1. Systems Immunology in Human Disease

We have developed a powerful platform “Immune Cellomics” to map all types of human immune cells and their subsets, which is based on Super-complex Flow Cytometry and Multi-spectral Imaging. With this platform, we first identify disease-specific immune cells/subsets, followed by in-depth analysis of their functions and molecular signatures (mainly via Transcriptomics and Epigenomics). Then we will integrate the data from laboratory and clinics to draw a Precision Immunology Map through advanced computational modeling, with the purpose to identify key pathogenic mechanisms and novel theranostic and prognostic immune biomarkers.

Targeted diseases:

*: Infectious diseases: Tuberculosis, Sepsis

*: Tumors: Hepatocellular Carcinoma, Breast cancer

*: Autoimmune disease: Systemic Lupus Erythematosus

2. B cell development and function

We are also interested in the molecular mechanisms in B1 vs. B2 fate decision, epigenetic regulation of antibody responses, and immune regulatory functions of B cells. 

2004-2007       PhD University of Paris 6/Institut Pasteur of Paris

2007-2012       Postdoc, Institut Pasteur of Paris, France

2012-present   Professor, Institut Pasteur of Shanghai, China

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1. Dong Z, Gong K, Huang D, Zhu W, Sun W, Zhang Y, Xin P, Shen Y, Wu P, Li J, Zhang XM^*, Wei M^* Myocardial infarction accelerates glomerular injury and microalbuminuria in diabetic rats via local hemodynamics and immunity. Int J Cardiol, 2015, 179:397-408. (^*: Corresponding author)

2. Zhang XM, Mozeleski B, Lemoine S, Dériaud E, Lim A, Zhivaki D, Azria E, Le Ray C, Roguet G, Launay O, Vanet A, Leclerc C, Lo-Man R. CD4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus. Sci Transl Med. 2014, 6(238):238ra72.

3. Zhang XM, Casartelli N, Lemoine S, Mozeleski B, Azria E, Le Ray C, Schwartz O, Launay O, Leclerc C, Lo-Man R. Plasmacytoid dendritic cells engagement by influenza vaccine as a surrogate strategy for driving T-helper type 1 responses in human neonatal settings.  J Infect Dis. 2014, 210(3):424-434.

4. Zhang XM. Regulatory functions of innate-like B cells. Cell Mol Immunol, 2013, 10(2): 113-121.

5. Zhang XM, Lepelley A, Azria A, Lebon P, Rouguet G, Schwartz O, Launay O, Leclerc C and Lo-Man R. Neonatal plasmacytoid dendritic cells (pDCs) display subset variation but can elicit potent anti-viral innate responses. Plos One, 2013, 8(1): e52003.

6. Freire T*, Zhang XM*, Deriaud E, Ganneau C, Vichier-Guerre S, Azria E, Launay O, Lo-Man R, Bay S, and Leclerc C. Glycosidic Tn-based vaccines targeting dermal DC favor germinal center B cell development and potent antibody responses in the absence of adjuvant. Blood, 2010, 116(18): 3526-3536. (*: equal contribution)

7. Zhang XM, Majlessi L, Deriaud E, Leclerc C and Lo-Man R. Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils. Immunity, 2009, 31 (5): 761-771.

8. Zhang XM, Deriaud E, Jiao XA, Braun D, Leclerc C and Lo-Man R. Type I interferons protect neonates from acute inflammation through IL-10 producing B cells. J Exp Med, 2007, 204(5): 1107-1118. 

Human Immunology, Tumor Immunology, Infection and Immunity, B cell immunobiology

现指导学生

方逸苑  01  19178  

邵殿慧  01  19178  

刘妹  01  19178  

王友平  01  19178  

王静  01  19182  

徐慧晖  01  19182