油脂与蛋白生物制造，发酵模拟与放大

081703-生物化工
085600-材料与化工

微生物蛋白与油脂的低碳生物制造
气体发酵

2004-09--2007-06   中国科学院海洋研究所   博士

研究生

博士

   

2022-06~现在, 中国科学院天津工业生物技术研究所, 研究员
2022-04~现在, 中国科学院天津工业生物技术研究所, 工业生物系统工程课题组组长
2019-01~2022-03,中国科学院天津工业生物技术研究所, 发酵模拟与放大小组负责人
2015-08~2016-08,华盛顿州立大学, 访问学者
2011-07~现在, 中国科学院天津工业生物技术研究所, 副研究员

2023-05-01-2028-04-30,全国专业标准化技术委员会工业发酵分技术委员会, 委员
2021-04-13-2023-04-13,COMSATS工业生物技术联合中心生物能源联合研究组, 协调人
2014-01-01-今,中科院创新促进会会员,

   

（1） 海洋能源藻类培育与生物炼制基础, 二等奖, 部委级, 2016
（2） 华荣生物奖∙奖学奖教金, 三等奖, 研究所（学校）, 2015
（3） 黄海浒苔绿潮爆发的生物学基础及其资源化利用技术研究, 二等奖, 部委级, 2012

[1] 童胜, 李德茂, 陈吴西, 马延和, 王钦宏, 孙媛霞. 丙酮酸脱羧酶基因FvPDC6及其在提高威尼斯镰刀菌菌丝蛋白产量中的应用. CN: CN116640753A, 2023-08-25.
[2] 陈利梅, 陈吴西, 童胜, 李德茂. 裂殖壶菌GCD2032电击诱变菌株及其制备方法和应用. 2023105809967, 2023-05-23.
[3] 马延和, 童胜, 李德茂, 安可心, 陈吴西, 王钦宏, 孙媛霞. 威尼斯镰刀菌TB01的整合位点及其应用. CN202211384512.3, 2022-11-07.
[4] 马延和, 童胜, 李德茂, 王钦宏, 陈吴西, 孙媛霞. 一种来源于威尼斯镰刀菌的启动子及可视化基因敲除筛选方法. CN202210314499.8, 2022-03-29.
[5] 马延和, 童胜, 李德茂, 王钦宏, 陈吴西, 孙媛霞. 威尼斯镰刀菌内源U6启动子及其基于CRISPR/Cas9的基因编辑方法. CN202210314506.4, 2022-03-29.
[6] 马延和, 童胜, 李德茂, 王钦宏, 陈吴西, 孙媛霞. 威尼斯镰刀菌内源U6启动子及其基于CRISPR/Cas9的基因编辑方法. CN: CN114410635A, 2022-04-29.
[7] 马延和, 童胜, 李德茂, 王钦宏, 陈吴西, 孙媛霞. 一种来源于威尼斯镰刀菌的启动子及可视化基因敲除筛选方法. CN: CN114410634A, 2022-04-29.
[8] 马延和, 李德茂, 陈吴西, 童胜, 齐显妮, 曾艳, 王钦宏, 孙媛霞. 一种利用糖蜜生产菌丝蛋白的方法. CN: CN114107073A, 2022-03-01.
[9] 李德茂, 黄群, 陈吴西, 童胜, 陈利梅. 泛养副球菌菌株MA3、生产方法及其应用. CN: CN114214229A, 2022-03-22.
[10] 张学文, 曾艳, 孙媛霞, 马延和, 王钦宏, 李德茂. 一种可食用乙酰化菌体纤维的制备方法及应用. CN: CN113785931A, 2021-12-14.
[11] 马延和, 曾艳, 张学文, 李德茂, 齐显尼, 王钦宏, 孙媛霞. 一种食用菌丝蛋白加工方法及应用. CN: CN113412932A, 2021-09-21.
[12] 马延和, 李德茂, 齐显尼, 曾艳, 王钦宏, 孙媛霞. 一株产蛋白的菌株及其应用. CN: CN112226373A, 2021-01-15.
[13] 李德茂, 赵立枝, 陈吴西, 陈利梅. 甲酸基单细胞蛋白菌株MA5及其应用. CN: CN112646740A, 2021-04-13.
[14] 陈利梅, 张军桥, 李德茂, 杜艳, 陈吴西, 张明, 郭蔚. 多不饱和脂肪酸微胶囊粉的制备工艺. CN: CN110419737A, 2019-11-08.
[15] 李德茂, 陈树林, 张藩, 高峰. 一株产褐藻胶裂解酶的菌株及其应用. CN: CN108018234A, 2018-05-11.
[16] 陈利梅, 李德茂, 胡伶, 陈世富, 叶露贞, 陈吴西, 张涵实. 一种黑果花楸粉微胶囊及其制备工艺. CN: CN107897920A, 2018-04-13.
[17] 李德茂, 张可, 陈树林, 丁梦迅, 高峰, 赵敏利, 陈吴西. 裂殖壶菌F6及其在生产DHA和类胡萝卜素中的应用. CN: CN106854624A, 2017-06-16.
[18] 李德茂, 张可, 赵敏利, 陈吴西, 陈树林. 外源调控因子促进裂殖壶菌合成角鲨烯的方法. CN: CN105803005A, 2016-07-27.
[19] 高峰, 李德茂, 陈树林, 叶乃好, 张晓雯, 徐东, 范晓. 海洋酵母及其在生物乙醇生产中的应用. CN: CN105543115A, 2016-05-04.
[20] Guo Wei, Li Demao, Chen Shulin. High concentration methanol tolerant methanotroph and its application. CN: US20160201106A1, 2016-07-14.
[21] 李德茂, 徐建, 陈树林. 利用丙氨酸母液生产DHA的发酵培养基和方法. CN: CN105441493A, 2016-03-30.
[22] 张可, 李德茂, 陈树林, 陈吴西, 王海军, 王迪, 闵青松, 徐建. 一种调控裂殖壶菌油脂中DPA/DHA比例的调控因子及其调控方法. CN: CN104894176A, 2015-09-09.
[23] 郭蔚, 李德茂, 陈树林. 一株耐受高浓度甲醇的甲基单胞菌及其应用. CN: CN104774792A, 2015-07-15.
[24] 陈吴西, 李德茂, 陈树林. 一种磷脂DHA的制备方法. CN: CN104531790A, 2015-04-22.
[25] 高峰, 李德茂, 陈树林. 一种应用褐藻生产海藻酸钠的方法. CN: CN104530254A, 2015-04-22.
[26] 郁亮, 汤若昊, 李德茂, 马晶伟, 陈树林. 一种无内构件的升流式厌氧反应器. CN: CN104556367A, 2015-04-29.
[27] 李德茂, 王迪, 陈树林, 张可, 王海军, 陈吴西. 裂殖壶菌STA-M-3及其应用和产生裂殖壶菌的方法. CN: CN104694402A, 2015-06-10.
[28] 李德茂, 陈树林, 张藩, 高峰. 一株产褐藻胶裂解酶的菌株及其应用. CN: CN103911315A, 2014-07-09.
[29] 李德茂, 张可, 陈树林, 王海军, 王迪, 高峰. 一株耐受低盐的裂殖壶菌及其应用. CN: CN103911292A, 2014-07-09.
[30] 高峰, 高乐, 李德茂, 张东远, 陈树林. 一种藻类预处理方法. CN: CN103555772A, 2014-02-05.
[31] 武改红, 陈树林, 马立娟, 张东远, 李德茂, 马延和. 一种高效降解木质纤维素的复合酶系的制备方法及其应用. CN: CN102994481A, 2013-03-27.
[32] 陈树林, 陈方见, 刘晨风, 刘智永, 李德茂. 一种利用氨絮凝微藻的方法. CN: CN102492624A, 2012-06-13.
[33] 王广策, 陈明强, 王君, 李德茂, 曾呈奎. 一种大型海藻热解成液体燃料和气体燃料的方法. CN: CN101033405A, 2007-09-12.
[34] 王广策, 李德茂, 彭 光, 叶乃好. 用配子体克隆法繁育能源海藻——巨藻孢子体的方法. CN: CN1865433A, 2006-11-22.
[35] 李德茂, 童胜, 王钦宏, 洪茹茹, 陈吴西, 柴梦丹. 一株产甜菜红素的威尼斯镰刀菌株及其应用. CN24B18925A, 2024-04-26.
[36] 李德茂, 翟艺达, 陈利梅, 哈立德哈比吧. 启动子文库、用于产醇梭菌的荧光报告系统及应用. 2024105001201, 2024-04-25.

   

[1] 崔会娟, 刘伟松, 马春玲, Pezhman Shiri, 朱之光, 江会峰, 李德茂, 张玲玲. Converting CO2 to single-cell protein via an integrated electrocatalytic-biosynthetic system. Applied Catalysis B: Environment and Energy[J]. 2024, 第 7 作者  通讯作者  
[2] 童胜, 陈吴西, 洪茹茹, 柴梦丹, 孙媛霞, 王钦宏, 李德茂. Efficient Mycoprotein Production with Low CO2 Emissions through Metabolic Engineering and Fermentation Optimization of Fusarium venenatum. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2024, 第 7 作者  通讯作者  
[3] 翟艺达, 童胜, 陈利梅, 张圆, 陈吴西, 陈国福, 李德茂. The enhancement of energy supply in syngas-fermenting microorganisms. Environmental Research[J]. 2024, 第 7 作者  通讯作者  
[4] Wenyuan Zhou, Sheng Tong, Farrukh Raza Amin, Wuxi Chen, Jinling Cai, Demao Li. Heterologous Expression and Biochemical Characterization of a Thermostable Endoglucanase (MtEG5-1) from Myceliophthora thermophila. Fermentation[J]. 2023, 第 6 作者  通讯作者  
[5] Limei Chen, Wuxi Chen, Demao Li, Xiumin Liu. Anthocyanin and proanthocyanidin from Aronia melanocarpa (Michx.) Ell.: Purification, fractionation, and enzyme inhibition. Food Science & Nutrition[J]. 2023, 第 3 作者
[6] Xu, Jian, Wang, Jie, Ma, Chunling, Wei, Zuoxi, Zhai, Yida, Tian, Na, Zhu, Zhiguang, Xue, Min, Li, Demao. Embracing a low-carbon future by the production and marketing of C1 gas protein. BIOTECHNOLOGY ADVANCES[J]. 2023, 第 9 作者  通讯作者  63: http://dx.doi.org/10.1016/j.biotechadv.2023.108096.
[7] Jinyang Li, Sheng Tong, Farrukh Raza Amin, Habiba Khalid, Kai Chen, Xiaoguang Zhao, Jinling Cai, Demao Li. Enhancing the Activity of a Self-Inducible Promoter in Escherichia coli through Saturation Mutation and High-Throughput Screening. Fermentation[J]. 2023, 第 8 作者  通讯作者  9(5): 468, 
[8] Tong, Sheng, An, Kexin, Chen, Wuxi, Chai, Mengdan, Sun, Yuanxia, Wang, Qinhong, Li, Demao. Identification of neutral genome integration sites with high expression and high integration efficiency in Fusarium venenatum TB01. SYNTHETIC AND SYSTEMS BIOTECHNOLOGY[J]. 2023, 第 7 作者  通讯作者  8(1): 141-147, http://dx.doi.org/10.1016/j.synbio.2022.12.006.
[9] 曾艳, 张学文, 李德茂, 王钦宏, 孙媛霞. 菌体蛋白替代鸡胸肉的炸鸡块品质变化. 现代食品科技. 2023, 第 3 作者39(1): 152-159, http://lib.cqvip.com/Qikan/Article/Detail?id=7108876081.
[10] 才金玲, 王乃可, 王娟, 李德茂. 水稻秸秆预处理技术研究进展. 中国稻米. 2023, 第 4 作者29(3): 24-27, http://lib.cqvip.com/Qikan/Article/Detail?id=7109655406.
[11] 陈大明, 朱成姝, 汪哲, 李德茂, 尤晓颜, 熊燕, 赵国屏. 生物合成科技与应用的监管. 科学通报[J]. 2023, 第 4 作者68(19): 2457-2469, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7515057&detailType=1.
[12] Khalid, Habiba, Amin, Farrukh Raza, Gao, Lian, Chen, Limei, Chen, Wuxi, Javed, Sundus, Li, Demao. Syngas conversion to biofuels and biochemicals: a review of process engineering and mechanisms. SUSTAINABLE ENERGY & FUELS[J]. 2023, 第 7 作者  通讯作者  8(1): 9-28, http://dx.doi.org/10.1039/d3se00916e.
[13] 刘雯茜, 王海军, 陈吴西, 李德茂, 刘秀敏, 李军. 高山被孢霉低温应激条件下油脂代谢研究. 粮食与油脂. 2023, 第 4 作者36(8): 46-51, http://lib.cqvip.com/Qikan/Article/Detail?id=7110312752.
[14] Limei Chen, Sheng Tong, Wenqian Liu, Yuan Zhang, Habiba Khalid, Liucheng Long, Yaxiang Li, Demao Li, Beibei Yan, Guanyi Chen. Electroporation-induced mutation and transcriptome analysis for high DHA production in Schizochytrium limacinum GCD2032. ALGAL RESEARCH[J]. 2023, 第 8 作者  通讯作者  76: http://dx.doi.org/10.1016/j.algal.2023.103297.
[15] 李德茂, 童胜, 曾艳, 杨建刚, 齐显尼, 王钦宏, 孙媛霞, , , , , , , . 未来食品的低碳生物制造. 生物工程学报[J]. 2022, 第 1 作者38(11): 4311-4328, https://cjb.ijournals.cn/cjbcn/article/abstract/gc22114311?st=article_issue.
[16] 才金玲, 谢雅欣, 王子苗, 关法春, 李德茂. 改性阳离子型淀粉絮凝剂的研究进展. 应用化工[J]. 2022, 第 5 作者51(9): 2767-2773, http://lib.cqvip.com/Qikan/Article/Detail?id=7108194608.
[17] Tong, Sheng, An, Kexin, Chen, Wuxi, Zhou, Wenyuan, Sun, Yuanxia, Wang, Qinhong, Li, Demao. Evasion of Cas9 toxicity to develop an efficient genome editing system and its application to increase ethanol yield in Fusarium venenatum TB01. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2022, 第 7 作者  通讯作者  106(19-20): 6583-6593, 
[18] Xiangyu Zhu, Chunxiao Meng, Fengjie Sun, Wei Zuoxi, Limei Chen, Demao, Li. Sustainable production of astaxanthin in microorganisms: the past, present, and future. Critical Reviews in Food Science and Nutrition[J]. 2022, 第 6 作者  通讯作者  
[19] Huang, Qun, Alengebawy, Ahmed, Zhu, Xiangyu, Raza, Amin Farrukh, Chen, Limei, Chen, Wuxi, Guo, Jiahao, Ai, Ping, Li, Demao. Performance of Paracoccus pantotrophus MA3 in heterotrophic nitrification-anaerobic denitrification using formic acid as a carbon source. BIOPROCESS AND BIOSYSTEMS ENGINEERING[J]. 2022, 第 9 作者  通讯作者  45(10): 1661-1672, http://dx.doi.org/10.1007/s00449-022-02771-3.
[20] Xiangyu Zhu, Chunxiao Meng, Huanmin Du, Limei Chen, Fengjie Sun, Wuxi Chen, Zuoxi Wei, Jiali Ren, Zhengquan Gao, Demao Li. Enhancement of astaxanthin production in Schizochytrium limacinum B4D1 under ethanol induction. ALGAL RESEARCH[J]. 2022, 第 10 作者61: 
[21] Sheng Tong, Kexin An, Wenyuan Zhou, Wuxi Chen, Yuanxia Sun, Qinhong Wang, Demao Li. Establishment of High-Efficiency Screening System for Gene Deletion in Fusarium venenatum TB01. JOURNAL OF FUNGI[J]. 2022, 第 7 作者  通讯作者  8(2): 
[22] Ren Jiali, wang haijun, Li, Demao. Transcriptomic Characterizations of the Molecular Mechanisms Regulating Lipid Production and Composition in Mortierella alpina in Response to Cold Stress. Agronomy[J]. 2022, 第 3 作者  通讯作者  
[23] Chen, Limei, Liu, Xiumin, Li, Chaofeng, Li, Hanchen, Chen, Wuxi, Li, Demao. Transcriptome analyses reveal the DHA enhancement mechanism in Schizochytrium limacinum LD11 mutant. ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS[J]. 2022, 第 6 作者  通讯作者  67: http://dx.doi.org/10.1016/j.algal.2022.102868.
[24] Guo, Wei, Li, Yang, He, Ronglin, Chen, Wuxi, Gao, Feng, Li, Demao, Liao, Xiaoping. Genome-scale revealing the central metabolic network of the fast growing methanotroph Methylomonas sp. ZR1. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY[J]. 2021, 第 6 作者  通讯作者  37(2): http://dx.doi.org/10.1007/s11274-021-02995-7.
[25] 李德茂, 曾艳, 周桔, 王钦宏, 孙际宾, 江会锋, 马延和. 生物制造食品原料市场准入政策比较及对我国的建议. 中国科学院院刊[J]. 2020, 第 1 作者35(8): 1041-1052, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFDLAST2020&filename=KYYX202008015&v=MDY5MDhITkhNcDQ5RVlZUjhlWDFMdXhZUzdEaDFUM3FUcldNMUZyQ1VSN3FlWnVkdUZ5bmxWYnJKTGpUU2RyRzQ=.
[26] Han, YiFan, Xie, BinTao, Wu, Guangxun, Guo, YaQiong, Li, DeMao, Huang, ZhiYong. Combination of Trace Metal to Improve Solventogenesis ofClostridium carboxidivoransP7 in Syngas Fermentation. FRONTIERS IN MICROBIOLOGY[J]. 2020, 第 5 作者11: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7546793/.
[27] Li, Demao, Tang, Ruohao, Yu, Liang, Chen, Limei, Chen, Shulin, Xu, Song, Gao, Feng. Effects of increasing organic loading rates on reactor performance and the methanogenic community in a new pilot upflow solid reactor for continuously processing food waste. RENEWABLE ENERGY[J]. 2020, 第 1 作者153: 420-429, http://dx.doi.org/10.1016/j.renene.2020.02.020.
[28] Li, Chen, Li, Demao, Feng, Jun, Fan, Xiang, Chen, Shulin, Zhang, Dongyuan, He, Ronglin. Duckweed (Lemna minor) is a novel natural inducer of cellulase production in Trichoderma reesei. JOURNAL OF BIOSCIENCE AND BIOENGINEERING[J]. 2019, 第 2 作者127(4): 486-491, http://dx.doi.org/10.1016/j.jbiosc.2018.09.017.
[29] 李德茂, 陈吴西, 郭蔚, 李超峰, , , , , . 工业生物发酵过程模拟：进展与发展趋势. 生物工程学报[J]. 2019, 第 1 作者35(10): 1974-1985, https://cjb.ijournals.cn/cjbcn/article/abstract/gc19101974?st=article_issue.
[30] Du, Huanmin, Liao, Xiaoping, Gao, Zhengquan, Li, Yang, Lei, Yu, Chen, Wuxi, Chen, Limei, Fan, Xiang, Zhang, Ke, Chen, Shulin, Ma, Yanhe, Meng, Chunxiao, Li, Demao. Effects of Methanol on Carotenoids as Well as Biomass and Fatty Acid Biosynthesis in Schizochytrium limacinum B4D1. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2019, 第 13 作者  通讯作者  85(19): https://www.webofscience.com/wos/woscc/full-record/WOS:000488849800019.
[31] Feng Gao, Xiumin Liu, Wuxi Chen, Wei Guo, Limei Chen, Demao Li. Hydroxyl radical pretreatment for low-viscosity sodium alginate production from brown seaweed. ALGAL RESEARCH. 2018, 第 6 作者  通讯作者  34: 191-197, http://dx.doi.org/10.1016/j.algal.2018.07.017.
[32] Xu, Jian, Zhu, Yujing, Li, Hanchen, Chen, Limei, Chen, Wuxi, Cui, Min, Han, Lina, Hou, Wenbo, Li, Demao. Alanine mother liquor as a nitrogen source for docosahexaenoic acid production by Schizochytrium sp B4D1. ELECTRONIC JOURNAL OF BIOTECHNOLOGY[J]. 2018, 第 9 作者  通讯作者  35: 10-17, http://dx.doi.org/10.1016/j.ejbt.2018.06.002.
[33] Li, Demao, Meng, Chunxiao, Wu, Guanxun, Xie, Bintao, Han, Yifan, Guo, Yaqiong, Song, Chunhui, Gao, Zhengquan, Huang, Zhiyong. Effects of zinc on the production of alcohol by Clostridium carboxidivorans P7 using model syngas. JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY[J]. 2018, 第 1 作者45(1): 61-69, http://dx.doi.org/10.1007/s10295-017-1992-2.
[34] Gao, Feng, Liu, Xiumin, Chen, Wuxi, Guo, Wei, Chen, Limei, Li, Demao. Hydroxyl radical pretreatment for low-viscosity sodium alginate production from brown seaweed. ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS[J]. 2018, 第 6 作者  通讯作者  34: 191-197, http://dx.doi.org/10.1016/j.algal.2018.07.017.
[35] 吴冠勋, 吴玉珊, 韩一凡, 李德茂, 孟春晓, 高政权. 产乙酸菌合成气发酵的研究进展. 微生物前沿[J]. 2017, 第 4 作者6(1): 1-9, http://lib.cqvip.com/Qikan/Article/Detail?id=HS723882017001001.
[36] 汤若昊, 郁亮, 贾士儒, 陈树林, 李德茂. 进料含固率对餐厨垃圾两阶段厌氧消化的影响. 中国沼气[J]. 2017, 第 5 作者35(3): 44-49, http://lib.cqvip.com/Qikan/Article/Detail?id=672426738.
[37] Zhang, Ke, Li, Huidong, Chen, Wuxi, Zhao, Minli, Cui, Haiyang, Min, Qingsong, Wang, Haijun, Chen, Shulin, Li, Demao. Regulation of the Docosapentaenoic Acid/Docosahexaenoic Acid Ratio (DPA/DHA Ratio) in Schizochytrium limacinum B4D1. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY[J]. 2017, 第 9 作者  通讯作者  182(1): 67-81, https://www.webofscience.com/wos/woscc/full-record/WOS:000400867300006.
[38] Li, Demao, Zhang, Ke, Chen, Limei, Ding, Mengxun, Zhao, Minli, Chen, Shulin. Selection of Schizochytrium limacinum mutants based on butanol tolerance. ELECTRONIC JOURNAL OF BIOTECHNOLOGY[J]. 2017, 第 1 作者30(C): 58-63, http://dx.doi.org/10.1016/j.ejbt.2017.08.009.
[39] Chen, Limei, Zhu, Tao, Fernandez, Jose Salomon Martinez, Chen, Shulin, Li, Demao. Recycling nutrients from a sequential hydrothermal liquefaction process for microalgae culture. ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS[J]. 2017, 第 5 作者  通讯作者  27: 311-317, http://dx.doi.org/10.1016/j.algal.2017.09.023.
[40] Zhang, Ke, Chen, Limei, Liu, Jianmin, Gao, Feng, He, Ronglin, Chen, Wuxi, Guo, Wei, Chen, Shulin, Li, Demao. Effects of butanol on high value product production in Schizochytrium limacinum B4D1. ENZYME AND MICROBIAL TECHNOLOGY[J]. 2017, 第 9 作者  通讯作者  102: 9-15, http://dx.doi.org/10.1016/j.enzmictec.2017.03.007.
[41] Chen, Wuxi, Guo, Wei, Gao, Feng, Chen, Limei, Chen, Shulin, Li, Demao. Phospholipase A1-Catalysed Synthesis of Docosahexaenoic Acid-Enriched Phosphatidylcholine in Reverse Micelles System. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY[J]. 2017, 第 6 作者  通讯作者  182(3): 1037-1052, https://www.webofscience.com/wos/woscc/full-record/WOS:000403431400013.
[42] Zhang, Yong, Min, Qingsong, Xu, Jian, Zhang, Ke, Chen, Shulin, Wang, Haijun, Li, Demao. Effect of malate on docosahexaenoic acid production from Schizochytrium sp B4D1. ELECTRONIC JOURNAL OF BIOTECHNOLOGY[J]. 2016, 第 7 作者  通讯作者  19(C): 56-60, http://dx.doi.org/10.1016/j.ejbt.2015.11.006.
[43] Chen, Wuxi, Wang, Haijun, Zhang, Ke, Gao, Feng, Chen, Shulin, Li, Demao. Physicochemical Properties and Storage Stability of Microencapsulated DHA-Rich Oil with Different Wall Materials. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY[J]. 2016, 第 6 作者  通讯作者  179(7): 1129-1142, http://124.16.173.210/handle/834782/2930.
[44] Chen, Limei, Liu, Xiumin, Li, Demao, Chen, Wuxi, Zhang, Ke, Chen, Shulin. Preparation of stable microcapsules from disrupted cell of Haematococcus pluvialis by spray drying. INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY[J]. 2016, 第 3 作者51(8): 1834-1843, http://124.16.173.210/handle/834782/2914.
[45] 汤若昊, 刘洋, 郁亮, 贾士儒, 陈树林, 李德茂. 食微比对丙氨酸菌渣厌氧消化的影响. 中国沼气[J]. 2016, 第 6 作者34(2): 13-17, http://lib.cqvip.com/Qikan/Article/Detail?id=668575843.
[46] Gao, Le, Li, Demao, Gao, Feng, Liu, Zhiyong, Hou, Yuyong, Chen, Shulin, Zhang, Dongyuan. Hydroxyl radical-aided thermal pretreatment of algal biomass for enhanced biodegradability. BIOTECHNOLOGY FOR BIOFUELS[J]. 2015, 第 2 作者8(1): http://124.16.173.210/handle/834782/1554.
[47] Ye, Naihao, Zhang, Xiaowen, Miao, Miao, Fan, Xiao, Zheng, Yi, Xu, Dong, Wang, Jinfeng, Zhou, Lin, Wang, Dongsheng, Gao, Yuan, Wang, Yitao, Shi, Wenyu, Ji, Peifeng, Li, Demao, Guan, Zheng, Shao, Changwei, Zhuang, Zhimeng, Gao, Zhengquan, Qi, Ji, Zhao, Fangqing. Saccharina genomes provide novel insight into kelp biology. NATURE COMMUNICATIONS[J]. 2015, 第 14 作者6: http://dx.doi.org/10.1038/ncomms7986.
[48] 王迪, 路福平, 王海军, 李德茂, 陈树林, 张可. 利用原生质体融合技术选育淀粉发酵产DHA的新型裂殖壶菌. 生物技术通报[J]. 2015, 第 4 作者31(2): 84-90, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5355094&detailType=1.
[49] Gao, Feng, Gao, Le, Zhang, Dongyuan, Ye, Naihao, Chen, Shulin, Li, Demao. Enhanced hydrolysis of Macrocystis pyrifera by integrated hydroxyl radicals and hot water pretreatment. BIORESOURCE TECHNOLOGY[J]. 2015, 第 6 作者  通讯作者  179: 490-496, http://dx.doi.org/10.1016/j.biortech.2014.12.040.
[50] 王海军, 杨恒星, 王迪, 陈树林, 贾士儒, 李德茂. 不同前体物质的添加对高山被孢霉生长及脂肪酸组分的影响. 中国油脂[J]. 2015, 第 6 作者40(10): 68-73, http://lib.cqvip.com/Qikan/Article/Detail?id=666328145.
[51] He, Ronglin, Ma, Lijuan, Li, Chen, Jia, Wendi, Li, Demao, Zhang, Dongyuan, Chen, Shulin. Trpac1, a pH response transcription regulator, is involved in cellulase gene expression in Trichoderma reesei. ENZYME AND MICROBIAL TECHNOLOGY[J]. 2014, 第 5 作者67: 17-26, http://dx.doi.org/10.1016/j.enzmictec.2014.08.013.
[52] Guo, Wei, He, Ronglin, Ma, Lijuan, Jia, Wendi, Li, Demao, Chen, Shulin. Construction of a constitutively expressed homo-fermentative pathway in Lactobacillus brevis. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2014, 第 5 作者98(15): 6641-6650, http://124.16.173.210/handle/834782/1392.
[53] 张璠, 李德茂, 周雨霞. 虾夷马粪海胆不同肠道中菌群组成及其PCR-DGGE图谱分析. 江苏农业科学[J]. 2014, 第 2 作者42(9): 43-44,45, http://lib.cqvip.com/Qikan/Article/Detail?id=662450849.
[54] Gao, Zhengquan, Xu, Dong, Meng, Chunxiao, Zhang, Xiaowen, Wang, Yitao, Li, Demao, Zou, Jian, Zhuang, Zhimeng, Ye, Naihao. The green tide-forming macroalga Ulva linza outcompetes the red macroalga Gracilaria lemaneiformis via allelopathy and fast nutrients uptake. AQUATIC ECOLOGY[J]. 2014, 第 6 作者48(1): 53-62, http://dx.doi.org/10.1007/s10452-013-9465-9.
[55] Zhang, Fan, Tian, Yi, Gao, Feng, Chen, Shulin, Li, Demao, Zhou, Yuxia. Bacterial community in the intestine of the sea urchin Strongylocentrotus intermedius during digestion of Macrocystis pyrifera. MARINE AND FRESHWATER BEHAVIOUR AND PHYSIOLOGY[J]. 2014, 第 5 作者  通讯作者  47(2): 117-127, http://124.16.173.210/handle/834782/1386.
[56] Gao, Zhengquan, Li, Demao, Meng, Chunxiao, Xu, Dong, Zhang, Xiaowen, Ye, Naihao. Survival and proliferation characteristics of the microalga Chlamydomonas sp ICE-L after hypergravitational stress pretreatment. ICARUS[J]. 2013, 第 2 作者226(1): 971-979, http://dx.doi.org/10.1016/j.icarus.2013.07.017.
[57] Xu, Dong, Gao, Zhengquan, Li, Feng, Fan, Xiao, Zhang, Xiaowen, Ye, Naihao, Mou, Shanli, Liang, Chengwei, Li, Demao. Detection and quantitation of lipid in the microalga Tetraselmis subcordiformis (Wille) Butcher with BODIPY 505/515 staining. BIORESOURCE TECHNOLOGY[J]. 2013, 第 9 作者127: 386-390, http://dx.doi.org/10.1016/j.biortech.2012.09.068.
[58] Liu, Junhai, Zhuang, Yingbin, Li, Yan, Chen, Limei, Guo, Jingxue, Li, Demao, Ye, Naihao. Optimizing the conditions for the microwave-assisted direct liquefaction of Ulva prolifera for bio-oil production using response surface methodology. ENERGY[J]. 2013, 第 6 作者  通讯作者  60: 69-76, http://dx.doi.org/10.1016/j.energy.2013.07.060.
[59] Dong Xu, Zhengquan Gao, Xiaowen Zhang, Xiao Fan, Yitao Wang, Demao Li, Wei Wang, Zhimeng Zhuang, Naihao Ye. Allelopathic interactions between the opportunistic species Ulva prolifera and the native macroalga Gracilaria lichvoides.. PLOS ONE[J]. 2012, 第 6 作者7(4): https://doaj.org/article/de087cbbeea64caead4e66cd1eb543df.
[60] Li, Demao, Chen, Limei, Xu, Dong, Zhang, Xiaowen, Ye, Naihao, Chen, Fangjian, Chen, Shulin. Preparation and characteristics of bio-oil from the marine brown alga Sargassum patens C. Agardh. BIORESOURCE TECHNOLOGY[J]. 2012, 第 1 作者104(X): 737-742, http://dx.doi.org/10.1016/j.biortech.2011.11.011.
[61] Zhuang, Yingbin, Guo, Jingxue, Chen, Limei, Li, Demao, Liu, Junhai, Ye, Naihao. Microwave-assisted direct liquefaction of Ulva prolifera for bio-oil production by acid catalysis. BIORESOURCE TECHNOLOGY[J]. 2012, 第 4 作者  通讯作者  116: 133-139, http://dx.doi.org/10.1016/j.biortech.2012.04.036.
[62] Chen, Fangjian, Liu, Zhiyong, Li, Demao, Liu, Chenfeng, Zheng, Ping, Chen, Shulin. Using ammonia for algae harvesting and as nutrient in subsequent cultures. BIORESOURCE TECHNOLOGY[J]. 2012, 第 3 作者121(X): 298-303, http://dx.doi.org/10.1016/j.biortech.2012.06.076.
[63] Li, Demao, Chen, Limei, Chen, Shulin, Zhang, Xiaowen, Chen, Fangjian, Ye, Naihao. Comparative evaluation of the pyrolytic and kinetic characteristics of a macroalga (Sargassum thunbergii) and a freshwater plant (Potamogeton crispus). FUEL[J]. 2012, 第 1 作者96(1): 185-191, http://dx.doi.org/10.1016/j.fuel.2012.01.005.
[64] Ma, Shufeng, Chen, Limei, Liu, Xiumin, Li, Demao, Ye, Naihao, Wang, Liqiang. THERMAL BEHAVIOR OF CARRAGEENAN: KINETIC AND CHARACTERISTIC STUDIES. INTERNATIONAL JOURNAL OF GREEN ENERGY[J]. 2012, 第 4 作者  通讯作者  9(1): 13-21, http://www.irgrid.ac.cn/handle/1471x/419212.
[65] Demao Li, Limei Chen, Xiaowen Zhang, Naihao Ye, Fuguo Xing. Pyrolytic characteristics and kinetic studies of three kinds of red algae. BIOMASS AND BIOENERGY. 2011, 第 1 作者35(5): 1765-1772, http://dx.doi.org/10.1016/j.biombioe.2011.01.011.
[66] Li, Demao, Chen, Limei, Zhao, Jinsheng, Zhang, Xiaowen, Wang, Qingyin, Wang, Hongxia, Ye, Naihao. Evaluation of the pyrolytic and kinetic characteristics of Enteromorpha prolifera as a source of renewable bio-fuel from the Yellow Sea of China. CHEMICAL ENGINEERING RESEARCH & DESIGN[J]. 2010, 第 1 作者88(5-6A): 647-652, http://ir.qdio.ac.cn/handle/337002/5865.
[67] Li, Y X, Gao, Z Q, Li, D M, Wang, G C, Wang, F. Isolation and characterization of the oxygen-evolving photosystem II complex from the economical red alga Bangia fusco-purpurea. RUSSIAN JOURNAL OF PLANT PHYSIOLOGY[J]. 2010, 57(5): 609-614, http://ir.qdio.ac.cn/handle/337002/5853.
[68] Naihao Ye, Demao Li, Limei Chen, Xiaowen Zhang, Dong Xu. Comparative Studies of the Pyrolytic and Kinetic Characteristics of Maize Straw and the Seaweed Ulva pertusa. PLOS ONE[J]. 2010, 第 2 作者5(9): https://doaj.org/article/041cee6f52224dda80b67ecf711bab56.
[69] Li, Demao, Chen, Limei, Yi, Xiujie, Zhang, Xiaowen, Ye, Naihao. Pyrolytic characteristics and kinetics of two brown algae and sodium alginate. BIORESOURCE TECHNOLOGY[J]. 2010, 第 1 作者101(18): 7131-7136, http://dx.doi.org/10.1016/j.biortech.2010.03.145.
[70] 王广策, 牛建峰, 李映霞, 李德茂. 坛紫菜丝状体类囊体膜和光系统Ⅱ的分离鉴定. 安徽农业科技[J]. 2009, 第 4 作者37(26): 12553-12556, http://ir.qdio.ac.cn/handle/337002/8497.
[71] Li, Demao, Wang, Guangce, Chen, Limei, Lue, Fang, Shen, Zonggen. Effects of Irradiance and Temperature on the Photosynthesis and Vegetative Propagation of Caulerpa serrulata. JOURNAL OF INTEGRATIVE PLANT BIOLOGY[J]. 2009, 第 1 作者51(2): 147-154, http://lib.cqvip.com/Qikan/Article/Detail?id=29450843.
[72] Demao Li, Guangce Wang, Limei Chen, Fang Lü, Zonggen Shen. Effects of Irradiance and Temperature on the Photosynthesis and Vegetative Propagation of Caulerpa serrulata. 植物学报：英文版[J]. 2009, 第 1 作者147-154, http://lib.cqvip.com/Qikan/Article/Detail?id=29450843.
[73] Li, D, Lue, F, Wang, G, Zhou, B. Assembly of the subcellular parts of Bryopsis hypnoides Lamouroux into new protoplasts. RUSSIAN JOURNAL OF PLANT PHYSIOLOGY[J]. 2009, 56(1): 110-117, http://ir.qdio.ac.cn/handle/337002/2945.
[74] Fan Xiaolei, Wang Guangce, Li Demao, Xu Pu, Shen Songdong. Study on early-stage development of conchospore in Porphyra yezoensis Ueda. AQUACULTURE[J]. 2008, 第 3 作者278(1-4): 143-149, http://ir.qdio.ac.cn/handle/337002/5541.
[75] Demao Li, Fang Lu, Guangce Wang, Baicheng Zhou. Assembly of the Protoplasm of Codium fragile (Bryopsidales, Chlorophyta)into New Protoplasts. 植物学报：英文版[J]. 2008, 第 1 作者50(6): 752-760, http://lib.cqvip.com/Qikan/Article/Detail?id=27329962.
[76] Li, Demao, Lue, Fang, Wang, Guangce, Zhou, Baicheng. Assembly of the protoplasm of Codium fragile (Bryopsidales, Chlorophyta) into new protoplasts. JOURNAL OF INTEGRATIVE PLANT BIOLOGY[J]. 2008, 第 1 作者50(6): 752-760, http://lib.cqvip.com/Qikan/Article/Detail?id=27329962.
[77] 李德茂. 单细胞多核管状绿藻原生质团聚及发育研究. 2007, 第 1 作者147, http://ir.qdio.ac.cn/handle/337002/324.
[78] 王君, 李德茂, 张明旭, 陈明强, 王广策, 闵凡飞, 陈明功, 张素平, 任铮伟, 颜涌捷. 三种海藻的热解特性及动力学分析. 海洋与湖沼[J]. 2006, 第 2 作者37(4): 304-308, http://lib.cqvip.com/Qikan/Article/Detail?id=22471049.
[79] 陈利梅, 李德茂, 马书凤. 叶黄素的研究进展. 江西食品工业[J]. 2005, 第 2 作者28-30, http://lib.cqvip.com/Qikan/Article/Detail?id=15896866.
[80] 李德茂, 王广策, 李兆生, 彭光, 王明曙, 曾呈奎. 光照强度和温度对营养生长的巨藻雌、雄配子体光合放氧的影响. 海洋科学[J]. 2005, 第 1 作者29(12): 51-55, http://qdhys.ijournal.cn/hykx/ch/reader/view_abstract.aspx?file_no=20051212&flag=1.
[81] Yaxiang Li, Limei Chen, Wuxi Chen, Jianyong Zhu, Yefu Chen, Demao Li. Transcriptomic analysis of the metabolic regulatory mechanism of Schizochytrium limacinum B4D1 using sodium acetate to produce DHA. BIOCHEMICAL ENGINEERING JOURNAL. 第 6 作者  通讯作者  http://dx.doi.org/10.1016/j.bej.2023.108963.

（1） 浒苔, Ulva prolifra, 中国海洋出版社, 2012-01, 第 2 作者

   

（ 1 ） 浒苔的生物炼制技术研究, 负责人, 其他任务, 2011-12--2012-12
（ 2 ） 褐藻胶工业废气渣液连续流水热液化制备生物油及其品质提升研究, 负责人, 地方任务, 2012-04--2015-04
（ 3 ） 微藻规模化培养及炼制关键技术联合研究, 负责人, 国家任务, 2014-04--2017-04
（ 4 ） 二十二碳六烯酸发酵生产的关键技术创新及产业化, 负责人, 国家任务, 2014-04--2017-04
（ 5 ） 甲烷发酵-渗透汽化膜分离耦合生产乙醇技术及装备, 负责人, 中国科学院计划, 2013-01--2015-12
（ 6 ） 新型餐厨垃圾厌氧处理技术创新与系统集成, 参与, 地方任务, 2012-04--2014-12
（ 7 ） 基于模型的丙氨酸发酵过程优化, 负责人, 企业委托, 2015-01--2016-12
（ 8 ） DHA藻油产业化, 负责人, 企业委托, 2018-01--2019-12
（ 9 ） 低劣生物质转化利用的人工多细胞体系高效转化与工程应用, 负责人, 国家任务, 2018-07--2023-06
（ 10 ） 天然有机碳一原料细胞的功能重塑, 负责人, 国家任务, 2018-06--2023-06
（ 11 ） 裂殖壶菌油脂细胞工厂的构建与优化, 负责人, 国家任务, 2020-01--2024-12
（ 12 ） 生物制造化学品的市场准入研究, 负责人, 中国科学院计划, 2019-01--2020-06
（ 13 ） 不同遗传背景谷氨酸棒杆菌的高通量准确筛选技术开发, 负责人, 地方任务, 2019-10--2020-09
（ 14 ） 菌丝蛋白的低成本制造技术, 负责人, 地方任务, 2020-10--2022-09
（ 15 ） 多元农业废弃物综合利用和靶向堆肥技术, 负责人, 中国科学院计划, 2021-06--2026-06
（ 16 ） 医药化工产品生物制造及微生物的功能关系研究, 负责人, 企业委托, 2021-12--2026-12
（ 17 ） 菌丝蛋白规模化生物制造技术, 负责人, 企业委托, 2021-12--2025-10

已指导学生

张可  硕士研究生  085216-化学工程  

赵敏利  硕士研究生  085238-生物工程  

李超峰  硕士研究生  085216-化学工程  

现指导学生

柴梦丹  硕士研究生  085600-材料与化工