1. 恶性肿瘤的发病机制和药理机制

2. 天然药物活性成分的发现与药理药效

   

070302-分析化学

细胞分子生物学，肿瘤生物学，生物化学，药物发现

2013-08--2017-06   中山大学   理学博士
2010-09--2013-06   东南大学   医学硕士
2006-09--2010-07   江西中医药大学   理学学士

博士研究生

理学博士

   

2021-01~现在, 中国科学院大连化学物理研究所, 研究组长/副研究员
2018-09~2019-09,美国辛辛那提大学医学院, 博士后
2017-04~2020-11,美国国立卫生研究院（NIH）, 博士后

   

（1） 江西省高层次人才, , 省级, 2024
（2） 江西省杰出青年基金获得者, 省级, 2022
（3） 赣江新区“赣江海智”人才, 市地级, 2021
（4） 大连市引进高层次人才, 市地级, 2021
（5） 大连市青年科技之星, 市地级, 2021
（6） 江西省“双千计划”创新领军人才, 省级, 2020
（7） 美国国立卫生研究院访问学者奖, 院级, 2019
（8） 美国国立卫生研究院访问学者奖, 院级, 2017
（9） 第五届国际暨第十四届全国膜生物学研讨会最佳墙报奖, 其他, 2016

   

（1） CCN1 Enhances Tumor Immunosuppression through Collagen-Mediated Chemokine Secretion in Pancreatic Cancer, Advanced Science, 2025, 第 10 作者  通讯作者
（2） Design, synthesis and biological evaluation of novel ��-caryophyllene derivatives as potential anti-cancer agents through the ROS-mediated apoptosis pathway, RSC Medicinal Chemistry, 2025, 第 2 作者
（3） Microbial riboflavin inhibits ceramide synthase 3 to lower ceramide (d18:1/26:0) and delay colorectal cancer progression, Cell Metabolism, 2025, 第 9 作者
（4） Bevacizumab in ovarian cancer therapy: current advances, clinical challenges, and emerging strategies, Frontiers in Bioengineering and Biotechnology, 2025, 第 8 作者  通讯作者
（5） Polygonatum kingianum polysaccharide alleviates dextran sulfate sodium-induced colitis by modulating gut microbiota and metabolic homeostasis, International Journal of Biological Macromolecules, 2025, 第 10 作者  通讯作者
（6） ITGAX promotes gastric cancer progression via epithelial-mesenchymal transition pathway, Frontiers in Pharmacology, 2025, 第 4 作者  通讯作者
（7） Deciphering endogenous SUMO-1 landscape: a novel combinatorial peptide enrichment strategy for global profiling and disease association, Chemical Science, 2025, 第 11 作者
（8） Kyasanur Forest disease virus NS3 helicase: Insights into structure, activity, and inhibitors, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 第 6 作者
（9） The role of ABCC10/MRP7 in anti-cancer drug resistance and beyond, DRUG RESISTANCE UPDATES, 2024, 第 5 作者  通讯作者
（10） Elucidation of the mechanism underlying the sequential catalysis of inulin by fructotransferase, International Journal of Biological Macromolecules, 2024, 第 8 作者  通讯作者
（11） Editorial: Advances of novel approaches to enhance therapeutic efficacy and safety in human solid cold tumor, Frontiers in Immunology, 2024, 第 3 作者
（12） Revolutionizing GPCR-ligand predictions: DeepGPCR with experimental validation for high-precision drug discovery, Briefings in Bioinformatics, 2024, 第 11 作者  通讯作者
（13） Effects of Surface IR783 Density on the In Vivo Behavior and Imaging Performance of Liposomes, Pharmaceutics, 2024, 第 8 作者
（14） Identification and Validation of New DNA-PKcs Inhibitors through High-Throughput Virtual Screening and Experimental Verification, International Journal of Molecular Sciences, 2024, 第 9 作者  通讯作者
（15） Targeting ATP catalytic activity of chromodomain helicase CHD1L for the anticancer inhibitor discovery, International Journal of Biological Macromolecules, 2024, 第 9 作者  通讯作者
（16） Targeting osteoblastic 11��-HSD1 to combat high-fat diet-induced bone loss and obesity, Nature Communications, 2024, 第 36 作者
（17） Polycomb repressor complex: Its function in human cancer and therapeutic target strategy, Biomedicine & Pharmacotherapy, 2023, 第 4 作者  通讯作者
（18） SETD7 promotes metastasis of triple-negative breast cancer by YY1 lysine methylation, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2023, 第 11 作者  通讯作者
（19） Editorial: Novel advances in gastrointestinal cancer treatment, FRONTIERS IN MOLECULAR BIOSCIENCES, 2023, 第 4 作者  通讯作者
（20） GPR35 acts a dual role and therapeutic target in inflammation, FRONTIERS IN IMMUNOLOGY, 2023, 第 7 作者  通讯作者
（21） Polycomb repressor complex: Its function in human cancer andtherapeutic target strategy, BIOMEDICINE & PHARMACOTHERAPY, 2023, 第 4 作者
（22） Development and Characterization of Fluorescent Probes for the G Protein-Coupled Receptor 35, ACS MEDICINAL CHEMISTRY LETTERS, 2023, 第 11 作者
（23） Rebuilding the lid region from conformational and dynamic features to engineering applications of lipase in foods: Current status and future prospects, Comprehensive Reviews in Food Science and Food Safety, 2022, 第 9 作者  通讯作者
（24） Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C, Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C, CANCER COMMUNICATIONS, 2021, 第 6 作者
（25） Prefused lysosomes cluster on autophagosomes regulated by VAMP8, CELL DEATH & DISEASE, 2021, 第 5 作者
（26） Brain-specific lipoprotein receptors interact with astrocyte derived apolipoprotein and mediate neuron-glia lipid shuttling, NATURE COMMUNICATIONS, 2021, 第 5 作者
（27） FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells, NUCLEIC ACIDS RESEARCH, 2020, 第 16 作者
（28） Molecular architecture of a cylindrical self-assembly at human centrosomes, NATURE COMMUNICATIONS, 2019, 第 5 作者
（29） AMPK��1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through the regulation of glutathione reductase phosphorylation, ONCOGENE, 2019, 第 14 作者
（30） Nanoscale monitoring of mitochondria and lysosome interactions for drug screening and discovery, NANO RESEARCH, 2019, 第 4 作者
（31） Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control, NATURE COMMUNICATIONS, 2018, 第 7 作者
（32） Mfn1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion, NATURE, 2017, 第 3 作者
（33） Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET, NATURE COMMUNICATIONS, 2017, 第 1 作者
（34） Structural analysis of tumor-related single amino acid mutations in human MxA protein, CHINESE JOURNAL OF CANCER, 2015, 第 3 作者
（35） Cytoplasmic Retention of a Nucleocytoplasmic Protein TBC1D3 by Microtubule Network Is Required for Enhanced EGFR Signaling, PLOS ONE, 2014, 第 5 作者

   

（ 1 ） 天然活性化合物发现和药理药效研究, 负责人, 地方任务, 2023-07--2026-06
（ 2 ） CHD1L基因在乳腺癌对紫杉醇耐药中的分子作用机理研究, 负责人, 地方任务, 2023-01--2025-12
（ 3 ） 癌蛋白TBC1D3的结构及其在胰腺癌发生中的功能研究, 负责人, 国家任务, 2022-01--2024-12
（ 4 ） TBC1D3 蛋白的结构测定及其与胰腺癌发生的关系研究, 负责人, 地方任务, 2022-01--2023-12
（ 5 ） CHD1L对乳腺癌化疗耐药的作用和结构机制研究, 负责人, 国家任务, 2021-01--2024-12
（ 6 ） 肿瘤疾病关键蛋白的结构和功能研究, 负责人, 地方任务, 2021-01--2022-12