基本信息
程靓  男  博导  中国科学院化学研究所
电子邮件： chengl@iccas.ac.cn
通信地址： 海淀区中关村北一街2号
邮政编码： 100190

学习工作经历

  • 2000-2004年，北京师范大学，学士

  • 2004-2009年，中国科学院化学研究所，博士

  • 2011-2014年，哥伦比亚大学，博士后

  • 2015年-至今，中国科学院化学研究所，研究员

研究兴趣与方向

RNA修饰的化学生物学研究

1）RNA表观修饰的精准化学干预； 

2）功能性RNA的化学改造与应用。

代表论著

  1. Cheng, L.* "Chemical Strategies to Modulate and Manipulate RNA Epigenetic Modifications", Acc. Chem. Res. 2025, DOI: 10.1021/acs.accounts.4c00844.

  2. He, Y.-M.; Burkard, A.; Wu, C.-S.; Jin, X.-Y.; Liu, L.; Helm, M.*; Cheng, L.* "A Direct Chemical Repair of Etheno-Type RNA Damages", Angew. Chem. Int. Ed. 2025, 64, e202415417.

  3. Wu, C.-S.; Sun, X.; Liu, L.; Cheng, L.* "A Live-Cell Epigenome Manipulation by Photo-Stimuli-Responsive Histone Methyltransferase Inhibitor", Adv. Sci. 2024, 11, 2404608. 

  4. Xie, L.-J.; Cheng, H.-P.; Chen, M.-Y.; Wang, X.; Liu, L.; Yuan, B.-F.; Cheng, L.* "A Bioorthogonal Post-Modification of N6-Isopentenyl Adenosine i6A RNA in live cells", CCS Chem. 2024, 6, 2241–2253.  

  5. Sun, Y.-J.; Chen, W.-D.; Liu, J.; Li, J.-J.; Zhang, Y.; Cai, W.-Q.; Liu, L.; Tang, X.-J.;* Hou, J.;* Wang, M.;* Cheng, L.* "A Conformational Restriction Strategy for the Control of CRISPR/Cas Gene Editing with Photoactivatable Guide RNAs", Angew. Chem. Int. Ed. 2023, 62, e202212413. 

  6. Jin, X.-Y.; Huang, Z.-R.; Xie, L.-J.; Liu, L.; Han, D.-L.;* Cheng, L.* "Photo-Facilitated Detection and Sequencing of 5-Formylcytidine RNA", Angew. Chem. Int. Ed. 2022, 61, e202210652. (VIP Article)

  7. Lan, L.; Sun, Y.-J.; Jin, X.-Y.; Xie, L.-J.; Liu, L.; Cheng, L.* "A Light-controllable Chemical Modulation of m6A RNA Methylation", Angew. Chem. Int. Ed. 2021, 60, 18116-18121.  

  8. Cheng, H.-P.; Yang, X.-H.; Lan, L.; Xie, L.-J.; Chen, C.; Liu, C.; Chu, J.; Li, Z.-Y.; Zhang, T.-Q.;* Luo, D.-Q.;* Cheng, L.* "Chemical Deprenylation of N6-Isopentenyladenosine (i6A) RNA", Angew. Chem. Int. Ed. 2020, 59, 10645-10650.

  9. Xie, L.-J.#; Yang, X.-T.#; Wang, R.-L.; Cheng, H.-P.; Li, Z.-Y.; Liu, L.; Mao, L. Q.; Wang, M.*; Cheng, L.* "Identification of Flavin Mononucleotide as Cell-Active Artificial N6-Methyladenosine RNA Demethylase", Angew. Chem. Int. Ed. 2019, 58, 5028-5032.

  10. Xie, L.-J.; Wang, R.-L.; Wang, D.; Liu, L.; Cheng, L.* "Visible-Light-Mediated Oxidative Demethylation of N6-Methyl Adenines", Chem. Commun. 2017, 53, 10734-10737.

  11. Cheng, L.; Charles, D.*; Breslow, R.* "Evidence for Tunneling in Base-catalyzed Isomerization of Glyceraldehyde to Dihydroxyacetone by Hydride Shift under Formose Conditions", Proc. Natl. Acad. Sci. USA 2015, 112, 4218-4220.

  12. Cheng, L.; Mahendran, A.; Gonzalez, R. L. Jr.*; Breslow, R.* "Deoxypolypeptides Bind and Cleave RNA", Proc. Natl. Acad. Sci. USA 2014, 111, 7920-7924.

  13. Cheng, L.; Abhilash, K. G.; Breslow, R.* "Binding and Biomimetic Cleavage of the RNA Poly(U) by Synthetic Polyimidazoles", Proc. Natl. Acad. Sci. USA 2012, 109, 12884-12887.