Biomaterials for hard tissue replacement/regeneration

Surface functionalization of biomaterials

Study on and controlling over interfacial celluar/biological behavior of biomaterials

2004.09—2009-07  Shanghai Institute of Ceramics, CAS      Ph.D

2000.09—2004.07  Tianjin Chengjian University                   Bachelor

2013-06--2015-06, CIC biomaGUNE, Spain                        Postdoctoral research associate

2009-10--2012-12, the University of Sydney, Australia        Postdoctoral research associate
2009-07--2009-10, Shanghai Institute of Ceramic, CAS       Assistant Professor  

·         Book chapter

G.C. Wang, Z.F.  Lu, and H. Zreiqat. Ceramics for skeletal bone regeneration. In: Bone  Substitute Biomaterials. K. Mallick (Ed.) Woodhead Publishing (08/2014,  ISBN: 978-0-85709-497-1)

·         Invited review paper

1.      G.C. Wang, H. Zreiqat. Functional coatings or films for hard-tissue applications. Materials 2010, 3, 3994-4050.

2.      G.C. Wang*，S.  Moya, Z.F. Lu, D. Gregurec, H. Zreiqat*. Enhancing orthopedic implant  biocompatibility: refining the nanotopography, 2015, Nanomedicine,  10(8), 1327-1341.

·         Peer-reviewed research paper

1.      Danijela Gregurec, Guocheng Wang,  Ricardo Pires, Marija Kosutic, Tanja Ludetke, Mihaela Delcea, Sergio  Enrique Moya, Bio-inspired titanium coatings: Self-assembly of  collagen-alginate films for enhanced osseointegration. 2016, Journal of  Materials Chemistry B, 4(11): 1978-1986. (IF: 4.872)

2.      G.C. Wang，X.B.  Zhao, M. Moller, S.E. Moya. Interfacial Reaction-Driven Formation of  Silica Carbonate Biomorphs with Subcellular Topographical Features and  Their Biological Activity. ACS Applied Materials & Interface. 2015,  7:23412-23417. (IF: 7.145)

3.      B.E. Li, Y. Li, Y. Min, J.Z. Hao, C.Y. Liang, H.P. Li*, G.C. Wang*,  S.M. Liu and H.S. Wang, Synergistic effects of hierarchical hybrid  micro/nanostructures on the biological properties of Ti-based  orthopaedic implants, 2015, RSC Advances, 5, 49552-49558. (*Corresponding author ) (IF: 3.840).

4.      H. Pu, Y.R. Niu, C. Hu, G.C. Wang，H.  Li, Y. Zeng, X.B. Zheng, Albation of vacuum plasma sprayed TaC-based  composite coating, Ceramics International, 2015, 41 (9), 11387-11395.  (IF: 2.758)

5.      L. Yate, L.E. Coy, D. Gregurec, W. Aperador, S.E. Moya, G.C. Wang*,  Nb-C nanocomposite films with enhanced biocompatibility and mechanical  properties for hard-tissue implant applications, ACS Applied Materials  & Interface 2015, 7(11), 6351-6358. *corresponding author (IF: 7.145)

6.      X.B. Zhao, G.C Wang*,  H. Zheng, Z.F. Lu, X.B. Cheng, H. Zreiqat*. Refining nanotopographical  features on bone implant surfaces by altering surface chemical  compositions. RSC Advances, 2014, 4, 54226-54234 (*Corresponding author) (IF: 3.289)

7.      G.C. Wang, Z.F. Lu, X.B. Zhao, A. Kondyurin and H. Zreiqat. Ordered  HAp nanoarchitecture formed on HAp/TCP bioceramics by ‘nanocarving’ and  mineralization deposition and its potential use for guiding cell  behavior. Journal of Materials Chemistry B, 2013, 1: 2455-2462. (Featured on outside front cover of the journal) (IF: 4.872)

8.      W.J. Zhang, G.C. Wang, Y. Liu, X.B. Zhao, D.H. Zou, C. Zhu, Y.Q. Jin, Q.F. Huang, J. Sun, X.Y. Liu, X.Q. Jiang, H. Zreiqat, The synergistic effect of hierarchical micro/nano-topography and bioactive ions for enhanced osseointegration. Biomaterials, 2013, 34: 3184-3195. (Co-first author with W.J. Zhang) (IF: 8.387)

9.      X.B. Zhao, G.C. Wang^*, H. Zheng, Z.F. Lu, X. Zhong, X.B. Cheng, H. Zreiqat. Delicate refinement of surface nanotopography by adjusting TiO₂ coating chemical composition for enhanced interfacial biocompatibility. ACS Applied Materials & Interfaces, 2013, 5(16): 8203–8209 (*Corresponding author) (IF: 7.145)

10.   Z.F. Lu, G.C. Wang,  S.I. Roohani-Esfahani, C. Dunstan, H. Zreiqat. Baghdadite Ceramics  Modulate the Crosstalk between Human Adipose Stem Cells and Osteoblasts  for Bone Regeneration. Tissue Engineering A, 2013, 14 doi:10.1089/ten.TEA.2013.0470. (IF: 3.892)

11.   Z.F. Lu, G.C. Wang,  C.R. Dunstan, Y.J. Chen, W.Y.R. Lu, B. Davies, H. Zreiqat. Activation  and promotion of adipose tissue-derived mesenchymal stem cells by tumour  necrosis factor-alpha preconditioning for bone tissue engineering. Journal of Cellular Physiology. 2013: 228(8): 1737-1744. (IF: 4.155)

12.   K.Y. Xie, Y. Wang, Y. Zhao, L. Chang, G.C. Wang, Z. Chen, Y. Cao, X. Liao etc. Nanocrystalline  β-Ti alloy with High Hardness, Low Young’s Modulus and Excellent in  vitro Biocompatibility for Biomedical Applications. Materials Science and Engineering C, 2013, 33(6):3530-3536. (IF: 3.420)

13.   G.C. Wang,  Z.F. Lu, K. Xie, W. Lu, S.I. Roohani-Esfahani, A. Kondyurin and H.  Zreiqat. Facile method to in-situ formation of hydroxyapatite single  crystal architecture for enhanced osteoblast adhesion. Journal of Materials Chemistry. 2012, 22 (36), 19081-19087. (IF: 6.626)

14.   Z.F. Lu, G.C. Wang,  C. Dunstan, H. Zreiqat. Short-term Exposure to Tumour Necrosis  Factor-alpha Enables Human Osteoblasts to Direct Adipose Tissue-Derived  Mesenchymal Stem Cells into Osteogenic Differentiation. Stem Cells and Development. 2012, 21(13): 2420-2429. (This article was highlighted in Mesenchymal Cells News 4.05) (IF: 3.777)

15.   G.C. Wang, Z.F. Lu, H. Zreiqat. Porous scaffolds with tailored reactivity modulate in-vitro osteoblast responses. Materials Science and Engineering C, 2012, 32(7): 1818-1826. (IF: 3.420)

16.   Z.F. Lu, S.I. Roohani-Esfahani, G.C. Wang,  H. Zreiqat. Bone biomimetic microenvironment induces osteogenic  differentiation of adipose tissue-derived mesenchymal stem cells. Nanomedicine, 2012, 8(4): 507-515. (IF: 5.671)

17.   G.C. Wang, Z.F. Lu, X.Y. Liu, X.M. Zhou, C.X. Ding, H. Zreiqat, Nanostructured glass-ceramic coatings for orthopaedic applications. Journal of the Royal Society Interface, 2011, 8(61): 1192-1203. (IF: 3.818)

18.   G.C. Wang,  X.Y. Liu, C.X. Ding, H. Zreiqat. Enhanced effects of nano-scale  topography on the bioactivity and osteoblast behaviors of micron rough  ZrO₂ coatings. Colloids and Surface B: Biointerface, 2011, 86 (2): 267-274. (IF: 3.902)

19.   G.C. Wang,  F.H. Meng, C.X. Ding, P.K. Chu, X.Y. Liu. Microstructure, bioactivity  and osteoblast behavior of monoclinic zirconia coating with  nanostructured surface. Acta Biomaterialia. 2010, 6(3):990-1000. (IF: 6.008)

20.   J.Y. Sun, J.Y. Li, X.Y. Liu, W. Li, G.C. Wang et  al. Proliferation and gene expression of osteoblasts cultured in DMEM  containing the ionic products of dicalcium silicate coating. Biomedicine & Pharmacotherapy. 2009, 63(9): 650-657. (IF: 2.326)

21.   G.C. Wang, X.Y. Liu, C.X. Ding. In vitro bioactivity and phase stability of plasma-sprayed nanostructured 3Y-TZP coatings. Acta Biomaterialia, 2009, 5(6): 2270-2278. (IF: 6.008)

22.   C.T. Wu, Y. Ramaswamy, X.Y. Liu, G.C. Wang, H. Zreiqat. Plasma-sprayed CaTiSiO₅ ceramic coating on Ti-6Al-4V with excellent bonding strength, stability and cellular bioactivity. Journal of the Royal Society Interface 2009; 6:159-168. (IF: 3.818)

23.   G.C. Wang, X.Y. Liu, C.X. Ding. Phase composition and in-vitro bioactivity of plasma sprayed calcia stabilized zirconia coatings.  Surface and Coatings Technology. 2008; 202:5824-5831. (IF: 2.138)

24.   J.Y. Sun, L. Wei, X.Y. Liu, J.Y. Li, B.E. Li, G.C. Wang  et al. Influences of ionic dissolution products of dicalcium silicate  coating on osteoblastic proliferation, differentiation and gene  expression. Acta Biomaterialia, 2008, 5(4): 1284-1293. (IF: 6.008)

G.C. Wang, X.Y. Liu, C.X. Ding. Fabrication and application of plasma sprayed monoclinic zirconia coating with low temperature stability, Chinese Patent No.: ZL200710046705.7.

Surface modification of biomaterials

Bone tissue replacement and regeneration materials

Nano-biomaterials

1.      G.C. Wang, Chinese Orthopaedic Society & Australian and New Zealand Orthopaedic Research Society Joint Symposium, 2016, Shenzhen, China (Ordinator)

2.      G.C. Wang, Xiaobing Zhao. Bioactive ceramics interfacial intervention and effects on their biological performance, World Biomaterials Congress, 2016.05, Montreal, Canada (Poster)

3.      G.C. Wang, Xiaobing Zhao. Refining nanotopographical features on bone implant surfaces by altering surface chemical compositions, the International Thermal Spraying Conference, 2016.10, Shanghai, China (Oral)

4.      G.C. Wang. Refining nanotopographical features on bone implant surfaces, 26^th GRIBOI, 2016-04, Shenzhen, China (Invited talk)

5.      G.C. Wang, Luis Yate, Emerson Coy, Sergio Moya, Haobo Pan, Nobium-Carbon nanocomposite films for orthopaedic implant applications, The AVS Shanghai Thin Film Conference, 2015.10, Shanghai (Invited talk)

6.      G.C. Wang, Z.F. Lu, H. Zreiqat. Novel method to in-situ formation of hydroxyapatite single crystal architecture for enhanced bioactivity. 4^rd Tissue Engineering Symposium (The SUTEN Symposium). Aug 28-29, 2012, Sydney, Australia. (Presentation)

7.      G.C. Wang, Z.F. Lu, K. Xie, W. Lu, S.I. Roohani-Esfahani, A. Kondyurin and H. Zreiqat. Biomimetic single crystal surface Engineering of Bioceramics for enhanced wettability and osteoblast attachment. 9^th World Biomaterials Congress. 2012. June 1-5, Chengdu, China (Oral Presentation)

8.      G.C. Wang, Z.F. Lu, K. Xie, W. Lu, S.I. Roohani-Esfahani, A. Kondyurin and H. Zreiqat. Biomimetic single crystal surface Engineering of Bioceramics for enhanced wettability and osteoblast attachment. International Forum of Biomedical Materials Nanobiomaterials for Tissue Regeneration, 2012, May 29-31, Hangzhou, China.

9.      G.C. Wang, Z.F. Lu, X.Y. Liu, X.M. Zhou, C.X. Ding, H. Zreiqat. Nanostructured glass-ceramic coatings for orthopaedic applications. The Australian and New Zealand Orthopaedic Research Society (ANZORS), 14^th-18^th Nov. 2010, Melbourne, Australia. (Presentation)

10.   G.C. Wang, Z.F. Lu, X.Y. Liu, X.M. Zhou, C.X. Ding, H. Zreiqat. Nanostructured Biomedical Coatings for Orthopaedic Applications. 3^rd Tissue Engineering Symposium (The SUTEN Symposium). Nov. 9-11, 2010, Sydney, Australia. (Presentation)

11.   G.C. Wang, X.Y. Liu, C.X. Ding. Effects of nanostructured surface on the bioactivity of biomedical coating. 2008 Academic Seminar of Biomaterials in Shanghai Area (Abstract)

12.   G.C. Wang, X.Y. Liu, J.H. Gao, C.X. Ding. Microstructure and bioactivity of plasma sprayed nanostructural zirconia coating. MRS International Materials Research Conference (IMRS2008), Chongqing, China, June 9-12, 2008. (Poster)

13.   G.C. Wang, X.Y. Liu, C.X. Ding. Bioactivity of plasma sprayed zirconia coating stabilized with different content of calcia. The 8th World Biomaterials Congress. Amsterdam, the Netherlands, May 28- June 1, 2008 (Poster)

14.   G.C. Wang, X.Y. Liu, C.X. Ding. Plasma-sprayed calcium oxide stabilized zirconia coatings for biomedical applications. Proceeding of International Thermal Spray Conference & Exposition ITSC, May 14-16, 2007, Beijing, China. P 377-380. (Presentation)

The University of Sydney, Australia-Prof. Hala Zreiqat

CIC biomaGUNE, Spain-Prof. Sergio Moya

School of Engineering, Universidad Militar Nueva Granada, Colombia-Prof. Willian Aperador

NanoBioMedical Center, Adam Mickiewicz University, Poland-Prof. Emmerson Coy

Centro de Investigación en Química Aplicada (CIQA), Mexico-Prof. Ron Ziolo

已指导学生

卢丹萍  硕士研究生  085204-材料工程  

邱实  硕士研究生  085204-材料工程  

现指导学生

纪佳雯  硕士研究生  085600-材料与化工  

徐正江  博士研究生  0703Z1-化学生物学  

芮昊  硕士研究生  086000-生物与医药  

罗锦妍  硕士研究生  085600-材料与化工  

l  Travel award for the annual meeting of Australian Health and Medical Research Congress (AHMRC), Melbourne, Australia, 2010

l  First-class scholarship of Shanghai Institute of Ceramics, China Academy of Science. 2007-2009

l  Third-class prize of College Students’ Mathematic Contest of Tianjin (Science and Engineering) 2002

l  ChenQi Scholarship for Excellent students, Three-good students, Second Scholarship of Tianjin Chengjian University. 2000-2004

l  Excellent volunteer honored by the committee of The International Federation for Housing and Planning forty-sixth World Congress-College Forum. 2002