General

Prof. Dr. Liang Cheng


CAS Key Laboratory of Molecular Recognition and Function

Institute of Chemistry, Chinese Academy of Sciences

​No. 2 Zhongguancun North 1st Street

Beijing 100190, China

Tel: +86-10-6194-3102

Fax: +86-10-6255-4449

E-mail: chengl@iccas.ac.cn

Research Areas

1) Targeting RNA (epigenetic) modifications with chemical tools;

2) Chemical modulation of Histone methylation modifications;

3) Total synthesis of novel DNA modifications.

Education

2000-2004 B.Sc. Beijing Normal University

2004-2009 Ph.D Institute of Chemistry, Chinese Academy of Sciences

2011-2014 Postdoc Columbia University (with Prof. Ronald Breslow)

Publications

  1. Sun, Y.-J.; Chen, W.-D.; Liu, L.; Li, J.-J.; Zhang, Y.; Cai, W.-Q.; Liu, L.; Tang, X.-J.;* Hou, J.;* Wang, M.;* Cheng, L.* "A Conformational Restriction Strategy for the Control of CRISPR/Cas Gene Editing with Photoactivatable Guide RNAs", Angew. Chem. Int. Ed. 2022, DOI: 10.1002/anie.202212413. 

  2. Jin, X.-Y.; Huang, Z.-R.; Xie, L.-J.; Liu, L.; Han, D.-L.;* Cheng, L.* "Photo-Facilitated Detection and Sequencing of 5-Formylcytidine RNA", Angew. Chem. Int. Ed. 2022, 61, e202210652. (VIP Article)

  3. Lan, L.; Sun, Y.-J.; Jin, X.-Y.; Xie, L.-J.; Liu, L.; Cheng, L.* "A Light-controllable Chemical Modulation of m6A RNA Methylation", Angew. Chem. Int. Ed. 2021, 60, 18116-18121.

  4. Cheng, H.-P.; Yang, X.-H.; Lan, L.; Xie, L.-J.; Chen, C.; Liu, C.; Chu, J.; Li, Z.-Y.; Zhang, T.-Q.;* Luo, D.-Q.;* Cheng, L.* "Artificial Deprenylation of N6‐isopentenyladenosine (i6A) RNA", Angew. Chem. Int. Ed. 2020, 59, 10645-10650.

  5. Xie, L.-J.#; Yang, X.-T.#; Wang, R.-L.; Cheng, H.-P.; Li, Z.-Y.; Liu, L.; Mao, L. Q.; Wang, M.*; Cheng, L.* "Identification of Flavin Mononucleotide as Cell-Active Artificial N6-Methyladenosine RNA Demethylase", Angew. Chem. Int. Ed. 2019, 58, 5028-5032.

  6. Cheng, L.; Charles, D.*; Breslow, R.* "Evidence for Tunneling in Base-catalyzed Isomerization of Glyceraldehyde to Dihydroxyacetone by Hydride Shift under Formose Conditions", Proc. Natl. Acad. Sci. USA 2015, 112, 4218-4220.

  7. Cheng, L.; Mahendran, A.; Gonzalez, R. L. Jr.*; Breslow, R.* "Deoxypolypeptides Bind and Cleave RNA", Proc. Natl. Acad. Sci. USA 2014, 111, 7920-7924.

  8. Cheng, L.; Abhilash, K. G.; Breslow, R.* "Binding and Biomimetic Cleavage of the RNA Poly(U) by Synthetic Polyimidazoles", Proc. Natl. Acad. Sci. USA 2012, 109, 12884-12887.


Honors & Distinctions

  • 2020  Thieme Chemistry Journals Award

  • 2016  CIFAR (Canadian Institute for Advanced Research) Azrieli Global Scholars Program, Finalist

  • 2015  Young Elite Scientist Sponsorship Program by China Association for Science and Technology

  • 2011  Centaurus BioPharma's Annual Outstanding Staff Award

  • 2009  Best Report Award in the 2nd "CCME-IOC & ICCAS-LMRF" Alfa Aesar® Symposium

  • 2009  Excellent Student of the Chinese Academy of Sciences

  • 2008  Excellent Student of the Chinese Academy of Sciences

  • 2008  Outstanding Young Scientist Award of the Chinese Academy of Sciences

  • 2007  Excellent Student of the Chinese Academy of Sciences