发育生物学、分子遗传学

   

研究生

博士

1992年8月-1994年10月：中国科学院水生生物研究所，研究实习员；从事鱼类寄生原生动物研究；

1994年11月-1998年10月：中国科学院水生生物研究所，助理研究员；从事鱼类寄生原生动物与鱼类协同进化研究；

1998年11月-2003年10月：美国Northwestern University医学院，博士后；从事肿瘤分子生物学研究；

2003年11月-2005年12月：美国Northwestern University医学院，研究助理教授；从事肿瘤分子生物学研究；

2006年1月-现在：中国科学院水生生物研究所，水生生物分子与细胞生物学研究中心，鱼类低氧生物学学科组责任研究员。2013年7月-至今，中国科学院水生生物研究所水生生物分子与细胞生物学研究中心主任。自组建学科组以来，主要从事鱼类低氧耐受与适应的分子机制、低氧信号转导与调控等方面的研究。

   

[1] PNAS. 2024,   通讯作者  
[2] Nature Communications. 2024,   通讯作者  
[3] Cell Reports. 2024,   通讯作者  
[4] PNAS. 2023,   通讯作者  
[5] Cell Reports. 2022,   通讯作者  
[6] Molecular Cell. 2021,   通讯作者  
[7] EMBO Journal. 2020,   通讯作者  
[8] 肖武汉. Zebrafish NF-κB/p65 Is Required for Antiviral Responses. The Journal of Immunology. 2020, 第 1 作者  通讯作者  
[9] Zhu, Junji, Liu, Xing, Cai, Xiaolian, Ouyang, Gang, Fan, Sijia, Wang, Jing, Xiao, Wuhan. Zebrafish prmt7 negatively regulates antiviral responses by suppressing the retinoic acid-inducible gene-I-like receptor signaling. FASEB JOURNAL[J]. 2020, 第 7 作者  通讯作者  34(1): 988-1000, https://www.webofscience.com/wos/woscc/full-record/WOS:000507308900067.
[10] Liu, Xing, Zhu, Chunchun, Zha, Huangyuan, Tang, Jinhua, Rong, Fangjing, Chen, Xiaoyun, Fan, Sijia, Xu, Chenxi, Du, Juan, Zhu, Junji, Wang, Jing, Ouyang, Gang, Yu, Guangqing, Cai, Xiaolian, Chen, Zhu, Xiao, Wuhan. SIRT5 impairs aggregation and activation of the signaling adaptor MAVS through catalyzing lysine desuccinylation. EMBO JOURNAL[J]. 2020, 第 16 作者  通讯作者  39(11): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265249/.
[11] Yu, Guangqing, Liu, Xing, Tang, Jinhua, Xu, Chenxi, Ouyang, Gang, Xiao, Wuhan. Neddylation Facilitates the Antiviral Response in Zebrafish. FRONTIERS IN IMMUNOLOGY[J]. 2019, 第 6 作者  通讯作者  10: https://doaj.org/article/c0d5d115758e4519b3c8fe8c65af1a30.
[12] Zhu, Junji, Zhang, Dawei, Liu, Xing, Yu, Guangqing, Cai, Xiaolian, Xu, Chenxi, Rong, Fangjing, Ouyang, Gang, Wang, Jing, Xiao, Wuhan. Zebrafish prmt5 arginine methyltransferase is essential for germ cell development. DEVELOPMENT[J]. 2019, 第 10 作者  通讯作者  146(20): 
[13] Chenxi Xu, Xing Liu, Huangyuan Zha, Sijia Fan, Dawei Zhang, Shan Li, Wuhan Xiao. A pathogen-derived effector modulates host glucose metabolism by arginine GlcNAcylation of HIF-1α protein.. PLOS PATHOGENS[J]. 2018, 第 7 作者14(8): https://doaj.org/article/0fa115f0267d447a9f506fc2f76d9b59.
[14] Cai, Xiaolian, Zhang, Dawei, Wang, Jing, Liu, Xing, Ouyang, Gang, Xiao, Wuhan. Deletion of the fih gene encoding an inhibitor of hypoxia-inducible factors increases hypoxia tolerance in zebrafish. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2018, 第 6 作者  通讯作者  293(40): 15370-15380, http://dx.doi.org/10.1074/jbc.RA118.003004.
[15] Jing Wang, Dawei Zhang, Juan Du, Chi Zhou, Zhi Li, Xing Liu, Gang Ouyang, Wuhan Xiao. Tet1 facilitates hypoxia tolerance by stabilizing the HIF-α proteins independent of its methylcytosine dioxygenase activity. NUCLEIC ACIDS RESEARCH. 2017, 第 8 作者45(22): 12700-12714, 
[16] 肖武汉. Forkhead trancription factor 3a (FOXO3a) modulates hypoxia signaling via up-regulation of von Hippel-Lindu gene (VHL).. Journal of Biological Chemistry. 2016, 第 1 作者  通讯作者  
[17] Liu, Xing, Cai, Xiaolian, Zhang, Dawei, Xu, Chenxi, Xiao, Wuhan. Zebrafish foxo3b Negatively Regulates Antiviral Response through Suppressing the Transactivity of irf3 and irf7. JOURNAL OF IMMUNOLOGY[J]. 2016, 第 5 作者  通讯作者  197(12): 4736-4749, https://www.webofscience.com/wos/woscc/full-record/WOS:000389635900024.
[18] 肖武汉. ELL targets c-Myc for proteasomal degradation and suppresses tumor growth. Nature Communications. 2016, 第 1 作者  通讯作者  
[19] Du, Juan, Zhang, Dawei, Zhang, Wei, Ouyang, Gang, Wang, Jing, Liu, Xing, Li, Shun, Ji, Wei, Liu, Wei, Xiao, Wuhan. pVHL Negatively Regulates Antiviral Signaling by Targeting MAVS for Proteasomal Degradation. JOURNAL OF IMMUNOLOGY[J]. 2015, 第 10 作者  通讯作者  195(4): 1782-1790, http://www.irgrid.ac.cn/handle/1471x/982578.
[20] Xing Liu, Zhu Chen, Chenxi Xu, Xiaoqian Leng, Hong Cao, Gang Ouyang, Wuhan Xiao. Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation. NUCLEIC ACIDS RESEARCH. 2015, 第 7 作者43(10): 5081-5098, 
[21] Hu, Bo, Zhang, Wei, Feng, Xi, Ji, Wei, Xie, Xunwei, Xiao, Wuhan. Zebrafish eaf1 suppresses foxo3b expression to modulate transcriptional activity of gata1 and spi1 in primitive hematopoiesis. DEVELOPMENTAL BIOLOGY[J]. 2014, 第 6 作者  通讯作者  388(1): 81-93, http://dx.doi.org/10.1016/j.ydbio.2014.01.005.
[22] Ji, Wei, Wang, Jing, Zhang, Wei, Liu, Xing, Ouyang, Gang, Xiao, Wuhan. pVHL acts as a downstream target of E2F1 to suppress E2F1 activity. BIOCHEMICAL JOURNAL[J]. 2014, 第 6 作者  通讯作者  457: 185-195, http://www.irgrid.ac.cn/handle/1471x/852679.
[23] Zhang, Wei, Ji, Wei, Liu, Xing, Ouyang, Gang, Xiao, Wuhan. ELL Inhibits E2F1 Transcriptional Activity by Enhancing E2F1 Deacetylation via Recruitment of Histone Deacetylase 1. MOLECULAR AND CELLULAR BIOLOGY[J]. 2014, 第 5 作者  通讯作者  34(4): 765-775, http://www.irgrid.ac.cn/handle/1471x/852677.
[24] Wang, Jing, Zhang, Wei, Ji, Wei, Liu, Xing, Ouyang, Gang, Xiao, Wuhan. The Von Hippel-Lindau Protein Suppresses Androgen Receptor Activity. MOLECULAR ENDOCRINOLOGY[J]. 2014, 第 6 作者  通讯作者  28(2): 239-248, http://www.irgrid.ac.cn/handle/1471x/852676.
[25] 肖武汉. EAF2 suppresses HIF-1alpha transcriptional activity by disrupting its interaction with the co-activator CBP/p300. Molecular and Cellular Biology. 2014, 第 1 作者  通讯作者  
[26] Liu, JingXia, Zhang, Dawei, Xie, Xunwei, Ouyang, Gang, Liu, Xing, Sun, Yonghua, Xiao, Wuhan. Eaf1 and Eaf2 negatively regulate canonical Wnt/beta-catenin signaling. DEVELOPMENT[J]. 2013, 第 7 作者  通讯作者  140(5): 1067-1078, http://www.irgrid.ac.cn/handle/1471x/733512.
[27] Xie, Xunwei, Liu, JingXia, Hu, Bo, Xiao, Wuhan. Zebrafish foxo3b Negatively Regulates Canonical Wnt Signaling to Affect Early Embryogenesis. PLOS ONE[J]. 2011, 第 4 作者  通讯作者  6(9): https://doaj.org/article/08f6247ed7c2404b8ec0296aee10ddf5.
[28] 肖武汉. p53 directly suppresses BNIP3 expression to protect against hypoxia-induced cell deaths. EMBO J. 2011, 第 1 作者  通讯作者  
[29] 肖武汉. E2F-1 directly up-regulates TSP-1 expression. Plos One. 2010, 第 1 作者  通讯作者  
[30] Wan, Xiaoyang, Ji, Wei, Mei, Xue, Zhou, Jiangang, Liu, Jingxia, Fang, Chengchi, Xiao, Wuhan. Negative Feedback Regulation of Wnt4 Signaling by EAF1 and EAF2/U19. PLOS ONE[J]. 2010, 第 7 作者  通讯作者  5(2): http://ir.ihb.ac.cn/handle/342005/13753.
[31] Xiao, Wuhan, Ai, Junkui, Habermacher, Geoffrey, Volpert, Olga, Yang, Ximing, Zhang, Aiyuan, Hahn, Junghyun, Cai, Xiaoyan, Wang, Zhou. U19/Eaf2 Binds to and Stabilizes von Hippel-Lindau Protein. CANCER RESEARCH[J]. 2009, 第 1 作者69(6): 2599-2606, http://ir.ihb.ac.cn/handle/152342/7810.
[32] 肖武汉. Zebrafish eaf1 and eaf2/u19 mediate effective convegence and extension movements through the maintenance of wnt11 and wnt5 expression. 2009, 第 1 作者  通讯作者  
[33] Xiao, W, Zhang, Q, Habermacher, G, Yang, X, Zhang, Ay, Cai, X, Hahn, J, Liu, J, Pins, M, Doglio, L, Dhir, R, Gingrich, J, Wang, Z. U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia. ONCOGENE[J]. 2008, 27(11): 1536-1544, http://ir.ihb.ac.cn/handle/152342/8228.
[34] Xiao, WH, Jiang, F, Wang, Z. ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation. PROSTATE[J]. 2006, 66(1): 1-12, https://www.webofscience.com/wos/woscc/full-record/WOS:000234121400001.
[35] Xiao, WH, Zhang, QH, Jiang, F, Pins, M, Kozlowski, JM, Wang, Z. Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer. CANCER RESEARCH[J]. 2003, 63(15): 4698-4704, https://www.webofscience.com/wos/woscc/full-record/WOS:000184562500060.
[36] Xiao, WH, Zhang, YP, Liu, HZ. Molecular systematics of Xenocyprinae (Teleostei : Cyprinidae): Taxonomy, biogeography, and coevolution of a special group restricted in east Asia. MOLECULAR PHYLOGENETICS AND EVOLUTION[J]. 2001, 18(2): 163-173, http://dx.doi.org/10.1006/mpev.2000.0879.
[37] Wan Xiaoyang, Hu Bo, Liu Jing-xia, Feng Xi, Xiao Wuhan. Zebrafish mll Gene Is Essential for Hematopoiesis. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 第 5 作者286(38): 33345-33357, http://dx.doi.org/10.1074/jbc.M111.253252.
[38] Zhou Jiangang, Feng Xi, Ban Bin, Liu Jingxia, Wang Zhou, Xiao Wuhan. Elongation Factor ELL (Eleven-Nineteen Lysine-rich Leukemia) Acts as a Transcription Factor for Direct Thrombospondin-1 Regulation. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 第 6 作者284(28): 19142-19152, http://dx.doi.org/10.1074/jbc.M109.010439.
[39] Mei Zhichao, Zhang Dawei, Hu Bo, Wang Jing, Shen Xian, Xiao Wuhan. FBXO32 Targets c-Myc for Proteasomal Degradation and Inhibits c-Myc Activity *. THE JOURNAL OF BIOLOGICAL CHEMISTRY. 第 6 作者290(26): 16202-16214, http://dx.doi.org/10.1074/jbc.M115.645978.