基本信息
白硕  男  博导  中国科学院过程工程研究所
电子邮件: baishuo@ipe.ac.cn
通信地址: 北京市海淀区中关村北二街1号
邮政编码:

研究领域

研究方向主要包括:(1)小分子、高分子凝胶材料的设计和生物力学性能研究,以及对肿瘤细胞在三维受限空间内迁移机理的研究;(2)基于凝胶材料的仿生催化体系的设计和研究;(3)功能化凝胶材料(形状记忆型材料、光电材料等)的设计和应用,以及生物3D打印技术。现已在Adv.Mater.Angew.Chem. Int. Ed.ACS Nano等国际重要学术期刊发表SCI论文30余篇。在英国申请发明专利1项。


招生信息

   
招生专业
081703-生物化工
招生方向
生物化工,凝胶生物材料,3D生物打印

教育背景

2007-08--2010-11   德国马普学会胶体与界面研究所   博士
学历
博士研究生

学位
博士

工作经历

2015.06-至今

中国科学院过程工程研究所

研究员,教授,博导

2012.04-2015.03

英国斯特拉斯克莱德大学

助理研究员

2011.04-2012.03

瑞士阿道夫·梅克尔研究所

博士后


工作简历
2012-04~2015-03,英国斯特拉斯克莱德大学, 研究助理
2011-04~2012-03,瑞士阿道夫•梅克尔研究所, 博士后

专利与奖励

   
专利成果
[1] 白硕, 荆雅峰, 王安河. 一种搅拌系统装置、其使用方法及用途. CN: CN112892291A, 2021-06-04.

[2] 李靖涛, 白硕, 任朋, 赵洪川. 一种消化道粘膜下注射短肽水凝胶及其应用. CN: CN112006976A, 2020-12-01.

[3] 闫学海, 邢蕊蕊, 沈桂芝, 白硕. 一种二肽水凝胶、其制备方法及应用. CN: CN106333922B, 2020-08-11.

出版信息

   
发表论文
[1] Wang, Shengtao, Wang, Anhe, Ma, Yuqi, Han, Qingquan, Chen, Yang, Li, Xin, Wu, Songyuan, Li, Jieling, Bai, Shuo, Yin, Jian. In situ synthesis of superorganism-like Au NPs within microgels with ultra-wide absorption in visible and near-infrared regions for combined cancer therapy. BIOMATERIALS SCIENCE[J]. 2021, 9(3): 774-779, https://www.webofscience.com/wos/woscc/full-record/WOS:000616677300012.
[2] 白硕. Role of Thermolysin in Catalytic-Controlled Self-Assembly of Fmoc-Dipeptides. CCS Chemistry. 2020, [3] 白硕. In situ synthesis of superorganism-like Au NPs within microgels with ultra-wide absorption in visible and near-infrared regions for combined cancer therapy.. Biomater. Sci.. 2020, [4] Chen, Yang, Duan, Li, Ma, Yuqi, Han, Qingquan, Li, Xin, Li, Jieling, Wang, Anhe, Bai, Shuo, Yin, Jian. Preparation of transient electronic devices with silk fibroin film as a flexible substrate. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2020, 600: http://dx.doi.org/10.1016/j.colsurfa.2020.124896.
[5] Wang, Meiyue, Wang, Anhe, Li, Jieling, Li, Qi, Bai, Shuo. Thermolysin-triggered short peptides self-assembly in confined space and application in cell culturing. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2020, 603: http://dx.doi.org/10.1016/j.colsurfa.2020.125213.
[6] Qiu, Zhichao, Hu, Jing, Li, Ziwei, Yang, Xiaoxue, Hu, Jun, You, Qingjun, Bai, Shuo, Mao, Yong, Hua, Dong, Yin, Jian. Graphene oxide-based nanocomposite enabled highly efficient targeted synergistic therapy for colorectal cancer. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2020, 593: http://dx.doi.org/10.1016/j.colsurfa.2020.124585.
[7] Liu, Dongdong, Miao, Zhe, Wu, Chengling, He, Fangfei, Ren, Peng, Bai, Shuo, Jiang, Xingyu, Gao, Yuan. Isothermal kinase-triggered supramolecular assemblies as drug sensitizers. CHEMICAL SCIENCE[J]. 2020, 11(4): 1132-1139, https://www.webofscience.com/wos/woscc/full-record/WOS:000510929600022.
[8] Tian, Yajie, Li, Jieling, Zhao, Luyang, Zhang, Xianglan, Wang, Anhe, Jian, Honglei, Bai, Shuo, Yan, Xuehai. Peptide assembly assisted triplet-triplet annihilation photon upconversion in non-deoxygenated water. BIOMATERIALS SCIENCE[J]. 2020, 8(11): 3072-3077, https://www.webofscience.com/wos/woscc/full-record/WOS:000539368700005.
[9] Ren, Peng, Li, Jingtao, Zhao, Luyang, Wang, Anhe, Wang, Meiyue, Li, Jieling, Jian, Honglei, Li, Xiaoou, Yan, Xuehai, Bai, Shuo. Dipeptide Self-assembled Hydrogels with Shear-Thinning and Instantaneous Self-healing Properties Determined by Peptide Sequences. ACS APPLIED MATERIALS & INTERFACES[J]. 2020, 12(19): 21433-21440, https://www.webofscience.com/wos/woscc/full-record/WOS:000535246100026.
[10] Ma, Yuqi, Wang, Anhe, Li, Jieling, Li, Qi, Han, Qingquan, Chen, Yang, Wang, Shengtao, Zheng, Xuefang, Cao, Hongyu, Bai, Shuo. Preparation of hydroxyapatite with high surface area and dispersity templated on calcium carbonate in dipeptide hydrogels. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2020, 596: http://dx.doi.org/10.1016/j.colsurfa.2020.124740.
[11] Wei, Peng, Ye, Zhou, Cao, Shuya, Bai, Shuo, Seeberger, Peter H, Yin, Jian, Hu, Jing. Combination therapy with amphotericin B and doxorubicin encapsulated in mannosylated nanomicelles for visceral leishmaniasis. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2020, 598: http://dx.doi.org/10.1016/j.colsurfa.2020.124804.
[12] Ye, Zhou, Hua, Dong, Rao, Yijian, Bai, Shuo, Seeberger, Peter H, Yin, Jian, Hu, Jing. Targeted photodynamic therapy with a novel photosensitizer cercosporin encapsulated multifunctional copolymer. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2020, 585: http://dx.doi.org/10.1016/j.colsurfa.2019.124136.
[13] Feng, Lu, Ren, Peng, Hao, Linna, Dong, Qianqian, Li, Jieling, Jian, Honglei, Wang, Meiyue, Li, Xin, Wang, Anhe, Bai, Shuo. Fabrication of short peptide cages by interfacial self-assembly on CaCO3 templates. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2019, 573: 22-29, http://ir.ipe.ac.cn/handle/122111/28135.
[14] Jian, Honglei, Wang, Meiyue, Dong, Qjanqian, Li, Jieling, Wang, Anhe, Li, Xin, Ren, Peng, Bai, Shuo. Dipeptide Self-Assembled Hydrogels with Tunable Mechanical Properties and Degradability for 3D Bioprinting. ACS APPLIED MATERIALS & INTERFACES[J]. 2019, 11(50): 46419-46426, [15] Li, Jieling, Wang, Anhe, Ren, Peng, Yan, Xuehai, Bai, Shuo. One-step co-assembly method to fabricate photosensitive peptide nanoparticles for two-photon photodynamic therapy. CHEMICAL COMMUNICATIONS[J]. 2019, 55(22): 3191-3194, http://ir.ipe.ac.cn/handle/122111/28282.
[16] Wang, Anhe, Li, Jieling, Dong, Qianqian, Wang, Shengtao, Jian, Honglei, Wang, Meiyue, Ren, Peng, Bai, Shuo. Preparation of Microgels with Ultrahigh Payload of Various Hydrophilic and Hydrophobic Inorganic Nanoparticle Composites up to 92 wt %. ACS APPLIED MATERIALS & INTERFACES[J]. 2019, 11(4): 4408-4415, http://ir.ipe.ac.cn/handle/122111/27843.
[17] Han, Qingquan, Chen, Yang, Song, Wei, Zhang, Milin, Wang, Shengtao, Ren, Peng, Hao, Linna, Wang, Anhe, Bai, Shuo, Yin, Jian. Fabrication of agarose hydrogel with patterned silver nanowires for motion sensor. BIO-DESIGN AND MANUFACTURING[J]. 2019, 2(4): 269-277, http://lib.cqvip.com/Qikan/Article/Detail?id=7100684599.
[18] Wang, Shengtao, Li, Jingtao, Ye, Zhou, Li, Jieling, Wang, Anhe, Hu, Jing, Bai, Shuo, Yin, Jian. Self-assembly of photosensitive and chemotherapeutic drugs for combined photodynamic-chemo cancer therapy with real-time tracing property. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2019, 574: 44-51, https://www.webofscience.com/wos/woscc/full-record/WOS:000471654700006.
[19] Duan, Li, Qin, ChenChen, Wang, Anhe, Wang, Shengtao, Li, Jieling, Bai, Shuo. Gelatin microgels with various nano-objects fabricated by "casting" strategy and application as a catalytic system. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2019, 580: http://dx.doi.org/10.1016/j.colsurfa.2019.123759.
[20] Wang, Di, Wang, Meiyue, Wang, Anhe, Li, Jieling, Li, Xin, Jian, Honglei, Bai, Shuo, Yin, Jian. Preparation of collagen/chitosan microspheres for 3D macrophage proliferation in vitro. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2019, 572: 266-273, http://ir.ipe.ac.cn/handle/122111/28146.
[21] Li, Jieling, Xing, Ruirui, Bai, Shuo, Yan, Xuehai. Recent advances of self-assembling peptide-based hydrogels for biomedical applications. SOFT MATTERnull. 2019, 15(8): 1704-1715, http://ir.ipe.ac.cn/handle/122111/27973.
[22] Song, Wei, Wang, Anhe, Chen, Yang, Bai, Shuo, Han, Qingquan, Lin, Zhonghang, Yan, Nan, Luo, Deng, Liao, Yiqiao, Zhang, Milin, Wang, Zhihua, Xie, Xiang. Design of a Flexible Wearable Smart sEMG Recorder Integrated Gradient Boosting Decision Tree Based Hand Gesture Recognition. IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS[J]. 2019, 13(6): 1563-1574, [23] Li, Jieling, Wang, Anhe, Zhao, Luyang, Dong, Qianqian, Wang, Meiyue, Xu, Haolan, Yan, Xuehai, Bai, Shuo. Self-Assembly of Monomeric Hydrophobic Photosensitizers with Short Peptides Forming Photodynamic Nanoparticles with Real-Time Tracking Property and without the Need of Release in Vivo. ACS APPLIED MATERIALS & INTERFACES[J]. 2018, 10(34): 28420-28427, http://www.irgrid.ac.cn/handle/1471x/1764420.
[24] Feng, Lu, Wang, Anhe, Ren, Peng, Wang, Meiyue, Dong, Qianqian, Li, Jieling, Bai, Shuo. Self-Assembled Peptide Hydrogel With Porphyrin as a Dopant for Enhanced Photocurrent Generation. COLLOID AND INTERFACE SCIENCE COMMUNICATIONS[J]. 2018, 23: 29-33, http://dx.doi.org/10.1016/j.colcom.2018.01.006.
[25] Jian, Honglei, Wang, Meiyue, Wang, Shengtao, Wang, Anhe, Bai, Shuo. 3D bioprinting for cell culture and tissue fabrication. BIO-DESIGN AND MANUFACTURINGnull. 2018, 1(1): 45-61, http://lib.cqvip.com/Qikan/Article/Detail?id=676543906.
[26] Cui, Lingyun, Jiao, Yang, Wang, Anhe, Zhao, Luyang, Dong, Qianqian, Yan, Xuehai, Bai, Shuo. Regulating morphologies and near-infrared photothermal conversion of perylene bisimide via sequence-dependent peptide self-assembly. CHEMICAL COMMUNICATIONS[J]. 2018, 54(18): 2208-2211, https://www.webofscience.com/wos/woscc/full-record/WOS:000426701900004.
[27] Wang, Anhe, Cui, Lingyun, Debnath, Sisir, Dong, Qianqian, Yan, Xuehai, Zhang, Xi, Ulijn, Rein V, Bai, Shuo. Tuning Supramolecular Structure and Functions of Peptide bola-Amphiphile by Solvent Evaporation-Dissolution. ACS APPLIED MATERIALS & INTERFACES[J]. 2017, 9(25): 21390-21396, http://ir.ipe.ac.cn/handle/122111/22800.
[28] Dong, Qianqian, Li, Jieling, Cui, Lingyun, Jian, Honglei, Wang, Anhe, Bai, Shuo. Using porous CaCO3/hyaluronic acid nanocages to accommodate hydrophobic photosensitizer in aqueous media for photodynamic therapy. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2017, 516: 190-198, http://dx.doi.org/10.1016/j.colsurfa.2016.12.027.
[29] Wang, Anhe, Yang, Yang, Yan, Xuehai, Ma, Guanghui, Bai, Shuo, Li, Junbai. Preparation of multicompartment silica-gelatin nanoparticles with self-decomposability as drug containers for cancer therapy in vitro. RSC ADVANCES[J]. 2016, 6(74): 70064-70071, http://ir.iccas.ac.cn/handle/121111/35391.
[30] Wang, Juan, Liu, Kai, Yan, Linyin, Wang, Anhe, Bai, Shuo, Yan, Xuehai. Trace Solvent as a Predominant Factor To Tune Dipeptide Self-Assembly. ACS NANO[J]. 2016, 10(2): 2138-2143, http://www.irgrid.ac.cn/handle/1471x/1048129.
[31] 白硕. 寡肽分子凝胶在微/纳米受限空间内自组装的调控. 中国化学会第30届学术年会摘要集-第二十四分会:超分子组装与软物质材料null. 2016, 2-, http://ir.ipe.ac.cn/handle/122111/25320.
[32] Li, Yongxin, Yan, Linyin, Liu, Kai, Wang, Juan, Wang, Anhe, Bai, Shuo, Yan, Xuehai. Solvothermally Mediated Self-Assembly of Ultralong Peptide Nanobelts Capable of Optical Waveguiding. SMALL[J]. 2016, 12(19): 2575-2579, http://ir.ipe.ac.cn/handle/122111/21174.
[33] Pappas, Charalampos G, Frederix, Pim W J M, Mutasa, Tapiwa, Fleming, Scott, AbulHaija, Yousef M, Kelly, Sharon M, Gachagan, Anthony, Kalafatovic, Daniela, Trevino, Jacob, Ulijn, Rein V, Bai, Shuo. Alignment of nanostructured tripeptide gels by directional ultrasonication. CHEMICAL COMMUNICATIONS[J]. 2015, 51(40): 8465-8468, https://www.webofscience.com/wos/woscc/full-record/WOS:000354043200017.
[34] Bai, Shuo, Zou, Hua, Dietsch, Herve, Simon, Yoan C, Weder, Christoph. Functional Iron Oxide Nanoparticles as Reversible Crosslinks for Magnetically Addressable Shape-Memory Polymers. MACROMOLECULAR CHEMISTRY AND PHYSICS[J]. 2014, 215(5): 398-404, https://www.webofscience.com/wos/woscc/full-record/WOS:000332337600001.
[35] Bai, Shuo, Pappas, Charalampos, Debnath, Sisir, Frederix, Pim W J M, Leckie, Joy, Fleming, Scott, Ulijn, Rein V. Stable Emulsions Formed by Self-Assembly of Interfacial Networks of Dipeptide Derivatives. ACS NANO[J]. 2014, 8(7): 7005-7013, https://www.webofscience.com/wos/woscc/full-record/WOS:000339463100056.
[36] Bai, Shuo, Debnath, Sisir, Javid, Nadeem, Frederix, Pim W J M, Fleming, Scott, Pappas, Charalampos, Ulijn, Rein V. Differential Self-Assembly and Tunable Emission of Aromatic Peptide Bola-Amphiphiles Containing Perylene Bisimide in Polar Solvents Including Water. LANGMUIR[J]. 2014, 30(25): 7576-7584, https://www.webofscience.com/wos/woscc/full-record/WOS:000338488600037.
[37] Bai, Shuo, Debnath, Sisir, Gibson, Kirsty, Schlicht, Barbara, Bayne, Lauren, Zagnoni, Michele, Ulijn, Rein V. Biocatalytic Self-Assembly of Nanostructured Peptide Microparticles using Droplet Microfluidics. SMALL[J]. 2014, 10(2): 285-293, https://www.webofscience.com/wos/woscc/full-record/WOS:000331112100009.
[38] Scott, Gary, Roy, Sangita, AbulHaija, Yousef M, Fleming, Scott, Bai, Shuo, Ulijn, Rein V. Pickering Stabilized Peptide Gel Particles as Tunable Microenvironments for Biocatalysis. LANGMUIR[J]. 2013, 29(46): 14321-14327, http://dx.doi.org/10.1021/la403448s.
[39] Wu, Changzhu, Bai, Shuo, AnsorgeSchumacher, Marion B, Wang, Dayang. Nanoparticle Cages for Enzyme Catalysis in Organic Media. ADVANCED MATERIALS[J]. 2011, 23(47): 5694-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000297788600017.
[40] Bai, Shuo, Wu, Changzhu, Gawlitza, Kornelia, von Klitzing, Regine, AnsorgeSchumacher, Marion B, Wang, Dayang. Using Hydrogel Microparticles To Transfer Hydrophilic Nanoparticles and Enzymes to Organic Media via Stepwise Solvent Exchange. LANGMUIR[J]. 2010, 26(15): 12980-12987, http://dx.doi.org/10.1021/la102042m.
[41] Bai, Shuo, Nguyen, TichLam, Mulvaney, Paul, Wang, Dayang. Using Hydrogels to Accommodate Hydrophobic Nanoparticles in Aqueous Media via Solvent Exchange. ADVANCED MATERIALS[J]. 2010, 22(30): 3247-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000281328500003.
[42] 白硕. 短肽自组装水凝胶的设计、调控与生物应用. 中国化学会2017全国高分子学术论文报告会摘要集——主题J:高分子组装与超分子体系null. 2-, http://ir.ipe.ac.cn/handle/122111/25281.

科研活动

   
科研项目
( 1 ) 3D打印寡肽分子自组装水凝胶:基于分子结构设计、自组装机理和凝胶性能调控的研究, 主持, 国家级, 2017-01--2017-12
( 2 ) 基于肽小分子自组装凝胶的分子设计、性能调控和3D生物打印, 主持, 国家级, 2018-01--2021-12
( 3 ) 基于3D生物打印干细胞诱导分化与肝组织体外构建的研究, 主持, 部委级, 2018-08--2022-12
( 4 ) 干细胞微载体培养工艺和规模化制备设备的研究, 主持, 国家级, 2020-10--2024-12

指导学生

已指导学生

王眉月  博士研究生  081703-生物化工  

现指导学生

李欣  博士研究生  081703-生物化工  

任朋  博士研究生  081703-生物化工  

郭圣楠  硕士研究生  085238-生物工程  

韩青权  博士研究生  081703-生物化工  

薛妍  博士研究生  081703-生物化工