基本信息
柏文琴  女  博导  中国科学院天津工业生物技术研究所
电子邮件: baiwq@tib.cas.cn
通信地址: 天津空港经济区西七道32号
邮政编码:

研究领域

围绕生物材料和活性聚合物的细胞工厂构建、过程优化及应用开发开展研究;设计构建蛋白纳米支架,组装多酶反应器,实现高附加值化合物的体内外合成。


招生信息

   
招生专业
071010-生物化学与分子生物学
071005-微生物学
0710Z1-基因组学
招生方向
代谢工程,合成生物学

教育背景

2010-09--2013-07   中国科学院微生物研究所   博士
2001-09--2004-07   中国科学院动物研究所   硕士
1997-09--2001-07   山西大学   本科

工作经历

   

专利与奖励

   
专利成果
[1] 柏文琴, 冯照喧, 陈淑宇. 一种普鲁兰多糖形状记忆材料的制备方法及其4D打印方法及制品. 202210480388.4, 2022-05-05.

[2] 马延和, 柏文琴, 陈淑宇. 一株高产高分子量普鲁兰多糖的出芽短梗霉及其应用. 202210480946.7, 2022-05-05.

[3] 马延和, 柏文琴, 王德信, 王思佳. 一株高产γ-聚谷氨酸的耐盐芽孢杆菌及其发酵条件优化. 202210374606.6, 2022-04-11.

[4] 訾祯祯, 柏文琴, 张婷, 白玉, 陶勇, 吕建仁, 马延和. 一种增强丝蛋白生产制备的表达系统. CN: CN107723287B, 2021-07-06.

[5] 马延和, 柏文琴, 薛燕芬. 一种耐盐木聚糖酶及其编码基因与应用. 中国: CN103060289A, 2013-04-24.

[6] 马延和, 柏文琴, 薛燕芬. 一种碱性木聚糖酶及其编码基因与应用. 中国: CN103060290A, 2013-04-24.

[7] 邱星辉, 柏文琴, 李梅, 何风琴. 一株可降解有机磷农药的降解菌及其用途. 中国: CN1306023, 2007-03-21.

出版信息

   
发表论文
[1] Feng, Zhaoxuan, Chen, Shuyu, Ahmad, Abdullah, Chen, Longjiao, Bai, Wenqin. Ultra-high molecular weight pullulan-based material with high deformability and shape-memory properties. CARBOHYDRATE POLYMERS[J]. 2022, 295: [2] Bai Wenqin, Winston E Anthony, Gautam Dantas, Fuzhong Zhang. Engineering diverse fatty acid compositions of phospholipids in Escherichia coli. Metabolic Engineering[J]. 2022, 74: 11-23, https://pubmed.ncbi.nlm.nih.gov/36058465/.
[3] Wenqin Bai, Cameron J Sargent, JeongMo Choi, Rohit V Pappu, Fuzhong Zhang. Covalently-assembled single-chain protein nanostructures with ultra-high stability. Nature Communications[J]. 2019, 10(1): 1-10, https://doaj.org/article/ec7cdad6dc2045c1b4932d232772c37b.
[4] Bai, Wenqin, Geng, Weitao, Wang, Shaojie, Zhang, Fuzhong. Biosynthesis, regulation, and engineering of microbially produced branched biofuels. Biotechnology for Biofuels[J]. 2019, 12(1): 1-12, https://doaj.org/article/a9f61764fffb4849958b9e3664a4e385.
[5] Wang, Jingyu, Wang, Jilong, Tai, Yishu, Zhang, Qiuge, Bai, Wenqin, Zhang, Kechun. Rerouting carbon flux for optimized biosynthesis of mesaconate in Escherichia coli. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2018, 102(17): 7377-7388, https://www.webofscience.com/wos/woscc/full-record/WOS:000441229200014.
[6] Bowen, Christopher H, Dai, Bin, Sargent, Cameron J, Bai, Wenqin, Ladiwala, Pranay, Feng, Huibao, Huang, Wenwen, Kaplan, David L, Galazka, Jonathan M, Zhang, Fuzhong. Recombinant Spidroins Fully Replicate Primary Mechanical Properties of Natural Spider Silk. BIOMACROMOLECULES[J]. 2018, 19(9): 3853-3860, https://www.webofscience.com/wos/woscc/full-record/WOS:000444527300024.
[7] Bai, Wenqin, Cao, Yufan, Liu, Jun, Wang, Qinhong, Jia, Zhenhu. Improvement of alkalophilicity of an alkaline xylanase Xyn11A-LC from Bacillus sp SN5 by random mutation and Glu135 saturation mutagenesis. BMC BIOTECHNOLOGY[J]. 2016, 16(1): http://www.irgrid.ac.cn/handle/1471x/1180901.
[8] Bai, Wenqin, Tai, YiShu, Wang, Jingyu, Wang, Jilong, Jambunathan, Pooja, Fox, Kevin J, Zhang, Kechun. Engineering nonphosphorylative metabolism to synthesize mesaconate from lignocellulosic sugars in Escherichia coli. METABOLIC ENGINEERING[J]. 2016, 38: 285-292, http://dx.doi.org/10.1016/j.ymben.2016.09.007.
[9] Bo Wenqin. Engineering Highly Efficient E. coli strain for Mevalonate Fermentation by Chromosomal Integration. Applied and Environmental Microbiology. 2016, [10] Bo Wenqin. Engineering Nonphosphorylative Metabolism to Synthesize Mesaconate from D-Xylose and L-Arabinose in Escherichia coli. Metabolic Engineering. 2016, [11] Bai, Wenqin, Zhou, Cheng, Zhao, Yueju, Wang, Qinhong, Ma, Yanhe. Structural Insight into and Mutational Analysis of Family 11 Xylanases: Implications for Mechanisms of Higher pH Catalytic Adaptation. PLOS ONE[J]. 2015, 10(7): http://dx.doi.org/10.1371/journal.pone.0132834.
[12] Bai, Wenqin, Xue, Yanfen, Zhou, Cheng, Ma, Yanhe. Cloning, expression, and characterization of a novel alkali-tolerant xylanase from alkaliphilic Bacillus sp SN5. BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY[J]. 2015, 62(2): 208-217, http://www.irgrid.ac.cn/handle/1471x/1111534.
[13] 柏文琴, 王钦宏, 马延和. 嗜热和嗜碱木聚糖酶研究进展. 生物工程学报[J]. 2014, 30(6): 828-837, [14] Bai, Wenqin, Zhou, Cheng, Xue, Yanfen, Huang, ChunHsiang, Guo, ReyTing, Ma, Yanhe. Three-dimensional structure of an alkaline xylanase Xyn11A-LC from alkalophilic Bacillus sp SN5 and improvement of its thermal performance by introducing arginines substitutions. BIOTECHNOLOGY LETTERS[J]. 2014, 36(7): 1495-1501, http://www.irgrid.ac.cn/handle/1471x/1111483.
[15] 柏文琴, 杨鲁红, 马延和. 通过N端引入芳香族氨基酸提高木聚糖酶的热稳定性. 生物工程学报[J]. 2014, 30(8): 1217-1224, [16] 柏文琴. 木聚糖酶的基因资源发掘、分子改造及嗜碱机制研究. 2013, [17] Bai, Wenqin, Xue, Yanfen, Zhou, Cheng, Ma, Yanhe. Cloning, expression and characterization of a novel salt-tolerant xylanase from Bacillus sp SN5. BIOTECHNOLOGY LETTERS[J]. 2012, 34(11): 2093-2099, http://www.irgrid.ac.cn/handle/1471x/1111518.
[18] Zhong, Qiuzan, Zhang, Haiyan, Bai, Wenqin, Li, Mei, Li, Baotong, Qiu, Xinghui. Degradation of aromatic compounds and degradative pathway of 4-nitrocatechol by Ochrobactrum sp B2. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING[J]. 2007, 42(14): 2111-2116, https://www.webofscience.com/wos/woscc/full-record/WOS:000251705600006.
[19] Qiu, Xinghui, Zhong, Qiuzan, Li, Mei, Bai, Wenqin, Li, Baotong. Biodegradation of p-nitrophenol by methyl parathion-degrading Ochrobactrum sp B2. INTERNATIONAL BIODETERIORATION & BIODEGRADATION[J]. 2007, 59(4): 297-301, http://dx.doi.org/10.1016/j.ibiod.2006.09.005.
[20] Qiu, X H, Bai, W Q, Zhong, Q Z, Li, M, He, F Q, Li, B T. Isolation and characterization of a bacterial strain of the genus Ochrobactrum with methyl parathion mineralizing activity. JOURNAL OF APPLIED MICROBIOLOGY[J]. 2006, 101(5): 986-994, https://www.webofscience.com/wos/woscc/full-record/WOS:000241199100002.
[21] 柏文琴, 李梅, 邱星辉, 何凤琴, 冷欣夫. 苍白杆菌B2对甲基对硫磷降解途径研究. 农药学学报[J]. 2004, 6(4): 48-54, http://lib.cqvip.com/Qikan/Article/Detail?id=11388174.
[22] 柏文琴, 何凤琴, 邱星辉. 有机磷农药生物降解研究进展. 应用与环境生物学报[J]. 2004, 10(5): 675-680, http://lib.cqvip.com/Qikan/Article/Detail?id=10852471.

科研活动

   
科研项目
( 1 ) 基于丝蛋白的功能材料的设计与合成, 主持, 省级, 2020-06--2023-05
( 2 ) 11家族木聚糖酶嗜碱分子机制研究, 主持, 国家级, 2015-01--2017-12

指导学生

现指导学生

高佳琪  博士研究生  071010-生物化学与分子生物学