2013-2017    PhD in Basic Medicne (Molecular Medicine), State Key Laboratory of Oncology in South China, Sun Yat-sen University (Cancer Center), China

2010-2013    Master of Medicine in Pathology and Pathophysiology, School of Medicine, Southeast University, China

2006-2010    BS in Biological Sciences, School of Basic Medicine, Jiangxi University of Chinese Medicine, China

Jan 2021-present             Group Leader and Associate Professor, Receptor Pharmacology Research Group, Chinese Medicine Science Center

                                         Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China

Apr 2017-Nov 2020         Postdoctoral Visiting Fellow, National Institutes of Health, USA

Sep 2018-Sep 2019         Postdoctoral Fellow, University of Cincinnati College of Medicine, USA

Aug 2013-Apr 2017         Research Assistant, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, China

Teaching Assistant in Advanced Pathophysiology, Southeast University, 2011 Spring

1. G. Chen, I.M. Khan, W.S. He, Y.X. Li, P. Jin, O.H. Campanella, H.H. Zhang, Y.R. Huo, Y. Chen^*, H.Q. Yang^*, M. Miao^*, Rebuilding the lid region from conformational and dynamic features to engineering applications of lipase in foods: Current status and future prospects. Comprehensive Reviews in Food Science and Food Safety 21(3), 2688-2714 (2022). (^*Corresponding Author)

2. Q.X. Chen, M.G. Hao, L. Wang, L.S. Li, Y. Chen, X.T. Shao, Z.Q. Tian, R.A. Pfuetzner, Q. Zhong, A.T. Brunger, J.L. Guan, J.J. Diao, Prefused lysosomes cluster on autophagosome regulated by VAMP8. Cell Death and Disease 12(10), 939 (2021).

3. H. Zhang, S.H. Zhang, J.L. Hu, Y.T. Wu, X.Y. Ma, Y. Chen, B. Yu, S. Liao, H.L. Huang, S. Gao, Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C. Cancer Communications 41(7), 615-630 (2021).

4. J. Yin, E. Spillman, E.S. Cheng, J. Short, Y. Chen, J.C. Lei, M. Gibbs, J.S. Rosenthal, C.Y. Sheng, Y.X. Chen, K. Veerasammy, T. Choetso, R. Abzalimov, B. Wang, C. Han, Y. He, Q. Yuan, Brain-specific lipoprotein receptors interact with derived apolipoprotein and mediate neuron-glia lipid shuttling. Nature Communications 12(1), 2408 (2021).

5. J.L. Hu, H. Liang, H. Zhang, M.Z. Yang, W. Sun, P. Zhang, L. Luo, J.X. Feng, H.J. Bai, F. Liu, T.P. Zhang, J.Y. Yang, Q.S. Gao, Y.K. Long, X.Y. Ma, Y. Chen, Q. Zhong, B. Yu, S. Liao, Y.B. Wang, Y. Zhao, M.S. Zeng, N. Cao, J.C. Wang, W. Chen, H.T. Yang, S. Gao, FAM46B is a prokaryote-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells. Nucleic Acids Research 48(5), 2733-2748 (2020).

6. Y.N. Wang, Y.X. Lu, J. Liu, Y. Jin, H.C. Bi, Q. Zhao, Z.X. Liu, Y.Q. Li, J.J. Hu, H. Sheng, Y.M. Jiang, C. Zhang, F. Tian, Y. Chen, Z.Z. Pan, G. Chen, Z.L. Zeng, K.Y. Liu, M. Ogasawara, J.P. Yun, H.Q. Ju, J.X. Feng, D. Xie, S. Gao, W.H. Jia, S. Kopetz, R.H. Xu, F. Wang, AMPKα1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through phosphorylation of glutathione reductase. Oncogene 39(3), 637-650 (2019).

7. Q.X. Chen, X.T. Shao, Z.Q. Tian, Y. Chen, P. Mondal, F. Liu, F.S. Wang, P.X. Ling, W.J. He, K. Zhang, Z.J. Guo, J.J. Diao, Nanoscale Monitoring of Mitochondria and Lysosomes Interactions for Drug Screening and Discovery Strategies. Nano Research 12(5), 1009-1015 (2019).

8. T.S. Kim, L. Zhang, J.I. Ahn, L.J. Meng, Y. Chen, E.H. Lee, J.K. Bang, J.M. Lim, R. Ghirlando, L.X. Fan, Y.X. Wang, B.Y. Kim, J.E. Park, K.S. Lee, Molecular architecture of a cylindrical self-assembly at human centrosomes. Nature Communications 10, 1151 (2019).

9. J.Y. Yang, X.Y. Deng, Y.S. Li, X.C. Ma, J.X. Feng, B. Yu, Y. Chen, Y.L. Luo, X. Wang, M.L. Chen, Z.X. Fang, F.X. Zheng, Y.P. Li, Q. Zhong, T.B. Kang, L.B. Song, R.H. Xu, M.S. Zeng, W. Chen, H. Zhang, W. Xie, S. Gao, Structure of Schlafen13 reveals a new class of tRNA/rRNA-targeting RNase engaged in translational control. Nature Communications 9, 1165 (2018).

10. Y. Chen, L. Zhang, L. Graf, B. Yu, Y. Liu, G. Kochs, Y.F. Zhao, S. Gao, Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET. Nature Communication 8, 15744 (2017).

11. Y.L. Cao, S.X. Meng, Y. Chen, J.X. Feng, D.D. Gu, B. Yu, Y.J Li, J.Y. Yang, S. Liao, D.C. Chan, S. Gao, MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion. Nature 542, 372-376 (2017).

12. J.L. Hu, Y.J. Hua, Y. Chen, B. Yu, S. Gao, Structural analysis of tumor-related single amino acid mutations in human MxA protein. Chinese Journal of Cancer 34, 583-593 (2015).

13. Z. He, T. Tian, D. Guo, H.J. Wu, Y. Chen, Y.C. Zhang, Q. Wan, H.Z. Zhao, C.Y. Wang, H.J. Shen, L. Zhao, X.D. Bu, M.L. Wan, C.L. Shen, Cytoplasmic retention of a nucleocytoplasmic protein TBC1D3 by microtubule network is required for enhanced EGFR signaling. PLOS One 9, e94134 (2014).

Cancer Biology, Molecular Biology, Biological Chemistry, Drug Discovery

2021    Dalian Youth Science and Technology Star

2021    Dalian Introduced High-Level Talent

2021    State-Level Ganjiang New Area High-Level Talent

2020   Jiangxi "Double Thousand Plan" Innovation Leading Talent

2019    NIH Visiting Fellow Award

2017    NIH Visiting Fellow Award

2016    Best Poster Award in the 5^th International Symposium on Membrane Biology