Minghai Chen is an Associate Professor in Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences. Dr. Chen received his B.Sc. degree in Biotechnology from Henan University. He obtained a Ph.D. in Microbiology from the Wuhan Institute of Virology, Chinese Academy of Sciences. He obtained his postdoctoral training at University of Virginia. His current research interest focuses on virus-host interaction, fluorescence imaging, biomolecular interaction.
07/2012 B.S. Biotechnology Henan University, China.
07/2017 Ph.D Microbiology Wuhan Institute of Virology, Chinese Academy of Sciences.
2017/09-2019/07：Postdoctoral Fellow, University of Virginia, USA.
2019/07-now：Associate Professor, Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences.
(1) Minghai Chen#, Shen Zhang#, Yuan Xing, Xinyu Li, Yi He, Yong Wang, José Oberholzer, and Hui-wang Ai*. Genetically Encoded, Photostable Indicators to Image Dynamic Zn2+ Secretion of Pancreatic Islets. Analytical Chemistry, 2019, 91(19):12212-12219.
(2) Hsien-Wei Yeh, Ying Xiong, Tianchen Wu, Minghai Chen, Ao Ji and Hui-wang Ai*. ATP-independent bioluminescent reporter variants to improve in vivo imaging. ACS Chemical Biology, 2019,14(5):959-965.
(3) Hsien-Wei Yeh, Tianchen Wu, Minghai Chen, and Hui-wang Ai*. Identification of Factors Complicating Bioluminescence Imaging. Biochemistry, 2019,58 (12):1689-1697.
(4) Minghai Chen#, Wei Li#, Zhi-Ping Zhang, Jingdi Pan, Yuhan Sun, Xiaowei Zhang, Xian-En Zhang and Zongqiang Cui*. Three-Fragment Fluorescence Complementation for Imaging of Ternary Complexes under Physiological Conditions. Analytical Chemistry, 2018,90:13299-13305.
(5) Minghai Chen#, Sanying Liu#, Wei Li, Zhi-Ping Zhang, Xiaowei Zhang, Xian-En Zhang* and Zongqiang Cui*. Three-Fragment Fluorescence Complementation Coupled with Photoactivated Localization Microscopy for Nanoscale Imaging of Ternary Complexes. ACS Nano, 2016,10(9):8482-90.
(6) Siting Li, Minghai Chen, Qian Xiong, Jia Zhang, Zongqiang Cui*, and Feng Ge*; Characterization of the translationally controlled tumor protein (TCTP) interactome reveals novel binding partners in human cancer cells. Journal of Proteome Research, 2016, 15(10):3741-3751.
(7) Minghai Chen, Wei Li, Zhiping Zhang, Sanying Liu, Xiaowei Zhang, Xian-En Zhang*, Zongqiang Cui*. Novel near-infrared BiFC systems from a bacterial phytochrome for imaging protein interactions and drug evaluation under physiological conditions. Biomaterials, 2015, 48:97-107.
biomolecular interaction, fluorescence imaging, biosensors, virus-host interaction