1.     人类重大疾病的精准免疫学研究

     建立了基于复杂流式细胞技术和多光谱成像技术 的“免疫细胞组学”研究平台，采用该平台系统解析健康人群和重大疾病患者体内复杂的免疫状态，鉴定出疾病高度相关的免疫细胞及亚群；再通过深入的功能探索和转录组学、表观遗传组学等分子水平的多组学研究，结合临床数据，采过先进的计算生物学整合建模策略，绘制出健康和疾病状态下的精准免疫图谱，凝炼出关键的致病机制，发现具有重要诊疗和预后价值的免疫学生物标志物，为疾病的个体化诊治和潜在的免疫治疗提供重要支撑。

在研疾病：

＊：感染性疾病：结核病、脓毒(败血)症

＊：肿瘤疾病：肝癌、乳腺癌

＊：自身免疫疾病：系统性红斑狼疮

 

2.     B细胞的发育和功能研究

我们还关注B1和B2细胞命运决定的分子机制，抗体生成的表观遗传调控机制，以及B细胞对免疫应答的正向和负向调控作用及其机制研究。

   

071005-微生物学
071009-细胞生物学
085238-生物工程

感染与免疫调控
免疫调节生物学
新型疫苗研制

2004-10--2007-09   法国巴黎第六大学   博士

   

2012-02~现在, 中科院上海巴斯德研究所, 研究员
2007-10~2012-01,法国巴斯德研究所, 博士后

   

（1） 教育部高等学校科学研究优秀成果奖, 二等奖, 部委级, 2009

（ 1 ） 非抗性筛选DNA疫苗载体及其构建方法, 发明, 2006, 第 2 作者, 专利号: ZL200310112640.3
（ 2 ） 镁离子调控的新型表达载体, 发明, 2009, 第 2 作者, 专利号: ZL200710020573.0
（ 3 ） 镁离子调控下的表达噬菌体裂解基因破壁方法, 发明, 2009, 第 2 作者, 专利号: ZL200710021820

   

[1] Jiaqiang Ma, Yingcheng Wu, Lifeng Ma, Jia Fan, Guoji Guo, Xiaoming Zhang, Qiang Gao. A blueprint for tumor-infiltrating B cells across human cancers. Science[J]. 2024, [2] Yingcheng Wu, Jiaqiang Ma, Xupeng Yang, Jia Fan, Xiaoming Zhang, Qiang Gao. Neutrophil profiling illuminates anti-tumor antigen-presenting potency. Cell[J]. 2024, [3] Meng, Lu, Zha, Jialu, Zhou, Bingjie, Cao, Long, Jiang, Congli, Zhu, Yuanfei, Li, Teng, Lu, Lu, Zhang, Junqi, Yang, Heng, Feng, Jian, Gu, Zhifeng, Tang, Hong, Jiang, Lubin, Li, Dianfan, Lavillette, Dimitri, Zhang, Xiaoming. A Spike-destructing human antibody effectively neutralizes Omicron-included SARS-CoV-2 variants with therapeutic efficacy. PLOS PATHOGENS[J]. 2023, 19(1): http://dx.doi.org/10.1371/journal.ppat.1011085.
[4] Bao, Shihua, Chen, Zechuan, Qin, Dengke, Xu, Huihui, Deng, Xujing, Zhang, Ruixiu, Ma, Jiaqiang, Lu, Zhouping, Jiang, Shan, Zhang, Xiaoming. Single-cell profiling reveals mechanisms of uncontrolled inflammation and glycolysis in decidual stromal cell subtypes in recurrent miscarriage. HUMAN REPRODUCTION[J]. 2023, 38(1): 57-74, [5] Wu, Yingcheng, Yang, Shuaixi, Ma, Jiaqiang, Chen, Zechuan, Song, Guohe, Rao, Dongning, Cheng, Yifei, Huang, Siyuan, Liu, Yifei, Jiang, Shan, Liu, Jinxia, Huang, Xiaowu, Wang, Xiaoying, Qiu, Shuangjian, Xu, Jianmin, Xi, Ruibin, Bai, Fan, Zhou, Jian, Fan, Jia, Zhang, Xiaoming, Gao, Qiang. Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level. CANCER DISCOVERY[J]. 2022, 12(1): 134-153, http://dx.doi.org/10.1158/2159-8290.CD-21-0316.
[6] Ye, Yan, Chen, Zechuan, Jiang, Shan, Jia, Fengyun, Li, Teng, Lu, Xia, Xue, Jing, Lian, Xinyue, Ma, Jiaqiang, Hao, Pei, Lu, Liangjing, Ye, Shuang, Shen, Nan, Bao, Chunde, Fu, Qiong, Zhang, Xiaoming. Single-cell profiling reveals distinct adaptive immune hallmarks in MDA5+dermatomyositis with therapeutic implications. NATURE COMMUNICATIONS[J]. 2022, 13(1): http://dx.doi.org/10.1038/s41467-022-34145-4.
[7] Ye, Yan, Zhang, Xueliang, Li, Teng, Ma, Jiaqiang, Wang, Ran, Wu, Chunmei, Wang, Runci, Bao, Chunde, Ye, Shuang, Shen, Nan, Guo, Qiang, Fu, Qiong, Zhang, Xiaoming. Two Distinct Immune Cell Signatures Predict the Clinical Outcomes in Patients With Amyopathic Dermatomyositis With Interstitial Lung Disease. ARTHRITIS & RHEUMATOLOGY[J]. 2022, 74(11): 1822-1832, http://dx.doi.org/10.1002/art.42264.
[8] Song, Guohe, Shi, Yang, Zhang, Meiying, Goswami, Shyamal, Afridi, Saifullah, Meng, Lu, Ma, Jiaqiang, Chen, Yi, Lin, Youpei, Zhang, Juan, Liu, Yuming, Jin, Zijie, Yang, Shuaixi, Rao, Dongning, Zhang, Shu, Ke, Aiwu, Wang, Xiaoying, Cao, Ya, Zhou, Jian, Fan, Jia, Zhang, Xiaoming, Xi, Ruibin, Gao, Qiang. Global immune characterization of HBV/HCV-related hepatocellular carcinoma identifies macrophage and T-cell subsets associated with disease progression. CELL DISCOVERY[J]. 2020, 6(1): https://doaj.org/article/c5a666494abc4fdc99a5041b4b14afe1.
[9] Yang, Huijuan, Ye, Shuang, Goswami, Shyamal, Li, Teng, Wu, Jingwen, Cao, Chunmei, Ma, Jiaqiang, Lu, Bin, Pei, Xuan, Chen, Yanan, Yu, Jing, Xu, Huihui, Qiu, Liwei, Afridi, Saifullah, Xiang, Libing, Zhang, Xiaoming. Highly immunosuppressive HLADR(hi) regulatory T cells are associated with unfavorable outcomes in cervical squamous cell carcinoma. INTERNATIONAL JOURNAL OF CANCER[J]. 2020, 146(7): 1993-2006, http://dx.doi.org/10.1002/ijc.32782.
[10] Wu, Chunmei, Fu, Qiong, Guo, Qiang, Chen, Sheng, Goswami, Shyamal, Sun, Shuhui, Li, Teng, Cao, Xingjian, Chu, Fuying, Chen, Zechuan, Liu, Mei, Liu, Yuanhua, Fu, Ting, Hao, Pei, Hao, Yi, Shen, Nan, Bao, Chunde, Zhang, Xiaoming. Lupus-associated atypical memory B cells are mTORC1-hyperactivated and functionally dysregulated. ANNALS OF THE RHEUMATIC DISEASES[J]. 2019, 78(8): 1090-1100, https://www.webofscience.com/wos/woscc/full-record/WOS:000484452500026.

   

（ 1 ） 青年****, 主持, 国家级, 2012-01--2014-12
（ 2 ） 中国科学院知识创新工程, 主持, 部委级, 2012-01--2014-12
（ 3 ） 新生期天然调节性 B 细胞激活的分子机制及其免疫调节功能研究, 主持, 国家级, 2013-01--2016-12
（ 4 ） B细胞亚群在狼疮免疫调节紊乱中的作用及分子机制研究, 主持, 国家级, 2014-01--2018-12
（ 5 ） 重症脓毒症外周浆细胞的产生机制、免疫调节功能及临床意义研究, 主持, 国家级, 2015-01--2018-12

（1）Glycosidic Tn-based vaccines targeting dermal MGL+CD103- dendritic cells favor Th2 and potent antibody responses   Xiaoming Zhang   2010-12-16

现指导学生

方逸苑  01  19178  

邵殿慧  01  19178  

刘妹  01  19178  

王友平  01  19178  

王静  01  19182  

徐慧晖  01  19182