基本信息
陈建军  男  博导  中国科学院武汉病毒研究所
电子邮件: chenjj@wh.iov.cn
通信地址: 武昌小洪山中区44号
邮政编码:

研究领域

1、流感病毒在家禽和野鸟中的流行趋势、遗传规律


2、流感病毒及呼吸道病毒新型疫苗设计与评价



招生信息

   
招生专业
071005-微生物学
招生方向
流感及呼吸道病毒传播与流行
流感及呼吸道病毒新型通用疫苗

教育背景

   
学历

l 1996.9-2000.6 湖南师范大学生科院   生物教育专业 学士学位

l 2000.9-2003.6 湖南师范大学生科院   生物化学与分子生物学专业 硕士学位

l 2005.9-2008.6 中国科学院武汉病毒所   微生物专业 博士学位

l 2011.62011.10 美国Emory大学 微生物与免疫学系 博士后


学位
博士学位

工作经历

l2003.7-2005.12   中科院武汉病毒所流感病毒学科组   实习研究员

l2005.12-2010.12 中科院武汉病毒所流感病毒学科组   助理研究员

l2010.12-2020.8   中科院武汉病毒所流感病毒学科组   副研究员

l2020.9-                中科院武汉病毒所流感病毒学科组   研究员



工作简历
2020-10~现在, 中国科学院武汉病毒研究所, 研究员
2010-09~2020-09,中国科学院武汉病毒研究所, 副研究员
社会兼职
2020-11-01-2024-12-31,中国疫苗行业协会核酸疫苗分会, 常务委员
2017-12-31-2021-12-30,中国微生物学会微生物生物安全专业委员会-青年委员会, 委员
2017-01-01-2021-12-31,国际应急管理协会亚太应急专业委员会, 常务委员

教授课程

病毒学

专利与奖励

   
专利成果
[1] 崔宗强, 陈建军, 齐咪, 张先恩. 一种纳米流感疫苗及构建方法和应用. CN: CN107344969B, 2021-03-05.

[2] 龚睿, 李明新, 陈建军. 广谱抗H7流感病毒的中和性人源单克隆抗体及其应用. CN: CN110028578A, 2019-07-19.

[3] 严兵, 陈建军. 检测甲型H1N1病毒抗原的免疫检测试剂. 中国: CN102041265A, 2011-05-04.

出版信息

   
发表论文
(1) Integrated characterization of SARS-CoV-2 genome, microbiome, antibiotic resistance and host response from single throat swabs, CELL DISCOVERY, 2021, 第 7 作者
(2) Rapid Acquisition of High-Quality SARS-CoV-2 Genome via Amplicon-Oxford Nanopore Sequencing, VIROLOGICA SINICA, 2021, 通讯作者
(3) Ecology of avian influenza viruses in migratory birds wintering within the Yangtze River wetlands, Science Bulletin, 2021, 通讯作者
(4) Potential m6A and m5C Methylations within the Genome of A Chinese African Swine Fever Virus Strain, VIROLOGICA SINICA, 2021, 第 2 作者
(5) Transcriptome Analyses Implicate Endogenous Retroviruses Involved in the Host Antiviral Immune System through the Interferon Pathway, VIROLOGICA SINICA, 2021, 第 4 作者
(6) Intratumoral Virotherapy with Wild-Type Newcastle Disease Virus in Carcinoma Krebs-2 Cancer Model, VIRUSES-BASEL, 2021, 第 5 作者
(7) Severe Acute Respiratory Syndrome Coronavirus 2-Specific Antibodies in Pets in Wuhan, China, JOURNAL OF INFECTION, 2020, 通讯作者
(8) Phylogenetics, Genomic Recombination, and NSP2 Polymorphic Patterns of Porcine Reproductive and Respiratory Syndrome Virus in China and the United States in 2014–2018, JOURNAL OF VIROLOGY, 2020, 第 13 作者
(9) Nanopore sequencing of African swine fever virus, SCIENCE CHINA-LIFE SCIENCES, 2020, 通讯作者
(10) Vaccination with Consensus H7 Elicits Broadly Reactive and Protective Antibodies against Eurasian and North American Lineage H7 Viruses, VACCINES, 2020, 通讯作者
(11) Genomic surveillance of COVID-19 cases in Beijing, NATURE COMMUNICATIONS, 2020, 第 19 作者
(12) Dominant subtype switch in avian influenza viruses during 2016-2019 in China, NATURE COMMUNICATIONS, 2020, 
(13) Co-infection of SARS-CoV-2 and Influenza virus in Early Stage of the COVID-19 Epidemic in Wuhan, China, JOURNAL OF INFECTION, 2020, 通讯作者
(14) Circulation, Evolution and Transmission of H5N8 virus, 2016–2018, JOURNAL OF INFECTION, 2019, 通讯作者
(15) Continued reassortment of avian h6 influenza viruses from southern china, 2014-2016, TRANSBOUNDARY AND EMERGING DISEASES, 2019, 第 8 作者
(16) The Emergence of Avian Orthoavulavirus 13 in Wild Migratory Waterfowl in China Revealed the Existence of Diversified Trailer Region Sequences and HN Gene Lengths within this Serotype, VIRUSES-BASEL, 2019, 通讯作者
(17) A cross-reactive human monoclonal antibody targets the conserved H7 antigenic site A from fifth wave H7N9-infected humans, ANTIVIRAL RESEARCH, 2019, 通讯作者
(18) Biological and phylogenetic characterization of a novel hemagglutination‐negative avian avulavirus 6 isolated from wild waterfowl in China, TRANSBOUNDARY AND EMERGING DISEASES, 2018, 第 4 作者
(19) Development of Multi-analyte Suspension Assay for Simultaneously Efficient Detection of Avian Influenza Virus A Subtypes, VIROLOGICA SINICA, 2018, 第 3 作者
(20) Cellular-beacon-mediated counting for the ultrasensitive detection of ebola virus on an integrated micromagnetic platform, ANALYTICAL CHEMISTRY, 2018, 第 7 作者
(21) Enhanced Replication of Virulent Newcastle Disease Virus in Chicken Macrophages Is due to Polarized Activation of Cells by Inhibition of TLR7, FRONTIERS IN IMMUNOLOGY, 2018, 第 13 作者
(22) Avian Influenza A(H7N9) Virus in a Wild Land Bird in Central China,Late 2015, Avian Influenza A(H7N9) Virus in a Wild Land Bird in Central China,Late 2015, 中国病毒学:英文版, 2018, 第 10 作者
(23) Intranasal nanovaccine confers homo- and hetero-subtypic influenza protection, SMALL, 2018, 通讯作者
(24) Two genetically diverse H7N7 avian influenza viruses isolated from migratory birds in central China, EMERGING MICROBES & INFECTIONS, 2018, 通讯作者
(25) Development of Multi-analyte Suspension Assay for Simultaneously Efficient Detection of Avian Influenza Virus A Subtypes, Development of Multi-analyte Suspension Assay for Simultaneously Efficient Detection of Avian Influenza Virus A Subtypes, 中国病毒学:英文版, 2018, 第 3 作者
(26) Dual-signal readout nanospheres for rapid point-of-care detection of ebola virus glycoprotein, ANALYTICAL CHEMISTRY, 2017, 通讯作者
(27) CASCIRE Surveillance Network and Work on Avian Influenza Viruses, SCIENCE CHINA-LIFE SCIENCES, 2017, 第 3 作者
(28) Ultrasensitive ebola virus detection based on electroluminescent nanospheres and immunomagnetic separation, ANALYTICAL CHEMISTRY, 2017, 第 5 作者
(29) Dispersal and Transmission of Avian Paramyxovirus Serotype 4 among Wild Birds and Domestic Poultry, FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2017, 通讯作者
(30) Highly Pathogenic Avian Influenza A(H5N8) Virus in Wild Migratory Birds, Qinghai Lake, China, EMERGING INFECTIOUS DISEASES, 2017, 通讯作者
(31) Characterization of a reassortant h11n9 subtype avian influenza virus isolated from bean goose along the east asian-australian flyway, VIRUS GENES, 2017, 第 5 作者
(32) A 3-year follow-up study of the seroprevalence of antibodies to avian influenza A H5, H6, H7 and H10 viruses among the general population of Wuhan, China, JOURNAL OF CLINICAL VIROLOGY, 2016, 通讯作者
(33) Highly Pathogenic Avian Influenza H5N1 Clade 2.3.2.1c Virus in Migratory Birds, 2014-2015, VIROLOGICA SINICA, 2016, 第 2 作者
(34) Influenza h7n9 lah-hbc virus-like particle vaccine with adjuvant protects mice against homologous and heterologous influenza viruses, VACCINE, 2016, 第 4 作者
(35) Novel Avian Influenza A (H5N6) Viruses Isolated in Migratory Waterfowl Before the First Human Case Reported in China, 2014, SCIENTIFIC REPORTS, 2016, 
(36) A Raf kinase inhibitor demonstrates antiviral activities both invitro and invivo against different genotypes of virulent Newcastle disease virus, ANTIVIRAL RESEARCH, 2016, 第 10 作者
(37) Intranasal Administration of Chitosan Against Influenza A (H7N9) Virus Infection in a Mouse Model, SCIENTIFIC REPORTS, 2016, 第 6 作者
(38) High Genetic Diversity of Newcastle Disease Virus in Wild and Domestic Birds in Northeastern China from 2013 to 2015 Reveals Potential Epidemic Trends, APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2016, 第 8 作者
(39) Genesis, evolution and prevalence of h5n6 avian influenza viruses in china, Cell Host & Microbe, 2016, 第 4 作者
(40) Biometallization-based electrochemical magnetoimmunosensing strategy for avian influenza a (h7n9) virus particle detection, CHEMISTRY-AN ASIAN JOURNAL, 2015, 通讯作者
(41) Rapid and Quantitative Detection of Avian Influenza A(H7N9) Virions in Complex Matrices Based on Combined Magnetic Capture and Quantum Dot Labeling, SMALL, 2015, 通讯作者
(42) Highly Pathogenic Avian Influenza A(H5N1) Virus Struck Migratory Birds in China in 2015, SCIENTIFIC REPORTS, 2015, 第 9 作者
(43) Two novel reassortants of avian influenza A (H5N6) virus in China, JOURNAL OF GENERAL VIROLOGY, 2015, 通讯作者
(44) Bifunctional magnetic nanobeads for sensitive detection of avian influenza A (H7N9) virus based on immunomagnetic separation and enzyme-induced metallization, Biosensors and Bioelectronics, 2015, 
(45) Bifunctional magnetic nanobeads for sensitive detection of avian influenza A (H7N9) virus based on immunomagnetic separation and enzyme-induced metallization, BIOSENSORS & BIOELECTRONICS, 2015, 通讯作者
(46) Comparative analysis of antibody induction and protection against influenza virus infection by DNA immunization with HA, HAe, and HA1 in mice, ARCHIVES OF VIROLOGY, 2014, 通讯作者
(47) Evaluation of neutralizing efficacy of monoclonal antibodies specific for 2009 pandemic H1N1 influenza A virus in vitro and in vivo, ARCHIVES OF VIROLOGY, 2014, 通讯作者
(48) Genotype Diversity of H9N2 Viruses Isolated from Wild Birds and Chickens in Hunan Province, China, PLOS ONE, 2014, 第 7 作者
(49) An adjuvanted inactivated murine cytomegalovirus (MCMV) vaccine induces potent and long-term protective immunity against a lethal challenge with virulent MCMV, BMC INFECTIOUS DISEASES, 2014, 第 7 作者
(50) Serological study of antibodies to influenza A viruses among general population in Wuhan city China, JOURNAL OF CLINICAL VIROLOGY, 2014, 通讯作者
(51) Perpetuation of H5N1 and H9N2 avian influenza viruses in natural water bodies, JOURNAL OF GENERAL VIROLOGY, 2014, 第 3 作者
(52) Immunization with Cytomegalovirus Envelope Glycoprotein M and Glycoprotein N DNA Vaccines can Provide Mice with Complete Protection against a Lethal Murine Cytomegalovirus Challenge, Immunization with Cytomegalovirus Envelope Glycoprotein M and Glycoprotein N DNA Vaccines can Provide Mice with Complete Protection against a Lethal Murine Cytomegalovirus Challenge, 中国病毒学:英文版, 2013, 第 5 作者
(53) Comparison of protection against H5N1 influenza virus in mouse offspring provided by maternal vaccination with HA DNA and inactivated vaccine, ARCHIVES OF VIROLOGY, 2013, 第 6 作者
(54) NA Proteins of Influenza A Viruses H1N1/2009, H5N1, and H9N2 Show Differential Effects on Infection Initiation, Virus Release, and Cell-Cell Fusion, PLOS ONE, 2013, 第 3 作者
(55) Complete Genome Sequence of a Novel Reassortant H3N6 Avian Influenza Virus Isolated from Domestic Green-Winged Teal, Genome Announcements, 2013, 
(56) Genome Sequence of a Reassortant H5N1 Avian Influenza Virus Isolated from Domestic Green-Winged Teal, MICROBIOLOGY RESOURCE ANNOUNCEMENTS, 2013, 通讯作者
(57) Avian Influenza A(H7N9) Virus Screening in Patients with Fever and Flu-Like Symptoms in a Tertiary Hospital in an Area with Confirmed Cases, PLOS ONE, 2013, 第 3 作者
(58) A Second CRM1-Dependent Nuclear Export Signal in the Influenza A Virus NS2 Protein Contributes to the Nuclear Export of Viral Ribonucleoproteins, JOURNAL OF VIROLOGY, 2013, 第 6 作者
(59) Enhanced Protective Efficacy of H5 Subtype Influenza Vaccine with Modification of the Multibasic Cleavage Site of Hemagglutinin in Retroviral Pseudotypes, Enhanced Protective Efficacy of H5 Subtype Influenza Vaccine with Modification of the Multibasic Cleavage Site of Hemagglutinin in Retroviral Pseudotypes, 中国病毒学:英文版, 2013, 第 2 作者
(60) Immunization with Cytomegalovirus Envelope Glycoprotein M and Glycoprotein N DNA Vaccines can Provide Mice with Complete Protection against a Lethal Murine Cytomegalovirus Challenge, Immunization with Cytomegalovirus Envelope Glycoprotein M and Glycoprotein N DNA Vaccines can Provide Mice with Complete Protection against a Lethal Murine Cytomegalovirus Challenge, 中国病毒学:英文版, 2013, 第 5 作者
(61) Characterization of low-pathogenic H6N6 avian influenza viruses in central China, ARCHIVES OF VIROLOGY, 2013, 第 6 作者
(62) Enhanced Protective Efficacy of H5 Subtype Influenza Vaccine with Modification of the Multibasic Cleavage Site of Hemagglutinin in Retroviral Pseudotypes, Enhanced Protective Efficacy of H5 Subtype Influenza Vaccine with Modification of the Multibasic Cleavage Site of Hemagglutinin in Retroviral Pseudotypes, 中国病毒学:英文版, 2013, 第 2 作者
(63) H5N1 influenza virus-like particles produced by transient expression in mammalian cells induce humoral and cellular immune responses in mice, CANADIAN JOURNAL OF MICROBIOLOGY, 2012, 第 2 作者
(64) Are the H5N1 Viruses Prepared for Inter-human Transmission?, Are the H5N1 Viruses Prepared for Inter-human Transmission?, 中国病毒学:英文版, 2012, 第 1 作者
(65) Are the H5N1 Viruses Prepared for Inter-human Transmission?, Are the H5N1 Viruses Prepared for Inter-human Transmission?, 中国病毒学:英文版, 2012, 第 1 作者
(66) Characterization of an H10N8 influenza virus isolated from Dongting lake wetland, 2011, 
(67) Characterization of an H10N8 influenza virus isolated from Dongting lake wetland, VIROLOGY JOURNAL, 2011, 第 4 作者
(68) A live bivalent influenza vaccine based on a H9N2 virus strain, VACCINE, 2010, 第 4 作者
(69) Effect of mucosal and systemic immunization with virus-like particles of severe acute respiratory syndrome coronavirus in mice, IMMUNOLOGY, 2010, 第 7 作者
(70) A single immunization with HA DNA vaccine by electroporation induces early protection against H5N1 avian influenza virus challenge in mice, 2009, 
(71) A single immunization with HA DNA vaccine by electroporation induces early protection against H5N1 avian influenza virus challenge in mice, BMC INFECTIOUS DISEASES, 2009, 第 4 作者
(72) Generation and evaluation of an h9n1 influenza vaccine derived by reverse genetics that allows utilization of a diva strategy for control of h9n2 avian influenza, ARCHIVES OF VIROLOGY, 2009, 第 4 作者
(73) Characterization of h5n1 influenza a viruses isolated from domestic green-winged teal, VIRUS GENES, 2009, 第 1 作者
(74) H5N1高致病性禽流感病毒研究进展, 临床内科杂志, 2009, 第 1 作者
(75) 流感DNA疫苗免疫BALB/c小鼠克服母源性抗体干扰的研究, Immunization of BALB/c mice with influenza DNA vaccine can overcome the interference of maternal antibody, 国际生物制品学杂志, 2009, 第 2 作者
(76) Characterization of highly pathogenic H5N1 avian influenza viruses isolated from poultry markets in central China, VIRUS RESEARCH, 2009, 第 1 作者
(77) 华中地区禽流感病毒遗传进化及其致病性研究, 2008, 第 1 作者
(78) Electroporation at low voltages enables dna vaccine to provide protection against a lethal h5n1 avian influenza virus challenge in mice, INTERVIROLOGY, 2008, 第 3 作者
(79) Vaccination with hemagglutinin or neuraminidase DNA protects BALB/c mice against influenza virus infection in presence of maternal antibody, 2007, 
(80) Vaccination with hemagglutinin or neuraminidase dna protects balb/c mice against influenza virus infection in presence of maternal antibody, BMC INFECTIOUS DISEASES, 2007, 第 1 作者
(81) Maternal immunization with both hemagglutinin- and neuraminidase-expressing dnas provides an enhanced protection against a lethal influenza virus challenge in infant and adult mice, DNA AND CELL BIOLOGY, 2005, 
(82) Protection against influenza virus infection in BALB/c mice immunized with a single dose of neuraminidase-expressing DNAs by electroporation, VACCINE, 2005, 
(83) Circulation, Evolution and Transmission of Highly Pathogenic Avian Influenza A (H5N8) virus, 2016-2018, Journal of Infection, 通讯作者

科研活动

   
科研项目
( 1 ) 武汉沉湖湿地候鸟、留鸟和家禽间禽流感病毒的传播, 主持, 国家级, 2016-01--2019-12
( 2 ) 湖北及周边省口岸输入性和烈性传染病病原体爆发预警与变异变迁研究, 主持, 国家级, 2017-01--2020-12
( 3 ) 新型冠状病毒追踪及环境风险评估, 主持, 国家级, 2020-03--2020-12
( 4 ) 青海湖禽流感病毒动态流行及病毒多样性研究, 主持, 国家级, 2020-01--2023-12
( 5 ) 中俄高致病性禽流感及其它禽类病毒的流行及跨洲传播研究, 主持, 国家级, 2020-01--2023-12
( 6 ) ******的筛选、鉴定和**分布差异研究的研究, 主持, 国家级, 2019-12--2022-12
( 7 ) 冰川、冻土等极端生境和水体环境中“休眠”病毒复苏的潜在传播风险, 主持, 部委级, 2020-01--2022-12

指导学生

已指导学生

熊超超  硕士研究生  085238-生物工程  

刘思玲  硕士研究生  071010-生物化学与分子生物学  

梁碧林  硕士研究生  085238-生物工程  

现指导学生

王彦海  硕士研究生  071005-微生物学  

关亦玮  硕士研究生  071005-微生物学  

张晓庆  硕士研究生  086000-生物与医药