General

Changhao Bi, Investigator,doctoral supervisor

 Email: bi_ch@tib.cas.cn
Telephone: 18302294563
Address: xiqidao 32, airport district, Tianjin  
Postcode: 300308

Research Areas

Synthetic Biology, Metabolic Engineering, Microbiology

Education

2004.08--2009.12  University of Florida, US, Doctor

2001.09--2004.07  Nankai University , Master

1997.09--2001.07  Nankai University ,Bachelor

Experience

2011.09--2014.08   Berkeley Laurence National Laboratory, US,   Biology Researcher

2009.09--2011.08  University of Delaware ,postdoctoral

Publications

(1) Balanced activation of IspG and IspH to eliminate MEP intermediate accumulation and improve isoprenoids production in Escherichia coli, Metab Eng., 2017, 通讯作者
(2) The CRISPR/Cas9-facilitated multiplex pathway optimization (CFPO) technique and its application to improve the Escherichia coli xylose utilization pathway., Metab Eng., 2017, 通讯作者
(3) Improving Succinate Productivity by Engineering a Cyanobacterial CO2 Concentrating System (CCM) in Escherichia coli., Biotechnol J., 2017, 通讯作者
(4) Membrane engineering - A novel strategy to enhance the production and accumulation of β-carotene in Escherichia coli., Metab Eng., 2017, 通讯作者
(5) A novel point mutation in RpoB improves osmotolerance and succinic acid production in Escherichia coli., BMC biotechnology, 2017, 第 4 作者
(6) Construction of a novel anaerobic pathway in Escherichia coli for propionate production, BMC biotechnology, 2017, 通讯作者
(7) Type IIs restriction based combinatory modulation technique for metabolic pathway optimization, Microbial Cell Factories, 2017, 通讯作者
(8) Development of a modularized two-step (M2S) chromosome integration technique for integration of multiple transcription units in Saccharomyces cerevisiae, Biotechnology for Biofuels, 2016, 通讯作者
(9) Development of a fast and easy method for Escherichia coli genome editing with CRISPR/Cas9, Microbial Cell Factories, 2016, 通讯作者
(10) Engineering Corynebacterium glutamicum for violacein hyper production, Microbial Cell Factories, 2016, 通讯作者
(11) Combinatory optimization of chromosomal integrated mevalonate pathway for β-carotene production in Escherichia coli, Microbial Cell Factories, 2016, 第 3 作者
(12) End-to-end automated microfluidic platform for synthetic biology: from design to functional analysis, Journal of Biological Engineering, 2016, 第 4 作者
(13) Cross-Platform Laboratory Automation system, ACS Synth. Biol, 2014, 第 4 作者
(14) Overexpression of the Lactobacillus plantarum peptidoglycan biosynthesis murA2 gene increases the tolerance of Escherichia coli to alcohols and enhances ethanol production, BIOENERGY AND BIOFUELS, 2014, 第 2 作者
(15) Developing and Applying a Broad-Host Synthetic Biology Tool Box for Metabolic Engineering of Ralstonia eutropha for Hydrocarbon Production., Microb Cell Fact, 2013, 第 1 作者
(16) Functionalizing Bacterial Cell Surfaces with a Phage Protein, Chem Comm, 2013, 第 3 作者
(17) PaR-PaR Laboratory Automation platform, ACS Synth. Biol, 2012, 第 4 作者
(18) SpoIIE is necessary for asymmetric division, sporulation, and the expression of σF, σE, and σG but does not control solvent production in Clostridium acetobutylicum., J. Bacteriol., 2011, 第 1 作者
(19)  Complete fermentation of xylose and methylglucuronoxylose derived from methylglucuronoxylan by Enterobacter asburiae strain JDR-1, Applied and Environmental Microbilogy, 2009, 第 1 作者
(20) Genetic engineering Enterobacter asburiae strain JDR-1 for efficient ethanol production from hemicellulose hydrolysate, Applied and Environmental Microbilogy, 2009, 第 1 作者
(21) Genetic engineering of Enterobacter asburiae strain JDR-1 for efficient latic acid production from hemicellulose hydrolysate, Biotechnology Letters, 2009, 第 1 作者

Research Interests

Genome editing techniques, microbial chassis design and construction, synthetic biology circuit design and construction,microbial robotics 

Students

已指导学生

李智  硕士研究生  071010-生物化学与分子生物学  

熊斌  博士研究生  071010-生物化学与分子生物学  

现指导学生

叶立军  博士研究生  071010-生物化学与分子生物学  

王婷  硕士研究生  071010-生物化学与分子生物学  

李博  博士研究生  071010-生物化学与分子生物学  

樊旭倩  博士研究生  071010-生物化学与分子生物学  

代英才  硕士研究生  086000-生物与医药  

费吉东  硕士研究生  086000-生物与医药