基本信息
陈明海  男  硕导  中国科学院深圳先进技术研究院
电子邮件: mh.chen1@siat.ac.cn
通信地址: 深圳市南山区西丽深圳大学城学苑大道1068号
邮政编码:

研究领域

生物分子相互作用,荧光成像,生物传感,病毒与宿主相互作用

招生信息

招生专业
071010-生物化学与分子生物学
071005-微生物学
招生方向
生物传感
病原-宿主相互作用
分子影像

教育背景

2012-09--2017-07   中国科学院武汉病毒研究所   博士
2008-09--2012-07   河南大学   学士

工作经历


工作简历
2019-07~现在, 中国科学院深圳先进技术研究院, 副研究员
2017-09~2019-07,弗吉尼亚大学, 博士后

专利与奖励

   
奖励信息
(1) 中国科学院优秀博士学位论文, 院级, 2018
(2) 中国科学院院长奖, 院级, 2017
(3) 中国科学院优秀毕业生, 院级, 2017
(4) 国家奖学金, 院级, 2016
(5) 国家奖学金, 院级, 2015
专利成果
[1] 陈明海, 张先恩, 严闯. 串联片段荧光互补系统及其构建方法及应用. CN: CN112592936A, 2021-04-02.

出版信息

   
发表论文
[1] Ma, Yingxin, Mao, Guobin, Wu, Guoqiang, Chen, Minghai, Qin, Fujun, Zheng, Luping, Zhang, XianEn. Dual-Fluorescence Labeling Pseudovirus for Real-Time Imaging of Single SARS-CoV-2 Entry in Respiratory Epithelial Cells. ACS APPLIED MATERIALS & INTERFACES[J]. 2021, 13(21): 24477-24486, http://dx.doi.org/10.1021/acsami.1c03897.
[2] Chen, Minghai, Zhang, XianEn. Construction and applications of SARS-CoV-2 pseudoviruses: a mini review. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCESnull. 2021, 17(6): 1574-1580, http://dx.doi.org/10.7150/ijbs.59184.
[3] Chen, Minghai, Yan, Chuang, Ma, Yingxin, Zhang, XianEn. A tandem near-infrared fluorescence complementation system with enhanced fluorescence for imaging protein-protein interactions in vivo. BIOMATERIALS[J]. 2021, 268: http://dx.doi.org/10.1016/j.biomaterials.2020.120544.
[4] Chen, Minghai, Li, Siting, Li, Wei, Zhang, ZhiPing, Zhang, Xiaowei, Zhang, XianEn, Ge, Feng, Cui, Zongqiang. Nanoscale Imaging of RNA-Protein Interactions with a Photoactivatable Trimolecular Fluorescence Complementation System. ACS CHEMICAL BIOLOGY[J]. 2021, 16(6): 1003-1010, http://dx.doi.org/10.1021/acschembio.0c00945.
[5] Chen, Minghai, Zhang, Shen, Xing, Yuan, Li, Xinyu, He, Yi, Wang, Yong, Oberholzer, Jose, Ai, Huiwang. Genetically Encoded, Photostable Indicators to Image Dynamic Zn2+ Secretion of Pancreatic Islets. ANALYTICAL CHEMISTRY[J]. 2019, 91(19): 12212-12219, https://www.webofscience.com/wos/woscc/full-record/WOS:000488993000065.
[6] Yeh, HsienWei, Xiong, Ying, Wu, Tianchen, Chen, Minghai, Ji, Ao, Li, Xinyu, Ai, Huiwang. ATP-Independent Bioluminescent Reporter Variants To Improve in Vivo Imaging. ACS CHEMICAL BIOLOGY[J]. 2019, 14(5): 959-965, https://www.webofscience.com/wos/woscc/full-record/WOS:000468696600015.
[7] Yeh, HsienWei, Wu, Tianchen, Chen, Minghai, Ai, Huiwang. Identification of Factors Complicating Bioluminescence Imaging. BIOCHEMISTRY[J]. 2019, 58(12): 1689-1697, [8] Chen, Minghai, Li, Wei, Zhang, ZhiPing, Pan, Jingdi, Sun, Yuhan, Zhang, Xiaowei, Zhang, XianEn, Cui, Zongqiang. Three-Fragment Fluorescence Complementation for Imaging of Ternary Complexes under Physiological Conditions. ANALYTICAL CHEMISTRY[J]. 2018, 90(22): 13299-13305, http://www.corc.org.cn/handle/1471x/2373219.
[9] Chen, Minghai, Liu, Sanying, Li, Wei, Zhang, Zhiping, Zhang, Xiaowei, Zhang, XianEn, Cui, Zongqiang. Three-Fragment Fluorescence Complementation Coupled with Photoactivated Localization Microscopy for Nanoscale Imaging of Ternary Complexes. ACS NANO[J]. 2016, 10(9): 8482-8490, http://www.corc.org.cn/handle/1471x/2375027.
[10] Li, Siting, Chen, Minghai, Xiong, Qian, Zhang, Jia, Cui, Zongqiang, Ge, Feng. Characterization of the Translationally Controlled Tumor Protein (TCTP) Interactome Reveals Novel Binding Partners in Human Cancer Cells. JOURNAL OF PROTEOME RESEARCH[J]. 2016, 15(10): 3741-3751, https://www.webofscience.com/wos/woscc/full-record/WOS:000385054100026.
[11] Chen, Minghai, Li, Wei, Zhang, Zhiping, Liu, Sanying, Zhang, Xiaowei, Zhang, XianEn, Cui, Zongqiang. Novel near-infrared BiFC systems from a bacterial phytochrome for imaging protein interactions and drug evaluation under physiological conditions. BIOMATERIALS[J]. 2015, 48: 97-107, http://dx.doi.org/10.1016/j.biomaterials.2015.01.038.

科研活动

   
科研项目
( 1 ) 单颗粒示踪技术研究病毒侵染过程与机制, 参与, 部委级, 2017-05--2021-12
( 2 ) 新型近红外蛋白片段互补系统用于活体内蛋白质相互作用研究, 主持, 省级, 2021-01--2023-12
( 3 ) 中国科协“青年人才托举工程”, 主持, 研究所(学校), 2021-01--2023-12
参与会议
(1)Novel near-infrared BiFC systems from a bacterial phytochrome for imaging protein interactions and drug evaluation under physiological conditions   首届全国病毒学青年学者学术研讨会   2014-09-24