071005-微生物学

放线菌氮代谢调控
合成生物学
微生物功能基因组学

1983-08--1990-12   美国普度大学生物化学系   博士
1978-10--1982-07   复旦大学生物系   学士

   

2002-02~现在, 生物芯片上海国家工程研究中心, 研究员、主任
2002-02~现在, 国家人类基因组南方研究中心, 研究员、执行主任
2002-02~现在, 中国科学院上海生命科学研究院植物生理生态研究所, 研究员、博导
1999-07~2002-02,中国科学院上海生命科学研究院, 研究员、研究组长、博导、副院长
1997-01~1999-07,中国科学院上海生物工程研究中心, 研究员、室主任、博导、主任
1994-12~1997-01,中国科学院上海植物生理研究所, 研究员、室主任、博导、副所长
1992-11~1994-12,上海普洛麦格生物产品有限公司, 副研究员、生产经理
1990-12~1992-11,美国普度大学生物系、生物化学系, 访问讲师、博士后

2004-03-01-今,复旦大学生命学院微生物与微生物工程系, 主任
2002-02-01-今,国家人类基因组南方研究中心, 执行主任
2001-07-01-今,生物芯片上海国家工程研究中心, 主任

   

（1） 谈家桢生命科学奖, 其他, 2015
（2） 国际基因工程机械比赛（2011年香港）金奖, 一等奖, 其他, 2011
（3） 高校自然科学奖(生物类)-生物实验技术一等奖, 一等奖, 研究所（学校）, 2010
（4） 上海市自然科学奖二等奖, 省级, 2008
（5） 上海市自然科学奖一等奖, 省级, 2006
（6） 何梁何利科学与技术奖, 其他, 2005
（7） 广东科技进步特别奖, 省级, 2004
（8） 上海科技进步二等奖, 省级, 2004
（9） 国家科技进步二等奖, 国家级, 2002
（10） 上海科技进步一等奖, 省级, 2002
（11） 上海科技进步二等奖, 省级, 2001

（ 1 ） 一种生产高活性和高纯度利福霉素SV 的方法, 发明, 2010, 第 1 作者, 专利号: 201010205439.X

   

[1] Tan, Wei, Liao, TianHua, Wang, Jin, Ye, Yu, Wei, YuChen, Zhou, HaoKui, Xiao, Youli, Zhi, XiaoYang, Shao, ZhiHui, Lyu, LiangDong, Zhao, GuoPing. A recently evolved diflavin-containing monomeric nitrate reductase is responsible for highly efficient bacterial nitrate assimilation. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2020, 第 11 作者  通讯作者  295(15): 5051-5066, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152768/.
[2] Shen, Laichuan, Xia, Jing, Zhang, Xichao, Ezawa, Motohiko, Tretiakov, Oleg A, Liu, Xiaoxi, Zhao, Guoping, Zhou, Yan. Current-Induced Dynamics and Chaos of Antiferromagnetic Bimerons. PHYSICAL REVIEW LETTERS[J]. 2020, 第 7 作者  通讯作者  124(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000509506300008.
[3] Yang, FangWei, Zhao, GuoPing, Ren, FaZheng, Pang, GuoFang, Li, YiXuan. Assessment of the endocrine-disrupting effects of diethyl phosphate, a nonspecific metabolite of organophosphorus pesticides, by in vivo and in silico approaches. ENVIRONMENT INTERNATIONAL[J]. 2020, 第 2 作者135: http://dx.doi.org/10.1016/j.envint.2019.105383.
[4] Zhang, Xiaonan, Tan, Yun, Ling, Yun, Lu, Gang, Liu, Feng, Yi, Zhigang, Jia, Xiaofang, Wu, Min, Shi, Bisheng, Xu, Shuibao, Chen, Jun, Wang, Wei, Chen, Bing, Jiang, Lu, Yu, Shuting, Lu, Jing, Wang, Jinzeng, Xu, Mingzhu, Yuan, Zhenghong, Zhang, Qin, Zhang, Xinxin, Zhao, Guoping, Wang, Shengyue, Chen, Saijuan, Lu, Hongzhou. Viral and host factors related to the clinical outcome of COVID-19. NATURE[J]. 2020, 第 22 作者583(7816): 437-+, http://dx.doi.org/10.1038/s41586-020-2355-0.
[5] Yang, Chengshuai, Li, Chaojing, Wei, Wei, Wei, Yongjun, Liu, Qunfang, Zhao, Guoping, Yue, Jianmin, Yan, Xing, Wang, Pingping, Zhou, Zhihua. The unprecedented diversity of UGT94-family UDP-glycosyltransferases in Panax plants and their contribution to ginsenoside biosynthesis. SCIENTIFIC REPORTS[J]. 2020, 第 6 作者10(1): https://doaj.org/article/f27d539fce584e50bb219a9d886a7d9d.
[6] Li, Peng, Zhang, Hong, Zhao, GuoPing, Zhao, Wei. Deacetylation enhances ParB-DNA interactions affecting chromosome segregation in Streptomyces coelicolor. NUCLEIC ACIDS RESEARCH[J]. 2020, 第 3 作者  通讯作者  48(9): 4902-4914, https://www.webofscience.com/wos/woscc/full-record/WOS:000573914600028.
[7] Liao, Tianhua, Wei, Yuchen, Luo, Mingjing, Zhao, GuoPing, Zhou, Haokui. tmap: an integrative framework based on topological data analysis for population-scale microbiome stratification and association studies. GENOME BIOLOGY[J]. 2019, 第 4 作者  通讯作者  20(1): http://dx.doi.org/10.1186/s13059-019-1871-4.
[8] Juncao Xu, Kaijie Cui, Liqiang Shen, Jing Shi, Lingting Li, Linlin You, Chengli Fang, Guoping Zhao, Yu Feng, Bei Yang, Yu Zhang. Crl activates transcription by stabilizing active conformation of the master stress transcription initiation factor. ELIFE[J]. 2019, 第 8 作者  通讯作者  8: https://doaj.org/article/7d66de756fe24a4bb02c35d7ddf80c6d.
[9] Li, Ning, Yang, Junjie, Zhang, Jiaming, Liang, Cheng, Wang, Ying, Chen, Bin, Zhao, Changying, Wang, Jingwen, Zhang, Guangye, Zhao, Dongmei, Liu, Yi, Zhang, Lehai, Yang, Jun, Li, Guimei, Gai, Zhongtao, Zhang, Lei, Zhao, Guoping. Correlation of Gut Microbiome Between ASD Children and Mothers and Potential Biomarkers for Risk Assessment. GENOMICS PROTEOMICS & BIOINFORMATICS[J]. 2019, 第 17 作者17(1): 26-38, http://lib.cqvip.com/Qikan/Article/Detail?id=7002172761.
[10] Shao, Yangyang, Lu, Ning, Cai, Chen, Zhou, Fan, Wang, Shanshan, Zhao, Zhihu, Zhao, Guoping, Zhou, JinQiu, Xue, Xiaoli, Qin, Zhongjun. A single circular chromosome yeast. CELL RESEARCH. 2019, 第 7 作者  通讯作者  29(1): 87-89, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6420106&detailType=1.
[11] Feifei Qi, Chao Lei, Fengwei Li, Xingwang Zhang, Jin Wang, Wei Zhang, Zhen Fan, Weichao Li, GongLi Tang, Youli Xiao, Guoping Zhao, Shengying Li. Deciphering the late steps of rifamycin biosynthesis. NATURE COMMUNICATIONS[J]. 2018, 第 11 作者9(1): http://www.irgrid.ac.cn/handle/1471x/1782302.
[12] Zhang, Hao, Liu, Yujie, Nie, Xiaoqun, Liu, Lixia, Hua, Qiang, Zhao, GuoPing, Yang, Chen. The cyanobacterial ornithine-ammonia cycle involves an arginine dihydrolase. NATURE CHEMICAL BIOLOGY[J]. 2018, 第 6 作者14(6): 575-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000435445100014.
[13] Li, ShiYuan, Cheng, QiuXiang, Liu, JiaKun, Nie, XiaoQun, Zhao, GuoPing, Wang, Jin. CRISPR-Cas12a has both cis- and trans-cleavage activities on single-stranded DNA. CELL RESEARCH[J]. 2018, 第 5 作者28(4): 491-493, http://lib.cqvip.com/Qikan/Article/Detail?id=675620514.
[14] Li, Chen, Liu, Xinqiang, Lei, Chao, Yan, Han, Shao, Zhihui, Wang, Ying, Zhao, Guoping, Wang, Jin, Ding, Xiaoming. RifZ(AMED_0655) Is a Pathway-Specific Regulator for Rifamycin Biosynthesis in Amycolatopsis mediterranei. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2017, 第 7 作者83(8): https://www.webofscience.com/wos/woscc/full-record/WOS:000398771200010.
[15] Lei, Chao, Li, ShiYuan, Liu, JiaKun, Zheng, Xuan, Zhao, GuoPing, Wang, Jin. The CCTL (Cpf1-assisted Cutting and Taq DNA ligase-assisted Ligation) method for efficient editing of large DNA constructs in vitro. NUCLEIC ACIDS RESEARCH[J]. 2017, 第 5 作者45(9): e74-e74, 
[16] Han, Xiaobiao, Shen, Liqiang, Wang, Qijun, Cen, Xufeng, Wang, Jin, Wu, Meng, Li, Peng, Zhao, Wei, Zhang, Yu, Zhao, Guoping. Cyclic AMP Inhibits the Activity and Promotes the Acetylation of Acetyl-CoA Synthetase through Competitive Binding to the ATP/AMP Pocket. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2017, 第 10 作者  通讯作者  292(4): 1374-1384, http://dx.doi.org/10.1074/jbc.M116.753640.
[17] Shao, ZhiHui, Deng, WanXin, Li, ShiYuan, He, JuanMei, Ren, ShuangXi, Huang, WeiRen, Lu, YinHua, Zhao, GuoPing, Cai, ZhiMing, Wang, Jin. GlnR-Mediated Regulation of ectABCD Transcription Expands the Role of the GlnR Regulon to Osmotic Stress Management. JOURNAL OF BACTERIOLOGY[J]. 2015, 第 8 作者197(19): 3041-3047, https://www.webofscience.com/wos/woscc/full-record/WOS:000360713300002.
[18] Shao, Zhi Hui, Ren, Shuang Xi, Liu, Xin Qiang, Xu, Jian, Yan, Han, Zhao, Guo Ping, Wang, Jin. A preliminary study of the mechanism of nitrate-stimulated remarkable increase of rifamycin production in Amycolatopsis mediterranei U32 by RNA-seq. MICROBIAL CELL FACTORIES[J]. 2015, 第 6 作者14(1): https://www.webofscience.com/wos/woscc/full-record/WOS:000355511800001.
[19] Wang, Jin, Wang, Ying, Zhao, GuoPing. Precise characterization of GlnR Box in actinomycetes. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2015, 第 3 作者458(3): 605-607, https://www.webofscience.com/wos/woscc/full-record/WOS:000351659200026.
[20] Ying Wang, Chen Li, Na Duan, Bin Li, XiaoMing Ding, YuFeng Yao, Jun Hu, GuoPing Zhao, Jin Wang. GlnR negatively regulates the transcription of the alanine dehydrogenase encoding gene ald in Amycolatopsis mediterranei U32 under nitrogen limited conditions via specific binding to its major transcription initiation site.. PLOS ONE[J]. 2014, 第 8 作者9(8): https://doaj.org/article/37702ac20eeb4f8f98547c6f0f95f0b1.
[21] Lin, Wei, Wang, Ying, Han, Xiaobiao, Zhang, Zilong, Wang, Chengyuan, Wang, Jin, Yang, Huaiyu, Lu, Yinhua, Jiang, Weihong, Zhao, GuoPing, Zhang, Peng. Atypical OmpR/PhoB Subfamily Response Regulator GlnR of Actinomycetes Functions as a Homodimer, Stabilized by the Unphosphorylated Conserved Asp-focused Charge Interactions. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2014, 第 10 作者  通讯作者  289(22): 15413-15425, http://dx.doi.org/10.1074/jbc.M113.543504.
[22] Zhang, Zilong, Wu, Jian, Lin, Wei, Wang, Jin, Yan, Han, Zhao, Wei, Ma, Jun, Ding, Jianping, Zhang, Peng, Zhao, GuoPing. Subdomain II of alpha-Isopropylmalate Synthase Is Essential for Activity INFERRING A MECHANISM OF FEEDBACK INHIBITION. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2014, 第 10 作者289(40): 27966-27978, https://www.webofscience.com/wos/woscc/full-record/WOS:000342852800050.
[23] Hui Ma, BiKui Tang, XiaoYong Fan, GuoPing Zhao, LiangDong Lyu. Mycobacterial MazG Safeguards Genetic Stability via Housecleaning of 5-OH-dCTP. PUBLIC LIBRARY OF SCIENCE. 2013, 第 4 作者http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201912010176177ZK.
[24] Chen, WeiHua, Qin, ZhongJun, Wang, Jin, Zhao, GuoPing. The MASTER (methylation-assisted tailorable ends rational) ligation method for seamless DNA assembly. NUCLEIC ACIDS RESEARCH[J]. 2013, 第 4 作者41(8): e93-e93, https://www.webofscience.com/wos/woscc/full-record/WOS:000318569700004.
[25] Wang, Ying, Wang, JingZhi, Shao, ZhiHui, Yuan, Hua, Lu, YinHua, Jiang, WeiHong, Zhao, GuoPing, Wang, Jin. Three of Four GlnR Binding Sites Are Essential for GlnR-Mediated Activation of Transcription of the Amycolatopsis mediterranei nas Operon. JOURNAL OF BACTERIOLOGY[J]. 2013, 第 7 作者  通讯作者  195(11): 2595-2602, https://www.webofscience.com/wos/woscc/full-record/WOS:000318811300016.

   

（ 1 ） 放线菌全局性调控蛋白GlnR 调控细胞代谢的分子机理, 主持, 国家级, 2015-01--2019-12
（ 2 ） 微生物代谢生理的系统与合成生物学研究, 主持, 国家级, 2015-01--2017-12
（ 3 ） 致病性钩端螺旋体遗传操作体系的建立, 主持, 国家级, 2014-01--2017-12
（ 4 ） 新功能人造生物器件的构建及集成, 主持, 国家级, 2012-01--2016-08