Zhao, Guoping
Academician of Chinese Academy of Sciences, professor

Institute of Plant Physiology and Ecology

Research Areas

Based on Genomics, functional genomics and comparative genomics information, special metabolic processes of microorganisms and the related genetic and biochemical/physiological molecular mechanisms of regulation under different environmental conditions are systematically studied. Metabolic regulation models are being developed based on the knowledge of characterizing signal transduction systems and transcription factors with respect to gene transcription, protein structure and function modification and interaction, as well as the biological small molecules.


1983-08--1990-12   Department of Biochemistry, Purdue University, USA, PHD
1978-10--1982-07   Department of Biology, Fudan University, China, Bachelor​


Work Experience

2002-02~present,  Shanghai National Engineering Research Center for Biochip, researcher, director
2002-02~present, National Southern Research Center for Human Genome, Researcher, Executive Director
2002-02~present, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China,Professor
1999-07~2002-02, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China,Professor, PI, vice president
1997-01~1999-07, Shanghai Biological Engineering Research Center, Chinese Academy of Sciences, Professor, PI
1994-12~1997-01, Shanghai Institute of Plant Physiology and Ecology, , Chinese Academy of Sciences, China, Professor, PI,
1992-11~1994-12, Promega, Shanghai , deputy researcher, production manager
1990-12~1992-11,  Department of Biology, Department of Biochemistry, Purdue University , visiting lecturer, postdoctoral



(1) GlnR-Mediated Regulation of ectABCD Transcription Expands the Role of the GlnR Regulon to Osmotic Stress Management, Journal of Bacteriology, 2015
(2) A Preliminary Study of the Mechanism of Nitrate-Stimulated Remarkable Increase of Rifamycin Production in Amycolatopsis mediterranei U32 by RNA-seq, Microbial Cell Factories, 2015
(3) Precise Characterization of GlnR Box in Actinomycetes, Biochem Biophys Res Commun, 2015
(4) Subdomain II of alpha-Isopropylmalate Synthase Is Essential for Activity Inferring A Mechanism of Feedback Inhibition, Journal of Biological Chemistry, 2014
(5) Atypical OmpR/PhoB Subfamily Response Regulator GlnR of Actinomycetes Functions as a Homodimer, Stabilized by the Unphosphorylated Conserved Asp-focused Charge Interactions, Journal of Biological Chemistry, 2014, 
(6) GlnR Negatively Regulates the Transcription of the Alanine Dehydrogenase Encoding Gene ald in Amycolatopsis mediterranei U32 under Nitrogen Limited Conditions via Specific Binding to Its Major Transcription Initiation Site, PloS One, 2014, 
(7) Mycobacterial MazG Safeguards Genetic Stability via Housecleaning of 5-OH-dCTP, PLoS Pathgens, 2013
(8) Three of Four GlnR Binding Sites Are Essential for GlnR-Mediated Activation of Transcription of the Amycolatopsis mediterranei nas Operon, Journal of Bacteriology, 2013
(9) The MASTER (Methylation-Assisted Tailorable Ends Rational) Ligation Method for Seamless DNA Assembly, Nucleic Acids Research, 2013​


Songcheng Z​HU

Qiaoli LI

Wei MA

Hao YU

Mingxuan XU

Qing Zhang

Jun MA

Xiang MAO

Zhihui SHAO 

Ying ZOU

Ling YANG 

Xiaodong SHANG


Nanqiu PENG

Yunyi Zhang  



Zilong ZHANG 

Hua YUAN  



Xufeng CEN  

Xiaobiao HAN 


Honors & Distinctions

(1) Tan Jiazhen Life Science Award, , 2015
(2) International Genetic Engineering Machinery Competition (2011 Hong Kong) Gold Award, first prize,  2011
(3) University of Natural Science Award (biology) - biological experimental technology first prize, first prize, Institute (school), 2010
(4) Shanghai Natural Science Award Second Prize, provincial, 2008
(5) Shanghai Natural Science Award first prize, provincial, 2006
(6)  He-Liang-He-Li Award for Science and Technology , 2005
(7) Guangdong Science and Technology Progress Award, the provincial, 2004
(8) Shanghai Science and Technology Progress Award, provincial, 2004
(9) National Science and Technology Progress Award, the national level, 2002
(10) Shanghai Science and Technology Progress Award, provincial, 2002
(11) Shanghai Science and Technology Progress Award, provincial, 2001