General

Xiao, Wuhan, Ph.D. Professor

Research Areas

Developmental Biology,  Molecular Genetics

Education


NAME

 

Xiao, Wuhan

 

POSITION TITLE

 

Professor

Contact information:

                Institute of Hydrobiology

                Chinese Academy of Sciences

                Wuhan, Hubei, 430072

                The People’s Republic of China

 

                Phone:   86-27-68780087 (office), 86-27-68780092 (lab)

                Fax:     86-27-68780087

                E-mail:   w-xiao@ihb.ac.cn       

 

EDUCATION/TRAINING 

INSTITUTION AND LOCATION

DEGREE

 

YEAR(s)

FIELD OF STUDY

Wuhan University, Wuhan, China

BS

1985-1989

Cell Biology

 

Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China

MS

1989-1992

Hydrobiology

 

Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China

PhD

1994-1997

Molecular Evolution

 

Northwestern University, Chicago, USA

Postdoc.

1998-2003

Molecular Biology

Experience

Developmetal Biology, Molecular Genetics

Work Experience

1992 – 1994      Research Associate, Institute of Hydrobiology, the Chinese Academy of Sciences, Wuhan, China

1994– 1998      Assistant Professor, Institute of Hydrobiology, the Chinese Academy of Sciences, Wuhan, China

 1998 – 2003      Research Associate, Northwestern University Feinberg School of Medicine, Chicago, IL

 2003 - 2005      Research Assistant Professor, Northwestern University Feinberg School of Medicine, Chicago, IL

2006.7-2006.10   Research Consultant, University of Pittsburgh Medical Center, Pittsburgh, PA

 2006- present     Professor, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China

Teaching Experience

Molecular Cell Biology

Publications

(1) Xing Liu, Xiaolian Cai, Dawei Zhang, Chenxi Xu, Wuhan Xiao*. Zebrafish foxo3b negatively regulates anti-viral response through suppressing the transactivity of irf3 and irf7. Journal of Immunology, 2016, 197(12): 4736-4749.

(2) Xing Liu, Xiaolian Cai, Bo Hu, Zhichao Mei, Dawei Zhang, Gang Ouyang, Jing Wang, Wei Zhang, Wuhan Xiao*. Forkhead transcription factor (FOXO3a) modulates hypoxia signaling via up-regulation of the von Hippel-Lindau gene (VHL). Journal of Biological Chemistry, 2016, 291(49): 25692-25705.

(3) Yu Chen, Chi Zhou, Wei Ji , Zhichao Mei, Bo Hu, Wei Zhang, Dawei Zhang, Jing Wang, Xing Liu, Gang Ouyang, Jiangang Zhou, Wuhan Xiao*. ELL targets c-Myc for proteasomal degradation and suppresses tumour growth. Nature Communications, 2016, 7: 11057.

(4) Xing Liu, Zhu Chen, Gang Ouyang, Tieshan Song, Huageng Liang, Wei Liu, Wuhan Xiao*. ELL associated factor 2 (EAF2) inhibits transforming growth factor beta signaling through a direct interaction with Smad3. Journal of Biological Chemistry, 2015, 290(43): 25933-25945. 

(5) Juan Du, Dawei Zhang. Wei Zhang, Gang Ouyang, Jing Wang, Xing Liu, Sun Li, Wei Liu, Wuhan Xiao*. pVHL negatively regulates antiviral signaling by targeting MAVS for proteasomal degradation. Journal of Immunology, 2015, 195(4): 1782-1790.

(6) Zhichao Mei, Dawei Zhang, Bo Hu, Jing Wang, Xian Shen, Wuhan Xiao*. FBXO32 targets c-Myc for proteasomal degradation and inhibits c-Myc activity. Journal of Biological Chemistry, 2015, 290(26): 16202-16214.

(7) Xing Liu, Zhu Chen, Chenxi Xu, Xiaoqian Leng, Hong Cao, Gang Ouyang, Wuhan Xiao*. Repression of hypoxia-inducible factor alpha signaling by Set7-mediated methylation. Nucleic Acids Research, 2015, 43(10): 5081-5098.

(8) Bo Hu, Wei Zhang, Xi Feng, Wei Ji, Xunwei Xie, Wuhan Xiao*. Zebrafish eaf1 suppresses foxo3b expression to modulate transcriptional activity of gata1 and spi1 in primitive hematopoiesis, Developmental Biology. 2014, 388: 81-93.

(9) Jing Wang, Wei Zhang, Wei Ji, Xing Liu, Gang Ouyang, Wuhan Xiao*. The Von Hippel-Lindau protein suppresses androgen receptor activity. Molecular Endocrinology, 2014, 28(2): 239-248.

(10) Zhu Chen, Xing Liu, Zhichao Mei, Zhou Wang*, Wuhan Xiao*. EAF2 suppresses HIF-1alpha transcriptional activity by disrupting its interaction with the co-activator CBP/p300. Molecular and Cellular Biology, 2014, 34(6): 1085-1099.

(11) Wei Zhang, Wei Ji, Xing Liu, Gang Ouyang, Wuhan Xiao*. ELL inhibits E2F1 transcriptional activity by enhancing E2F1 deacetylation via recruitment of Histone Deacetylase 1. Molecular and Cellular Biology, 2014, 34(4): 765-775.

(12) Wei Ji, Jing Wang, Wei Zhang, Xing Liu, Gang Ouyang, Wuhan Xiao*. pVHL acts as a downstream target of E2F1 to suppress E2F1 activity. Biochemical Journal, 2014, 457: 185-195. 

(13) Jing-xia Liu, Dawei Zhang, Xunwei Xie, Gang Ouyang, Xing Liu, Yonghua Sun, Wuhan Xiao*. Eaf1 and Eaf2 negatively regulate canonical Wnt/beta-catenin signaling. Development, 2013, 140: 1067-1078. 

(14) Xiaoyang Wan, Bo Hu, Jing-xia Liu, Xi Feng, Wuhan Xiao*. Zebrafish mll gene is essential for hematopoiesis. Journal of Biological Chemistry, 2011, 286: 33345-33357

(15) Xi Feng, Xing Liu, Wei Zhang, Wuhan Xiao*. p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell death. EMBO Journal, 2011, 30: 3397-3415.

(16) Jiangang Zhou, Xi Feng, Bing Ban, Jing-xia Liu, Zhou Wang*, Wuhan Xiao*. The elongation factor ELL (Eleven-Nineteen Lysine-Rich Leukemia) acts as a transcription factor for direct thrombospondin-1 regulation. Journal of Biological Chemistry, 2009, 284(28):19142-19152.

(17) Jing-xia Liu, Bo Hu, Yang Wang, Jianfang Gui, Wuhan Xiao*. Zebrafish eaf1 and eaf2/u19 mediate effective convergence and extension movements through the maintenance of wnt11 and wnt5 expression. Journal of Biological Chemistry, 2009, 284(24):16679-16692.

(18) Wuhan Xiao, Junkui Ai, Geoffrey Habermacher, Olga Volpert , Ximing Yang, Ai-yuan Zhang, Junghyun Hahn, Xiaoyan Cai , Zhou Wang*. U19/Eaf2 binds to and stabilizes von Hippel-Lindau protein. Cancer Research, 2009, 69(6):2599-606.

(19) Wuhan Xiao, Qiuheng Zhang, Geoffrey Habermacher, Ximing Yang, Ai-yuan Zhang, Xiaoyan Cai, Junghyun Hahn, Jun Liu , Michael Pins, L Doglio, R Dhir, J Gingrich, Zhou Wang*. U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia. Oncogene, 2008, 27 (11): 1536-44. 

(20) Wuhan Xiao, Qiuheng Zhang, Feng Jiang, Michael Pins, JM Kozlowski, Zhou Wang*. Suppression of prostate tumor growth by U19 – a novel testosterone-regulated apoptosis inducer. Cancer Research, 2003, 63(15):4698-704.

(21) Wuhan Xiao*, Yaping Zhang and Huanzhang Liu. Molecular systematics of Xenocyprinae (Teleostei: Cyprinidae):Taxonomy, biogeography and coevolution of a special group restricted in East-Asia. Molecular Phylogenetics and Evolution, 2001, 18(2): 163-173.

 

Research Interests

1. Genetic basis of hypoxic tolerance and adaptation in fish.

2. Regulation of hypoxia signaling pathway.

3. Hypoxia in cancer progression and innate immunity.

 

Students

5 Ph.D. Students, 2 Master Degree students