王国成  男  博导  中国科学院深圳先进技术研究院
电子邮件: gc.wang@siat.ac.cn
通信地址: 深圳市南山区西丽深圳大学城学苑大道1068号
邮政编码:

研究领域

1.   硬组织再生和生物密封(biological sealing);

2.   细胞/组织微环境设计及行为调控;

3.   表面图案化设计及应用开发研究;

4.   抗菌生物材料;

5.   纳米生物材料。

招生信息

材料和化学相关的博士/硕士研究生

招生专业
070304-物理化学
071009-细胞生物学
071005-微生物学
招生方向
生物材料表面改性
基于材料界面性能的细胞行为调控
骨替换和再生材料

教育背景

2004-09--2009-07   中国科学院上海硅酸盐研究所   博士
2000-09--2004-07   天津城建大学   本科
学历

博士研究生

学位

博士

工作经历

   
工作简历
2020-12~现在, 中国科学院深圳先进技术研究院, 研究员
2015-06~2020-12,中国科学院深圳先进技术研究院, 副研究员
2013-06~2015-06,西班牙CIC biomaGUNE生物材料研究中心, 博士后
2009-10~2012-12,澳大利亚悉尼大学(the University of Sydney), 博士后
2009-07~2009-10,中国科学院上海硅酸盐研究所, 助理研究员
社会兼职
2022-06-30-今,Materials, 期刊编委
2022-06-22-今,Biofunctional Materials, 期刊编委
2019-04-29-今,波兰科学基金合作专家(FN-SOP),
2017-12-01-今,"Alliance for Design and Application in Tissue Engineering" International Partner,
2016-03-31-2019-03-31,中国医促会骨科生物材料学组委员暨骨科分会委员,

出版信息

   
发表论文
(1) Nanosurfacing Ti alloy by weak alkalinity-activated solid-state dewetting (AAD) and its biointerfacial enhancement effect, MATERIALS HORIZONS, 2021, 通讯作者
(2) Recent advances in surface manipulation using micro-contact printing for biomedical applications, Smart Materials in Medicine, 2021, 第 8 作者
(3) Corrigendum to "Enhancement and orchestration of osteogenesis and angiogenesis by a dual-modular design of growth factors delivery scaffolds and 26SCS decoration" Biomaterials 232 (2020) 119645, Biomaterials, 2021, 第 6 作者
(4) Silicon incorporation into hydroxyapatite nanocarrier counteracts the side effects of vancomycin for efficient chronic osteomyelitis treatment, CHEMICAL ENGINEERING JOURNAL, 2021, 通讯作者
(5) Strontium modulates osteogenic activity of bone cement composed of bioactive borosilicate glass particles by activating Wnt/beta-catenin signaling pathway (vol 5, pg 334, 2020), BIOACTIVE MATERIALS, 2021, 第 10 作者
(6) The synergistic strategies for the immuno-oncotherapy with photothermal nanoagents, WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 2021, 第 3 作者
(7) Strontium modulates osteogenic activity of bone cement composed of bioactive borosilicate glass particles by activating Wnt/β-catenin signaling pathway, Bioactive Materials, 2020, 第 10 作者
(8) Aligned Biofunctional Electrospun PLGA-LysoGM1 Scaffold for Traumatic Brain Injury Repair, ACS BIOMATERIALS SCIENCE & ENGINEERING, 2020, 第 8 作者
(9) Electron transfer correlated antibacterial activity of biocompatible graphene Nanosheets-TiO2 coatings, CARBON, 2020, 通讯作者
(10) Bispecific T-cell engager (BiTE) immunotherapy of ovarian cancer based on MIL-88A MOF/MC gene delivery system, APPLIED MATERIALS TODAY, 2020, 通讯作者
(11) Enhancement and orchestration of osteogenesis and angiogenesis by a dual-modular design of growth factors delivery scaffolds and 26SCS decoration, BIOMATERIALS, 2020, 通讯作者
(12) Strontium modulates osteogenic activity of bone cement composed of bioactive borosilicate glass particles by activating Wnt/beta-catenin signaling pathway, BIOACTIVE MATERIALS, 2020, 第 10 作者
(13) MODULATION OF THE MICRO/NANOTOPOGRAPHY OF PLASMA-SPRAYED BIOMEDICAL COATINGS FOR ENHANCED OSTEOGENIC ACTIVITY, SURFACE REVIEW AND LETTERS, 2019, 通讯作者
(14) Strong mineralization ability of strontium zinc silicate: Formation of a continuous biomorphic mineralized layer with enhanced osteogenic activity, COLLOIDS AND SURFACES B-BIOINTERFACES, 2019, 通讯作者
(15) Potential of niobium-based thin films as a protective and osteogenic coating for dental implants: The role of the nonmetal elements, Materials Science & Engineering C, 2019, 第 8 作者
(16) 钛种植体表面CuO和Nb2O5共掺杂TiO2涂层的制备及抗菌性能和生物相容性, Preparation of CuO and Nb2O5 Co-doped TiO2 Coating on Titanium Implants and Its Antibacterial Properties and Biocompatibility, 中国表面工程, 2019, 第 5 作者
(17) Sol-gel derived nanosized Sr5(PO4)2SiO4 powder with enhanced in vitro osteogenesis and angiogenesis for bone regeneration applications, CERAMICS INTERNATIONAL, 2019, 第 4 作者
(18) Antibacterial Mesoporous Titania Films with Embedded Gentamicin and Surface Modified with Bone Morphogenetic Protein 2 to Promote Osseointegration in Bone Implants, ADVANCED MATERIALS INTERFACES, 2019, 第 7 作者
(19) Ca、Ag掺杂对TiO2涂层结构、体外矿化和抗菌性能的影响, Effect of Ca and Ag Doping on Structure, In-vitro Mineralization, and Anti-Bacterial Properties of TiO2 Coatings, 硅酸盐学报, 2019, 第 5 作者
(20) Potential of niobium-based thin films as a protective and osteogenic coating for dental implants: The role of the nonmetal elements, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2019, 通讯作者
(21) 3D Printing of Mechanically Stable Calcium-Free Alginate-Based Scaffolds with Tunable Surface Charge to Enable Cell Adhesion and Facile Biofunctionalization, ADVANCED FUNCTIONAL MATERIALS, 2019, 第 8 作者
(22) Microstructure Evolution of Plasma- Sprayed MoSi2 Coating at RT-1200 degrees C in Air, JOURNAL OF THERMAL SPRAY TECHNOLOGY, 2018, 第 3 作者
(23) Enhanced osteogenic activity of ti alloy implants by modulating strontium configuration in their surface oxide layers., RSC ADVANCES, 2018, 第 6 作者
(24) Application of MBG as a coating material on mechanically stronger but less degradable ceramic scaffolds for enhanced osteogenesis, MATERIALS LETTERS, 2018, 通讯作者
(25) 抗菌元素对纳米TiO2涂层结构和性能的影响, Influence of Antibacterial Elements on the Structure and Properties of Nanostructured Ti02 Coatings, 表面技术, 2018, 第 7 作者
(26) Strontium incorporation improves the bone-forming ability of scaffolds derived from porcine bone., COLLOIDS AND SURFACES B-BIOINTERFACES, 2018, 第 5 作者
(27) Layered titanates with fibrous nanotopographic features as reservoir for bioactive ions to enhance osteogenesis, APPLIED SURFACE SCIENCE, 2018, 通讯作者
(28) Bioinspired titanium coatings: self-assembly of collagen-alginate films for enhanced osseointegration, JOURNAL OF MATERIALS CHEMISTRY B, 2016, 第 2 作者
(29) Nb-C Nanocomposite Films with Enhanced Biocompatibility and Mechanical Properties for Hard-Tissue Implant Applications, ACS APPLIED MATERIALS & INTERFACES, 2015, 通讯作者
(30) Synergistic effects of hierarchical hybrid micro/nanostructures on the biological properties of Ti-based orthopaedic implants, RSC Advances, 2015, 通讯作者
(31) Interfacial Reaction-Driven Formation of Silica Carbonate Biomorphs with Subcellular Topographical Features and Their Biological Activity, ACS APPLIED MATERIALS & INTERFACES, 2015, 通讯作者
(32) Enhancing orthopedic implant biocompatibility: refining the nanotopography, Nanomedicine, 2015, 第 1 作者
(33) Refining nanotopographical features on bone implant surfaces by altering surface chemical compositions, RSC ADVANCES, 2014, 通讯作者
(34) Ordered HAp nanoarchitecture formed on HAp/TCP bioceramics by ‘nanocarving’ and mineralization deposition and its potential use for guiding cell behavior, Journal of Materials Chemistry B, 2013, 第 1 作者
(35) Delicate Refinement of Surface Nanotopography by Adjusting TiO2 Coating Chemical Composition for Enhanced Interfacial Biocompatibility, ACS APPLIED MATERIALS & INTERFACES, 2013, 通讯作者
(36) Activation and promotion of adipose tissue-derived mesenchymal stem cells by tumour necrosis factor-alpha preconditioning for bone tissue engineering, Journal of Cellular Physiology, 2013, 第 1 作者
(37) The synergistic effect of hierarchical micro/nano-topography and bioactive ions for enhanced osseointegration, BIOMATERIALS, 2013, 第 2 作者
(38) Baghdadite Ceramics Modulate the Crosstalk between Human Adipose Stem Cells and Osteoblasts for Bone Regeneration, Tissue Engineering A, 2013, 第 1 作者
(39) A facile method to in situ formation of hydroxyapatite single crystal architecture for enhanced osteoblast adhesion, JOURNAL OF MATERIALS CHEMISTRY, 2012, 第 1 作者
(40) Bone biomimetic microenvironment induces osteogenic differentiation of adipose tissue-derived mesenchymal stem cells, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2012, 第 3 作者
(41) Porous scaffolds with tailored reactivity modulate in-vitro osteoblast responses, Materials Science & Engineering C, 2012, 第 1 作者
(42) Short-term Exposure to Tumour Necrosis Factor-alpha Enables Human Osteoblasts to Direct Adipose Tissue-Derived Mesenchymal Stem Cells into Osteogenic Differentiation, Stem Cells and Development, 2012, 第 1 作者
(43) Nanostructured glass–ceramic coatings for orthopaedic applications, JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2011, 第 1 作者
(44) Enhanced effects of nano-scale topography on the bioactivity and osteoblast behaviors of micron rough ZrO 2 coatings, COLLOIDS AND SURFACES B-BIOINTERFACES, 2011, 第 1 作者
(45) Microstructure, bioactivity and osteoblast behavior of monoclinic zirconia coating with nanostructured surface, ACTA BIOMATERIALIA, 2010, 第 1 作者
(46) Functional Coatings or Films for Hard-Tissue Applications, MATERIALS, 2010, 第 1 作者
(47) Plasma-sprayed CaTiSiO5 ceramic coating on Ti-6Al-4V with excellent bonding strength, stability and cellular bioactivity, JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2009, 第 4 作者
(48) 等离子喷涂纳米氧化锆涂层研究进展, Research Progress in Plasma Sprayed Nanostructured Zirconia Coatings, 中国表面工程, 2009, 第 3 作者
(49) In vitro bioactivity and phase stability of plasma-sprayed nanostructured 3Y-TZP coatings, ACTA BIOMATERIALIA, 2009, 第 1 作者
(50) Phase composition and in-vitro bioactivity of plasma sprayed calcia stabilized zirconia coatings, SURFACE & COATINGS TECHNOLOGY, 2008, 第 1 作者
发表著作
(1) Bioceramics for skeletal bone regeneration, Woodhead Publishing, 2014-08, 第 1 作者

科研活动

   
科研项目
( 1 ) 新型仿生骨材料的关键技术研发, 负责人, 地方任务, 2016-01--2018-01
( 2 ) 新型高骨诱导活性人工关节涂层的研发, 负责人, 地方任务, 2017-01--2018-12
( 3 ) 华南生物医用材料与植入器械创新示范基地, 负责人, 国家任务, 2017-07--2020-12
( 4 ) 组织工程骨仿生活化及快速血管化研究, 负责人, 地方任务, 2017-06--2020-06
( 5 ) 生物活性陶瓷表面微环境预调制及其对巨噬细胞行为和骨再生的影响机制, 负责人, 国家任务, 2019-01--2022-12
( 6 ) 钛合金表面原位介孔化及生长因子负载的促骨整合作用研究, 负责人, 地方任务, 2018-05--2021-04
( 7 ) 生物材料与组织工程制品调控的免疫微环境对组织再生的影响及机制研究, 参与, 国家任务, 2018-09--2021-06
( 8 ) 医用聚醚醚酮表面免疫反应时序调控及其促组织修复研究, 参与, 国家任务, 2022-01--2025-12
( 9 ) 特异占取S蛋白侵染位点的纳米材料设计及其抗新冠研究, 负责人, 国家任务, 2021-10--2023-09
参与会议
(1)Accelerated bone formation by bioactive ions and growth factor delivery   2019-10-14
(2)Nano-topographic modification of biomaterials for enhanced biological responses   2019-06-05
(3)Surface modification of biomaterials for enhanced biological performance   2018-12-06
(4)基于界面反应的生物形态碳酸锶晶体的形成及其对生物活性的影响研究   中国生物材料大会   2015-11-19
(5)Nobium-Carbon nanocomposite films for orthopaedic implant applications   2015-10-24
(6)Novel method to in-situ formation of hydroxyapatite single crystal architecture for enhanced bioactivity   2012-08-28
(7) Biomimetic single crystal surface Engineering of Bioceramics for enhanced wettability and osteoblast attachment   2012-06-01

合作情况

The University of Sydney, Australia-Prof. Hala Zreiqat

CIC biomaGUNE, Spain-Prof. Sergio Moya

School of Engineering, Universidad Militar Nueva Granada, Colombia-Prof. Willian Aperador

NanoBioMedical Center, Adam Mickiewicz University, Poland-Prof. Emmerson Coy

Centro de Investigación en Química Aplicada (CIQA), Mexico-Prof. Ron Ziolo


项目协作单位

深圳第二人民医院,第四军医大学,上海长海医院


指导学生

已指导学生

卢丹萍  硕士研究生  085204-材料工程  

邱实  硕士研究生  085204-材料工程  

现指导学生

纪佳雯  硕士研究生  085600-材料与化工  

徐正江  博士研究生  0703Z1-化学生物学  

芮昊  硕士研究生  086000-生物与医药  

罗锦妍  硕士研究生  085600-材料与化工  

联合培养硕士生

丘才杰(常州大学);

陈晓艺(中科大纳米学院);

孙伟(中科大纳米学院);

吴犇(常州大学)。