Lipids and protein bioproduction

Fermentation simulation and scale up

• July, 2004 ~ June, 2007 PhD from Institute of Oceanology, Chinese Academy of Sciences

• July, 2001~June, 2004 Master degree from Hainan University

• July, 1997~June, 2001 Bachelor degree from Qingdao Agriculture University

• July, 2011~ until now, Tianjin institute of industry biotechnology, Chinese academy of Sciences

• Aug, 2015~ July, 2016, visiting scholar of Washington State University, Pullman, USA

• July, 2007 ~ July, 2011, Working at Liaocheng University

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• • （1） Heterologous Expression and Biochemical Characterization of a Thermostable Endoglucanase (MtEG5-1) from Myceliophthora thermophila, Fermentation, 2023, 通讯作者
    （2） Anthocyanin and proanthocyanidin from Aronia melanocarpa (Michx.) Ell.: Purification, fractionation, and enzyme inhibition, Food Science & Nutrition, 2023, 第 3 作者
    （3） Embracing a low-carbon future by the production and marketing of C1 gas protein, BIOTECHNOLOGY ADVANCES, 2023, 通讯作者
    （4） Enhancing the Activity of a Self-Inducible Promoter in Escherichia coli through Saturation Mutation and High-Throughput Screening, Fermentation, 2023, 通讯作者
    （5） Identification of neutral genome integration sites with high expression and high integration efficiency in Fusarium venenatum TB01, SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2023, 通讯作者
    （6） 菌体蛋白替代鸡胸肉的炸鸡块品质变化, Quality Change of Fried Chicken Nuggets with Chicken Breast Substituted by Mycoprotein, 现代食品科技, 2023, 第 3 作者
    （7） 改性阳离子型淀粉絮凝剂的研究进展, Research progress of modification of cationic starch flocculant, 应用化工, 2022, 第 5 作者
    （8） 未来食品的低碳生物制造, Low carbon biomanufacturing for future food, 生物工程学报, 2022, 第 1 作者
    （9） Evasion of Cas9 toxicity to develop an efficient genome editing system and its application to increase ethanol yield in Fusarium venenatum TB01, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2022, 通讯作者
    （10） Sustainable production of astaxanthin in microorganisms: the past, present, and future, Critical Reviews in Food Science and Nutrition, 2022, 通讯作者
    （11） Performance of Paracoccus pantotrophus MA3 in heterotrophic nitrification-anaerobic denitrification using formic acid as a carbon source, BIOPROCESS AND BIOSYSTEMS ENGINEERING, 2022, 通讯作者
    （12） Enhancement of astaxanthin production in Schizochytrium limacinum B4D1 under ethanol induction, ALGAL RESEARCH, 2022, 第 10 作者
    （13） Establishment of High-Efficiency Screening System for Gene Deletion in Fusarium venenatum TB01, JOURNAL OF FUNGI, 2022, 通讯作者
    （14） Transcriptomic Characterizations of the Molecular Mechanisms Regulating Lipid Production and Composition in Mortierella alpina in Response to Cold Stress, Agronomy, 2022, 通讯作者
    （15） Transcriptome analyses reveal the DHA enhancement mechanism in Schizochytrium limacinum LD11 mutant, ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS, 2022, 通讯作者
    （16） Genome-scale revealing the central metabolic network of the fast growing methanotroph Methylomonas sp. ZR1, WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2021, 通讯作者
    （17） 生物制造食品原料市场准入政策比较及对我国的建议, Regulation and Guidance for Marketing of Food Ingredients from Biomanufacturing and Policy Suggestions for China, 中国科学院院刊, 2020, 第 1 作者
    （18） Combination of Trace Metal to Improve Solventogenesis ofClostridium carboxidivoransP7 in Syngas Fermentation, FRONTIERS IN MICROBIOLOGY, 2020, 第 5 作者
    （19） Effects of increasing organic loading rates on reactor performance and the methanogenic community in a new pilot upflow solid reactor for continuously processing food waste, RENEWABLE ENERGY, 2020, 第 1 作者
    （20） Duckweed (Lemna minor) is a novel natural inducer of cellulase production in Trichoderma reesei, JOURNAL OF BIOSCIENCE AND BIOENGINEERING, 2019, 第 2 作者
    （21） 工业生物发酵过程模拟：进展与发展趋势, Simulation of industrial fermentation:current status and future perspectives, 生物工程学报, 2019, 第 1 作者
    （22） Effects of Methanol on Carotenoids as Well as Biomass and Fatty Acid Biosynthesis in Schizochytrium limacinum B4D1, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2019, 通讯作者
    （23） Hydroxyl radical pretreatment for low-viscosity sodium alginate production from brown seaweed, ALGAL RESEARCH, 2018, 通讯作者
    （24） Alanine mother liquor as a nitrogen source for docosahexaenoic acid production by Schizochytrium sp B4D1, ELECTRONIC JOURNAL OF BIOTECHNOLOGY, 2018, 通讯作者
    （25） Effects of zinc on the production of alcohol by Clostridium carboxidivorans P7 using model syngas, JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY, 2018, 第 1 作者
    （26） Hydroxyl radical pretreatment for low-viscosity sodium alginate production from brown seaweed, ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS, 2018, 通讯作者
    （27） 产乙酸菌合成气发酵的研究进展, Research Progress of Fermentation of Synthetic Gas from Acetogen, 微生物前沿, 2017, 第 4 作者
    （28） 进料含固率对餐厨垃圾两阶段厌氧消化的影响, Influence of Solid Concentration of Kitchen Waste on Its Two-stage Anaerobic Digestion, 中国沼气, 2017, 第 5 作者
    （29） Regulation of the Docosapentaenoic Acid/Docosahexaenoic Acid Ratio (DPA/DHA Ratio) in Schizochytrium limacinum B4D1, APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2017, 通讯作者
    （30） Selection of Schizochytrium limacinum mutants based on butanol tolerance, ELECTRONIC JOURNAL OF BIOTECHNOLOGY, 2017, 第 1 作者
    （31） Recycling nutrients from a sequential hydrothermal liquefaction process for microalgae culture, ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS, 2017, 通讯作者
    （32） Effects of butanol on high value product production in Schizochytrium limacinum B4D1, ENZYME AND MICROBIAL TECHNOLOGY, 2017, 通讯作者
    （33） Phospholipase A1-Catalysed Synthesis of Docosahexaenoic Acid-Enriched Phosphatidylcholine in Reverse Micelles System, APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2017, 通讯作者
    （34） Effect of malate on docosahexaenoic acid production from Schizochytrium sp B4D1, ELECTRONIC JOURNAL OF BIOTECHNOLOGY, 2016, 通讯作者
    （35） Physicochemical Properties and Storage Stability of Microencapsulated DHA-Rich Oil with Different Wall Materials, APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2016, 通讯作者
    （36） 食微比对丙氨酸菌渣厌氧消化的影响, Influence of Food to Microorganism Ratio on Anaerobic Digestion of Bacterial Residues from Alanine Production, 中国沼气, 2016, 第 6 作者
    （37） Preparation of stable microcapsules from disrupted cell of Haematococcus pluvialis by spray drying, INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 2016, 第 3 作者
    （38） Hydroxyl radical-aided thermal pretreatment of algal biomass for enhanced biodegradability, BIOTECHNOLOGY FOR BIOFUELS, 2015, 第 2 作者
    （39） Saccharina genomes provide novel insight into kelp biology, NATURE COMMUNICATIONS, 2015, 第 14 作者
    （40） 利用原生质体融合技术选育淀粉发酵产DHA的新型裂殖壶菌, Screening a New Type of Schizochxtrium Strain Producing DHA Using Starch by Protoplast Fusion Technology, 生物技术通报, 2015, 第 4 作者
    （41） Enhanced hydrolysis of Macrocystis pyrifera by integrated hydroxyl radicals and hot water pretreatment, BIORESOURCE TECHNOLOGY, 2015, 通讯作者
    （42） 不同前体物质的添加对高山被孢霉生长及脂肪酸组分的影响, Effect of different precursors on the growth and fatty acid components of Mortierella alpine, 中国油脂, 2015, 第 6 作者
    （43） Trpac1, a pH response transcription regulator, is involved in cellulase gene expression in Trichoderma reesei, ENZYME AND MICROBIAL TECHNOLOGY, 2014, 第 5 作者
    （44） Construction of a constitutively expressed homo-fermentative pathway in Lactobacillus brevis, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2014, 第 5 作者
    （45） 虾夷马粪海胆不同肠道中菌群组成及其PCR-DGGE图谱分析, 江苏农业科学, 2014, 第 2 作者
    （46） The green tide-forming macroalga Ulva linza outcompetes the red macroalga Gracilaria lemaneiformis via allelopathy and fast nutrients uptake, AQUATIC ECOLOGY, 2014, 第 6 作者
    （47） Bacterial community in the intestine of the sea urchin Strongylocentrotus intermedius during digestion of Macrocystis pyrifera, MARINE AND FRESHWATER BEHAVIOUR AND PHYSIOLOGY, 2014, 通讯作者
    （48） Survival and proliferation characteristics of the microalga Chlamydomonas sp ICE-L after hypergravitational stress pretreatment, ICARUS, 2013, 第 2 作者
    （49） Detection and quantitation of lipid in the microalga Tetraselmis subcordiformis (Wille) Butcher with BODIPY 505/515 staining, BIORESOURCE TECHNOLOGY, 2013, 第 9 作者
    （50） Optimizing the conditions for the microwave-assisted direct liquefaction of Ulva prolifera for bio-oil production using response surface methodology, ENERGY, 2013, 通讯作者
    （51） Allelopathic Interactions between the Opportunistic Species Ulva prolifera and the Native Macroalga Gracilaria lichvoides, PLOS ONE, 2012, 第 6 作者
    （52） Preparation and characteristics of bio-oil from the marine brown alga Sargassum patens C. Agardh, BIORESOURCE TECHNOLOGY, 2012, 第 1 作者
    （53） Microwave-assisted direct liquefaction of Ulva prolifera for bio-oil production by acid catalysis, BIORESOURCE TECHNOLOGY, 2012, 通讯作者
    （54） Using ammonia for algae harvesting and as nutrient in subsequent cultures, BIORESOURCE TECHNOLOGY, 2012, 第 3 作者
    （55） Comparative evaluation of the pyrolytic and kinetic characteristics of a macroalga (Sargassum thunbergii) and a freshwater plant (Potamogeton crispus), FUEL, 2012, 第 1 作者
    （56） THERMAL BEHAVIOR OF CARRAGEENAN: KINETIC AND CHARACTERISTIC STUDIES, INTERNATIONAL JOURNAL OF GREEN ENERGY, 2012, 通讯作者
    （57） Pyrolytic characteristics and kinetic studies of three kinds of red algae, BIOMASS AND BIOENERGY, 2011, 第 1 作者
    （58） Evaluation of the pyrolytic and kinetic characteristics of enteromorpha prolifera as a source of renewable bio-fuel from the yellow sea of china, CHEMICAL ENGINEERING RESEARCH & DESIGN, 2010, 第 1 作者
    （59） Isolation and characterization of the oxygen-evolving photosystem ii complex from the economical red alga bangia fusco-purpurea, RUSSIAN JOURNAL OF PLANT PHYSIOLOGY, 2010, 
    （60） Comparative Studies of the Pyrolytic and Kinetic Characteristics of Maize Straw and the Seaweed Ulva pertusa, PLOS ONE, 2010, 第 2 作者
    （61） Pyrolytic characteristics and kinetics of two brown algae and sodium alginate, BIORESOURCE TECHNOLOGY, 2010, 第 1 作者
    （62） 坛紫菜丝状体类囊体膜和光系统Ⅱ的分离鉴定, 安徽农业科技, 2009, 第 4 作者
    （63） Effects of Irradiance and Temperature on the Photosynthesis and Vegetative Propagation of Caulerpa serrulata, JOURNAL OF INTEGRATIVE PLANT BIOLOGY, 2009, 第 1 作者
    （64） Effects of Irradiance and Temperature on the Photosynthesis and Vegetative Propagation of Caulerpa serrulata, Effects of Irradiance and Temperature on the Photosynthesis and Vegetative Propagation of Caulerpa serrulata, 植物学报：英文版, 2009, 第 1 作者
    （65） Assembly of the subcellular parts of bryopsis hypnoides lamouroux into new protoplasts, RUSSIAN JOURNAL OF PLANT PHYSIOLOGY, 2009, 
    （66） Assembly of the Protoplasm of Codium fragile (Bryopsidales, Chlorophyta)into New Protoplasts, Assembly of the Protoplasm of Codium fragile (Bryopsidales, Chlorophyta)into New Protoplasts, 植物学报：英文版, 2008, 第 1 作者
    （67） Assembly of the protoplasm of codium fragile (bryopsidales, chlorophyta) into new protoplasts, JOURNAL OF INTEGRATIVE PLANT BIOLOGY, 2008, 第 1 作者
    （68） Study on early-stage development of conchospore in Porphyra yezoensis Ueda, AQUACULTURE, 2008, 第 3 作者
    （69） 单细胞多核管状绿藻原生质团聚及发育研究, 2007, 第 1 作者
    （70） 三种海藻的热解特性及动力学分析, THERMOLYSIS AND KINETICS OF THREE KINDS OF SEAWEED, 海洋与湖沼, 2006, 第 2 作者
    （71） 叶黄素的研究进展, 江西食品工业, 2005, 第 2 作者
    （72） 光照强度和温度对营养生长的巨藻雌、雄配子体光合放氧的影响, The effects of light intensity and temperature on photosynthetic oxygen evolution of the female and male gametophytes of Macrocystis pyri f era, 海洋科学, 2005, 第 1 作者
    （73） Transcriptomic analysis of the metabolic regulatory mechanism of Schizochytrium limacinum B4D1 using sodium acetate to produce DHA, BIOCHEMICAL ENGINEERING JOURNAL, 通讯作者
    
• • 
    

1. High concentration methanol tolerant methanotroph and its application US 20160201106 A1

2. One high methanol conventration tolerance methane-oxidizing bacterial and application. Application number: 201510171096.2

3. A regulator for the ratio of DPA/DHA and its regulation method. Application number: 201510266854.9

4. The culture with alanine mother solution as nitrogen and methods. Application number: 201510926396.7

5. A bacterial for algin lyase production and undurstrilization. Application number: 201410008138.6

6. Schizochytrium STA-M-3, application and method for production. Application number: 201410345189.8

7. An anarobic digestion reactor withor out inner component. Application number: 201410465959.2

8. A method for DHA-phospholipid production. Application number: 201410789098.3

9. A low salt tolerent Schizochytrium and its application. Application number: 201310660051.2

10. A method for algae pretreatment. ZL201310537582.2

11. A method for algin from brown algae. Application number: 201410781084.7

12. The breeding method of the alga for energy production - Macrocystis pyrifera. Chinese National Invention Patent. Announcement No, CN1865433.

13. A method of thermal pyrolysis of the macroalgae to biofuel. Chinese National Invention Patent. Announcement No, CN101033405.

14. A health Porphyra wine and itsproduction method. Chinese National Invention Patent. Announcement No, CN101033405.

15. A method to produce biofuel and biogas with algae and / or aquatic plants as feedstock. Announcement No, 201010132494.0

16. A method and equipment for improve the product yield and cooling speed of the reactor. Application number: 201010239525.2.

17. An equipment for improve the product yield and cooling speed of the reactor. Application number: 201020274614.6.

18. A steam explosion pretreatment method for converting algae to bioethanol. Application number : 201010554826.4

Low carbon Biomanufature of microbial protein and fatty acids

Syngas bioconversion

已指导学生

张可  硕士研究生  085216-化学工程  

赵敏利  硕士研究生  085238-生物工程  

李超峰  硕士研究生  085216-化学工程  

现指导学生

柴梦丹  硕士研究生  085600-材料与化工