基本信息
程靓  男  博导  中国科学院化学研究所
电子邮件： chengl@iccas.ac.cn
通信地址： 海淀区中关村北一街2号
邮政编码： 100190

学习工作经历

  • 2000-2004年，北京师范大学化学系，学士

  • 2004-2009年，中国科学院化学研究所，博士

  • 2011-2014年，美国哥伦比亚大学，博士后

  • 2015年-至今，中国科学院化学研究所，研究员，博士生导师

  • 2020年-至今，中国科学院大学杭州高等研究院分子医学院，研究员，硕士生导师

招生信息

   
招生专业
0703Z1-化学生物学
070303-有机化学
071010-生物化学与分子生物学
招生方向
化学生物学
有机化学

教授课程

高等有机合成

研究兴趣与方向

生物大分子修饰的化学生物学研究

  1. RNA修饰的化学调控与应用

  2. 组蛋白甲基修饰的化学干预

  3. 复杂DNA修饰的选择性合成

代表论著

  1. Chen, W.-D.; Cheng, L.* "Synthesis and application of stimulus-triggered cyclic caged oligonucleotides for gene expression regulation", Tetrahedron Chem 2023, DOI: 10.1016/j.tchem.2023.100051. 

  2. Cheng, L.* "Chemical Modulation of RNA Epigenetic Modifications", Pak. J. Chem. 2023, 13, 57-66.

  3. He, Y.-M.; Liu, L.; Cheng, L.* "A Short Review of Research Progress on the Synthesis Approaches of Aza-Dibenzocyclooctyne Derivatives", Molecules, 2023, 28, 3715. 

  4. Wang, Z.-L.; Liu, A.-D.; Liu, L.; Cheng, L.* "Recent Advances in the Synthesis of 5-(Hetero)aryl Uracil Derivatives", Synlett, 2023, DOI: 10.1055/a-2091-1071. 

  5. 贺胤铭,# 孔素东,# 林建国, 谢敏浩, 程靓* "N4-乙酰胞苷ac4C RNA检测技术的研究进展", 高等学校化学学报, 2023, 44, 20220319. 

  6. Sun, X.; Liu, L.; Cheng, L.* "Photo- and tetrazine-responsive modulation of trans-zeatin", J. Org. Chem. 2023, 88, 2921-2930.

  7. Liu, A.-D.; Liu, L.; Cheng, L.* "DMSO/PhPOCl2 Mediated Direct Methanethiolation of Uracils", ChemistrySelect, 2023, 8, e20220448.  

  8. Sun, Y.-J.; Chen, W.-D.; Liu, L.; Li, J.-J.; Zhang, Y.; Cai, W.-Q.; Liu, L.; Tang, X.-J.;* Hou, J.;* Wang, M.;* Cheng, L.* "A Conformational Restriction Strategy for the Control of CRISPR/Cas Gene Editing with Photoactivatable Guide RNAs", Angew. Chem. Int. Ed. 2023, 62, e202212413. 

  9. Jin, X.-Y.; Huang, Z.-R.; Xie, L.-J.; Liu, L.; Han, D.-L.;* Cheng, L.* "Photo-Facilitated Detection and Sequencing of 5-Formylcytidine RNA", Angew. Chem. Int. Ed. 2022, 61, e202210652. (VIP Article)

  10. Wu, C.-S.; Cheng, L.* "Recent Advances towards the Reversible Chemical Modification of Proteins", ChemBioChem, 2023, 24, e202200468. (VIP Article)

  11. Liu, A.-D.; Wang, Z.-L.; Liu, L.; Cheng, L.* "A Visible-Light-Promoted C−H arylation and heteroarylation of Uracil Derivatives with Diazoniums in Aqueous Conditions", Curr. Protoc. Nucleic Acid Chem. 2022, 2, e432. 

  12. Jin, X.-Y.; Wu, C.-S.; Liu, A.-D.; Liu, L.; Cheng, L.* "Synthesis of rigid rod, trigonal and tetrahedral nucleobase-terminated molecules", Synthesis, 2022, 54, 1643-1651. 

  13. Xie, L.-J.; Lin, C.-L.; Liu, L.; Cheng, L.* "A Chemical Labelling of N6-Formyl Adenosine (f6A) RNA", Chin. Chem. Lett. 2022, 33, 1563-1566.  

  14. Sun, Y.-J.; Cheng, L.* "The Chemistry behind ThiC rearrangement", ChemBioChem, 2022, 23, e202100385.

  15. Liu, A.-D.; Wang, Z.-L.; Liu, L.; Cheng, L.* "An aqueous and visible-light promoted C-H (hetero)arylation of uracil derivatives with diazoniums", J. Org. Chem. 2021, 86, 16434–16447.

  16. Lan, L.;# Sun, Y. J.;# Liu, L.; Cheng, L.* "A Photo-Responsive Chemical Modulation of m6A RNA demethylase FTO", Chem. Commun. 2021, 57, 10548-10551.   

  17. Lan, L.; Sun, Y.-J.; Jin, X.-Y.; Xie, L.-J.; Liu, L.; Cheng, L.* "A Light-controllable Chemical Modulation of m6A RNA Methylation", Angew. Chem. Int. Ed. 2021, 60, 18116-18121.  

  18. Sun, Y.-J.; Liu, L.; Cheng, L.* "Regioselective Synthesis and Anticancer Evaluation of H2O2-Activatable Nucleosides", Chem. Commun. 2020, 56, 6484-6487 (Insider front cover article).

  19. Cheng, H.-P.; Yang, X.-H.; Lan, L.; Xie, L.-J.; Chen, C.; Liu, C.; Chu, J.; Li, Z.-Y.; Zhang, T.-Q.;* Luo, D.-Q.;* Cheng, L.* "Chemical Deprenylation of N6-Isopentenyladenosine (i6A) RNA", Angew. Chem. Int. Ed. 2020, 59, 10645-10650.

  20. Xie, L.-J.; Liu, L.; Cheng, L.* "Modifying Methionine on Proteins", ChemBioChem, 2020, 21, 461-463 (Invited review).  

  21. Xie, L.-J.; Liu, L.; Cheng, L.* "Selective Inhibitors of AlkB Family of Nucleic Acid Demethylases", Biochemistry, 2020, 59, 230-239 (Invited review, Future of Biochemistry: The Asia-Pacific Issue). 

  22. Wang, R. -L.; Lan, L.; Liu, L.; Cheng, L.* "Asymmetric Polymerase Chain Reaction and Loop-mediated Isothermal Amplification (AP-LAMP) for ultrasensitive detection of microRNAs", Chin. Chem. Lett. 2020, 31, 159-162.

  23. Wang, R.-L.;# Jin, X.-Y.;# Kong, D.-L.; Chen, Z.-G.; Liu, J.; Liu, L.; Cheng, L.* "Visible-Light Facilitated Fluorescence "Switch-On" Labelling of 5-Formylpyrimidine RNA", Adv. Synth. Catal. 2019, 361, 5406-5411.

  24. Wang, C.; Zou, P.; Yang, C.; Liu, L.; Cheng, L.; He, X.; Zhang, L.; Zhang, Y.; Jiang, H.*; Chen, P. R.* "Dynamic Modifications of Biomacromolecules: Mechanism and Chemical Interventions", Sci. China Life Sci. 2019, 62, 1459-1471.

  25. Li, X.-D.;# Gao, Y.-T.;# Sun, Y.-J.; Jin, X.-Y.; Wang, D.; Liu, L.; Cheng, L.* "A NaI/H2O2 Mediated Sulfenylation and Selenylation of Unprotected Uracil and its Derivatives", Org. Lett. 2019, 21, 6643-6647.

  26. Jin, X.-Y.; Wang, R.-L.; Xie, L.-J.; Kong, D.-L.; Liu, L.; Cheng, L.* "A chemical photo-oxidation of 5-methyl cytidines", Adv. Synth. Catal. 2019, 361, 4685-4690. (VIP Article)

  27. Lan, L.; Wang, R. L.; Liu , L.; Cheng, L.* "A Label-free Colorimetric Detection of microRNA via G-Quadruplex-based Signal Quenching Strategy", Anal. Chim. Acta. 2019, 1079, 207-211.

  28. Xie, L.-J.#; Yang, X.-T.#; Wang, R.-L.; Cheng, H.-P.; Li, Z.-Y.; Liu, L.; Mao, L. Q.; Wang, M.*; Cheng, L.* "Identification of Flavin Mononucleotide as Cell-Active Artificial N6-Methyladenosine RNA Demethylase", Angew. Chem. Int. Ed. 2019, 58, 5028-5032.

  29. Li, X.-D.; Liu, L.; Cheng, L.* "Identification of Thienopyridine Carboxamides as Selective Binders of HIV-1 Trans Activation Response (TAR) and Rev Response Element (RRE) RNAs", Org. Biomol. Chem. 2018, 16, 9191-9196.

  30. Li, X.-D.; Chen, B.; Lan, L.; Wang, R.-L.; Luo, D.-Q.; Liu, L.; Cheng, L.* "Selective Recognition of HIV RNA by Dinuclear Metallic Ligands", Chin. Chem. Lett. 2018, 29, 1637-1640.

  31. Xie, L.-J.; Wang, R.-L.; Wang, D.; Liu, L.; Cheng, L.* "Visible-Light-Mediated Oxidative Demethylation of N6-Methyl Adenines", Chem. Commun. 2017, 53, 10734-10737.

  32. Cheng, L.; Charles, D.*; Breslow, R.* "Evidence for Tunneling in Base-catalyzed Isomerization of Glyceraldehyde to Dihydroxyacetone by Hydride Shift under Formose Conditions", Proc. Natl. Acad. Sci. USA 2015, 112, 4218-4220.

  33. Cheng, L.; Mahendran, A.; Gonzalez, R. L. Jr.*; Breslow, R.* "Deoxypolypeptides Bind and Cleave RNA", Proc. Natl. Acad. Sci. USA 2014, 111, 7920-7924.

  34. Cheng, L.; Abhilash, K. G.; Breslow, R.* "Binding and Biomimetic Cleavage of the RNA Poly(U) by Synthetic Polyimidazoles", Proc. Natl. Acad. Sci. USA 2012, 109, 12884-12887.