Yang Chen, PhD
Associate Professor and Group Leader
Dalian Institute of Chemical Physics, CAS.
457 Zhongshan Rd, Dalian 116023, China.
E-mail: chenyang2808@dicp.ac.cn
Research Areas
1. Mechanisms of pathogenesis and drug resistance in malignant tumors
2. Discovery of bioactive compounds from natural products
Education
2013-2017, PhD in Basic Medicne (Molecular Medicine), Cancer Center/State Key Laboratory of Oncology in South China, Sun Yat-sen University, China
2010-2013, Master of Medicine in Pathology and Pathophysiology, School of Medicine, Southeast University, China
2006-2010, BS in Biological Sciences, School of Basic Medicine, Jiangxi University of Chinese Medicine, China
Experience
Work Experience
Jan 2021-present, Group Leader and Associate Professor, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, China
Apr 2017-Nov 2020, Postdoctoral Visiting Fellow, National Institutes of Health, USA
Sep 2018-Sep 2019, Postdoctoral Fellow, University of Cincinnati College of Medicine, USA
Aug 2013-Apr 2017, Research Assistant, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, China
Teaching Experience
Teaching Assistant in Advanced Pathophysiology, Southeast University, 2011 Spring
Publications
Papers
29. Xiaoyu Zhang, Bowen Zhong, Yue Sun, Dan Liu, Xiancheng Zhang, Dongdong Wang, Cunli Wang, Huiling Gao, Manli Zhong, Haijuan Qin, Yang Chen, Zhiying Yang, Yan Li, Haijie Wei, Xindi Yang, Yukui Zhang, Bo Jiang, Lihua Zhang, Guangyan Qing. Deciphering endogenous SUMO-1 landscape: a novel combinatorial peptide enrichment strategy for global profiling and disease association. Chemical Science, 2025, 16(6), 2634-2647.
28. Jiali Hu, Jing Cao, Shanshan Huang, Yang Chen*. ITGAX promotes gastric cancer progression via epithelial-mesenchymal transition pathway. Frontiers in Pharmacology, 2025, 15, 1536478.
27. Chuanxin Zhong, Nanxi Li, Shengzheng Wang, Dijie Li, Zhihua Yang, Lin Du, Guangxin Huang, Haitian Li, Wing Sze Yeung, Shan He, Shuting Ma, Zhuqian Wang, Hewen Jiang, Huarui Zhang, Zhanghao Li, Xiaoxin Wen, Song Xue, Xiaohui Tao, Haorui Li, Duoli Xie, Yihao Zhang, Zefeng Chen, Junqin Wang, Jianfeng Yan, Zhengming Liang, Zongkang Zhang, Zhigang Zhong, Zeting Wu, Chao Wan, Chao Liang, Luyao Wang, Sifan Yu, Yuan Ma, Yuanyuan Yu, Fangfei Li, Yang Chen, Baoting Zhang, Aiping Lyu, Fuzeng Ren, Hong Zhou, Jin Liu, Ge Zhang. Targeting osteoblastic 11β-HSD1 to combat high-fat diet-induced bone loss and obesity. Nature Communications, 2024, 15(1), 8588.
26. Caiying Zhang, Haiping Zhang, Qiuyun Zhang, Hongjie Fan, Pengfei Yu, Wei Xia, John Z.H. Zhang, Xinmiao Liang*, Yang Chen*. Targeting ATP catalytic activity of chromodomain helicase CHD1L for the anticancer inhibitor discovery. International Journal of Biological Macromolecules, 2024, 281(Pt4), 134446.
25. Gang Chen, Zhao-Xi Wang, Yuqi Yang, Yungao Li, Tao Zhang, Songying Ouyang, Liang Zhang*, Yang Chen*, Xinglin Ruan*, Ming Miao*. Elucidation of the mechanism underlying the sequential catalysis of inulin by fructotransferase. International Journal of Biological Macromolecules, 2024, 277(Pt3), 134446.
24. Liujiang Dai, Pengfei Yu, Hongjie Fan, Wei Xia, Yaopeng Zhao, Pengfei Zhang, John Z.H. Zhang, Haiping Zhang*, Yang Chen*. Identification and Validation of New DNA-PKcs Inhibitors through High-Throughput Virtual Screening and Experimental Verification. International Journal of Molecular Science, 2024, 25(14), 7982.
23. Haiping Zhang, Hongjie Fan, Jixia Wang, Tao Hou, Konda Mani Saravanan, Wei Xia, Hei Wun Kan, Junxin Li, John Z.H. Zhang*, Xinmiao Liang*, Yang Chen*. Revolutionizing GPCR-ligand predictions: DeepGPCR with experimental validation for high-precision drug discovery. Briefings in Bioinformatics, 2024, 25(4), bbae281.
22. Qianqian Long, Xinmin Zhao, Lili Gao, Mengyuan Liu, Feng Pan, Xinhua Gao, Changyou Zhan, Yang Chen, Jialei Wang, Jun Qian. Effects of Surface IR783 Density on the In Vivo Behavior and Imaging Performance of Liposomes. Pharmaceutics, 2024, 16(6), 744.
21. Shicheng Guo, Xiaoting Xie, Yang Chen, Yanqing Liu, Lianxiang Luo. Editorial: Advances of novel approaches to enhance therapeutic efficacy and safety in human solid cold tumor. Frontiers in Immunology, 2024, 15, 1398270.
20. Da-Qian Chen, Yuhao Xie, Lu-Qi Cao, Joshua S Fleishman, Yang Chen*, Tiesong Wu*, Dong-Hua Yang*. The role of ABCC10/MRP7 in anti-cancer drug resistance and beyond. Drug Resistance Updates, 2024, 73, 101062.
19. Caiying Zhang, Yuelong Li, Abdus Samad, Hongliang He, Huan Ma, Yang Chen, Tengchuan Jin. Kyasanur Forest disease virus NS3 helicase: Insights into structure, activity, and inhibitors. International Journal of Biological Macromolecules, 2024, 254(Pt3), 127856.
18. Jingrong Liu, Hongjie Fan, Xinmiao Liang*, Yang Chen*. Polycomb repressor complex: Its function in human cancer and therapeutic target strategy. Biomedicine & Pharmacotherapy, 2023, 169, 115897.
17. Yetian Wu, Pei Zhang, Hongjie Fan, Caiying Zhang, Pengfei Yu, Xinmiao Liang*, Yang Chen*. GPR35 acts a dual role and therapeutic target in inflammation. Frontiers in Immunology, 2023, 14, 1254446.
16. Yanqing Liu, Shicheng Guo, Tao Yuan, Yang Chen*. Editorial: Novel advances in gastrointestinal cancer treatment. Frontiers in Molecular Biosciences, 2023, 10, 1238098.
15. Lili Gao, Junzhe Zhang, Qianqian Long, Yang Yang, Yiming Li, Guoqiang Li, Peng Pu, Shanshi Tong, Yamin He, Qing Li, Yang Chen*, Yingbin Liu*, Xianming Kong*. SETD7 promotes metastasis of triple-negative breast cancer by YY1 lysine methylation. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2023, 1869(7), 166780.
14. Lai Wei, Kaijing Xiang, Hongjian Kang, Yancheng Yu, Hongjie Fan, Han Zhou, Tao Hou, Yonglin Ge, Jixia Wang, Zhimou Guo, Yang Chen, Yaopeng Zhao, Xinmiao Liang. Development and Characterization of Fluorescent Probes for the G Protein-Coupled Receptor 35. ACS Medicinal Chemistry Letters, 2023, 14(4), 411-416.
13. Gang Chen, Imran Mahmood Khan, Wensen He, Yongxin Li, Peng Jin, Osvaldo H Campanella, Haihua Zhang, Yanrong Huo, Yang Chen*, Huqing Yang*, Ming Miao*. Rebuilding the lid region from conformational and dynamic features to engineering applications of lipase in foods: Current status and future prospects. Comprehensive Reviews in Food Science and Food Safety, 2022, 21(3), 2688-2714.
12. Qixin Chen, Minggang Hao, Lei Wang, Linsen Li, Yang Chen, Xintian Shao, Zhiqi Tian, Richard A Pfuetzner, Qing Zhong, Axel T Brunger, Jun-Lin Guan, Jiajie Diao. Prefused lysosomes cluster on autophagosome regulated by VAMP8. Cell Death & Disease, 2021, 12(10), 939.
11. Hong Zhang, Shihui Zhang, Jiali Hu, Yutong Wu, Xiaoyan Ma, Yang Chen, Bing Yu, Shuang Liao, Huilin Huang, Song Gao. Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C. Cancer Communications, 2021, 41(7), 615-630.
10. Jun Yin, Emma Spillman, Ethan S Cheng, Jacob Short, Yang Chen, Jingce Lei, Mary Gibbs, Justin S Rosenthal, Chengyu Sheng, Yuki X Chen, Kelly Veerasammy, Tenzin Choetso, Rinat Abzalimov, Bei Wang, Chun Han, Ye He, Quan Yuan. Brain-specific lipoprotein receptors interact with derived apolipoprotein and mediate neuron-glia lipid shuttling. Nature Communications, 2021 12(1), 2408.
9. Jiali Hu, He Liang, Hong Zhang, Mingzhu Yang, Wei Sun, Peng Zhang, Li Luo, Jianxiong Feng, Huajun Bai, Fang Liu, Tianpeng Zhang, Jinyu Yang, Qingsong Gao, Yongkang Long, Xiaoyan Ma, Yang Chen, Qian Zhong, Bing Yu, Shuang Liao, Yongbo Wang, Yong Zhao, Musheng Zeng, Nan Cao, Jichang Wang, Wei Chen, Huangtian Yang, Song Gao. FAM46B is a prokaryote-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells. Nucleic Acids Research, 2020, 48(5), 2733-2748.
8. Yingnan Wang, Yunxin Lu, Jie Liu, Ying Jin, Huichang Bi, Qi Zhao, Zexian Liu, Yingqin Li, Jjiajia Hu, Hui Sheng, Yiming Jiang, Chao Zhang, Feng Tian, Yang Chen, Zhizhong Pan, Gong Chen, Zhaolei Zeng, Kaiyan Liu, Marcia Ogasawara, Jingping Yun, Huaiqiang Ju, Jianxiong Feng, Dan Xie, Song Gao, Weihua Jia, Scott Kopetz, Ruihua Xu, Feng Wang. AMPKα1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through phosphorylation of glutathione reductase. Oncogene, 2019, 39(3), 637-650.
7. Qixin Chen, Xintian Shao, Ziqi Tian, Yang Chen, Payel Mondal, Fei Liu, Fengshan Wang, Peixue Ling, Weijiang He, Kai Zhang, Zijian Guo, Jiajie Diao. Nanoscale monitoring of mitochondria and lysosomes interactions for drug screening and discovery strategies. Nano Research, 2019, 12(5), 1009-1015.
6. Tae-Sung Kim, Liang Zhang, JongIl Ah, Lingjun Meng, Yang Chen, Eunhye Lee, Jeong Kyu Bang, Jung Mi Lim, Rodolfo Ghirlando, Lixin Fan, Yunxing Wang, Bo Yeon Kim, Jung Eun Park, Kyung S Lee. Molecular architecture of a cylindrical self-assembly at human centrosomes. Nature Communications, 2019, 10, 1151.
5. Jinyu Yang, Xiangyu Deng, Yisheng Li, Xiancai Ma, Jianxiong Feng, Bing Yu, Yang Chen, Yiling Luo, Xi Wang, Meiling Chen, Zhixin Fang, Fuxiang Zheng, Yiping Li, Qian Zhong, Tie-Bang Kang, Libing Song, Ruihua Xu, Musheng Zeng, Wei Chen, Hui Zhang, Wei Xie, Song Gao. Structure of Schlafen13 reveals a new class of tRNA/rRNA-targeting RNase engaged in translational control. Nature Communications, 2019, 9(1), 1165.
4. Yang Chen, Lei Zhang, Laura Graf, Bing Yu, Yue Liu, Georg Kochs, Yongfang Zhao, Song Gao. Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET. Nature Communications, 2017, 8, 15744.
3. Yulu Cao, Shuxia Meng, Yang Chen, Jianxiong Feng, Dongdong Gu, Bing Yu, Yujie Li, Jinyu Yang, Shuang Liao, David C Chan, Song Gao. MFN1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion. Nature, 217, 542(7641), 372-376.
2. Jiali Hu, Yijun Hua, Yang Chen, Bing Yu, Song Gao. Structural analysis of tumor-related single amino acid mutations in human MxA protein. Cancer Communications, 2015, 34 (3), 583-593.
1. Ze He, Tian Tian, Dan Guo, Huijuan Wu, Yang Chen, Yongchen Zhang, Qing Wan, Huzi Zhao, Congyang Wang, Hongjing Shen, Lei Zhao, Xiaodong Bu, Meiling Wan, Chuanlu Shen. Cytoplasmic retention of a nucleocytoplasmic protein TBC1D3 by microtubule network is required for enhanced EGFR signaling. PLOS One, 2014, 9(4), e94134.
Research Interests
Cancer Biology, Molecular Biology, Biological Chemistry, Drug Discovery