

工学博士

   

2021-07~现在, 中国科学院大连化学物理研究所, 副研究员
2021-02~2021-06,中国科学院大连化学物理研究所, 助理研究员
2016-08~2021-01,中国科学院大连化学物理研究所, 博士后

   

[1] 陈迪, 朴海龙. 一种基于药物多维相似度的药物交互作用预测方法. CN: CN111243659A, 2020-06-05.
[2] 陈迪, 朴海龙. 一种基于多维关联特征的E3泛素连接酶-底物相互作用识别方法. CN: CN110021343A, 2019-07-16.

   

[1] 王稳, 陈迪, 朴海龙. 基于超高效液相色谱-飞行时间质谱法测定LAMTOR1在肝脏炎症恶性转化中调控的代谢物. 色谱[J]. 2021, 39(10): 1118-1127, http://lib.cqvip.com/Qikan/Article/Detail?id=7105506368.
[2] Guo, Xin, Wang, Aman, Wang, Wen, Wang, Ya, Chen, Huan, Liu, Xiaolong, Xia, Tian, Zhang, Aijia, Chen, Di, Qi, Huan, Ling, Ting, Piao, Hailong, Wang, Hongjiang. HRD1 inhibits fatty acid oxidation and tumorigenesis by ubiquitinating CPT2 in triple-negative breast cancer. MOLECULAR ONCOLOGY[J]. 2021, 15(2): 642-656, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7858277/.
[3] Wang, Yawei, Qi, Huan, Liu, Yu, Duan, Chao, Liu, Xiaolong, Xia, Tian, Chen, Di, Piao, Hailong, Liu, HongXu. The double-edged roles of ROS in cancer prevention and therapy. THERANOSTICSnull. 2021, 11(10): 4839-4857, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7978298/.
[4] Chen, Di, Zhang, Yiran, Wang, Wen, Chen, Huan, Ling, Ting, Yang, Renyu, Wang, Yawei, Duan, Chao, Liu, Yu, Guo, Xin, Fang, Lei, Liu, Wuguang, Liu, Xiumei, Liu, Jing, Otkur, Wuxiyar, Qi, Huan, Liu, Xiaolong, Xia, Tian, Liu, HongXu, Piao, HaiLong. Identification and Characterization of Robust Hepatocellular Carcinoma Prognostic Subtypes Based on an Integrative Metabolite-Protein Interaction Network. ADVANCED SCIENCE[J]. 2021, 8(17): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000671658500001.
[5] Liu, Xiumei, Chen, Di, Chen, Huan, Wang, Wen, Liu, Yu, Wang, Yawei, Duan, Chao, Ning, Zhen, Guo, Xin, Otkur, Wuxiyar, Liu, Jing, Qi, Huan, Liu, Xiaolong, Lin, Aifu, Xia, Tian, Liu, Hongxu, Piao, Hailong. YB1 regulates miR-205/200b-ZEB1 axis by inhibiting microRNA maturation in hepatocellular carcinoma. CANCER COMMUNICATIONS[J]. 2021, 41(7): 576-595, http://dx.doi.org/10.1002/cac2.12164.
[6] Chen, Di, Ning, Zhen, Chen, Huan, Lu, Chang, Liu, Xiaolong, Xia, Tian, Qi, Huan, Wang, Wen, Ling, Ting, Guo, Xin, Tekcham, Dinesh Singh, Liu, Xiumei, Liu, Jing, Wang, Aman, Yan, Qiu, Liu, JiWei, Tan, Guang, Piao, Hailong. An integrative pan-cancer analysis of biological and clinical impacts underlying ubiquitin-specific-processing proteases. ONCOGENE[J]. 2020, 39(3): 587-602, http://dx.doi.org/10.1038/s41388-019-1002-4.
[7] Wang, Zhichao, Chen, Di, Piao, HaiLong, Hua, Xiangdong. PTEN-deficient cells prefer glutamine for metabolic synthesis. ACTA BIOCHIMICA ET BIOPHYSICA SINICA[J]. 2020, 52(3): 251-258, http://lib.cqvip.com/Qikan/Article/Detail?id=7101881663.
[8] Chen, Di, Zhao, Xinjie, Sui, Zhigang, Niu, Huan, Chen, Luonan, Hu, Cheng, Xuan, Qiuhui, Hou, Xuhong, Zhang, Rong, Zhou, Lina, Li, Yanli, Yuan, Huiming, Zhang, Yukui, Wu, Jiarui, Zhang, Lihua, Wu, Renan, Piao, HaiLong, Xu, Guowang, Jia, Weiping. A multi-omics investigation of the molecular characteristics and classification of six metabolic syndrome relevant diseases. THERANOSTICS[J]. 2020, 10(5): 2029-2046, https://www.webofscience.com/wos/woscc/full-record/WOS:000508008300004.
[9] He, Hui, Chen, Di, Cui, Shimeng, Wu, Gang, Piao, Hailong, Wang, Xun, Ye, Peng, Jin, Shi. HDNA methylation data-based molecular subtype classification related to the prognosis of patients with hepatocellular carcinoma. BMC MEDICAL GENOMICS[J]. 2020, 13(1): http://dx.doi.org/10.1186/s12920-020-00770-5.
[10] Wang, Wen, Liu, Xiaolong, Chen, Huan, Ling, Ting, Xia, Tian, Liu, Xiumei, Liu, Jing, Otkur, Wuxiyar, Shi, Xianzhe, Qi, Huan, Chen, Di, Piao, HaiLong. Cholesterol as a functional metabolite cooperates with metadherin in cancer cells. CHINESE CHEMICAL LETTERS[J]. 2020, 31(7): 1831-1834, http://lib.cqvip.com/Qikan/Article/Detail?id=7103028900.
[11] Tekcham, Dinesh Singh, Chen, Di, Liu, Yu, Ling, Ting, Zhang, Yi, Chen, Huan, Wang, Wen, Otkur, Wuxiyar, Qi, Huan, Xia, Tian, Liu, Xiaolong, Piao, Hailong, Liu, Hongxu. F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects. THERANOSTICSnull. 2020, 10(9): 4150-4167, https://www.webofscience.com/wos/woscc/full-record/WOS:000518773300022.
[12] Yan, Min, Qi, Huan, Xia, Tian, Zhao, Xinjie, Wang, Wen, Wang, Zhichao, Lu, Chang, Ning, Zhen, Chen, Huan, Li, Tongming, Tekcham, Dinesh Singh, Liu, Xiumei, Liu, Jing, Chen, Di, Liu, Xiaolong, Xu, Guowang, Piao, Hailong. Metabolomics profiling of metformin-mediated metabolic reprogramming bypassing AMPK alpha. METABOLISM-CLINICAL AND EXPERIMENTAL[J]. 2019, 91: 18-29, https://www.webofscience.com/wos/woscc/full-record/WOS:000470301900003.
[13] Chen, Di, Liu, Xiaolong, Xia, Tian, Tekcham, Dinesh Singh, Wang, Wen, Chen, Huan, Li, Tongming, Lu, Chang, Ning, Zhen, Liu, Xiumei, Liu, Jing, Qi, Huan, He, Hui, Piao, Hailong. A Multidimensional Characterization of E3 Ubiquitin Ligase and Substrate Interaction Network. ISCIENCE[J]. 2019, 16: 177-+, http://dx.doi.org/10.1016/j.isci.2019.05.033.
[14] He, Hui, Chen, Di, Cui, Shimeng, Piao, Hailong, Tang, Haibo, Wang, Xun, Ye, Peng, Jin, Shi. Identification of a long non-coding RNA-mediated competitive endogenous RNA network in hepatocellular carcinoma. ONCOLOGY REPORTS[J]. 2019, 42(2): 745-752, 

承担国家自然科学基金委、博士后基金委、辽宁省科技厅和大连市青年科技之星等多个项目