基本信息

陈洋 男 硕导 中国科学院大连化学物理研究所
电子邮件: chenyang2808@dicp.ac.cn
通信地址: 辽宁省大连市沙河口区中山路457号
邮政编码: 116023
研究领域
1. 恶性肿瘤的发病机制和药理机制
2. 天然药物活性成分的发现与药理药效
招生信息
招生专业
070302-分析化学
招生方向
细胞分子生物学,肿瘤生物学,生物化学,药物发现
教育背景
2013-08--2017-06 中山大学 理学博士2010-09--2013-06 东南大学 医学硕士2006-09--2010-07 江西中医药大学 理学学士
学历
博士研究生
学位
理学博士
工作经历
工作简历
2021-01~现在, 中国科学院大连化学物理研究所, 研究组长/副研究员2018-09~2019-09,美国辛辛那提大学医学院, 博士后2017-04~2020-11,美国国立卫生研究院(NIH), 博士后
专利与奖励
奖励信息
(1) 江西省高层次人才, , 省级, 2024(2) 江西省杰出青年基金获得者, 省级, 2022(3) 赣江新区“赣江海智”人才, 市地级, 2021(4) 大连市引进高层次人才, 市地级, 2021(5) 大连市青年科技之星, 市地级, 2021(6) 江西省“双千计划”创新领军人才, 省级, 2020(7) 美国国立卫生研究院访问学者奖, 院级, 2019(8) 美国国立卫生研究院访问学者奖, 院级, 2017(9) 第五届国际暨第十四届全国膜生物学研讨会最佳墙报奖, 其他, 2016
出版信息
发表论文
(1) CCN1 Enhances Tumor Immunosuppression through Collagen-Mediated Chemokine Secretion in Pancreatic Cancer, Advanced Science, 2025, 第 10 作者 通讯作者(2) Design, synthesis and biological evaluation of novel ��-caryophyllene derivatives as potential anti-cancer agents through the ROS-mediated apoptosis pathway, RSC Medicinal Chemistry, 2025, 第 2 作者(3) Microbial riboflavin inhibits ceramide synthase 3 to lower ceramide (d18:1/26:0) and delay colorectal cancer progression, Cell Metabolism, 2025, 第 9 作者(4) Bevacizumab in ovarian cancer therapy: current advances, clinical challenges, and emerging strategies, Frontiers in Bioengineering and Biotechnology, 2025, 第 8 作者 通讯作者(5) Polygonatum kingianum polysaccharide alleviates dextran sulfate sodium-induced colitis by modulating gut microbiota and metabolic homeostasis, International Journal of Biological Macromolecules, 2025, 第 10 作者 通讯作者(6) ITGAX promotes gastric cancer progression via epithelial-mesenchymal transition pathway, Frontiers in Pharmacology, 2025, 第 4 作者 通讯作者(7) Deciphering endogenous SUMO-1 landscape: a novel combinatorial peptide enrichment strategy for global profiling and disease association, Chemical Science, 2025, 第 11 作者(8) Kyasanur Forest disease virus NS3 helicase: Insights into structure, activity, and inhibitors, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2024, 第 6 作者(9) The role of ABCC10/MRP7 in anti-cancer drug resistance and beyond, DRUG RESISTANCE UPDATES, 2024, 第 5 作者 通讯作者(10) Elucidation of the mechanism underlying the sequential catalysis of inulin by fructotransferase, International Journal of Biological Macromolecules, 2024, 第 8 作者 通讯作者(11) Editorial: Advances of novel approaches to enhance therapeutic efficacy and safety in human solid cold tumor, Frontiers in Immunology, 2024, 第 3 作者(12) Revolutionizing GPCR-ligand predictions: DeepGPCR with experimental validation for high-precision drug discovery, Briefings in Bioinformatics, 2024, 第 11 作者 通讯作者(13) Effects of Surface IR783 Density on the In Vivo Behavior and Imaging Performance of Liposomes, Pharmaceutics, 2024, 第 8 作者(14) Identification and Validation of New DNA-PKcs Inhibitors through High-Throughput Virtual Screening and Experimental Verification, International Journal of Molecular Sciences, 2024, 第 9 作者 通讯作者(15) Targeting ATP catalytic activity of chromodomain helicase CHD1L for the anticancer inhibitor discovery, International Journal of Biological Macromolecules, 2024, 第 9 作者 通讯作者(16) Targeting osteoblastic 11��-HSD1 to combat high-fat diet-induced bone loss and obesity, Nature Communications, 2024, 第 36 作者(17) Polycomb repressor complex: Its function in human cancer and therapeutic target strategy, Biomedicine & Pharmacotherapy, 2023, 第 4 作者 通讯作者(18) SETD7 promotes metastasis of triple-negative breast cancer by YY1 lysine methylation, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2023, 第 11 作者 通讯作者(19) Editorial: Novel advances in gastrointestinal cancer treatment, FRONTIERS IN MOLECULAR BIOSCIENCES, 2023, 第 4 作者 通讯作者(20) GPR35 acts a dual role and therapeutic target in inflammation, FRONTIERS IN IMMUNOLOGY, 2023, 第 7 作者 通讯作者(21) Polycomb repressor complex: Its function in human cancer andtherapeutic target strategy, BIOMEDICINE & PHARMACOTHERAPY, 2023, 第 4 作者(22) Development and Characterization of Fluorescent Probes for the G Protein-Coupled Receptor 35, ACS MEDICINAL CHEMISTRY LETTERS, 2023, 第 11 作者(23) Rebuilding the lid region from conformational and dynamic features to engineering applications of lipase in foods: Current status and future prospects, Comprehensive Reviews in Food Science and Food Safety, 2022, 第 9 作者 通讯作者(24) Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C, Structural and functional characterization of multiple myeloma associated cytoplasmic poly(A) polymerase FAM46C, CANCER COMMUNICATIONS, 2021, 第 6 作者(25) Prefused lysosomes cluster on autophagosomes regulated by VAMP8, CELL DEATH & DISEASE, 2021, 第 5 作者(26) Brain-specific lipoprotein receptors interact with astrocyte derived apolipoprotein and mediate neuron-glia lipid shuttling, NATURE COMMUNICATIONS, 2021, 第 5 作者(27) FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells, NUCLEIC ACIDS RESEARCH, 2020, 第 16 作者(28) Molecular architecture of a cylindrical self-assembly at human centrosomes, NATURE COMMUNICATIONS, 2019, 第 5 作者(29) AMPK��1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through the regulation of glutathione reductase phosphorylation, ONCOGENE, 2019, 第 14 作者(30) Nanoscale monitoring of mitochondria and lysosome interactions for drug screening and discovery, NANO RESEARCH, 2019, 第 4 作者(31) Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control, NATURE COMMUNICATIONS, 2018, 第 7 作者(32) Mfn1 structures reveal nucleotide-triggered dimerization critical for mitochondrial fusion, NATURE, 2017, 第 3 作者(33) Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET, NATURE COMMUNICATIONS, 2017, 第 1 作者(34) Structural analysis of tumor-related single amino acid mutations in human MxA protein, CHINESE JOURNAL OF CANCER, 2015, 第 3 作者(35) Cytoplasmic Retention of a Nucleocytoplasmic Protein TBC1D3 by Microtubule Network Is Required for Enhanced EGFR Signaling, PLOS ONE, 2014, 第 5 作者
科研活动
科研项目
( 1 ) 天然活性化合物发现和药理药效研究, 负责人, 地方任务, 2023-07--2026-06( 2 ) CHD1L基因在乳腺癌对紫杉醇耐药中的分子作用机理研究, 负责人, 地方任务, 2023-01--2025-12( 3 ) 癌蛋白TBC1D3的结构及其在胰腺癌发生中的功能研究, 负责人, 国家任务, 2022-01--2024-12( 4 ) TBC1D3 蛋白的结构测定及其与胰腺癌发生的关系研究, 负责人, 地方任务, 2022-01--2023-12( 5 ) CHD1L对乳腺癌化疗耐药的作用和结构机制研究, 负责人, 国家任务, 2021-01--2024-12( 6 ) 肿瘤疾病关键蛋白的结构和功能研究, 负责人, 地方任务, 2021-01--2022-12